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Entry version 68 (10 Feb 2021)
Sequence version 1 (20 Apr 2010)
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Protein
Submitted name:

Ellis van Creveld syndrome 2 homolog (Human) (Predicted)

Gene

Evc2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-5632684, Hedgehog 'on' state

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ellis van Creveld syndrome 2 homolog (Human) (Predicted)Imported
Submitted name:
EvC ciliary complex subunit 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Evc2Imported
Synonyms:Evc2_predictedImported
ORF Names:rCG_35913Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Rat genome database

More...
RGDi
1310417, Evc2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 35HelicalSequence analysisAdd BLAST24
Transmembranei210 – 231HelicalSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membraneARBA annotation, Cell projectionARBA annotation, Cytoplasm, CytoskeletonARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
D3ZWN3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000007025, Expressed in kidney and 21 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000009914

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3ZWN3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni41 – 72DisorderedSequence analysisAdd BLAST32
Regioni1073 – 1095DisorderedSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili373 – 400Sequence analysisAdd BLAST28
Coiled coili617 – 644Sequence analysisAdd BLAST28
Coiled coili687 – 707Sequence analysisAdd BLAST21
Coiled coili929 – 949Sequence analysisAdd BLAST21
Coiled coili985 – 1012Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQ5U, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154127

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007621_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
ENMETDT

Database of Orthologous Groups

More...
OrthoDBi
90381at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022076, Limbin
IPR026501, Limbin/Ellis-van_Creveld

The PANTHER Classification System

More...
PANTHERi
PTHR16795, PTHR16795, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12297, EVC2_like, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3ZWN3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGATGLTGTG GQATWVLAGN ILAAALVLGV GPCALPPSFP ALGPGSPSPP
60 70 80 90 100
DPVGPRASSQ HSDISRDAQG PSENGVIFQK CSLVSGQSES QTMHVQLSVN
110 120 130 140 150
NTRTPMSANL SDLLVLDDIT GLTVKESPGN VTQEGIQTFR KRFLQVGECY
160 170 180 190 200
SVSYMASLDP TALGPGESLD LPAQLIFQRP SQNRTQLRAR FTITVEEKIM
210 220 230 240 250
VLPNHGLHTA GFIAAFLISF LLTLAALFFL ARGRCLQGSM LLRCRVQHPE
260 270 280 290 300
NKLEPSPFTS ANGVSQDLSL NDQLVAILTS EEPGSMLQAL EELEIATLNQ
310 320 330 340 350
ADADLEACRN QISKDIIALL MKNLISGGHL SLQTERKMAA AFKKQFLLLE
360 370 380 390 400
NEIQEEYERK MLALTAECDL EVRKKTENQY QREMVAMEEA EEVLKRVSER
410 420 430 440 450
SAAECSSLLR TLHGLEQEDL QRSLTLQQAE DFAQAHRQLA VFQRNELHSI
460 470 480 490 500
VYTQIQSAVA KGELRPEVAK MLLQDYSKTQ ESIEELMDFF QATKRYHLSK
510 520 530 540 550
RFGHREYLVQ RLQAMETRVQ GLLSTAATQL TSLIHKHERA GYLDEDQMEM
560 570 580 590 600
LLERAQTETF SIKQKLDNDL KQEKKRLHQK LITKRRRELL QKHKEQQKEQ
610 620 630 640 650
VSLGEASSTA EDAIQYLQQW RSVMAEHTTA LEELQERLDQ AALDDLRVLT
660 670 680 690 700
VSLSEKATEE LRRLQSTAMT QELLKRSAPW LFLQQILEEH SRESAARTAQ
710 720 730 740 750
LEAEERERGQ ELVQGVRQRL QQDAPEACTE EQAELRHWEH LVFTKLCSAA
760 770 780 790 800
ISLSEEDLLR VRQEAQGCFT QLDRSLALPR VRARVLQQQM QMTWREAEFR
810 820 830 840 850
KLDQALAVPE LQSKSRKLRS KGRGKADLLK KNLEDKIRLF EERAPEDLAD
860 870 880 890 900
QVRGELLQER VQRLEAQEAH FAESLVALQF QKVARAAETL SVYTALLSIQ
910 920 930 940 950
DLLLGELSES ETLTKSACVQ ILESHRPELL ELERMLEDRL VQQEEAEQRR
960 970 980 990 1000
VLESRQRWAA DGPALGEPEE IDPERQVSAV LRQALNKGQK LLEQYQQRVR
1010 1020 1030 1040 1050
EEQQNGAVLE DSLESMETDT MASLCSQGLR LVSYLSRMTM VPGGTLLRLL
1060 1070 1080 1090 1100
SVVLPAASQP QLLALLDAVS EKHSDHTAEN ESGGEQAQAE QGKRRKHQSW
1110 1120 1130 1140 1150
WKALDSRFRA DLVSQGLERM LWARRKKESI LKKRYVPVQE RVVFPGKGSW
1160 1170 1180 1190 1200
PHLSLEPIGE LAPIPITGLD TMDILNTGEK IFVFRSPKEP EISLRVPPRR
1210
KKNFLNAKAA SRALGLD
Length:1,217
Mass (Da):137,238
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i275DB6F98329DCDB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07015810 Genomic DNA No translation available.
CH473963 Genomic DNA Translation: EDM00024.1

NCBI Reference Sequences

More...
RefSeqi
NP_001099482.1, NM_001106012.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000009914; ENSRNOP00000009914; ENSRNOG00000007025

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
289711

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:289711

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07015810 Genomic DNA No translation available.
CH473963 Genomic DNA Translation: EDM00024.1
RefSeqiNP_001099482.1, NM_001106012.1

3D structure databases

SMRiD3ZWN3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009914

Proteomic databases

PRIDEiD3ZWN3

Genome annotation databases

EnsembliENSRNOT00000009914; ENSRNOP00000009914; ENSRNOG00000007025
GeneIDi289711
KEGGirno:289711

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
132884
RGDi1310417, Evc2

Phylogenomic databases

eggNOGiENOG502QQ5U, Eukaryota
GeneTreeiENSGT00940000154127
HOGENOMiCLU_007621_0_0_1
OMAiENMETDT
OrthoDBi90381at2759

Enzyme and pathway databases

ReactomeiR-RNO-5632684, Hedgehog 'on' state

Gene expression databases

BgeeiENSRNOG00000007025, Expressed in kidney and 21 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR022076, Limbin
IPR026501, Limbin/Ellis-van_Creveld
PANTHERiPTHR16795, PTHR16795, 1 hit
PfamiView protein in Pfam
PF12297, EVC2_like, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3ZWN3_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZWN3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: February 10, 2021
This is version 68 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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