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Entry version 82 (22 Apr 2020)
Sequence version 2 (03 Apr 2013)
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Protein
Submitted name:

Histone deacetylase 6

Gene

LOC108348065

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1071 – 1132UBP-typePROSITE-ProRule annotationAdd BLAST62

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseSAAS annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-3371511 HSF1 activation
R-RNO-350054 Notch-HLH transcription pathway
R-RNO-5617833 Cilium Assembly
R-RNO-9646399 Aggrephagy

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Histone deacetylase 6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC108348065Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Rat genome database

More...
RGDi
11442569 LOC108348065

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
D3ZVD8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D3ZVD8

PeptideAtlas

More...
PeptideAtlasi
D3ZVD8

PRoteomics IDEntifications database

More...
PRIDEi
D3ZVD8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000047281 Expressed in adult mammalian kidney and 3 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000063689

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3ZVD8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1071 – 1132UBP-typeInterPro annotationAdd BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 61DisorderedSequence analysisAdd BLAST61
Regioni944 – 1014DisorderedSequence analysisAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 28PolarSequence analysisAdd BLAST28
Compositional biasi47 – 61PolyampholyteSequence analysisAdd BLAST15
Compositional biasi944 – 1010PolarSequence analysisAdd BLAST67

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1071 – 1132UBP-typePROSITE-ProRule annotationAdd BLAST62

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1343 Eukaryota
COG0123 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159563

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007727_2_1_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
DPLGHCD

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit
3.40.800.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000286 His_deacetylse
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
IPR013083 Znf_RING/FYVE/PHD
IPR001607 Znf_UBP

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00850 Hist_deacetyl, 2 hits
PF02148 zf-UBP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01270 HDASUPER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00290 ZnF_UBP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52768 SSF52768, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50271 ZF_UBP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

D3ZVD8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSTGQDSST RQRKSRHNPQ SPLQDSSATL KRGGKKGAVP HSSPNLAEVK
60 70 80 90 100
KKGKMKKLSQ PAEEDLIVGL QGLDLNSETR VPVGTGLVFD EQLNDFHCLW
110 120 130 140 150
DDSFPENPER LHAIKEQLIL EGLLGRCVSF QARFAEKEEL MLVHSLEYID
160 170 180 190 200
LMETTQYMNE GELRVLAGTY DSVYLHPNSY SCACLATGSV LRLVDAVMGA
210 220 230 240 250
EIRNGMAVIR PPGHHAQRSL MDGYCMFNHL AVAARYAQKK HRIQRILIVD
260 270 280 290 300
WDVHHGQGTQ FIFDQDPSVL YFSIHRYEHG RFWPHLKASN WSTTGFGQGQ
310 320 330 340 350
GYTINVPWNQ VGMRDADYIA AFLHILLPVA FEFQPQLVLV AAGFDALHGD
360 370 380 390 400
PKVRQGEMSA TPAGFAHLTH FLMGLAGGKL ILSLEGGYNL HALAKGVSGS
410 420 430 440 450
LHTLLGDPCP MLESPVAPCA SAQTSISCTL EALEPFWEVL ERSVEPQDED
460 470 480 490 500
EVEGDMLEDE EEEGHWEATA LPMDTWPLLQ NRTGLVYDER MMSHCNLWDN
510 520 530 540 550
HHPETPQRIL RIMCHLEEVG LAARCLILPA RPALDSELLT CHSAEYVERL
560 570 580 590 600
RATEKMKTRD LHREGANFES IYICPSTFAC AQLATGAACR LVEAVLSGEV
610 620 630 640 650
LNGIAIVRPP GHHAEPDAAC GFCFFNSVAV AARHAQVIAG RALRILIVDW
660 670 680 690 700
DVHHGNGTQH IFEEDPSVLY VSLHRYDRGT FFPMGDEGAS SQVGRAAGTG
710 720 730 740 750
FTVNVPWNGP RMGDADYLAT WHRLVLPIAY EFNPELVLIS AGFDAAQGDP
760 770 780 790 800
LGGCQVTPEG YAHLTHLLMG LAGGRIILIL EGGYNLTSIS ESMAACTHSL
810 820 830 840 850
LGDPPPQLTS LRPPQSGALA SISEVIQVHR KYWRSLRLMK MEDKEERSSS
860 870 880 890 900
RLVIKKLPQS ASPVSAKGMT TPKGKVLEAG MRKPTAALPT KESTLGQAKA
910 920 930 940 950
KTAKALLAQG QSSEQAAKGT TLDLATSKDT VGGATTDQCA SVAATENSAN
960 970 980 990 1000
QTTSGEEASG ETESFGTSPS SNASKQTTGA SPLHGAAAQQ SPELGLSSTL
1010 1020 1030 1040 1050
ELSSEAQEVQ ESEEGLLGEA AGGQDMNSLM LTQGFGDFNT QDVFYAVTPL
1060 1070 1080 1090 1100
SWCPHLMAVC PIPAAGLDVS QPCKTCGSVQ ENWVCLTCYQ VYCSRYVNAH
1110 1120 1130 1140 1150
MVCHHEASEH PLVLSCVDLS TWCYLCQAYV HHEDLQDVKN AAHQNKFGEG

MPHLQ
Length:1,155
Mass (Da):125,878
Last modified:April 3, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB0DEA1101E78B88F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2QC41A0A0G2QC41_RAT
Histone deacetylase 6
Hdac6 LOC103689963, LOC108348065
1,152Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07073519 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000064924; ENSRNOP00000063689; ENSRNOG00000047281

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07073519 Genomic DNA No translation available.

3D structure databases

SMRiD3ZVD8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063689

Proteomic databases

jPOSTiD3ZVD8
PaxDbiD3ZVD8
PeptideAtlasiD3ZVD8
PRIDEiD3ZVD8

Genome annotation databases

EnsembliENSRNOT00000064924; ENSRNOP00000063689; ENSRNOG00000047281

Organism-specific databases

RGDi11442569 LOC108348065

Phylogenomic databases

eggNOGiKOG1343 Eukaryota
COG0123 LUCA
GeneTreeiENSGT00940000159563
HOGENOMiCLU_007727_2_1_1
OMAiDPLGHCD

Enzyme and pathway databases

ReactomeiR-RNO-3371511 HSF1 activation
R-RNO-350054 Notch-HLH transcription pathway
R-RNO-5617833 Cilium Assembly
R-RNO-9646399 Aggrephagy

Gene expression databases

BgeeiENSRNOG00000047281 Expressed in adult mammalian kidney and 3 other tissues

Family and domain databases

Gene3Di3.30.40.10, 1 hit
3.40.800.20, 2 hits
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
IPR013083 Znf_RING/FYVE/PHD
IPR001607 Znf_UBP
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 2 hits
PF02148 zf-UBP, 1 hit
PRINTSiPR01270 HDASUPER
SMARTiView protein in SMART
SM00290 ZnF_UBP, 1 hit
SUPFAMiSSF52768 SSF52768, 2 hits
PROSITEiView protein in PROSITE
PS50271 ZF_UBP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3ZVD8_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZVD8
Secondary accession number(s): F1LSE3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 3, 2013
Last modified: April 22, 2020
This is version 82 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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