UniProtKB - D3ZZP8 (D3ZZP8_RAT)
Protein
Submitted name:
Cullin 9
Gene
Cul9
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- ubiquitin protein ligase binding Source: InterPro
GO - Biological processi
- microtubule cytoskeleton organization Source: RGD
- protein ubiquitination Source: RGD
- regulation of mitotic nuclear division Source: RGD
- ubiquitin-dependent protein catabolic process Source: InterPro
Keywordsi
Molecular function | TransferaseARBA annotation |
Biological process | Ubl conjugation pathwayARBA annotation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-RNO-8951664, Neddylation |
Names & Taxonomyi
Protein namesi | Submitted name: Cullin 9Imported |
Gene namesi | Name:Cul9Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1562008, Cul9 |
Subcellular locationi
Other locations
- Cytoplasm ARBA annotation
Cytosol
- cytosol Source: Ensembl
Other locations
- cullin-RING ubiquitin ligase complex Source: RGD
PTM / Processingi
Keywords - PTMi
Ubl conjugationARBA annotationProteomic databases
PaxDbi | D3ZZP8 |
PeptideAtlasi | D3ZZP8 |
PRIDEi | D3ZZP8 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000018372, Expressed in brain and 21 other tissues |
ExpressionAtlasi | D3ZZP8, baseline and differential |
Interactioni
GO - Molecular functioni
- ubiquitin protein ligase binding Source: InterPro
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000028786 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1136 – 1315 | DOCInterPro annotationAdd BLAST | 180 | |
Domaini | 1537 – 1805 | CULLIN_2InterPro annotationAdd BLAST | 269 | |
Domaini | 2060 – 2277 | RING-typeInterPro annotationAdd BLAST | 218 | |
Domaini | 2230 – 2273 | RING-typeInterPro annotationAdd BLAST | 44 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 275 – 294 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 576 – 631 | DisorderedSequence analysisAdd BLAST | 56 | |
Regioni | 1426 – 1458 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 2433 – 2514 | DisorderedSequence analysisAdd BLAST | 82 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 112 – 132 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 1649 – 1669 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 2359 – 2379 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 601 – 617 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1437 – 1458 | PolarSequence analysisAdd BLAST | 22 | |
Compositional biasi | 2433 – 2452 | PolarSequence analysisAdd BLAST | 20 | |
Compositional biasi | 2453 – 2490 | AcidicSequence analysisAdd BLAST | 38 |
Sequence similaritiesi
Belongs to the cullin family.PROSITE-ProRule annotation
Keywords - Domaini
Coiled coilSequence analysis, RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG1815, Eukaryota |
GeneTreei | ENSGT00940000153954 |
HOGENOMi | CLU_001067_0_0_1 |
InParanoidi | D3ZZP8 |
OMAi | KPWKPNH |
OrthoDBi | 469819at2759 |
TreeFami | TF101154 |
Family and domain databases
Gene3Di | 2.30.30.30, 1 hit 2.60.120.260, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR004939, APC_su10/DOC_dom IPR016024, ARM-type_fold IPR021097, CPH_domain IPR031222, CUL9 IPR016157, Cullin_CS IPR016158, Cullin_homology IPR036317, Cullin_homology_sf IPR001373, Cullin_N IPR019559, Cullin_neddylation_domain IPR008979, Galactose-bd-like_sf IPR002867, IBR_dom IPR014722, Rib_L2_dom2 IPR044066, TRIAD_supradom IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
PANTHERi | PTHR22771:SF2, PTHR22771:SF2, 1 hit |
Pfami | View protein in Pfam PF03256, ANAPC10, 1 hit PF11515, Cul7, 1 hit PF00888, Cullin, 1 hit PF01485, IBR, 2 hits |
SMARTi | View protein in SMART SM01337, APC10, 1 hit SM00884, Cullin_Nedd8, 1 hit SM00647, IBR, 2 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF49785, SSF49785, 1 hit SSF75632, SSF75632, 1 hit |
PROSITEi | View protein in PROSITE PS01256, CULLIN_1, 1 hit PS50069, CULLIN_2, 1 hit PS51284, DOC, 1 hit PS51873, TRIAD, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
D3ZZP8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVGEQRAGDL MVPLGPRLQA YPEELIRQRP GHDGHPEYLI RWRVLKCSEE
60 70 80 90 100
GKVSLEEEKT EYLLMWLSAP EVYANCPMLL RERSVSKGPQ YEPTGEVGSF
110 120 130 140 150
PRDPGGLDEL AMAEMEDDVR ALVRRAARQL AEGGASNLTV AVLHTIHVLS
160 170 180 190 200
AYASIGPLTG VFRETGALDL LMHMLCSPEP QIRRSAGKML QALAAHDAGS
210 220 230 240 250
RAHVLLSLSQ HEGIEQHMDF DSRYTLLELF AETTSTEEHC MALEGIHLPQ
260 270 280 290 300
LPGKLLFSLV KRYLCVTSLL DQLNNSPESG AGDQSSPCLP KEKSRGQREL
310 320 330 340 350
EFSMAVGNLI SELVRSMGWA RNLSEQGALP PRPSRSIFQP CLSGPPLLLP
360 370 380 390 400
TIVTTPRKPG RAFRGRSEFS SRSGYGEYVQ QTVQPGMRVR ILDDYEEISA
410 420 430 440 450
GDEGEFQQSN NGVPPVQVFW QSTGRTYWVH WHMLEILGPE EATREPASAA
460 470 480 490 500
VEKGAGATAL GTACPSWDRK PAHGLYSLPY LQPESQKSEE PGYLTQGEWW
510 520 530 540 550
ELLFFIKKLD LCEQQPIFQN LHEKLDKEAV GEKTLGEISV PIEMAEGVLQ
560 570 580 590 600
VLSNRFEGSN LCDLLNSHIY TKYGRLPKEP GRLPPSRGHS CTSEPEEGSE
610 620 630 640 650
SAASFSEKEE SPKAEAEPAG AKPESPKAQS DSQLFNQLLV TEGMALAPET
660 670 680 690 700
QAAATEMART LRGPGPRSSL DQHVAAVLAT VQISSLDTNL QLSGLGALSQ
710 720 730 740 750
AVEEVTERDH PLVRPDRSLR EKLVKTLVDL LTNQVGEKMV VVLALRLLYL
760 770 780 790 800
LMTKHEWRPL FAREGGIYAV LICMQEYKTS VLVQQAGLAA LKMLAIANSS
810 820 830 840 850
EVPTFVTGRD SIQPLFDTQM TREIFASIDS ATRPGSESLL LSVPAAVVLM
860 870 880 890 900
LNTEGCSSAV RNGLLLLNLL LCNHHTLGDQ IITQELRDTL FRHSGIAPGT
910 920 930 940 950
EPMPTTRTIL MMLLSRYSEP WGSPERAALE TPSTQGQDGS PESLIRSLVG
960 970 980 990 1000
DLSAELFLDL ERVLCHEGSP QGAMTPLLKR LQQETQPFLL LLRTLDAPGP
1010 1020 1030 1040 1050
NRALLLTVLR VMTRLLDYPE TMVLPWHEVL EPCLNCLNGP SSDSEVVQEL
1060 1070 1080 1090 1100
TCFLHRLALM HKDYAVVLCC LGAKEALSKV LDKHSTQLLL ASELRHLVTE
1110 1120 1130 1140 1150
CEKYAQLYTN LTSSLLAACI QMVLGQIEDH RRTYKPINIP FFDVFLRHLC
1160 1170 1180 1190 1200
QGSSVEVKED RCWEKVEVSS NPHRASKLTD RNPKTYWESN GSTGSHSITL
1210 1220 1230 1240 1250
HMHRGVLIRQ LTLLVASEDS SYMPARVVVF GGDSVGCIST ELNTVNVVPS
1260 1270 1280 1290 1300
ASRVTLLENL SRFWPIIQIR IKRCQQGGID TRVRGVEVLG PKPTFWPLFR
1310 1320 1330 1340 1350
EQLCRRTCLF YTIRAQAWSR DIAEDRQRLL QLYPRLNRVL RHEQNFADRF
1360 1370 1380 1390 1400
LPDDEAAQAL GKTCWEALVS PLVQNITSPD AGGVSSLGWL LDQYLEHREK
1410 1420 1430 1440 1450
ARSRQGQAAS FASQVRRLCH LLVHVEAPPG PSPEPSSQPL SKSSKSQDGS
1460 1470 1480 1490 1500
PAPAPVRPST TLRNITQCWL AVVQGQASRF LASAWRASDF VPRYCDLYER
1510 1520 1530 1540 1550
LQRAGSELFG PRAAFTLALR SGFSGALLQQ SFLTAAHISE QFARHIDQQI
1560 1570 1580 1590 1600
QGGLLGGAAG VEMLGRLQRH LEPIMVLSGL ELATTFEHFY QYYMADRLLS
1610 1620 1630 1640 1650
LGSSWLEGAV LEQIGLCFPN RLPQLMLQSL RTSEELQRGF LLFQLQQLDR
1660 1670 1680 1690 1700
QLLEQGEQEE WKLERLEEED RGQETGRELL TEDPGPAISV LVLSPRCWPV
1710 1720 1730 1740 1750
SPLCYLHQPR KHLPTEFCDA LDGFSSFYSH SQHYPVLDMG PHRRLQWTWL
1760 1770 1780 1790 1800
GRAELQFGDQ TLHVSTVQMW LLLNFNQTEE VSVEILLRNS GLSPELLHQA
1810 1820 1830 1840 1850
LLPLTSDSGP LTLEEAQDFP QGGVLRLREP RSQTHEEVLW LIPPQTYLSV
1860 1870 1880 1890 1900
EKDEGRTLEQ KRNLLSCLLV RILKAHGEKG LHIDQLVCLV LEAWQKGPNP
1910 1920 1930 1940 1950
PGRLGRSAAV GVACSSTDVL SCILHLLGQG YVERRDDRPQ VLMYATPEPM
1960 1970 1980 1990 2000
GHCRGQADVP FCGNQSTETS KPSPEAVVAL ASLQLPAGRT MSPQEVEGLM
2010 2020 2030 2040 2050
EQTVRQVQET LNLEPDVAQH LLAYSHWGTE QLLQSYSEDP EPLLLAAGLR
2060 2070 2080 2090 2100
VPQPQEVPAR PDQCPVCISP LGPNDDSPSL CCLHCCCKSC WNEYLTTRIE
2110 2120 2130 2140 2150
QNFVLNCTCP IADCPAQPTG AFIRNIVSSP EVISKYEKAL LRGYVESCSN
2160 2170 2180 2190 2200
LTWCTNPQGC DRILCRQGLG SGTTCSKCGW ASCFNCSFPE AHYPASCGHM
2210 2220 2230 2240 2250
SQWVDDGGYY DGMSVEAQSK HLAKLISKRC PSCQAPIEKN EGCLHMTCAR
2260 2270 2280 2290 2300
CNHGFCWRCL RSWKPSHKDY YNCSAMVSKA ARQEKRFQDY NERCTFHHQA
2310 2320 2330 2340 2350
REFAVNLRNQ ASAIHEVPPP KSFTFLQDAC RALEQARKVL AYACVYSFYS
2360 2370 2380 2390 2400
QGTEYMDVVE QQTENLELHT NALQILLEET LLRCQDLASS LRLLRADCLS
2410 2420 2430 2440 2450
TGTELLRRIQ ERLLAILQHS TQDFRVGLQS PSVETREVKG SNVPSDQPQG
2460 2470 2480 2490 2500
SSGLEVEDEE EEEEEEEEED VPEWQHEFDE ELDNDSFSYD EESENLDRET
2510
FFFGDEDDDD ESYD
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2K652 | A0A0G2K652_RAT | Cullin 9 | Cul9 | 2,513 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07066803 Genomic DNA No translation available. AABR07066804 Genomic DNA No translation available. AABR07066805 Genomic DNA No translation available. AABR07066806 Genomic DNA No translation available. AABR07066807 Genomic DNA No translation available. AABR07066808 Genomic DNA No translation available. AABR07066809 Genomic DNA No translation available. AABR07066810 Genomic DNA No translation available. |
RefSeqi | NP_001178511.1, NM_001191582.1 |
Genome annotation databases
Ensembli | ENSRNOT00000028786; ENSRNOP00000028786; ENSRNOG00000018372 |
GeneIDi | 316228 |
KEGGi | rno:316228 |
UCSCi | RGD:1562008, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07066803 Genomic DNA No translation available. AABR07066804 Genomic DNA No translation available. AABR07066805 Genomic DNA No translation available. AABR07066806 Genomic DNA No translation available. AABR07066807 Genomic DNA No translation available. AABR07066808 Genomic DNA No translation available. AABR07066809 Genomic DNA No translation available. AABR07066810 Genomic DNA No translation available. |
RefSeqi | NP_001178511.1, NM_001191582.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000028786 |
Proteomic databases
PaxDbi | D3ZZP8 |
PeptideAtlasi | D3ZZP8 |
PRIDEi | D3ZZP8 |
Genome annotation databases
Ensembli | ENSRNOT00000028786; ENSRNOP00000028786; ENSRNOG00000018372 |
GeneIDi | 316228 |
KEGGi | rno:316228 |
UCSCi | RGD:1562008, rat |
Organism-specific databases
CTDi | 23113 |
RGDi | 1562008, Cul9 |
Phylogenomic databases
eggNOGi | KOG1815, Eukaryota |
GeneTreei | ENSGT00940000153954 |
HOGENOMi | CLU_001067_0_0_1 |
InParanoidi | D3ZZP8 |
OMAi | KPWKPNH |
OrthoDBi | 469819at2759 |
TreeFami | TF101154 |
Enzyme and pathway databases
Reactomei | R-RNO-8951664, Neddylation |
Gene expression databases
Bgeei | ENSRNOG00000018372, Expressed in brain and 21 other tissues |
ExpressionAtlasi | D3ZZP8, baseline and differential |
Family and domain databases
Gene3Di | 2.30.30.30, 1 hit 2.60.120.260, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR004939, APC_su10/DOC_dom IPR016024, ARM-type_fold IPR021097, CPH_domain IPR031222, CUL9 IPR016157, Cullin_CS IPR016158, Cullin_homology IPR036317, Cullin_homology_sf IPR001373, Cullin_N IPR019559, Cullin_neddylation_domain IPR008979, Galactose-bd-like_sf IPR002867, IBR_dom IPR014722, Rib_L2_dom2 IPR044066, TRIAD_supradom IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
PANTHERi | PTHR22771:SF2, PTHR22771:SF2, 1 hit |
Pfami | View protein in Pfam PF03256, ANAPC10, 1 hit PF11515, Cul7, 1 hit PF00888, Cullin, 1 hit PF01485, IBR, 2 hits |
SMARTi | View protein in SMART SM01337, APC10, 1 hit SM00884, Cullin_Nedd8, 1 hit SM00647, IBR, 2 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF49785, SSF49785, 1 hit SSF75632, SSF75632, 1 hit |
PROSITEi | View protein in PROSITE PS01256, CULLIN_1, 1 hit PS50069, CULLIN_2, 1 hit PS51284, DOC, 1 hit PS51873, TRIAD, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D3ZZP8_RAT | |
Accessioni | D3ZZP8Primary (citable) accession number: D3ZZP8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 3, 2013 | |
Last modified: | December 2, 2020 | |
This is version 87 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |