Zkscan2

Functionⁱ

GO - Molecular functionⁱ

DNA-binding transcription factor activity Source: InterPro
metal ion binding Source: UniProtKB-KW
nucleic acid binding Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transcription, Transcription regulationSAAS annotation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Zinc finger with KRAB and SCAN domains 2Imported
Gene namesⁱ	Name:Zkscan2Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 1

Organism-specific databases

Rat genome database More...RGDⁱ	1359568 Zkscan2

RGDⁱ

1359568 Zkscan2

Keywords - Cellular componentⁱ

NucleusPROSITE-ProRule annotationSAAS annotation

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	D3ZXU0
PRIDEⁱ	D3ZXU0

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000024245 Expressed in 2 organ(s), highest expression level in brain

Bgeeⁱ

ENSRNOG00000024245 Expressed in 2 organ(s), highest expression level in brain

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000020281

STRINGⁱ

10116.ENSRNOP00000020281

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	D3ZXU0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	45 – 126	SCAN boxInterPro annotationAdd BLAST	82
Domainⁱ	222 – 293	KRABInterPro annotationAdd BLAST	72
Domainⁱ	768 – 795	C2H2-typeInterPro annotationAdd BLAST	28
Domainⁱ	796 – 823	C2H2-typeInterPro annotationAdd BLAST	28
Domainⁱ	824 – 851	C2H2-typeInterPro annotationAdd BLAST	28
Domainⁱ	852 – 879	C2H2-typeInterPro annotationAdd BLAST	28
Domainⁱ	880 – 907	C2H2-typeInterPro annotationAdd BLAST	28
Domainⁱ	908 – 935	C2H2-typeInterPro annotationAdd BLAST	28

Keywords - Domainⁱ

RepeatSAAS annotation, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063287
InParanoidⁱ	D3ZXU0
KEGG Orthology (KO) More...KOⁱ	K09229
OMAⁱ	TFRKCFR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KC
TreeFamⁱ	TF336839

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07936 SCAN, 1 hit
Gene3Dⁱ	1.10.4020.10, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR003309 SCAN_dom IPR038269 SCAN_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02023 SCAN, 1 hit PF00096 zf-C2H2, 6 hits
SMARTⁱ	View protein in SMART SM00431 SCAN, 1 hit SM00355 ZnF_C2H2, 6 hits
SUPFAMⁱ	SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS50804 SCAN_BOX, 1 hit PS00028 ZINC_FINGER_C2H2_1, 6 hits PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

D3ZXU0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MATVINPQMD VEVEECLIMK VEKDSGWASE PILERSDSTE CESFRKCFRQ 
        60         70         80         90        100
FCYEDVTGPH EAFSKLWELC CRWLKPEMRS KEQILEQLVI EQFLTILPEK 
       110        120        130        140        150
IQAWAQRQCP ESGEEAVALV VHLEKETRRL RKQVSGPQHS EKQAPPRTVW 
       160        170        180        190        200
EVANYEPEQL ETQHRVVSRE EAGNFHSGHQ EQLNQKREHR PLPKNAHSSV 
       210        220        230        240        250
WAPVPSSEWT AVDEEATTQE PVRDIHTVRS FPYKRSVQQV PAHRDLYHEI 
       260        270        280        290        300
RKESACSVVS LGDTVSAPNK IAQLEQKKEP WTVGLHSSNK RTSVLQSKIS 
       310        320        330        340        350
KEKSVHAVQI PARNAGKVWR EQQQWGLEDE KIAGVHWSYE ETKTFLAILK 
       360        370        380        390        400
ESRFYETLQA CPRNSQVYGA VAEWLRECGF LRTPEQCRTK FKSLQKSYRK 
       410        420        430        440        450
VRNGHMLEPC AFFEDMDALL NPEAHTSSTE RPKAVISLPL KRTAVSAKEQ 
       460        470        480        490        500
VSLVEEEEGA EDSDGDEVGI EFVRKSEIRA APILFQNLSG VHWGYEETKT 
       510        520        530        540        550
FLDILQETRF YEALQACHRK SKLYGVVAEQ LRECGFLRTP EQCRTKFKSL 
       560        570        580        590        600
QKSYRKVKNG HVLESCAFYK EMDALVNCRT AALPTNTSEE IPSLSRQERG 
       610        620        630        640        650
HIEVEPQEPT TWEPEESSQE AVLEDSGSER MSEEEITEEP EFEGSAGLPQ 
       660        670        680        690        700
SPTDFEIGNI IKEAPTQVIF KDTESHRALI EKPKRFVSQN TNPSKYGKRE 
       710        720        730        740        750
CFSGRHWENL QGVRQGKLMS QPRDTGKAVV HQRPFVGRRP YRLLKYGENF 
       760        770        780        790        800
GRSARLVCRM THQKENPYKC GVCGKCFGRS RSLIRHQRIH TGEKPFKCLD 
       810        820        830        840        850
CGKSFNDSSN FGAHLRIHTG EKPYRCRECG KCFSQSSSLI IHQRTHTGEK 
       860        870        880        890        900
PYQCEECGKS FTNSSHFSAH RRAHTGENPY KCGDCEKSFN NCTRFREHRR 
       910        920        930        940        950
IHTGEKPYTC AQCGKHFNKS SFLTKHREIH IREKPLPYSP SVYSPENLLK 
       960
ARSAELRKTF

Length:960

Mass (Da):110,506

Last modified:April 3, 2013 - v2

Checksum:ⁱA89CD08133F9FE88

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07005667 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	XP_001079250.1, XM_001079250.6 XP_006230261.1, XM_006230199.3
UniGeneⁱ	Rn.162453

Genome annotation databases

Ensemblⁱ	ENSRNOT00000020281; ENSRNOP00000020281; ENSRNOG00000024245
GeneIDⁱ	368120
KEGGⁱ	rno:368120

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
D3ZXU0	Zkscan2 protein (Fragment)		RAT		369	UniRef100_D3ZXU0

Protein	Similar proteins		Species	Score	Length	Source
D3ZXU0	Zkscan2 protein (Fragment)		RAT		369	UniRef90_D3ZXU0
MCG20985, isoform CRA_a		MOUSE		960
UPI000A315C60		MUSCR		966
UPI000A307CC6		MUSPA		965
Zkscan2 protein		MOUSE		292
+3

Protein	Similar proteins		Species	Score	Length	Source
D3ZXU0	Zinc finger protein with KRAB and SCAN domains 2		HUMAN		967	UniRef50_Q63HK3
Uncharacterized protein		CHLSB		968
Uncharacterized protein		MACMU		967
ZKSCAN2 isoform 1		PONAB		967
Uncharacterized protein		MACNE		967
+129

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07005667 Genomic DNA No translation available.
RefSeqⁱ	XP_001079250.1, XM_001079250.6 XP_006230261.1, XM_006230199.3
UniGeneⁱ	Rn.162453

3D structure databases

ProteinModelPortalⁱ	D3ZXU0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000020281

STRINGⁱ

10116.ENSRNOP00000020281

Proteomic databases

PaxDbⁱ	D3ZXU0
PRIDEⁱ	D3ZXU0

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000020281; ENSRNOP00000020281; ENSRNOG00000024245
GeneIDⁱ	368120
KEGGⁱ	rno:368120

Organism-specific databases

CTDⁱ	342357
RGDⁱ	1359568 Zkscan2

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00530000063287
InParanoidⁱ	D3ZXU0
KOⁱ	K09229
OMAⁱ	TFRKCFR
OrthoDBⁱ	EOG091G02KC
TreeFamⁱ	TF336839

Gene expression databases

Bgeeⁱ	ENSRNOG00000024245 Expressed in 2 organ(s), highest expression level in brain

Bgeeⁱ

ENSRNOG00000024245 Expressed in 2 organ(s), highest expression level in brain

Family and domain databases

CDDⁱ	cd07936 SCAN, 1 hit
Gene3Dⁱ	1.10.4020.10, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR003309 SCAN_dom IPR038269 SCAN_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF02023 SCAN, 1 hit PF00096 zf-C2H2, 6 hits
SMARTⁱ	View protein in SMART SM00431 SCAN, 1 hit SM00355 ZnF_C2H2, 6 hits
SUPFAMⁱ	SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS50804 SCAN_BOX, 1 hit PS00028 ZINC_FINGER_C2H2_1, 6 hits PS50157 ZINC_FINGER_C2H2_2, 6 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D3ZXU0_RAT
Accessionⁱ	D3ZXU0Primary (citable) accession number: D3ZXU0
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 20, 2010
	Last sequence update:	April 3, 2013
	Last modified:	November 7, 2018
	This is version 68 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - D3ZXU0 (D3ZXU0_RAT)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Zinc finger with KRAB and SCAN domains 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ