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Protein

Myogenic factor

Gene

Myf5

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-375170 CDO in myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Myogenic factorUniRule annotation
Gene namesi
Name:Myf5Imported
Synonyms:Myf5_predictedImported
ORF Names:rCG_48648Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1308322 Myf5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiD3ZVU3

Expressioni

Gene expression databases

BgeeiENSRNOG00000004768 Expressed in 1 organ(s), highest expression level in skeletal muscle tissue

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006453

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 134BHLHInterPro annotationAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili124 – 144Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3960 Eukaryota
ENOG4111SED LUCA
GeneTreeiENSGT00530000063004
KOiK18484
OMAiSFDSVYC
OrthoDBiEOG091G0GKD
TreeFamiTF316344

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR002546 Basic
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR022032 Myf5
IPR039704 Myogenic_factor
PANTHERiPTHR11534 PTHR11534, 1 hit
PfamiView protein in Pfam
PF01586 Basic, 1 hit
PF00010 HLH, 1 hit
PF12232 Myf5, 1 hit
SMARTiView protein in SMART
SM00520 BASIC, 1 hit
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

D3ZVU3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDMTDSCQFS PSEYFYDGSC IPSPEDEFGD QFEPRVAAFG AHKAKLQGSD
60 70 80 90 100
DEEHVRAPTG HHQAGHCLMW ACKACKRKST TMDRRKAATM RERRRLKKVN
110 120 130 140 150
QAFETLKRCT TTNPNQRLPK VEILRNAIRY IESLQELLRE QVENYYSLPG
160 170 180 190 200
QSCSQPTSPT SNCSDGMPEC NSPVWSRKNS SFDSIYCPDV SNACASDKSS
210 220 230 240 250
LSSLDCLSSI VDRITSAEPS ELALQDTASL SPAASTNSQP ATPGSSSSRL

IYHVL
Length:255
Mass (Da):28,233
Last modified:April 20, 2010 - v1
Checksum:i367781C202E7DC2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07056975 Genomic DNA No translation available.
CH473960 Genomic DNA Translation: EDM16769.1
RefSeqiNP_001100253.1, NM_001106783.1
UniGeneiRn.218675

Genome annotation databases

EnsembliENSRNOT00000006453; ENSRNOP00000006453; ENSRNOG00000004768
GeneIDi299766
KEGGirno:299766
UCSCiRGD:1308322 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07056975 Genomic DNA No translation available.
CH473960 Genomic DNA Translation: EDM16769.1
RefSeqiNP_001100253.1, NM_001106783.1
UniGeneiRn.218675

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006453

Proteomic databases

PRIDEiD3ZVU3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006453; ENSRNOP00000006453; ENSRNOG00000004768
GeneIDi299766
KEGGirno:299766
UCSCiRGD:1308322 rat

Organism-specific databases

CTDi4617
RGDi1308322 Myf5

Phylogenomic databases

eggNOGiKOG3960 Eukaryota
ENOG4111SED LUCA
GeneTreeiENSGT00530000063004
KOiK18484
OMAiSFDSVYC
OrthoDBiEOG091G0GKD
TreeFamiTF316344

Enzyme and pathway databases

ReactomeiR-RNO-375170 CDO in myogenesis

Gene expression databases

BgeeiENSRNOG00000004768 Expressed in 1 organ(s), highest expression level in skeletal muscle tissue

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR002546 Basic
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR022032 Myf5
IPR039704 Myogenic_factor
PANTHERiPTHR11534 PTHR11534, 1 hit
PfamiView protein in Pfam
PF01586 Basic, 1 hit
PF00010 HLH, 1 hit
PF12232 Myf5, 1 hit
SMARTiView protein in SMART
SM00520 BASIC, 1 hit
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD3ZVU3_RAT
AccessioniPrimary (citable) accession number: D3ZVU3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: November 7, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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