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Entry version 52 (07 Apr 2021)
Sequence version 2 (25 Apr 2018)
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Protein

Protein TOPAZ1

Gene

Topaz1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Spermatogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein TOPAZ1By similarity
Alternative name(s):
Testis- and ovary-specific PAZ domain-containing protein 1By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Topaz1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Rat genome database

More...
RGDi
1563398, Topaz1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004160621 – 1646Protein TOPAZ1Add BLAST1646

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D3ZUC6

PRoteomics IDEntifications database

More...
PRIDEi
D3ZUC6

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
D3ZUC6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000025601, Expressed in kidney and 7 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000032345

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3ZUC6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QPIV, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012495

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003190_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D3ZUC6

Identification of Orthologs from Complete Genome Data

More...
OMAi
NIFMEYY

Database of Orthologous Groups

More...
OrthoDBi
347766at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
D3ZUC6

TreeFam database of animal gene trees

More...
TreeFami
TF338635

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038952, TOPAZ1
IPR029435, TOPAZ1_dom

The PANTHER Classification System

More...
PANTHERi
PTHR35671, PTHR35671, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14669, Asp_Glu_race_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3ZUC6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPPTTPPVP TTAPGRQGAT GGLRKRGLRL TPEPGEGGGC SLEARGREEE
60 70 80 90 100
SRQKRRMVAQ ASGREETEAK ENGKVTEAPS DEPQPGTDLV RKTSITNSES
110 120 130 140 150
LQTVECSEFQ SMAFLQSLAK EELVEGIKRR IQIKKCKSSE NPPLKITKNE
160 170 180 190 200
ATQNIMVESQ DELFKNTPKY SCNSLSPGVE KNCSFESHDF SFLHSEGCNN
210 220 230 240 250
KNGFEDEPHG VCLHAEENSL KSKKENLRNL AEKDDTKTTK FLKTEKNVIA
260 270 280 290 300
SKLLLEESHL YQNKNNGLTS CLQSEKNKYS VEENNTGRKH RKKMKLSEKE
310 320 330 340 350
EKGIDLTLSN VCNNSELVLQ EHQIGMEGKE TETLEHKKSF LKALRKMNHN
360 370 380 390 400
TLPPVDHLCL PETVGKTSCR HSTNVVLQKT LESSLKEDTK NASETLGCRR
410 420 430 440 450
LQPEEYFKSM TSSTVKSPSD SHPMGKRSPR GDLKTDTEES KVSCRRIIPM
460 470 480 490 500
TGKRVWPLYS CARITAECWK KTSLSDLNDS LPGSLGNVRQ HDFLMHQTNQ
510 520 530 540 550
THLPDSKRLQ PSLIERTIES SSKEVYDSEL SSLSSVSSVE PTLLDIKETI
560 570 580 590 600
PHDKKTKLEE PSRNGTEVVS SATEDIQLSN ITQILTGNKK KKGNLSKLNL
610 620 630 640 650
TVAPQESQEA NNCANKTVHR KACITKQTLV APDLVKILNT GRLTNFKIPL
660 670 680 690 700
LKNKTGKRGE VSARSSEREA YSPLELLDSL SGVEAKQNRN KENICTTSGP
710 720 730 740 750
QSLNIHSVTP GQTSSHTFYN KNSCTSPSFT KKGYDNKTCN HISETGNTIS
760 770 780 790 800
NKESLSIKIE NNTFSCDLGY MEQSSFCSKK QEAFVPISSE ISGRKMTKSI
810 820 830 840 850
SELKLGFPDI LKAYEDDVLL IDVIQDDPEL FGISSEGDLS FASEVSKISQ
860 870 880 890 900
EPRVSEEHPS ADFKHRHLPG KKEPGDLSKE VALLDPGLLK LEICPSLSAA
910 920 930 940 950
KEPQHDPKGA AISLEATEET VISENLEDLS EQARASDSDT KCVSSDKATV
960 970 980 990 1000
VEEQENTHEV CKSKDSRSVE AVSTECHLAL GPNTLCSSAP PLTLSSHQDV
1010 1020 1030 1040 1050
APAPWTNDFR FPGRYSVLQL QNPETCEIFK REKNFGVFQK PLGLMIPHRY
1060 1070 1080 1090 1100
CKLHFNTLRG CERAQCKFVH VPEQGDEKIC MDVFKKYIRV NEQRLLHRAA
1110 1120 1130 1140 1150
YIFLEYYRKF PPGIHFSLQV LNDLLISLLK HCLLKEVFQV VQLSIMAKML
1160 1170 1180 1190 1200
PALKILLKIF EYVAAMKLRN AVPALIEIFC KFIEAGMIPD PEHLNYIVKL
1210 1220 1230 1240 1250
LHQAQASQQE ISAVLEAKSR LQVRQLRKNW TCDLDSALSE VENCKEKGDW
1260 1270 1280 1290 1300
TKLGNLYISI KMGCEEFADF QRFCACVAET LTEDYKEERP GVPFCEFAET
1310 1320 1330 1340 1350
VSKDPQYSEV DKTLLGRIGI SAVYFYHRLL LWSKGRKVLD ILYELKIHFT
1360 1370 1380 1390 1400
SLKGLTGPEK IAPRCQIVNV AAEIFIKSGS LDGAIWVLRE SEWITSTPLW
1410 1420 1430 1440 1450
PCDRADVLHR HNLLCAIAHE ILGKNLYKQT FEVLRNLPGF QNSQEAMGVS
1460 1470 1480 1490 1500
QSSLLFNELL DACIESNSLG ISSSVADFMV AKSIPIDFSF LRRLITSLGR
1510 1520 1530 1540 1550
SCLWLKARAH YKSALSLGCY PPLEGNVYRK LLLVPSYLSE IEMLLAIEIF
1560 1570 1580 1590 1600
LVSNASSIQS PGAPTQVLQI VLKRCEESKP RSKDDYQAAV ERLIMAARIS
1610 1620 1630 1640
DPKLFIKHMT VNINKEQVYS LEHCSAVKWL KENMKWAGKV WLFTNH
Length:1,646
Mass (Da):184,593
Last modified:April 25, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i46B759B161E328A2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07071813 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_006244267.1, XM_006244205.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000036545; ENSRNOP00000032345; ENSRNOG00000025601

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
301075

UCSC genome browser

More...
UCSCi
RGD:1563398, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07071813 Genomic DNA No translation available.
RefSeqiXP_006244267.1, XM_006244205.3

3D structure databases

SMRiD3ZUC6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032345

PTM databases

PhosphoSitePlusiD3ZUC6

Proteomic databases

PaxDbiD3ZUC6
PRIDEiD3ZUC6

Genome annotation databases

EnsembliENSRNOT00000036545; ENSRNOP00000032345; ENSRNOG00000025601
GeneIDi301075
UCSCiRGD:1563398, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
375337
RGDi1563398, Topaz1

Phylogenomic databases

eggNOGiENOG502QPIV, Eukaryota
GeneTreeiENSGT00390000012495
HOGENOMiCLU_003190_0_0_1
InParanoidiD3ZUC6
OMAiNIFMEYY
OrthoDBi347766at2759
PhylomeDBiD3ZUC6
TreeFamiTF338635

Miscellaneous databases

Protein Ontology

More...
PROi
PR:D3ZUC6

Gene expression databases

BgeeiENSRNOG00000025601, Expressed in kidney and 7 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR038952, TOPAZ1
IPR029435, TOPAZ1_dom
PANTHERiPTHR35671, PTHR35671, 1 hit
PfamiView protein in Pfam
PF14669, Asp_Glu_race_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTOPZ1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZUC6
Secondary accession number(s): R9PXW9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: April 25, 2018
Last modified: April 7, 2021
This is version 52 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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