E3 ubiquitin-protein ligase Mdm2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

• S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.UniRule annotation

  <p>Information which has been generated by the UniProtKB automatic annotation system, without manual validation.</p> <p><a href="/manual/evidences#ECO:0000256">More...</a></p> Automatic assertion according to rulesⁱ

  • PIRNR:PIRNR006748

  ARBA annotation

  Automatic assertion according to rulesⁱ

  • ARBA:ARBA00000900

  EC:2.3.2.27

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• 5S rRNA binding Source: RGD
• disordered domain specific binding Source: RGD
• enzyme binding Source: RGD
• identical protein binding Source: RGD
• ligase activity Source: RGD
• NEDD8 ligase activity Source: RGD
• p53 binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Ubiquitin-dependent degradation of p53 protein despite phosphorylation at its N terminus by acetaminophen."
    Lee Y.S., Wan J., Kim B.J., Bae M.A., Song B.J.
    J Pharmacol Exp Ther 317:202-208(2006) [PubMed] [Europe PMC] [Abstract]
  • "Caveolin-1/PTRF upregulation constitutes a mechanism for mediating p53-induced cellular senescence: implications for evidence-based therapy of delayed wound healing in diabetes."
    Bitar M.S., Abdel-Halim S.M., Al-Mulla F.
    Am J Physiol Endocrinol Metab 305:E951-63(2013) [PubMed] [Europe PMC] [Abstract]
• peroxisome proliferator activated receptor binding Source: RGDInferred from physical interactionⁱ
  • "Regulation of peroxisome proliferator-activated receptor-alpha by MDM2."
    Gopinathan L., Hannon D.B., Peters J.M., Vanden Heuvel J.P.
    Toxicol Sci 108:48-58(2009) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: RGD
• protein N-terminus binding Source: RGD
• receptor serine/threonine kinase binding Source: RGDInferred from physical interactionⁱ
  • "The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein-coupled receptor kinase 2 in the regulation of GPR17 receptor desensitization."
    Fumagalli M., Bonfanti E., Daniele S., Zappelli E., Lecca D., Martini C., Trincavelli M.L., Abbracchio M.P.
    Glia 63:2327-2339(2015) [PubMed] [Europe PMC] [Abstract]
• ribonucleoprotein complex binding Source: RGD
• scaffold protein binding Source: RGD
• SUMO transferase activity Source: RGD
• ubiquitin binding Source: RGD
• ubiquitin protein ligase activity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression."
    Colledge M., Snyder E.M., Crozier R.A., Soderling J.A., Jin Y., Langeberg L.K., Lu H., Bear M.F., Scott J.D.
    Neuron 40:595-607(2003) [PubMed] [Europe PMC] [Abstract]
• ubiquitin protein ligase binding Source: RGD
• ubiquitin-protein transferase activity Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Ubiquitin-dependent degradation of p53 protein despite phosphorylation at its N terminus by acetaminophen."
    Lee Y.S., Wan J., Kim B.J., Bae M.A., Song B.J.
    J Pharmacol Exp Ther 317:202-208(2006) [PubMed] [Europe PMC] [Abstract]
• zinc ion binding Source: RGD

GO - Biological processⁱ

• amyloid fibril formation Source: RGD
• atrial septum development Source: RGD
• atrioventricular valve morphogenesis Source: RGD
• blood vessel development Source: RGD
• blood vessel remodeling Source: RGD
• cardiac septum morphogenesis Source: RGD
• cellular response to actinomycin D Source: RGD
• cellular response to alkaloid Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Role of polyamines in p53-dependent apoptosis of intestinal epithelial cells."
    Bhattacharya S., Ray R.M., Johnson L.R.
    Cell Signal 21:509-522(2009) [PubMed] [Europe PMC] [Abstract]
• cellular response to antibiotic Source: RGDInferred from expression patternⁱ
  • "Identification and characterization of a novel Mdm2 splice variant acutely induced by the chemotherapeutic agents adriamycin and actinomycin D."
    Lents N.H., Wheeler L.W., Baldassare J.J., Dynlacht B.D.
    Cell Cycle 7:1580-1586(2008) [PubMed] [Europe PMC] [Abstract]
• cellular response to estrogen stimulus Source: RGDInferred from expression patternⁱ
  • "Induction of p53 expression and function by estrogen in osteoblasts."
    Bovenkerk S., Lanciloti N., Chandar N.
    Calcif Tissue Int 73:274-280(2003) [PubMed] [Europe PMC] [Abstract]
• cellular response to gamma radiation Source: RGD
• cellular response to growth factor stimulus Source: RGDInferred from expression patternⁱ
  • "FGF1 inhibits p53-dependent apoptosis and cell cycle arrest via an intracrine pathway."
    Bouleau S., Grimal H., Rincheval V., Godefroy N., Mignotte B., Vayssiere J.L., Renaud F.
    Oncogene 24:7839-7849(2005) [PubMed] [Europe PMC] [Abstract]
• cellular response to hydrogen peroxide Source: RGDInferred from expression patternⁱ
  • "Regulation of expression of the rat orthologue of mouse double minute 2 (MDM2) by H(2)O(2)-induced oxidative stress in neonatal rat cardiac myocytes."
    Pikkarainen S., Kennedy R.A., Marshall A.K., Tham e.l. L., Lay K., Kriz T.A., Handa B.S., Clerk A., Sugden P.H.
    J Biol Chem 284:27195-27210(2009) [PubMed] [Europe PMC] [Abstract]
• cellular response to hypoxia Source: RGD
• cellular response to organic cyclic compound Source: RGDInferred from expression patternⁱ
  • "Delta(9)-tetrahydrocannabinol regulates the p53 post-translational modifiers Murine double minute 2 and the Small Ubiquitin MOdifier protein in the rat brain."
    Gowran A., Murphy C.E., Campbell V.A.
    FEBS Lett 583:3412-3418(2009) [PubMed] [Europe PMC] [Abstract]
• cellular response to organic substance Source: RGDInferred from expression patternⁱ
  • "PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2."
    Choy M.K., Movassagh M., Bennett M.R., Foo R.S.
    J Cell Physiol 222:635-639(2010) [PubMed] [Europe PMC] [Abstract]
• cellular response to peptide hormone stimulus Source: RGDInferred from expression patternⁱ
  • "Inflammatory cells regulate p53 and caspases in acute pancreatitis."
    Nakamura Y., Do J.H., Yuan J., Odinokova I.V., Mareninova O., Gukovskaya A.S., Pandol S.J.
    Am J Physiol Gastrointest Liver Physiol 298:G92-100(2010) [PubMed] [Europe PMC] [Abstract]
• cellular response to UV-C Source: RGDInferred from expression patternⁱ
  • "Thyrotropin effects on ultraviolet radiation-dependent apoptosis in FRTL-5 cells."
    Del Terra E., Francesconi A., Donnini D., Curcio F., Ambesi-Impiombato F.S.
    Thyroid 13:747-753(2003) [PubMed] [Europe PMC] [Abstract]
• cellular response to vitamin B1 Source: RGDInferred from expression patternⁱ
  • "[The expression of p53, MDM2 and Ref1 gene in cultured retina neurons of SD rats treated with vitamin B1 and/or elevated pressure]."
    Yang Z., Ge J., Yin W., Shen H., Liu H., Guo Y.
    Yan Ke Xue Bao 20:259-263(2004) [PubMed] [Europe PMC] [Abstract]
• DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: RGD
• endocardial cushion morphogenesis Source: RGD
• establishment of protein localization Source: RGD
• heart development Source: RGD
• heart valve development Source: RGD
• negative regulation of apoptotic process Source: RGDInferred from mutant phenotypeⁱ
  • "p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis."
    Amaral J.D., Castro R.E., Sola S., Steer C.J., Rodrigues C.M.
    J Biol Chem 282:34250-34259(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell cycle arrest Source: RGD
• negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGDInferred from mutant phenotypeⁱ
  • "Inflammatory cells regulate p53 and caspases in acute pancreatitis."
    Nakamura Y., Do J.H., Yuan J., Odinokova I.V., Mareninova O., Gukovskaya A.S., Pandol S.J.
    Am J Physiol Gastrointest Liver Physiol 298:G92-100(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of DNA damage response, signal transduction by p53 class mediator Source: RGD
• negative regulation of gene expression Source: RGDInferred from mutant phenotypeⁱ
  • "Inflammatory cells regulate p53 and caspases in acute pancreatitis."
    Nakamura Y., Do J.H., Yuan J., Odinokova I.V., Mareninova O., Gukovskaya A.S., Pandol S.J.
    Am J Physiol Gastrointest Liver Physiol 298:G92-100(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator Source: RGD
• negative regulation of neuron projection development Source: RGDInferred from mutant phenotypeⁱ
  • "SCYL1BP1 modulates neurite outgrowth and regeneration by regulating the Mdm2/p53 pathway."
    Liu Y., Chen Y., Lu X., Wang Y., Duan Y., Cheng C., Shen A.
    Mol Biol Cell 23:4506-4514(2012) [PubMed] [Europe PMC] [Abstract]
• negative regulation of protein processing Source: RGDInferred from mutant phenotypeⁱ
  • "Regulation of expression of the rat orthologue of mouse double minute 2 (MDM2) by H(2)O(2)-induced oxidative stress in neonatal rat cardiac myocytes."
    Pikkarainen S., Kennedy R.A., Marshall A.K., Tham e.l. L., Lay K., Kriz T.A., Handa B.S., Clerk A., Sugden P.H.
    J Biol Chem 284:27195-27210(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of signal transduction by p53 class mediator Source: RGD
• negative regulation of transcription, DNA-templated Source: RGDInferred from direct assayⁱ
  • "Regulation of peroxisome proliferator-activated receptor-alpha by MDM2."
    Gopinathan L., Hannon D.B., Peters J.M., Vanden Heuvel J.P.
    Toxicol Sci 108:48-58(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: RGD
• peptidyl-lysine modification Source: RGD
• positive regulation of cell cycle Source: RGD
• positive regulation of gene expression Source: RGDInferred from mutant phenotypeⁱ
  • "Regulation of peroxisome proliferator-activated receptor-alpha by MDM2."
    Gopinathan L., Hannon D.B., Peters J.M., Vanden Heuvel J.P.
    Toxicol Sci 108:48-58(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of mitotic cell cycle Source: RGD
• positive regulation of muscle cell differentiation Source: RGD
• positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: RGD
• positive regulation of protein export from nucleus Source: RGDInferred from mutant phenotypeⁱ
  • "p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis."
    Amaral J.D., Castro R.E., Sola S., Steer C.J., Rodrigues C.M.
    J Biol Chem 282:34250-34259(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: GOC
• positive regulation of vascular associated smooth muscle cell migration Source: RGDInferred from mutant phenotypeⁱ
  • "Inhibition of MDM2 attenuates neointimal hyperplasia via suppression of vascular proliferation and inflammation."
    Hashimoto T., Ichiki T., Ikeda J., Narabayashi E., Matsuura H., Miyazaki R., Inanaga K., Takeda K., Sunagawa K.
    Cardiovasc Res 91:711-719(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of vascular associated smooth muscle cell proliferation Source: RGDInferred from mutant phenotypeⁱ
  • "Inhibition of MDM2 attenuates neointimal hyperplasia via suppression of vascular proliferation and inflammation."
    Hashimoto T., Ichiki T., Ikeda J., Narabayashi E., Matsuura H., Miyazaki R., Inanaga K., Takeda K., Sunagawa K.
    Cardiovasc Res 91:711-719(2011) [PubMed] [Europe PMC] [Abstract]
• protein autoubiquitination Source: RGD
• protein-containing complex assembly Source: RGD
• protein destabilization Source: RGD
• protein localization to nucleus Source: RGD
• protein ubiquitination Source: UniProtKBInferred from direct assayⁱ
  • "Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression."
    Colledge M., Snyder E.M., Crozier R.A., Soderling J.A., Jin Y., Langeberg L.K., Lu H., Bear M.F., Scott J.D.
    Neuron 40:595-607(2003) [PubMed] [Europe PMC] [Abstract]
• proteolysis involved in cellular protein catabolic process Source: RGD
• regulation of gene expression Source: RGD
• regulation of heart rate Source: RGD
• regulation of protein catabolic process Source: RGD
• regulation of transcription by RNA polymerase II Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• response to antibiotic Source: RGD
• response to cocaine Source: RGDInferred from expression patternⁱ
  • "Up-regulation of murine double minute clone 2 (MDM2) gene expression in rat brain after morphine, heroin, and cocaine administrations."
    Jiang Y., Yang W., Zhou Y., Ma L.
    Neurosci Lett 352:216-220(2003) [PubMed] [Europe PMC] [Abstract]
• response to drug Source: RGDInferred from expression patternⁱ
  • "Role of polyamines in p53-dependent apoptosis of intestinal epithelial cells."
    Bhattacharya S., Ray R.M., Johnson L.R.
    Cell Signal 21:509-522(2009) [PubMed] [Europe PMC] [Abstract]
• response to ether Source: RGDInferred from expression patternⁱ
  • "The long-term effect of sevoflurane on neuronal cell damage and expression of apoptotic factors after cerebral ischemia and reperfusion in rats."
    Pape M., Engelhard K., Eberspacher E., Hollweck R., Kellermann K., Zintner S., Hutzler P., Werner C.
    Anesth Analg 103:173-179(2006) [PubMed] [Europe PMC] [Abstract]
• response to formaldehyde Source: RGDInferred from expression patternⁱ
  • "Identification of formaldehyde-responsive genes by suppression subtractive hybridization."
    Lee M.H., Kim Y.A., Na T.Y., Kim S.H., Shin Y.K., Lee B.H., Shin H.S., Lee M.O.
    Toxicology 243:224-235(2008) [PubMed] [Europe PMC] [Abstract]
• response to iron ion Source: RGDInferred from expression patternⁱ
  • "Iron-dependent regulation of MDM2 influences p53 activity and hepatic carcinogenesis."
    Dongiovanni P., Fracanzani A.L., Cairo G., Megazzini C.P., Gatti S., Rametta R., Fargion S., Valenti L.
    Am J Pathol 176:1006-1017(2010) [PubMed] [Europe PMC] [Abstract]
• response to magnesium ion Source: RGDInferred from expression patternⁱ
  • "A molecular basis for the efficacy of magnesium treatment following traumatic brain injury in rats."
    Lee J.S., Han Y.M., Yoo D.S., Choi S.J., Choi B.H., Kim J.H., Kim Y.H., Huh P.W., Ko Y.J., Rha H.K., Cho K.S., Kim D.S.
    J Neurotrauma 21:549-561(2004) [PubMed] [Europe PMC] [Abstract]
• response to morphine Source: RGDInferred from expression patternⁱ
  • "Up-regulation of murine double minute clone 2 (MDM2) gene expression in rat brain after morphine, heroin, and cocaine administrations."
    Jiang Y., Yang W., Zhou Y., Ma L.
    Neurosci Lett 352:216-220(2003) [PubMed] [Europe PMC] [Abstract]
• response to steroid hormone Source: RGDInferred from expression patternⁱ
  • "p53-independent induction of rat hepatic Mdm2 following administration of phenobarbital and pregnenolone 16alpha-carbonitrile."
    Nelson D.M., Bhaskaran V., Foster W.R., Lehman-McKeeman L.D.
    Toxicol Sci 94:272-280(2006) [PubMed] [Europe PMC] [Abstract]
• response to toxic substance Source: RGDInferred from expression patternⁱ
  • "Inhibition of PP2A, but not PP5, mediates p53 activation by low levels of okadaic acid in rat liver epithelial cells."
    Messner D.J., Romeo C., Boynton A., Rossie S.
    J Cell Biochem 99:241-255(2006) [PubMed] [Europe PMC] [Abstract]
  • "Transcriptomics analysis of interactive effects of benzene, trichloroethylene and methyl mercury within binary and ternary mixtures on the liver and kidney following subchronic exposure in the rat."
    Hendriksen P.J., Freidig A.P., Jonker D., Thissen U., Bogaards J.J., Mumtaz M.M., Groten J.P., Stierum R.H.
    Toxicol Appl Pharmacol 225:171-188(2007) [PubMed] [Europe PMC] [Abstract]
• response to water-immersion restraint stress Source: RGDInferred from direct assayⁱ
  • "Selective increase in the association of the beta2 adrenergic receptor, beta Arrestin-1 and p53 with Mdm2 in the ventral hippocampus one month after underwater trauma."
    Sood R., Ritov G., Richter-Levin G., Barki-Harrington L.
    Behav Brain Res 240:26-28(2013) [PubMed] [Europe PMC] [Abstract]
• traversing start control point of mitotic cell cycle Source: RGD
• ubiquitin-dependent protein catabolic process Source: RGD
• ventricular septum development Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• disordered domain specific binding Source: RGD
• enzyme binding Source: RGD
• identical protein binding Source: RGD
• p53 binding Source: RGDInferred from physical interactionⁱ
  • "Ubiquitin-dependent degradation of p53 protein despite phosphorylation at its N terminus by acetaminophen."
    Lee Y.S., Wan J., Kim B.J., Bae M.A., Song B.J.
    J Pharmacol Exp Ther 317:202-208(2006) [PubMed] [Europe PMC] [Abstract]
  • "Caveolin-1/PTRF upregulation constitutes a mechanism for mediating p53-induced cellular senescence: implications for evidence-based therapy of delayed wound healing in diabetes."
    Bitar M.S., Abdel-Halim S.M., Al-Mulla F.
    Am J Physiol Endocrinol Metab 305:E951-63(2013) [PubMed] [Europe PMC] [Abstract]
• peroxisome proliferator activated receptor binding Source: RGDInferred from physical interactionⁱ
  • "Regulation of peroxisome proliferator-activated receptor-alpha by MDM2."
    Gopinathan L., Hannon D.B., Peters J.M., Vanden Heuvel J.P.
    Toxicol Sci 108:48-58(2009) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: RGD
• protein N-terminus binding Source: RGD
• receptor serine/threonine kinase binding Source: RGDInferred from physical interactionⁱ
  • "The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein-coupled receptor kinase 2 in the regulation of GPR17 receptor desensitization."
    Fumagalli M., Bonfanti E., Daniele S., Zappelli E., Lecca D., Martini C., Trincavelli M.L., Abbracchio M.P.
    Glia 63:2327-2339(2015) [PubMed] [Europe PMC] [Abstract]
• scaffold protein binding Source: RGD
• ubiquitin binding Source: RGD
• ubiquitin protein ligase binding Source: RGD

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MCNTNMSVST EGAAGTSQIP ASEQETLIIF YIGQYIMTKR LYDEKQQHIV 
        60         70         80         90        100
YCSNDLLGDV FGVPSFSVKE HRKIYAMIYR NLVVVSQQDS GTSPSESRCQ 
       110        120        130        140        150
PEGGSDLKDP VQASQEEKPS SSDVVSRPST SSRRRAISET EENTDELPGE 
       160        170        180        190        200
RQRKRHRALS FDESLGLCVL REICCERSSS SEATDTPSHQ DLDDGVSDHS 
       210        220        230        240        250
ADCLDQDSVS DQFSVEFEVE SLDSEDYSLS DEGHELSDED DEVYRVTVYQ 
       260        270        280        290        300
AGESDADSFE GDPEISLADY WKCTSCNEMN PPLPSHCNRC WTLRENWLPD 
       310        320        330        340        350
DKGKDKVEIS EKAKLESSDQ AEEGLDVPDG KKVTEDDAKE SSAEDSEEKV 
       360        370        380        390        400
AQMLLSQESD DYSQPSTSSS IVYSSQESGK ELKEDTQDKE ESMESSFSLN 
       410        420        430        440        450
AIEPCVICQG RPKNGCIVHG KTGHLMSCFT CAKKLKKRNK PCPVCRQPIQ 

MIVLTYFN                                               

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ