Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 103 (29 Sep 2021)
Sequence version 1 (20 Apr 2010)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Scribble planar cell polarity protein

Gene

Scrib

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-9013148, CDC42 GTPase cycle
R-RNO-9013406, RHOQ GTPase cycle
R-RNO-9696264, RND3 GTPase cycle
R-RNO-9696270, RND2 GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Scribble planar cell polarity proteinImported
Submitted name:
Similar to PDZ-domain protein scribble (Predicted), isoform CRA_bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ScribImported
Synonyms:RGD1565055_predictedImported
ORF Names:rCG_60094Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Rat genome database

More...
RGDi
1565055, Scrib

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
D3ZWS0

PRoteomics IDEntifications database

More...
PRIDEi
D3ZWS0

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
D3ZWS0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
D3ZWS0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000032574, Expressed in esophagus and 20 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
D3ZWS0, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000044022

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3ZWS0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini712 – 799PDZInterPro annotationAdd BLAST88
Domaini846 – 934PDZInterPro annotationAdd BLAST89
Domaini988 – 1077PDZInterPro annotationAdd BLAST90
Domaini1084 – 1172PDZInterPro annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni420 – 599DisorderedSequence analysisAdd BLAST180
Regioni636 – 687DisorderedSequence analysisAdd BLAST52
Regioni1211 – 1247DisorderedSequence analysisAdd BLAST37
Regioni1263 – 1499DisorderedSequence analysisAdd BLAST237
Regioni1526 – 1576DisorderedSequence analysisAdd BLAST51
Regioni1631 – 1663DisorderedSequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi423 – 443Polar residuesSequence analysisAdd BLAST21
Compositional biasi461 – 497Basic and acidic residuesSequence analysisAdd BLAST37
Compositional biasi517 – 534Polar residuesSequence analysisAdd BLAST18
Compositional biasi562 – 585Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi659 – 677Acidic residuesSequence analysisAdd BLAST19
Compositional biasi1275 – 1293Polar residuesSequence analysisAdd BLAST19
Compositional biasi1389 – 1411Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi1559 – 1573Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LAP (LRR and PDZ) protein family.ARBA annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Leucine-rich repeatARBA annotation, RepeatARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154025

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000288_18_20_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
HGLASQC

Database of Orthologous Groups

More...
OrthoDBi
284114at2759

TreeFam database of animal gene trees

More...
TreeFami
TF351429

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 4 hits
3.80.10.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR001478, PDZ
IPR036034, PDZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855, LRR_8, 2 hits
PF00595, PDZ, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369, LRR_TYP, 12 hits
SM00228, PDZ, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156, SSF50156, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450, LRR, 3 hits
PS50106, PDZ, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3ZWS0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLKCIPLWRC NRHVESVDKR HCSLQVVPEE IYRYSRSLEE LLLDANQLRE
60 70 80 90 100
LPKPFFRLLN LRKLGLSDNE IQRLPPEVAN FMQLVELDVS RNDIPEIPES
110 120 130 140 150
IKFCKALEIA DFSGNPLSRL PDGFTQLRSL AHLALNDVSL QALPGDVGNL
160 170 180 190 200
ANLVTLELRE NLLKSLPASL SFLVKLEQLD LGGNDLEVLP DTLGALPNLR
210 220 230 240 250
ELWLDRNQLS ALPPELGNLR RLVCLDVSEN RLEELPVELG GLALLTDLLL
260 270 280 290 300
SQNLLQRLPE GIGQLKQLSI LKVDQNRLCE VTEAIGDCEN LSELILTENL
310 320 330 340 350
LTALPRSLGK LTKLTNLNVD RNHLEVLPPE IGGCVALSVL SLRDNRLAVL
360 370 380 390 400
PPELAHTAEL HVLDVAGNRL RSLPFALTHL NLKALWLAEN QAQPMLRFQT
410 420 430 440 450
EDDAQTGEKV LTCYLLPQQP LPSLEDPGQQ SSPSESCSDA PLSRVSVIQF
460 470 480 490 500
EDPLEGEEDA EEAAAEKRGL QRRATPHPSE LKVMKRGIEE RRNEAFVCKP
510 520 530 540 550
DPSPPSPSEE ERRLSAESAL SGNSVPSAST ASDGEPETLP AEVQGLGQQE
560 570 580 590 600
AMPGQEEYPE EDYNEPTVHF AEDTLIPRED GEGEEGQPEA PWPLPSGRQR
610 620 630 640 650
LIRKDTPHYK KHFKISKLPQ PEAVVALLQG VQTDREGPTA GWHNGPHTPW
660 670 680 690 700
APRAHEEEEE EENRDEEEGE ASMEEDDKEE AVASAPSVKG VSFDQANNLL
710 720 730 740 750
IEPARIEEEE LTLTIVRQTG GLGISIAGGK GSTPYKGDDE GIFISRVSEE
760 770 780 790 800
GPAAHAGVRV GDKLLEVNGV ALQDAEHHEA VEALRGAGAA VQMRVWRERM
810 820 830 840 850
VEPENAVTIT PLRPEDDYSP REWRGGGLRL PLLQPETPVP LRQRHAACLV
860 870 880 890 900
RSEKGLGFSI AGGKGSTPYR AGDAGIFISR IAEGGAAHRA GTLQVGDRVL
910 920 930 940 950
SINGVDMTEA RHDHAVSLLT AASTTISLLL ERETGGAYPP SPPPHSSSTP
960 970 980 990 1000
TATVAATMTT AIPGEPLLPR LSPSLLATAL EGPYPVEEIC LPRAGGPLGL
1010 1020 1030 1040 1050
SIVGGSDHSS HPFGVQDPGV FISKVLPRGL AARCGLRVGD RILAVNGQDV
1060 1070 1080 1090 1100
REATHQEAVS ALLRPCLELC LLVRRDPPPP GMRELCIQKA PGEKLGISIR
1110 1120 1130 1140 1150
GGAKGHAGNP CDPTDEGIFI SKVSPTGAAG RDGRLRVGLR LLEVNQQSLL
1160 1170 1180 1190 1200
GLTHAEAVQL LRSVGDTLTV LVCDGFDTST TTALEVSPGV IANPFAAGLG
1210 1220 1230 1240 1250
HRNSLESISS IDRELSPEGP GKEKELASQT LPWEPESAET TGRNQEPLKL
1260 1270 1280 1290 1300
DYRVLAAVPS AGSLQRGPCA TTGGKMTEAP SSPGSQQTKP GVIQPLAQAW
1310 1320 1330 1340 1350
PRDSPAPRGR DGPCSPPSPD ELPANVKQAY RAFAAVPTVH PPENSATQPP
1360 1370 1380 1390 1400
TPGPAASPEQ LSFRERQKYF ELEVRVPQAE GPPKRVSLVG ADDLRKMQEE
1410 1420 1430 1440 1450
EARKLQQKRA QMLREEAVTS GPDTGLASDR ESLDDEQEAE QPWAGPSHAG
1460 1470 1480 1490 1500
GLSPSSPTPL GGSAPVRTAK AERRHQERLR MQSPELPAPE RALSPAERRA
1510 1520 1530 1540 1550
LEAEKRALWR AARMKSLEQD ALRAQMVLSK SQEGRGKRGP LERLAEAPSP
1560 1570 1580 1590 1600
APTPSPTPLE DFGLQTSTSP GRLPLSGKKF DYRAFAALPS SRPVYDIQSP
1610 1620 1630 1640 1650
DFVEELRTLD PSPSPGPQEE DGEVALVLLG RPSPGTVGPE DMTLCSSRRA
1660
MRPGRRGLGP VPS
Length:1,663
Mass (Da):179,854
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2CDC0E50B9473F7B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC126537 Genomic DNA No translation available.
CH473950 Genomic DNA Translation: EDM16018.1

NCBI Reference Sequences

More...
RefSeqi
NP_001178808.1, NM_001191879.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000045280; ENSRNOP00000044022; ENSRNOG00000032574

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
362938

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:362938

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126537 Genomic DNA No translation available.
CH473950 Genomic DNA Translation: EDM16018.1
RefSeqiNP_001178808.1, NM_001191879.3

3D structure databases

SMRiD3ZWS0
ModBaseiSearch...

Protein-protein interaction databases

IntActiD3ZWS0, 2 interactors
STRINGi10116.ENSRNOP00000044022

PTM databases

PhosphoSitePlusiD3ZWS0
SwissPalmiD3ZWS0

Proteomic databases

PeptideAtlasiD3ZWS0
PRIDEiD3ZWS0

Genome annotation databases

EnsembliENSRNOT00000045280; ENSRNOP00000044022; ENSRNOG00000032574
GeneIDi362938
KEGGirno:362938

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23513
RGDi1565055, Scrib

Phylogenomic databases

eggNOGiKOG0619, Eukaryota
GeneTreeiENSGT00940000154025
HOGENOMiCLU_000288_18_20_1
OMAiHGLASQC
OrthoDBi284114at2759
TreeFamiTF351429

Enzyme and pathway databases

ReactomeiR-RNO-9013148, CDC42 GTPase cycle
R-RNO-9013406, RHOQ GTPase cycle
R-RNO-9696264, RND3 GTPase cycle
R-RNO-9696270, RND2 GTPase cycle

Gene expression databases

BgeeiENSRNOG00000032574, Expressed in esophagus and 20 other tissues

Family and domain databases

Gene3Di2.30.42.10, 4 hits
3.80.10.10, 4 hits
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR001478, PDZ
IPR036034, PDZ_sf
PfamiView protein in Pfam
PF13855, LRR_8, 2 hits
PF00595, PDZ, 4 hits
SMARTiView protein in SMART
SM00369, LRR_TYP, 12 hits
SM00228, PDZ, 4 hits
SUPFAMiSSF50156, SSF50156, 4 hits
PROSITEiView protein in PROSITE
PS51450, LRR, 3 hits
PS50106, PDZ, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3ZWS0_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZWS0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: September 29, 2021
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again