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UniProtKB - D3ZVG6 (D3ZVG6_RAT)
Protein
Submitted name:
Kruppel-like factor 14
Gene
Klf14
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- chromatin binding Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- positive regulation of sphingolipid mediated signaling pathway Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Kruppel-like factor 14 |
Gene namesi | Name:Klf14Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1306012, Klf14 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000027557, Expressed in liver and 6 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 195 – 224 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 225 – 254 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 255 – 282 | C2H2-typeInterPro annotationAdd BLAST | 28 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 29 – 59 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 96 – 183 | DisorderedSequence analysisAdd BLAST | 88 | |
Regioni | 270 – 321 | DisorderedSequence analysisAdd BLAST | 52 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 111 – 146 | Polar residuesSequence analysisAdd BLAST | 36 | |
Compositional biasi | 277 – 295 | Basic and acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 306 – 321 | Polar residuesSequence analysisAdd BLAST | 16 |
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163415 |
HOGENOMi | CLU_002678_33_2_1 |
InParanoidi | D3ZVG6 |
OMAi | GVLWIPP |
OrthoDBi | 1308225at2759 |
PhylomeDBi | D3ZVG6 |
TreeFami | TF351003 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
i Sequence
Sequence statusi: Complete.
D3ZVG6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSASVACLDY FAAECLVSMS TRAVLHRRAT DSEGAGAAAV SEVGEVSRES
60 70 80 90 100
AGKGTGSRGV LWIPPVLEVP APSPGEGDGA PHLLAASALA DLSCGAREGT
110 120 130 140 150
KEDSEEAPCA STSCFEPTQC SSPTGCSEPT QTFGEDELSD AESSCSESAI
160 170 180 190 200
LGAPEVPEEP DDSGEVPEGP PGARPGPAVG PTYRRRQITP ASKRHQCSFH
210 220 230 240 250
GCNKAYYKSS HLKSHQRTHT GERPFSCDWL DCDKKFTRSD ELARHYRTHT
260 270 280 290 300
GEKRFSCPLC PKQFSRSDHL TKHARRHPTY HPDMIEYRGR RRTPRPEPPP
310 320
PAMVESSGSD SGQETSFTAC P
Sequence databases
RefSeqi | NP_001128566.1, NM_001135094.1 |
Genome annotation databases
Ensembli | ENSRNOT00000048436.4; ENSRNOP00000049169.2; ENSRNOG00000027557.5 |
GeneIDi | 312203 |
KEGGi | rno:312203 |
UCSCi | RGD:1306012, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | NP_001128566.1, NM_001135094.1 |
3D structure databases
AlphaFoldDBi | D3ZVG6 |
SMRi | D3ZVG6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000049169 |
PTM databases
PhosphoSitePlusi | D3ZVG6 |
Proteomic databases
PaxDbi | D3ZVG6 |
Genome annotation databases
Ensembli | ENSRNOT00000048436.4; ENSRNOP00000049169.2; ENSRNOG00000027557.5 |
GeneIDi | 312203 |
KEGGi | rno:312203 |
UCSCi | RGD:1306012, rat |
Organism-specific databases
CTDi | 136259 |
RGDi | 1306012, Klf14 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163415 |
HOGENOMi | CLU_002678_33_2_1 |
InParanoidi | D3ZVG6 |
OMAi | GVLWIPP |
OrthoDBi | 1308225at2759 |
PhylomeDBi | D3ZVG6 |
TreeFami | TF351003 |
Gene expression databases
Bgeei | ENSRNOG00000027557, Expressed in liver and 6 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | D3ZVG6_RAT | |
Accessioni | D3ZVG6Primary (citable) accession number: D3ZVG6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | May 25, 2022 | |
This is version 78 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |