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UniProtKB - D3ZXU0 (D3ZXU0_RAT)
Protein
Submitted name:
Zinc finger with KRAB and SCAN domains 2
Gene
Zkscan2
Organism
Rattus norvegicus (Rat)
Status
Functioni
May be involved in transcriptional regulation.
ARBA annotationGO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Zinc finger with KRAB and SCAN domains 2Imported |
Gene namesi | Name:Zkscan2Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1359568, Zkscan2 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000024245, Expressed in frontal cortex and 5 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 45 – 126 | SCAN boxInterPro annotationAdd BLAST | 82 | |
Domaini | 222 – 293 | KRABInterPro annotationAdd BLAST | 72 | |
Domaini | 768 – 795 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 796 – 823 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 824 – 851 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 852 – 879 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 880 – 907 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 908 – 935 | C2H2-typeInterPro annotationAdd BLAST | 28 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 173 – 201 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 587 – 654 | DisorderedSequence analysisAdd BLAST | 68 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 173 – 194 | Basic and acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 594 – 608 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.ARBA annotation
Keywords - Domaini
RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161884 |
HOGENOMi | CLU_002678_88_0_1 |
InParanoidi | D3ZXU0 |
OMAi | NGHMLEP |
OrthoDBi | 1318335at2759 |
TreeFami | TF336839 |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR044822, Myb_DNA-bind_4 IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF13837, Myb_DNA-bind_4, 2 hits PF02023, SCAN, 1 hit PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
i Sequence
Sequence statusi: Complete.
D3ZXU0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATVINPQMD VEVEECLIMK VEKDSGWASE PILERSDSTE CESFRKCFRQ
60 70 80 90 100
FCYEDVTGPH EAFSKLWELC CRWLKPEMRS KEQILEQLVI EQFLTILPEK
110 120 130 140 150
IQAWAQRQCP ESGEEAVALV VHLEKETRRL RKQVSGPQHS EKQAPPRTVW
160 170 180 190 200
EVANYEPEQL ETQHRVVSRE EAGNFHSGHQ EQLNQKREHR PLPKNAHSSV
210 220 230 240 250
WAPVPSSEWT AVDEEATTQE PVRDIHTVRS FPYKRSVQQV PAHRDLYHEI
260 270 280 290 300
RKESACSVVS LGDTVSAPNK IAQLEQKKEP WTVGLHSSNK RTSVLQSKIS
310 320 330 340 350
KEKSVHAVQI PARNAGKVWR EQQQWGLEDE KIAGVHWSYE ETKTFLAILK
360 370 380 390 400
ESRFYETLQA CPRNSQVYGA VAEWLRECGF LRTPEQCRTK FKSLQKSYRK
410 420 430 440 450
VRNGHMLEPC AFFEDMDALL NPEAHTSSTE RPKAVISLPL KRTAVSAKEQ
460 470 480 490 500
VSLVEEEEGA EDSDGDEVGI EFVRKSEIRA APILFQNLSG VHWGYEETKT
510 520 530 540 550
FLDILQETRF YEALQACHRK SKLYGVVAEQ LRECGFLRTP EQCRTKFKSL
560 570 580 590 600
QKSYRKVKNG HVLESCAFYK EMDALVNCRT AALPTNTSEE IPSLSRQERG
610 620 630 640 650
HIEVEPQEPT TWEPEESSQE AVLEDSGSER MSEEEITEEP EFEGSAGLPQ
660 670 680 690 700
SPTDFEIGNI IKEAPTQVIF KDTESHRALI EKPKRFVSQN TNPSKYGKRE
710 720 730 740 750
CFSGRHWENL QGVRQGKLMS QPRDTGKAVV HQRPFVGRRP YRLLKYGENF
760 770 780 790 800
GRSARLVCRM THQKENPYKC GVCGKCFGRS RSLIRHQRIH TGEKPFKCLD
810 820 830 840 850
CGKSFNDSSN FGAHLRIHTG EKPYRCRECG KCFSQSSSLI IHQRTHTGEK
860 870 880 890 900
PYQCEECGKS FTNSSHFSAH RRAHTGENPY KCGDCEKSFN NCTRFREHRR
910 920 930 940 950
IHTGEKPYTC AQCGKHFNKS SFLTKHREIH IREKPLPYSP SVYSPENLLK
960
ARSAELRKTF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07005667 Genomic DNA No translation available. |
RefSeqi | XP_001079250.1, XM_001079250.6 XP_006230261.1, XM_006230199.3 |
Genome annotation databases
Ensembli | ENSRNOT00000020281; ENSRNOP00000020281; ENSRNOG00000024245 |
GeneIDi | 368120 |
KEGGi | rno:368120 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07005667 Genomic DNA No translation available. |
RefSeqi | XP_001079250.1, XM_001079250.6 XP_006230261.1, XM_006230199.3 |
3D structure databases
SMRi | D3ZXU0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000020281 |
Proteomic databases
PaxDbi | D3ZXU0 |
Genome annotation databases
Ensembli | ENSRNOT00000020281; ENSRNOP00000020281; ENSRNOG00000024245 |
GeneIDi | 368120 |
KEGGi | rno:368120 |
Organism-specific databases
CTDi | 342357 |
RGDi | 1359568, Zkscan2 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161884 |
HOGENOMi | CLU_002678_88_0_1 |
InParanoidi | D3ZXU0 |
OMAi | NGHMLEP |
OrthoDBi | 1318335at2759 |
TreeFami | TF336839 |
Gene expression databases
Bgeei | ENSRNOG00000024245, Expressed in frontal cortex and 5 other tissues |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR044822, Myb_DNA-bind_4 IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF13837, Myb_DNA-bind_4, 2 hits PF02023, SCAN, 1 hit PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | D3ZXU0_RAT | |
Accessioni | D3ZXU0Primary (citable) accession number: D3ZXU0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 3, 2013 | |
Last modified: | January 19, 2022 | |
This is version 84 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |