Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Receptor (TNFRSF)-interacting serine-threonine kinase 1 (Predicted)

Gene

Ripk1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseImported, ReceptorImported, Transferase

Enzyme and pathway databases

ReactomeiR-RNO-3295583 TRP channels
R-RNO-3371378 Regulation by c-FLIP
R-RNO-5213460 RIPK1-mediated regulated necrosis
R-RNO-5218900 CASP8 activity is inhibited
R-RNO-5357786 TNFR1-induced proapoptotic signaling
R-RNO-5357905 Regulation of TNFR1 signaling
R-RNO-5357956 TNFR1-induced NFkappaB signaling pathway
R-RNO-5689880 Ub-specific processing proteases
R-RNO-5689896 Ovarian tumor domain proteases
R-RNO-69416 Dimerization of procaspase-8
R-RNO-75893 TNF signaling

Names & Taxonomyi

Protein namesi
Submitted name:
Receptor (TNFRSF)-interacting serine-threonine kinase 1 (Predicted)Imported
Submitted name:
Receptor-interacting serine/threonine kinase 1Imported
Gene namesi
Name:Ripk1Imported
Synonyms:Ripk1_predictedImported
ORF Names:rCG_43941Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1310158 Ripk1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSRNOG00000017787

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023962

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 289Protein kinaseInterPro annotationAdd BLAST273
Domaini570 – 656DeathInterPro annotationAdd BLAST87

Phylogenomic databases

eggNOGiKOG0192 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00550000074536
KOiK02861
OMAiVMEYMEK
OrthoDBiEOG091G0479
TreeFamiTF106506

Family and domain databases

CDDicd08777 Death_RIP1, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR025735 RHIM_dom
IPR037934 RIP1_Death
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF12721 RHIM, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

D3ZYL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPDMSLDNI KMASDDLLER KDLDSGGFGK VSLCFHRTHG FVILKKVYTG
60 70 80 90 100
PNRAEYNEAL LEEGKMMHRL RHDRVVKLLG IIIEEGNYSL VMEYMEQGNL
110 120 130 140 150
MHVLKTKESV PLSVKGRIIV EIIEGMHYLH DEGVIHKDLK PENILVDRDF
160 170 180 190 200
HIKIADLGVA SFKTWSKLTK EEHNKQREAS SVTKKNGGTL YYMAPEHLTD
210 220 230 240 250
INTKPTEKSD VYSFAIVLWA IFANKEPYEN VICTEQFLVC INSGNRPNVE
260 270 280 290 300
DILEFCPREI ISLMERCWQT NPEDRPTFFG IEKEFKPFYL SQFEEYVEED
310 320 330 340 350
VASLKKEYPS QSPVLKRMFS LQHDCVPLPP SRSNSEQPGS LHSSQGLPMG
360 370 380 390 400
PVEESWFSSS PEYPQEENER SVQAKLQEEA SYHAFGIFAE KQTKSQPRLN
410 420 430 440 450
EAYNREEERK RRVSHDPFAQ QRVHENVKSA GAKGLPYPST TSHGNAAHQL
460 470 480 490 500
SGPASQIKVP LWNNGVYNHH GFGATGTGVW YGPSVSQSYN AYKTPVPETN
510 520 530 540 550
LPGSIPTMPY ISLAPPDDSI RCTIYNSSRV QIGNYNYMDL GPSSQPPTNT
560 570 580 590 600
CKVESTSRHQ AVFANTTSLT DKHLNPIREN MGKQWKNCAR KLGFTESQID
610 620 630 640 650
EIDHDYERDG LKEKVYQMLQ KWLMREGTKG ATVGKLAQAL HQCCRTDLLN

QLIQASQS
Length:658
Mass (Da):74,756
Last modified:April 20, 2010 - v1
Checksum:i3AB7A360FB800DF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07027441 Genomic DNA No translation available.
CH473977 Genomic DNA Translation: EDL98323.1
RefSeqiNP_001100820.1, NM_001107350.1
XP_017456012.1, XM_017600523.1
XP_017456013.1, XM_017600524.1
XP_017456014.1, XM_017600525.1
XP_017456015.1, XM_017600526.1
XP_017456016.1, XM_017600527.1
XP_017456017.1, XM_017600528.1
XP_017456018.1, XM_017600529.1
UniGeneiRn.7572

Genome annotation databases

EnsembliENSRNOT00000023962; ENSRNOP00000023962; ENSRNOG00000017787
GeneIDi306886
KEGGirno:306886
UCSCiRGD:1310158 rat

Similar proteinsi

Entry informationi

Entry nameiD3ZYL0_RAT
AccessioniPrimary (citable) accession number: D3ZYL0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: July 18, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health