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Protein
Submitted name:

TNFRSF1A-associated via death domain

Gene

Tradd

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • death domain binding Source: Ensembl
  • identical protein binding Source: Ensembl
  • kinase binding Source: Ensembl
  • molecular adaptor activity Source: Ensembl
  • protein-containing complex binding Source: RGD
  • tumor necrosis factor receptor binding Source: RGD

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-3371378 Regulation by c-FLIP
R-RNO-5213460 RIPK1-mediated regulated necrosis
R-RNO-5218900 CASP8 activity is inhibited
R-RNO-5357786 TNFR1-induced proapoptotic signaling
R-RNO-5357905 Regulation of TNFR1 signaling
R-RNO-5357956 TNFR1-induced NFkappaB signaling pathway
R-RNO-69416 Dimerization of procaspase-8
R-RNO-75893 TNF signaling

Names & Taxonomyi

Protein namesi
Submitted name:
TNFRSF1A-associated via death domainImported
Gene namesi
Name:TraddImported
ORF Names:rCG_51460Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi621313 Tradd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSRNOG00000015179

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020405

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini213 – 303DeathInterPro annotationAdd BLAST91

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili270 – 290Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IF81 Eukaryota
ENOG4111IRA LUCA
GeneTreeiENSGT00390000002016
KOiK03171
OMAiFCGRQPC
OrthoDBiEOG091G0DXR
TreeFamiTF331882

Family and domain databases

Gene3Di3.30.70.680, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR035712 TRADD
IPR009095 TRADD_N
IPR036729 TRADD_N_sf
PANTHERiPTHR14913 PTHR14913, 1 hit
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF09034 TRADD_N, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD182470 TRADD_N, 1 hit
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF55044 SSF55044, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

D3ZZC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAADQNGHEE WVGSAYLFLE SSMDKVVLSE AYTDPKKKVA IYKALQAALS
60 70 80 90 100
ESGDSPDVLQ ILKIHCSDPQ LIVQLRFCGR LLCGRFLQAY REGALRTALQ
110 120 130 140 150
RCMAAALAQE AVRLQLELRA GAEQLDSWLT DEERCLNYIL AQKPDRLRDE
160 170 180 190 200
ELAELEDEFC KLTCDSTGQG GATQVAPAGS KSLVSSPAEE KPLPAAGQTF
210 220 230 240 250
LFHGQLIVNR PLNLQDQQTF ARSVGLKWRR VGRSLQRSCR ALRDPALDSL
260 270 280 290 300
AYEYERDGLY EQAFQLLRRF IQAEGRRATL QRLVEALEEN ELTSLAEDLL
310
GQAEPEGGQA
Length:310
Mass (Da):34,530
Last modified:April 20, 2010 - v1
Checksum:i22B3A0A700B03F51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120484 Genomic DNA No translation available.
CH473972 Genomic DNA Translation: EDL92353.1
RefSeqiNP_001093950.1, NM_001100480.1
XP_006255506.1, XM_006255444.3
UniGeneiRn.18545

Genome annotation databases

EnsembliENSRNOT00000020405; ENSRNOP00000020405; ENSRNOG00000015179
GeneIDi246756
KEGGirno:246756

Similar proteinsi

Entry informationi

Entry nameiD3ZZC5_RAT
AccessioniPrimary (citable) accession number: D3ZZC5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: July 18, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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