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Entry version 64 (12 Aug 2020)
Sequence version 1 (20 Apr 2010)
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Protein

GRIP and coiled-coil domain-containing protein 2

Gene

Gcc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2 (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-6811440, Retrograde transport at the Trans-Golgi-Network

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GRIP and coiled-coil domain-containing protein 2
Alternative name(s):
185 kDa Golgi coiled-coil protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gcc2
Synonyms:Gcc185
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced
  • UP000234681 Componentsi: Chromosome 20, Unassembled WGS sequence

Organism-specific databases

Rat genome database

More...
RGDi
1305732, Gcc2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004011971 – 1679GRIP and coiled-coil domain-containing protein 2Add BLAST1679

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei1474PhosphoserineBy similarity1
Modified residuei1478PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
D3ZZL9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D3ZZL9

PeptideAtlas

More...
PeptideAtlasi
D3ZZL9

PRoteomics IDEntifications database

More...
PRIDEi
D3ZZL9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
D3ZZL9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
D3ZZL9

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
D3ZZL9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
D3ZZL9, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts (via GRIP domain) with RAB6A (preferentially in its GTP-bound form). May interact (RAB6A-dependent) with ARL1; might be involved in GCC2 Golgi localization.

Interacts with CLASP1 and CLASP2; recruits both proteins to membranes of the TGN.

Interacts with STX16 (By similarity).

Interacts (probably via GRIP domain) with RAB9A (preferentially in its GTP-bound form).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000001092

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3ZZL9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1604 – 1654GRIPPROSITE-ProRule annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1569 – 1679Mediates interaction with RAB9ABy similarityAdd BLAST111
Regioni1569 – 1608Mediates interaction with RAB6ABy similarityAdd BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili35 – 1469Sequence analysisAdd BLAST1435

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Extended rod-like protein with coiled-coil domains.

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0864, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002922_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D3ZZL9

KEGG Orthology (KO)

More...
KOi
K20282

Database for complete collections of gene phylogenies

More...
PhylomeDBi
D3ZZL9

TreeFam database of animal gene trees

More...
TreeFami
TF332907

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032023, GCC2_Rab_bind
IPR000237, GRIP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01465, GRIP, 1 hit
PF16704, Rab_bind, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00755, Grip, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50913, GRIP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

D3ZZL9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDSAQDAVT AAPSGTPKSK LETLPREDLI KFAKKQMMLL QKAKARCTEL
60 70 80 90 100
DKEVEELKSK PVDGGTDDMI KVLTERLDAL LLEKAETEQQ CLCLKKENIK
110 120 130 140 150
MKQEVEDSVT KLEETQKEFE QSHRNYVREM ESVKNELIAV HSEHSKEKAA
160 170 180 190 200
LQRDLEGAVH RQAELLEQLK SQSDSEDNVK KLQEEIQNIT AAFEEQTSCL
210 220 230 240 250
QKQLEATSDE KQQEIIHLQK VIEDNAQHYQ KDINTFQEEI VQLRATHKEE
260 270 280 290 300
VNELMSQMET LAKEHEAAVN KLKENRVTLC ETSETIPENY QCESESLNED
310 320 330 340 350
TSDASQENQK CSVALQEDPF AEHTVYDKVR QLEDSLKELE SQHSILKDEV
360 370 380 390 400
TYMNNLKLKL EMDAQHIKDE FFHEREDLEF KINELLLAKE EQSYVVEKLK
410 420 430 440 450
YEREDLNRQL CCTVEQHNKE IQRLQEHHQK EISELSETFM SGSEKEKLAL
460 470 480 490 500
MFEIQGLKEQ CENLQHEKQE VVLNYESLRE MMEILQTELG ESAGKISQEF
510 520 530 540 550
ETMKQQQASD VHELQQKLRT AFNEKDALLE TINRLQGENE KLLSQELVSE
560 570 580 590 600
LESTMKNLKA DNSMYLASLG QKDTLLQELE AKISSLAEEK DDFISKIKTS
610 620 630 640 650
REEIDDLHQK WEREQKLSVE LREAAEQAAQ HNSELRQRVS ELTGKLDEIL
660 670 680 690 700
REKSQNDQNI MVQMKTMTED QEALSSKIKS LYEENNRLHS EKVQLSRDLE
710 720 730 740 750
ALQSQQDFAY KEHVAEFEKK LQLMVEERDD LNKLLENEQL QKSFVKTQLY
760 770 780 790 800
EFLKQMRPSI LEDNEEEDVV TVLKAVGESL VTVKEEKHNL VFEYDARVLE
810 820 830 840 850
LERRIKCLQE ESVVQCEELR ALVRDSEQEK ILLRKELDEV TSTKEALQCD
860 870 880 890 900
ILEMKNTNEK TSLENQTLST RVEELSRSLH SKNEVHNEKD LVIEHENLRL
910 920 930 940 950
SLEQRESELQ DVRAELMLLK DSLEKSPSVK NDQLSLVKEL EEKIESLEKE
960 970 980 990 1000
SKDKDEKISK IKLVAVRAKK ELDSNRKEAQ TLRDELESVQ SEKDRLSASM
1010 1020 1030 1040 1050
KEFIQGAESY KNLLLEYDKQ SEQLDVEKER ANNFEHHIED LTKQLRDSTC
1060 1070 1080 1090 1100
QYEKLTSDNE DLLARIETLQ ANARLLEAQI LEVQRAKGVV EKELEAEKLQ
1110 1120 1130 1140 1150
KEQKIKEHVS TTNELEELQL QFQKEKKQLQ KTMQELELVK KDAQQTTLMN
1160 1170 1180 1190 1200
MEIADYERLM KELNQKLTNK NSKIEDLEQE MKIQKQKQET LQEEMTSLQS
1210 1220 1230 1240 1250
SVQHYEEKNA QIKQLLVKTK KELADAKQAE TDHLLLQASL KGELEASQQQ
1260 1270 1280 1290 1300
VEVYKIQLAE MTSEKHKIHE HLKTSAEQHQ RTLSAYQQRV VALQEESRTA
1310 1320 1330 1340 1350
KAEQAAVTSE FENYKVRVHN VLKQQKNKSV SQAETEGAKQ EREHLEMLID
1360 1370 1380 1390 1400
QLKIKLQDSQ NSLQISVSEF QTLQSEHDTL LERHNRMLQE TVTKEAELRE
1410 1420 1430 1440 1450
KLCSAQSENT MLKSEHAQTM CQLTSQNEAL RNSFRDQVRH LQDEHRKTVE
1460 1470 1480 1490 1500
TLQHQLSKVE TQLFQLKSEP PTKSPASSHQ PSKSLRERRT TDLPLLDMHT
1510 1520 1530 1540 1550
VTREEGEGME TTDSESVSSA GTHIQSLEQL LSSPDSKLER LTEASLWHTE
1560 1570 1580 1590 1600
FTKEELAEKL SSTTKSADHL NGLLRETEAT NAILMEQIKL LKSEIRRLER
1610 1620 1630 1640 1650
NQEREKSVAN LEYLKNVLLR FIFLKPGSER ERLLPVIDTM LQLSPEEKGK
1660 1670
LATVAQGEEE SASRSSGWAS YLHSWSGLR
Length:1,679
Mass (Da):195,083
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD208E89250B0CF22
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0H2UH94A0A0H2UH94_RAT
GRIP and coiled-coil domain-contain...
Gcc2
1,681Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC114045 Genomic DNA No translation available.
CH474016 Genomic DNA Translation: EDL93092.1

NCBI Reference Sequences

More...
RefSeqi
NP_001101103.1, NM_001107633.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
309798

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:309798

UCSC genome browser

More...
UCSCi
RGD:1305732, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114045 Genomic DNA No translation available.
CH474016 Genomic DNA Translation: EDL93092.1
RefSeqiNP_001101103.1, NM_001107633.1

3D structure databases

SMRiD3ZZL9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001092

PTM databases

iPTMnetiD3ZZL9
PhosphoSitePlusiD3ZZL9
SwissPalmiD3ZZL9

Proteomic databases

jPOSTiD3ZZL9
PaxDbiD3ZZL9
PeptideAtlasiD3ZZL9
PRIDEiD3ZZL9

Genome annotation databases

GeneIDi309798
KEGGirno:309798
UCSCiRGD:1305732, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9648
RGDi1305732, Gcc2

Phylogenomic databases

eggNOGiKOG0864, Eukaryota
HOGENOMiCLU_002922_0_0_1
InParanoidiD3ZZL9
KOiK20282
PhylomeDBiD3ZZL9
TreeFamiTF332907

Enzyme and pathway databases

ReactomeiR-RNO-6811440, Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

Protein Ontology

More...
PROi
PR:D3ZZL9

Gene expression databases

GenevisibleiD3ZZL9, RN

Family and domain databases

InterProiView protein in InterPro
IPR032023, GCC2_Rab_bind
IPR000237, GRIP_dom
PfamiView protein in Pfam
PF01465, GRIP, 1 hit
PF16704, Rab_bind, 1 hit
SMARTiView protein in SMART
SM00755, Grip, 1 hit
PROSITEiView protein in PROSITE
PS50913, GRIP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGCC2_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZZL9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: April 20, 2010
Last modified: August 12, 2020
This is version 64 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
UniProt is an ELIXIR core data resource
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