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UniProtKB - D3ZW33 (D3ZW33_RAT)
Protein
Submitted name:
BTB domain and CNC homolog 2
Gene
Bach2
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: RGD
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- import into nucleus Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- primary adaptive immune response involving T cells and B cells Source: RGD
- regulation of transcription, DNA-templated Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: BTB domain and CNC homolog 2 |
Gene namesi | Name:Bach2Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1562865, Bach2 |
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: RGD
- RNA polymerase II transcription regulator complex Source: RGD
Keywords - Cellular componenti
NucleusARBA annotationPTM / Processingi
Keywords - PTMi
Ubl conjugationARBA annotationProteomic databases
PaxDbi | D3ZW33 |
PTM databases
iPTMneti | D3ZW33 |
PhosphoSitePlusi | D3ZW33 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000006170, Expressed in spleen and 20 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 37 – 103 | BTBInterPro annotationAdd BLAST | 67 | |
Domaini | 650 – 695 | BZIPInterPro annotationAdd BLAST | 46 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 150 – 170 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 255 – 334 | DisorderedSequence analysisAdd BLAST | 80 | |
Regioni | 398 – 419 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 582 – 607 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 778 – 814 | DisorderedSequence analysisAdd BLAST | 37 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 670 – 690 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 255 – 270 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 295 – 309 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 582 – 603 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 780 – 796 | Polar residuesSequence analysisAdd BLAST | 17 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG3863, Eukaryota |
GeneTreei | ENSGT00940000158228 |
HOGENOMi | CLU_015243_0_0_1 |
InParanoidi | D3ZW33 |
OMAi | ESMQCCS |
OrthoDBi | 521871at2759 |
PhylomeDBi | D3ZW33 |
TreeFami | TF326681 |
Family and domain databases
CDDi | cd14719, bZIP_BACH, 1 hit |
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR004827, bZIP IPR043321, bZIP_BACH IPR004826, bZIP_Maf IPR046347, bZIP_sf IPR011333, SKP1/BTB/POZ_sf IPR008917, TF_DNA-bd_sf |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF03131, bZIP_Maf, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit SM00225, BTB, 1 hit |
SUPFAMi | SSF47454, SSF47454, 1 hit SSF54695, SSF54695, 1 hit SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
D3ZW33-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVDEKPDSP MYVYESTVHC ANILLGLNDQ RKKDILCDVT LIVERKEFRA
60 70 80 90 100
HRAVLAACSE YFWQALVGQT KDDLVVSLPE EVTARGFGPL LQFAYTAKLL
110 120 130 140 150
LSRENIREVI RCAEFLRMHN LEDSCFSFLQ TQLLNREDGL FVCRKDSACQ
160 170 180 190 200
RPQEDHGNSA GEEEEEEETM DSETARMACA TDQMLPDPIS FEATAIPVAE
210 220 230 240 250
KEEALLPESE VPTDTKENSE KGALTQYPRY KKYQLACTKN VYSAASHGTS
260 270 280 290 300
GFAGTFSEES PGNSLKPGLS VGQIKSEPPN EETEEESITL CLSGDETDIK
310 320 330 340 350
DRPGDVEMDR KQPSPAPPPG TPTGATSLDR SRSVSSPSCL RSLFSIAKGV
360 370 380 390 400
ESTGLPSTSQ QHFVRSSACP FNKGISQGDL KTDYTPLAGN YGQPHVGQKD
410 420 430 440 450
VSNFAMGSPL RGPGPETLCK QEGELDRRSV IFSASTCDQP NTPVHSYSSV
460 470 480 490 500
SSLDKDLSEP VPKSLWVGAG QSLPSSQAYS HGGLMADHLP GRIRPNTSCP
510 520 530 540 550
VPIKVCPRSP PLETRTRTSS SCSSYSYAED GSGGSPCSLP LCEFSSSPCS
560 570 580 590 600
QGARFLATEH QEPGLMGDGM YNQVRPQIKC EQSYGTNSSD ESGSFSEADS
610 620 630 640 650
ESCPVQDRGQ EVKLPFPVDQ ITDLPRNDFQ MMIKMHKLTS EQLEFIHDIR
660 670 680 690 700
RRSKNRIAAQ RCRKRKLDCI QNLECEIRKL VCEKEKLLSE RNQLKVCMGE
710 720 730 740 750
LLDNFSCLSQ EVCRDIQSPE QIQALHRYCP VLIPMDLPGA SVNPPPLGVE
760 770 780 790 800
QSLAPSQCAV GGSVPCCLEP GAAPPGLPWV PSNTSENCTS GRRLEGSDPG
810 820 830
TFSERGPPLE ARSQSVTVDF CQEMTEKCTT DEQPRKDYA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A8I5Y0R0 | A0A8I5Y0R0_RAT | BTB domain and CNC homolog 2 | Bach2 | 83 | Annotation score: | ||
A0A8I6AMQ4 | A0A8I6AMQ4_RAT | BTB domain and CNC homolog 2 | Bach2 | 102 | Annotation score: |
Sequence databases
Genome annotation databases
Ensembli | ENSRNOT00000065882.2; ENSRNOP00000063410.1; ENSRNOG00000006170.6 |
GeneIDi | 313125 |
KEGGi | rno:313125 |
UCSCi | RGD:1562865, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
AlphaFoldDBi | D3ZW33 |
SMRi | D3ZW33 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000063410 |
PTM databases
iPTMneti | D3ZW33 |
PhosphoSitePlusi | D3ZW33 |
Proteomic databases
PaxDbi | D3ZW33 |
Genome annotation databases
Ensembli | ENSRNOT00000065882.2; ENSRNOP00000063410.1; ENSRNOG00000006170.6 |
GeneIDi | 313125 |
KEGGi | rno:313125 |
UCSCi | RGD:1562865, rat |
Organism-specific databases
CTDi | 60468 |
RGDi | 1562865, Bach2 |
Phylogenomic databases
eggNOGi | KOG3863, Eukaryota |
GeneTreei | ENSGT00940000158228 |
HOGENOMi | CLU_015243_0_0_1 |
InParanoidi | D3ZW33 |
OMAi | ESMQCCS |
OrthoDBi | 521871at2759 |
PhylomeDBi | D3ZW33 |
TreeFami | TF326681 |
Gene expression databases
Bgeei | ENSRNOG00000006170, Expressed in spleen and 20 other tissues |
Family and domain databases
CDDi | cd14719, bZIP_BACH, 1 hit |
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR004827, bZIP IPR043321, bZIP_BACH IPR004826, bZIP_Maf IPR046347, bZIP_sf IPR011333, SKP1/BTB/POZ_sf IPR008917, TF_DNA-bd_sf |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF03131, bZIP_Maf, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit SM00225, BTB, 1 hit |
SUPFAMi | SSF47454, SSF47454, 1 hit SSF54695, SSF54695, 1 hit SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | D3ZW33_RAT | |
Accessioni | D3ZW33Primary (citable) accession number: D3ZW33 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | May 25, 2022 | |
This is version 97 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |