Hes7

Functionⁱ

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sequence-specific double-stranded DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription corepressor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
Notch signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
post-anal tail morphogenesis Source: Ensembl
regulation of neurogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of somitogenesis Source: Ensembl
rhythmic process Source: Ensembl
skeletal system development Source: Ensembl
somitogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription, DNA-templated Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transcription, Transcription regulationPROSITE-ProRule annotationSAAS annotation

Biological process

Transcription, Transcription regulationPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Hairy and enhancer of split 7 (Drosophila) (Predicted)Imported Submitted name: Hes family bHLH transcription factor 7Imported
Gene namesⁱ	Name:Hes7Imported Synonyms:Hes7_predictedImported ORF Names:rCG_33876Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 10

Organism-specific databases

Rat genome database More...RGDⁱ	1305914 Hes7

RGDⁱ

1305914 Hes7

Keywords - Cellular componentⁱ

NucleusPROSITE-ProRule annotationSAAS annotation

PTM / Processingⁱ

Proteomic databases

PRIDEⁱ	D3ZV20

PRIDEⁱ

D3ZV20

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000007391 Expressed in 9 organ(s), highest expression level in testis

Bgeeⁱ

ENSRNOG00000007391 Expressed in 9 organ(s), highest expression level in testis

Interactionⁱ

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000009757

STRINGⁱ

10116.ENSRNOP00000009757

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	12 – 69	BHLHInterPro annotationAdd BLAST		58
Domainⁱ	92 – 122	OrangeInterPro annotationAdd BLAST		31

Phylogenomic databases

eggNOGⁱ	KOG4304 Eukaryota ENOG4111F0X LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111282
KEGG Orthology (KO) More...KOⁱ	K09087
OMAⁱ	AQSMWRP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XFV
TreeFamⁱ	TF351373

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR032644 HES-7 IPR036638 HLH_DNA-bd_sf IPR003650 Orange_dom
PANTHERⁱ	PTHR10985:SF84 PTHR10985:SF84, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS51054 ORANGE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

D3ZV20-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVTRERAENR DGPKMLKPLV EKRRRDRINR SLEELRLLLL ERTRDQNLRN 
        60         70         80         90        100
PKLEKAEILE FAVGYLRERS RVEPPGVPRS PGQDAEALAS CYLSGFRECL 
       110        120        130        140        150
LRLAAFAHDA SPAARSQLFS ALNGYRRPKP PRPEAADPGL PAPRPPLDPA 
       160        170        180        190        200
SPILGPALHQ RPPVHQGPPS PRLAWSPSHC SPRAGDSGAP APLTGLLPPP 
       210        220 
PPPYRQDGAP KAPPLPPPAF WRPWP

Length:225

Mass (Da):24,859

Last modified:April 20, 2010 - v1

Checksum:ⁱA2D31EB8B7A9D970

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC129753 Genomic DNA No translation available. CH473948 Genomic DNA Translation: EDM04844.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001099262.1, NM_001105792.1
UniGeneⁱ	Rn.218470

Genome annotation databases

Ensemblⁱ	ENSRNOT00000009757; ENSRNOP00000009757; ENSRNOG00000007391
GeneIDⁱ	287423
KEGGⁱ	rno:287423
UCSC genome browser More...UCSCⁱ	RGD:1305914 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
D3ZV20	Transcription factor HES-7		MOUSE		225	UniRef90_Q8BKT2
transcription factor HES-7 isoform X2		MESAU		230
UPI000A319C54		MUSCR		225
UPI00042AE3B4		PERMB		225
UPI000A305966		MUSPA		225
+5

Protein	Similar proteins		Species	Score	Length	Source
D3ZV20	Transcription factor HES-7		MOUSE		225	UniRef50_Q8BKT2
transcription factor HES-7 isoform X2		MESAU		230
Uncharacterized protein		PAPAN		230
Hes family bHLH transcription factor 7		CHLSB		230
Hes family bHLH transcription factor 7		CALJA		285
+36

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC129753 Genomic DNA No translation available. CH473948 Genomic DNA Translation: EDM04844.1
RefSeqⁱ	NP_001099262.1, NM_001105792.1
UniGeneⁱ	Rn.218470

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000009757

STRINGⁱ

10116.ENSRNOP00000009757

Proteomic databases

PRIDEⁱ	D3ZV20

PRIDEⁱ

D3ZV20

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000009757; ENSRNOP00000009757; ENSRNOG00000007391
GeneIDⁱ	287423
KEGGⁱ	rno:287423
UCSCⁱ	RGD:1305914 rat

Organism-specific databases

CTDⁱ	84667
RGDⁱ	1305914 Hes7

Phylogenomic databases

eggNOGⁱ	KOG4304 Eukaryota ENOG4111F0X LUCA
GeneTreeⁱ	ENSGT00730000111282
KOⁱ	K09087
OMAⁱ	AQSMWRP
OrthoDBⁱ	EOG091G0XFV
TreeFamⁱ	TF351373

Gene expression databases

Bgeeⁱ	ENSRNOG00000007391 Expressed in 9 organ(s), highest expression level in testis

Bgeeⁱ

ENSRNOG00000007391 Expressed in 9 organ(s), highest expression level in testis

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR032644 HES-7 IPR036638 HLH_DNA-bd_sf IPR003650 Orange_dom
PANTHERⁱ	PTHR10985:SF84 PTHR10985:SF84, 1 hit
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS51054 ORANGE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D3ZV20_RAT
Accessionⁱ	D3ZV20Primary (citable) accession number: D3ZV20
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 20, 2010
	Last sequence update:	April 20, 2010
	Last modified:	November 7, 2018
	This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - D3ZV20 (D3ZV20_RAT)

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Hairy and enhancer of split 7 (Drosophila) (Predicted)

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ