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UniProtKB - D3ZV20 (D3ZV20_RAT)
Protein
Submitted name:
Hairy and enhancer of split 7 (Drosophila) (Predicted)
Gene
Hes7
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- anterior/posterior pattern specification Source: GO_Central
- negative regulation of transcription, DNA-templated Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- Notch signaling pathway Source: RGD
- post-anal tail morphogenesis Source: RGD
- regulation of neurogenesis Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
- rhythmic process Source: RGD
- skeletal system development Source: RGD
- somitogenesis Source: RGD
Keywordsi
Molecular function | RepressorARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Hairy and enhancer of split 7 (Drosophila) (Predicted)ImportedSubmitted name: Hes family bHLH transcription factor 7 |
Gene namesi | ORF Names:rCG_33876Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1305914, Hes7 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000007391, Expressed in testis and 19 other tissues |
Interactioni
Subunit structurei
Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.
ARBA annotationGO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000009757 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 69 | BHLHInterPro annotationAdd BLAST | 58 | |
Domaini | 92 – 122 | OrangeInterPro annotationAdd BLAST | 31 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 123 – 225 | DisorderedSequence analysisAdd BLAST | 103 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 134 – 152 | Pro residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 193 – 225 | Pro residuesSequence analysisAdd BLAST | 33 |
Phylogenomic databases
eggNOGi | KOG4304, Eukaryota |
GeneTreei | ENSGT00730000111282 |
HOGENOMi | CLU_068550_6_0_1 |
OMAi | CSTPCHD |
TreeFami | TF351373 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR032644, HES-7 IPR036638, HLH_DNA-bd_sf IPR003650, Orange_dom |
PANTHERi | PTHR10985:SF84, PTHR10985:SF84, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS51054, ORANGE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
D3ZV20-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVTRERAENR DGPKMLKPLV EKRRRDRINR SLEELRLLLL ERTRDQNLRN
60 70 80 90 100
PKLEKAEILE FAVGYLRERS RVEPPGVPRS PGQDAEALAS CYLSGFRECL
110 120 130 140 150
LRLAAFAHDA SPAARSQLFS ALNGYRRPKP PRPEAADPGL PAPRPPLDPA
160 170 180 190 200
SPILGPALHQ RPPVHQGPPS PRLAWSPSHC SPRAGDSGAP APLTGLLPPP
210 220
PPPYRQDGAP KAPPLPPPAF WRPWP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A8I6ACV0 | A0A8I6ACV0_RAT | Hes family bHLH transcription facto... | Hes7 | 211 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473948 Genomic DNA Translation: EDM04844.1 |
RefSeqi | NP_001099262.1, NM_001105792.1 |
Genome annotation databases
Ensembli | ENSRNOT00000009757.5; ENSRNOP00000009757.4; ENSRNOG00000007391.5 |
GeneIDi | 287423 |
KEGGi | rno:287423 |
UCSCi | RGD:1305914, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473948 Genomic DNA Translation: EDM04844.1 |
RefSeqi | NP_001099262.1, NM_001105792.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000009757 |
Genome annotation databases
Ensembli | ENSRNOT00000009757.5; ENSRNOP00000009757.4; ENSRNOG00000007391.5 |
GeneIDi | 287423 |
KEGGi | rno:287423 |
UCSCi | RGD:1305914, rat |
Organism-specific databases
CTDi | 84667 |
RGDi | 1305914, Hes7 |
Phylogenomic databases
eggNOGi | KOG4304, Eukaryota |
GeneTreei | ENSGT00730000111282 |
HOGENOMi | CLU_068550_6_0_1 |
OMAi | CSTPCHD |
TreeFami | TF351373 |
Gene expression databases
Bgeei | ENSRNOG00000007391, Expressed in testis and 19 other tissues |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR032644, HES-7 IPR036638, HLH_DNA-bd_sf IPR003650, Orange_dom |
PANTHERi | PTHR10985:SF84, PTHR10985:SF84, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS51054, ORANGE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | D3ZV20_RAT | |
Accessioni | D3ZV20Primary (citable) accession number: D3ZV20 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | May 25, 2022 | |
This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |