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Protein

Obscurin-like protein 1

Gene

Obsl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (By similarity). Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons.By similarity1 Publication

GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • muscle alpha-actinin binding Source: GO_Central
  • structural constituent of muscle Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
Obscurin-like protein 1By similarity
Gene namesi
Name:Obsl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1306073 Obsl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004221231 – 1805Obscurin-like protein 1Add BLAST1805

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineBy similarity1
Disulfide bondi33 ↔ 84PROSITE-ProRule annotation
Disulfide bondi149 ↔ 209PROSITE-ProRule annotation
Disulfide bondi267 ↔ 319PROSITE-ProRule annotation
Disulfide bondi362 ↔ 412PROSITE-ProRule annotation
Disulfide bondi738 ↔ 788PROSITE-ProRule annotation
Disulfide bondi829 ↔ 879PROSITE-ProRule annotation
Disulfide bondi920 ↔ 970PROSITE-ProRule annotation
Disulfide bondi1011 ↔ 1061PROSITE-ProRule annotation
Disulfide bondi1103 ↔ 1153PROSITE-ProRule annotation
Disulfide bondi1195 ↔ 1245PROSITE-ProRule annotation
Disulfide bondi1558 ↔ 1608PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiD3ZZ80
PRIDEiD3ZZ80

Expressioni

Tissue specificityi

Expressed in granule neurons, with levels decreasing with neuronal maturation.1 Publication

Gene expression databases

BgeeiENSRNOG00000015346 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiD3ZZ80 RN

Interactioni

Subunit structurei

Component of the 3M complex, composed of core components CUL7, CCDC8 and OBSL1. Interacts with CCDC8. Interacts with CUL7; the interaction is direct. Interacts with FBXW8. Interacts (via N-terminal Ig-like domain) with TTN/titin (via C-terminal Ig-like domain); the interaction is direct (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020673

Structurei

3D structure databases

ProteinModelPortaliD3ZZ80
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 100Ig-like 1Sequence analysisAdd BLAST89
Domaini128 – 225Ig-like 2Sequence analysisAdd BLAST98
Domaini240 – 330Ig-like 3Sequence analysisAdd BLAST91
Domaini339 – 425Ig-like 4Sequence analysisAdd BLAST87
Domaini517 – 615Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST99
Domaini720 – 800Ig-like 5Sequence analysisAdd BLAST81
Domaini804 – 891Ig-like 6Sequence analysisAdd BLAST88
Domaini902 – 982Ig-like 7Sequence analysisAdd BLAST81
Domaini986 – 1075Ig-like 8Sequence analysisAdd BLAST90
Domaini1078 – 1165Ig-like 9Sequence analysisAdd BLAST88
Domaini1176 – 1261Ig-like 10Sequence analysisAdd BLAST86
Domaini1266 – 1351Ig-like 11Sequence analysisAdd BLAST86
Domaini1355 – 1442Ig-like 12Sequence analysisAdd BLAST88
Domaini1536 – 1628Ig-like 13Sequence analysisAdd BLAST93
Domaini1702 – 1798Ig-like 14Sequence analysisAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni17 – 19Interaction with TTNBy similarity3
Regioni85 – 94Interaction with TTNBy similarity10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi117 – 121Poly-ProSequence analysis5

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiKOG0613 Eukaryota
ENOG410XQFD LUCA
GeneTreeiENSGT00860000133679
InParanoidiD3ZZ80
KOiK19574
OMAiRYRMEQK
OrthoDBiEOG091G0003
PhylomeDBiD3ZZ80

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 19 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF07679 I-set, 13 hits
SMARTiView protein in SMART
SM00409 IG, 17 hits
SM00408 IGc2, 14 hits
SUPFAMiSSF48726 SSF48726, 17 hits
SSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS50835 IG_LIKE, 14 hits

Sequencei

Sequence statusi: Complete.

D3ZZ80-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKASSGDQGS PPCFLRFPRP VRVVSGAEAE LKCVVLGEPP PTVLWEKGGQ
60 70 80 90 100
QLVASERLSF PEDGAEHGLL LSGALPTDAG VYVCRARNAA GEAYAAAAVT
110 120 130 140 150
VLEPPAPEPE PQSSECPPPP PGTGEGAPVF LTGPQSQWVL RGAEVVLTCQ
160 170 180 190 200
VGGLPEPKLY WEKDGMALDE VWDSSHYTLE PDRGASDGGA SLTLRILAAR
210 220 230 240 250
LPDSGVYVCH ARNAHGHAQA GALLQVHQPH ENPPQDPDEP PVRVIEPLKC
260 270 280 290 300
APKTFWVNEG KHAKFRCYVM GKPEPEIEWH LEGRPLLPDR RRLMYRDRDG
310 320 330 340 350
GFVLKVLYCQ AKDRGLYVCA ARNSAGQTLS AVQLHVKEPR LRFTRPLQDV
360 370 380 390 400
EGREHGIVVL ECKVPNSRIP TAWFREDQRL LPCRKYEQIE EGTVRRLVIH
410 420 430 440 450
RLKADDDGVY LCEMRGRVRT VANVTVKGPI LKRLPRKLDV LEGENAVLLV
460 470 480 490 500
ETQEAGVQGC WSRDGEELPA TCQSSCGHMH ALVLPGVTRE DAGEVTFSLG
510 520 530 540 550
NSRTTTLLRV KCVKHSPPGP PVLVEMFKGQ KNTVLLTWKP PEPPPETSFI
560 570 580 590 600
YRLERQEVGS EDWIQCFSIE KAGAVEVPGD CVPTEGDYRF RICTVSEHGR
610 620 630 640 650
SPHVVFNGSA HLVPTARLVS GLEDVQVYDG EDAVFSLDLS TIIQGSWFLN
660 670 680 690 700
GELLKNDEAE GQVEPGALRY RIEQKGLQHR LILQTVKHQD NGALVGFICP
710 720 730 740 750
GVQDSAALSI QESPVHILSP QDKVLLTFTT SERVVLTCEL SRVDFPATWY
760 770 780 790 800
KDGQKVEESE SLVVKMDGRK HRLILPEAQV RDSGEFECRT EGISAFFSVT
810 820 830 840 850
VQDPPVHIVD PQEHVFVHAI TSESVMLTCE VDREDAAVHW YKDGQEVEES
860 870 880 890 900
AVIVLEKEGP RHRLVLPAAQ PSDGGEFQCV VGDERAYFTV TITDVSSWIV
910 920 930 940 950
YPNGKVYVAA VRLERVVLTC ELCRPWAEVR WTKDGEEVLE SPALLLEKED
960 970 980 990 1000
TIRRLVLPSV QLEDSGEYLC EIHDESASFT ITVTEPPVRI IYPQDEVTLH
1010 1020 1030 1040 1050
AVSLECVVLT CELSRVDAPV RWYKDGLEVE ETEALVLQSD GPRRRLVLPA
1060 1070 1080 1090 1100
AQPEDGGEFV CDAGDDSAFF TVTVTAPPER IVHPVARSLD LQFGAPGHVE
1110 1120 1130 1140 1150
LRCEVAPAGS QVRWYKDGLE VEVSDALQLG AEGPARTLTL PHAQPEDAGE
1160 1170 1180 1190 1200
YVCETRDEAV TFNVSLAELP VQFLAPEAVP NPLCVVPGEP VMLSCELSRA
1210 1220 1230 1240 1250
SAHVSWSHNG NPVKQGEGLE LRAEGPRRIL CIQAADLAHT GVYTCQSGTA
1260 1270 1280 1290 1300
PGAPSLSFNV QVAEPPPVKL VSELTPLTVH EGDDATFQCE VSPPDAEVTW
1310 1320 1330 1340 1350
LRNGAIVTPG PQLEMVHSGS SRTLIIRGCQ LKDAGTVTAR AGATDTSARL
1360 1370 1380 1390 1400
HVRETELLFL RRLQDVRAEE GQDVYLEVET GRVGAPGAVR WLRGGEPLPL
1410 1420 1430 1440 1450
DSRLTTAQDG HVHRLSIHGV LLTDQGTYGC ESHHDRTLAR LSVRPRQLRE
1460 1470 1480 1490 1500
LRPLEDVTVH EGGSATFQLE LSQEGVTGEW AQGGVRLHPG PKCHIHSEGR
1510 1520 1530 1540 1550
THCLVLSGLG LADSGCISFT ADTLRCAARL TVREVPVTIV QGPQDLEVTE
1560 1570 1580 1590 1600
GDTATFECEL SQTLADVIWE KDGQALSLSP RLRLQSLGTR RLLLLRRCSS
1610 1620 1630 1640 1650
SDAGTYCCAV GTARSGPARL TVREREVSVL GELRSLSARE GDSATFECTV
1660 1670 1680 1690 1700
SESETTGRWE LGGRALRPGG RVRIRQEGKK HILVLSELRT EDTGEVCFQA
1710 1720 1730 1740 1750
GPAQSLARLE VEALPLQMCR RPPREKTVLV DRRAVLEVTV SRPGGHVCWM
1760 1770 1780 1790 1800
REGVELCPGS KYEMRSHGTT HSLVIHDVRP EDQGTYSCQA GQDSADTQLL

VEGDD
Length:1,805
Mass (Da):197,865
Last modified:May 1, 2013 - v3
Checksum:iF5B9FBBD2DC719BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112361 Genomic DNA No translation available.
RefSeqiXP_006226950.1, XM_006226888.2
XP_006245367.1, XM_006245305.2

Genome annotation databases

EnsembliENSRNOT00000020673; ENSRNOP00000020673; ENSRNOG00000015346
GeneIDi363259
KEGGirno:363259

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112361 Genomic DNA No translation available.
RefSeqiXP_006226950.1, XM_006226888.2
XP_006245367.1, XM_006245305.2

3D structure databases

ProteinModelPortaliD3ZZ80
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020673

Proteomic databases

PaxDbiD3ZZ80
PRIDEiD3ZZ80

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020673; ENSRNOP00000020673; ENSRNOG00000015346
GeneIDi363259
KEGGirno:363259

Organism-specific databases

CTDi23363
RGDi1306073 Obsl1

Phylogenomic databases

eggNOGiKOG0613 Eukaryota
ENOG410XQFD LUCA
GeneTreeiENSGT00860000133679
InParanoidiD3ZZ80
KOiK19574
OMAiRYRMEQK
OrthoDBiEOG091G0003
PhylomeDBiD3ZZ80

Enzyme and pathway databases

ReactomeiR-RNO-8951664 Neddylation

Miscellaneous databases

PROiPR:D3ZZ80

Gene expression databases

BgeeiENSRNOG00000015346 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiD3ZZ80 RN

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 19 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF07679 I-set, 13 hits
SMARTiView protein in SMART
SM00409 IG, 17 hits
SM00408 IGc2, 14 hits
SUPFAMiSSF48726 SSF48726, 17 hits
SSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS50835 IG_LIKE, 14 hits
ProtoNetiSearch...

Entry informationi

Entry nameiOBSL1_RAT
AccessioniPrimary (citable) accession number: D3ZZ80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2013
Last sequence update: May 1, 2013
Last modified: November 7, 2018
This is version 64 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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