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UniProtKB - D3ZW33 (D3ZW33_RAT)

Entry version 97 (25 May 2022)
Sequence version 1 (20 Apr 2010)
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Protein
Submitted name:

BTB domain and CNC homolog 2

Gene

Bach2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingARBA annotation
Biological processTranscription, Transcription regulationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
BTB domain and CNC homolog 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Bach2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Rat genome database

More...RGDi		1562865, Bach2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Ubl conjugationARBA annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		D3ZW33

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		D3ZW33

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		D3ZW33

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000006170, Expressed in spleen and 20 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000063410

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		D3ZW33

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		D3ZW33

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 103BTBInterPro annotationAdd BLAST67
Domaini650 – 695BZIPInterPro annotationAdd BLAST46

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni150 – 170DisorderedSequence analysisAdd BLAST21
Regioni255 – 334DisorderedSequence analysisAdd BLAST80
Regioni398 – 419DisorderedSequence analysisAdd BLAST22
Regioni582 – 607DisorderedSequence analysisAdd BLAST26
Regioni778 – 814DisorderedSequence analysisAdd BLAST37

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili670 – 690Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi255 – 270Polar residuesSequence analysisAdd BLAST16
Compositional biasi295 – 309Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi582 – 603Polar residuesSequence analysisAdd BLAST22
Compositional biasi780 – 796Polar residuesSequence analysisAdd BLAST17

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3863, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158228

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_015243_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		D3ZW33

Identification of Orthologs from Complete Genome Data

More...OMAi		ESMQCCS

Database of Orthologous Groups

More...OrthoDBi		521871at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		D3ZW33

TreeFam database of animal gene trees

More...TreeFami		TF326681

Family and domain databases

Conserved Domains Database

More...CDDi		cd14719, bZIP_BACH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.710.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000210, BTB/POZ_dom
IPR004827, bZIP
IPR043321, bZIP_BACH
IPR004826, bZIP_Maf
IPR046347, bZIP_sf
IPR011333, SKP1/BTB/POZ_sf
IPR008917, TF_DNA-bd_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00651, BTB, 1 hit
PF03131, bZIP_Maf, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00338, BRLZ, 1 hit
SM00225, BTB, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47454, SSF47454, 1 hit
SSF54695, SSF54695, 1 hit
SSF57959, SSF57959, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50097, BTB, 1 hit
PS50217, BZIP, 1 hit
PS00036, BZIP_BASIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

D3ZW33-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVDEKPDSP MYVYESTVHC ANILLGLNDQ RKKDILCDVT LIVERKEFRA 
        60         70         80         90        100
HRAVLAACSE YFWQALVGQT KDDLVVSLPE EVTARGFGPL LQFAYTAKLL 
       110        120        130        140        150
LSRENIREVI RCAEFLRMHN LEDSCFSFLQ TQLLNREDGL FVCRKDSACQ 
       160        170        180        190        200
RPQEDHGNSA GEEEEEEETM DSETARMACA TDQMLPDPIS FEATAIPVAE 
       210        220        230        240        250
KEEALLPESE VPTDTKENSE KGALTQYPRY KKYQLACTKN VYSAASHGTS 
       260        270        280        290        300
GFAGTFSEES PGNSLKPGLS VGQIKSEPPN EETEEESITL CLSGDETDIK 
       310        320        330        340        350
DRPGDVEMDR KQPSPAPPPG TPTGATSLDR SRSVSSPSCL RSLFSIAKGV 
       360        370        380        390        400
ESTGLPSTSQ QHFVRSSACP FNKGISQGDL KTDYTPLAGN YGQPHVGQKD 
       410        420        430        440        450
VSNFAMGSPL RGPGPETLCK QEGELDRRSV IFSASTCDQP NTPVHSYSSV 
       460        470        480        490        500
SSLDKDLSEP VPKSLWVGAG QSLPSSQAYS HGGLMADHLP GRIRPNTSCP 
       510        520        530        540        550
VPIKVCPRSP PLETRTRTSS SCSSYSYAED GSGGSPCSLP LCEFSSSPCS 
       560        570        580        590        600
QGARFLATEH QEPGLMGDGM YNQVRPQIKC EQSYGTNSSD ESGSFSEADS 
       610        620        630        640        650
ESCPVQDRGQ EVKLPFPVDQ ITDLPRNDFQ MMIKMHKLTS EQLEFIHDIR 
       660        670        680        690        700
RRSKNRIAAQ RCRKRKLDCI QNLECEIRKL VCEKEKLLSE RNQLKVCMGE 
       710        720        730        740        750
LLDNFSCLSQ EVCRDIQSPE QIQALHRYCP VLIPMDLPGA SVNPPPLGVE 
       760        770        780        790        800
QSLAPSQCAV GGSVPCCLEP GAAPPGLPWV PSNTSENCTS GRRLEGSDPG 
       810        820        830 
TFSERGPPLE ARSQSVTVDF CQEMTEKCTT DEQPRKDYA
Length:839
Mass (Da):91,944
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i250FBF6C5AC9AEDE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A8I5Y0R0A0A8I5Y0R0_RAT
BTB domain and CNC homolog 2
Bach2
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8I6AMQ4A0A8I6AMQ4_RAT
BTB domain and CNC homolog 2
Bach2
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...RefSeqi		NP_001129226.1, NM_001135754.1
XP_008761840.1, XM_008763618.2
XP_017448834.1, XM_017593345.1
XP_017448835.1, XM_017593346.1
XP_017448836.1, XM_017593347.1
XP_017448837.1, XM_017593348.1
XP_017448838.1, XM_017593349.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000065882.2; ENSRNOP00000063410.1; ENSRNOG00000006170.6

Database of genes from NCBI RefSeq genomes

More...GeneIDi		313125

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:313125

UCSC genome browser

More...UCSCi		RGD:1562865, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_001129226.1, NM_001135754.1
XP_008761840.1, XM_008763618.2
XP_017448834.1, XM_017593345.1
XP_017448835.1, XM_017593346.1
XP_017448836.1, XM_017593347.1
XP_017448837.1, XM_017593348.1
XP_017448838.1, XM_017593349.1

3D structure databases

AlphaFoldDBiD3ZW33
SMRiD3ZW33
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063410

PTM databases

iPTMnetiD3ZW33
PhosphoSitePlusiD3ZW33

Proteomic databases

PaxDbiD3ZW33

Genome annotation databases

EnsembliENSRNOT00000065882.2; ENSRNOP00000063410.1; ENSRNOG00000006170.6
GeneIDi313125
KEGGirno:313125
UCSCiRGD:1562865, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		60468
RGDi1562865, Bach2

Phylogenomic databases

eggNOGiKOG3863, Eukaryota
GeneTreeiENSGT00940000158228
HOGENOMiCLU_015243_0_0_1
InParanoidiD3ZW33
OMAiESMQCCS
OrthoDBi521871at2759
PhylomeDBiD3ZW33
TreeFamiTF326681

Gene expression databases

BgeeiENSRNOG00000006170, Expressed in spleen and 20 other tissues

Family and domain databases

CDDicd14719, bZIP_BACH, 1 hit
Gene3Di3.30.710.10, 1 hit
InterProiView protein in InterPro
IPR000210, BTB/POZ_dom
IPR004827, bZIP
IPR043321, bZIP_BACH
IPR004826, bZIP_Maf
IPR046347, bZIP_sf
IPR011333, SKP1/BTB/POZ_sf
IPR008917, TF_DNA-bd_sf
PfamiView protein in Pfam
PF00651, BTB, 1 hit
PF03131, bZIP_Maf, 1 hit
SMARTiView protein in SMART
SM00338, BRLZ, 1 hit
SM00225, BTB, 1 hit
SUPFAMiSSF47454, SSF47454, 1 hit
SSF54695, SSF54695, 1 hit
SSF57959, SSF57959, 1 hit
PROSITEiView protein in PROSITE
PS50097, BTB, 1 hit
PS50217, BZIP, 1 hit
PS00036, BZIP_BASIC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3ZW33_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZW33
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 25, 2022
This is version 97 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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