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Protein
Submitted name:

Cbl proto-oncogene

Gene

Cbl

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-1059683 Interleukin-6 signaling
R-RNO-1295596 Spry regulation of FGF signaling
R-RNO-1433559 Regulation of KIT signaling
R-RNO-182971 EGFR downregulation
R-RNO-2173789 TGF-beta receptor signaling activates SMADs
R-RNO-5654726 Negative regulation of FGFR1 signaling
R-RNO-5654727 Negative regulation of FGFR2 signaling
R-RNO-5654732 Negative regulation of FGFR3 signaling
R-RNO-5654733 Negative regulation of FGFR4 signaling
R-RNO-6807004 Negative regulation of MET activity
R-RNO-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
R-RNO-8856825 Cargo recognition for clathrin-mediated endocytosis
R-RNO-8856828 Clathrin-mediated endocytosis
R-RNO-912631 Regulation of signaling by CBL
R-RNO-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Names & Taxonomyi

Protein namesi
Submitted name:
Cbl proto-oncogeneImported
Gene namesi
Name:CblImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1561386 Cbl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiD3ZV15
PeptideAtlasiD3ZV15
PRIDEiD3ZV15

PTM databases

iPTMnetiD3ZV15
PhosphoSitePlusiD3ZV15

Expressioni

Gene expression databases

BgeeiENSRNOG00000008444 Expressed in 9 organ(s), highest expression level in spleen
GenevisibleiD3ZV15 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063226

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 350Cbl-PTBInterPro annotationAdd BLAST305
Domaini380 – 419RING-typeInterPro annotationAdd BLAST40
Domaini864 – 903UBAInterPro annotationAdd BLAST40

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1785 Eukaryota
ENOG410YDNH LUCA
GeneTreeiENSGT00390000011617
InParanoidiD3ZV15
KOiK04707
OMAiCEHPKIK
OrthoDBiEOG091G0GPE
TreeFamiTF314210

Family and domain databases

CDDicd09920 SH2_Cbl-b_TKB, 1 hit
Gene3Di1.20.930.20, 1 hit
3.30.40.10, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR024162 Adaptor_Cbl
IPR014741 Adaptor_Cbl_EF_hand-like
IPR036537 Adaptor_Cbl_N_dom_sf
IPR003153 Adaptor_Cbl_N_hlx
IPR014742 Adaptor_Cbl_SH2-like
IPR024159 Cbl_PTB
IPR011992 EF-hand-dom_pair
IPR036860 SH2_dom_sf
IPR015940 UBA
IPR009060 UBA-like_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR23007 PTHR23007, 1 hit
PfamiView protein in Pfam
PF02262 Cbl_N, 1 hit
PF02761 Cbl_N2, 1 hit
PF02762 Cbl_N3, 1 hit
PF00627 UBA, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SM00165 UBA, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF47473 SSF47473, 1 hit
SSF47668 SSF47668, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS51506 CBL_PTB, 1 hit
PS50030 UBA, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

D3ZV15-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGNVKKSSG AGGSGSGGSG AGGLIGLMKD AFQPHHHHHH HLSPHPPCTV
60 70 80 90 100
DKKMVEKCWK LMDKVVRLCQ NPKLALKNSP PYILDLLPDT YQHLRTVLSR
110 120 130 140 150
YEGKMETLGE NEYFRVFMEN LMKKTKQTIS LFKEGKERMY EENSQPRRNL
160 170 180 190 200
TKLSLIFSHM LAELKGIFPS GLFQGDTFRI TKADAAEFWR KAFGEKTIVP
210 220 230 240 250
WKSFRQALHE VHPISSGLEA MALKSTIDLT CNDYISVFEF DIFTRLFQPW
260 270 280 290 300
SSLLRNWNSL AVTHPGYMAF LTYDEVKARL QKFIHKPGSY IFRLSCTRLG
310 320 330 340 350
QWAIGYVTAD GNILQTIPHN KPLFQALIDG FREGFYLFPD GRNQNPDLTG
360 370 380 390 400
LCEPTPQDHI KVTQEQYELY CEMGSTFQLC KICAENDKDV KIEPCGHLMC
410 420 430 440 450
TSCLTSWQES EGQGCPFCRC EIKGTEPIVV DPFDPRGSGS LLRQGAEGAP
460 470 480 490 500
SPNYDDDDDE RADDSLFMMK ELAGAKVERP SSPFSMAPQA SLPPVPPRLD
510 520 530 540 550
LLQQRAPVPA STSVLGTASK ASSSSLHKDK PLPIPPTLRD LPPPPPPDRP
560 570 580 590 600
YSVGTETRPQ RRPLPCTPGD CPSRDKLPPV PSSRPGDSWL SRPIPKVPVA
610 620 630 640 650
TPNPGDPWNG RELTNRHSLP FSLPSQMEPR ADVPRLGSTF SLDTSTTMNS
660 670 680 690 700
SPVAGPESEH PKIKPSSSAN AIYSLAARPL PVPKLPPGEQ GDSEEDTEYM
710 720 730 740 750
TPTSRPVGVQ KPEPKRPAET AQSSRACDCD QQIDSCTYEA MYNIQSQALS
760 770 780 790 800
VAENSACGEG NLATAHTSTG PEESENEDDG YDVPKPPVPA VLARRTLSDI
810 820 830 840 850
SNASSSFGWL SLDGEPTNFN EGSQVPERPP KPFPRRINSE RKASSYQQGG
860 870 880 890 900
GAMANPAAAA PSPQLSSEIE RLMSQGYSYQ DIQKALVIAH NNIEMAKNIL
910
REFVSISSPA HVAT
Length:914
Mass (Da):100,691
Last modified:April 20, 2010 - v1
Checksum:i6611E312B9E2C1B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112557 Genomic DNA No translation available.
RefSeqiXP_001066453.2, XM_001066453.6
XP_576396.3, XM_576396.7
UniGeneiRn.232835

Genome annotation databases

EnsembliENSRNOT00000067902; ENSRNOP00000063226; ENSRNOG00000008444
GeneIDi500985
KEGGirno:500985

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112557 Genomic DNA No translation available.
RefSeqiXP_001066453.2, XM_001066453.6
XP_576396.3, XM_576396.7
UniGeneiRn.232835

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063226

PTM databases

iPTMnetiD3ZV15
PhosphoSitePlusiD3ZV15

Proteomic databases

PaxDbiD3ZV15
PeptideAtlasiD3ZV15
PRIDEiD3ZV15

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000067902; ENSRNOP00000063226; ENSRNOG00000008444
GeneIDi500985
KEGGirno:500985

Organism-specific databases

CTDi867
RGDi1561386 Cbl

Phylogenomic databases

eggNOGiKOG1785 Eukaryota
ENOG410YDNH LUCA
GeneTreeiENSGT00390000011617
InParanoidiD3ZV15
KOiK04707
OMAiCEHPKIK
OrthoDBiEOG091G0GPE
TreeFamiTF314210

Enzyme and pathway databases

ReactomeiR-RNO-1059683 Interleukin-6 signaling
R-RNO-1295596 Spry regulation of FGF signaling
R-RNO-1433559 Regulation of KIT signaling
R-RNO-182971 EGFR downregulation
R-RNO-2173789 TGF-beta receptor signaling activates SMADs
R-RNO-5654726 Negative regulation of FGFR1 signaling
R-RNO-5654727 Negative regulation of FGFR2 signaling
R-RNO-5654732 Negative regulation of FGFR3 signaling
R-RNO-5654733 Negative regulation of FGFR4 signaling
R-RNO-6807004 Negative regulation of MET activity
R-RNO-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
R-RNO-8856825 Cargo recognition for clathrin-mediated endocytosis
R-RNO-8856828 Clathrin-mediated endocytosis
R-RNO-912631 Regulation of signaling by CBL
R-RNO-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Gene expression databases

BgeeiENSRNOG00000008444 Expressed in 9 organ(s), highest expression level in spleen
GenevisibleiD3ZV15 RN

Family and domain databases

CDDicd09920 SH2_Cbl-b_TKB, 1 hit
Gene3Di1.20.930.20, 1 hit
3.30.40.10, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR024162 Adaptor_Cbl
IPR014741 Adaptor_Cbl_EF_hand-like
IPR036537 Adaptor_Cbl_N_dom_sf
IPR003153 Adaptor_Cbl_N_hlx
IPR014742 Adaptor_Cbl_SH2-like
IPR024159 Cbl_PTB
IPR011992 EF-hand-dom_pair
IPR036860 SH2_dom_sf
IPR015940 UBA
IPR009060 UBA-like_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR23007 PTHR23007, 1 hit
PfamiView protein in Pfam
PF02262 Cbl_N, 1 hit
PF02761 Cbl_N2, 1 hit
PF02762 Cbl_N3, 1 hit
PF00627 UBA, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SM00165 UBA, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF47473 SSF47473, 1 hit
SSF47668 SSF47668, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS51506 CBL_PTB, 1 hit
PS50030 UBA, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD3ZV15_RAT
AccessioniPrimary (citable) accession number: D3ZV15
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: September 12, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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