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Protein

Ubiquitin carboxyl-terminal hydrolase 42

Gene

Usp42

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Deubiquitinating enzyme which may play an important role during spermatogenesis.By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei119NucleophilePROSITE-ProRule annotation1
Active sitei370Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processDifferentiation, Spermatogenesis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-RNO-5689880 Ub-specific processing proteases

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 42 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 42
Ubiquitin thioesterase 42
Ubiquitin-specific-processing protease 42
Gene namesi
Name:Usp42
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1305231 Usp42

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004042001 – 1325Ubiquitin carboxyl-terminal hydrolase 42Add BLAST1325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei74PhosphoserineBy similarity1
Modified residuei482PhosphoserineBy similarity1
Modified residuei858PhosphoserineBy similarity1
Modified residuei1190PhosphoserineBy similarity1
Modified residuei1228PhosphoserineCombined sources1
Modified residuei1231PhosphoserineCombined sources1
Modified residuei1235PhosphoserineCombined sources1
Modified residuei1256PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiD3ZU96
PeptideAtlasiD3ZU96
PRIDEiD3ZU96

PTM databases

iPTMnetiD3ZU96
PhosphoSitePlusiD3ZU96

Expressioni

Gene expression databases

BgeeiENSRNOG00000001059 Expressed in 9 organ(s), highest expression level in testis
GenevisibleiD3ZU96 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001404

Structurei

3D structure databases

SMRiD3ZU96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 411USPAdd BLAST302

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi787 – 790Poly-Val4
Compositional biasi1185 – 1255Lys-richAdd BLAST71

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

eggNOGiKOG1865 Eukaryota
ENOG410XQ92 LUCA
GeneTreeiENSGT00890000139343
InParanoidiD3ZU96
KOiK11855
OMAiLPSHMIK
OrthoDBiEOG091G02D8
PhylomeDBiD3ZU96
TreeFamiTF315281

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

D3ZU96-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTIVDKTEPS DPSTCQNQPG SSEAVSPEDM DTGSASWGAV SSISDVSNHT
60 70 80 90 100
LSLGPVPGAV VYNNSSVPEK SKPSPPKDQV LGDGIAPPQK VLFPSEKICL
110 120 130 140 150
KWQQSHRVGA GLQNLGNTCF ANAALQCLTY TPPLANYMLS HEHSKTCHAE
160 170 180 190 200
GFCMMCTMQT HITQALSNPG DVIKPMFVIN EMRRIARHFR FGNQEDAHEF
210 220 230 240 250
LQYTVDAMQK ACLNGSNKLD RHTQATTLVC QIFGGYLRSR VKCLNCKGVS
260 270 280 290 300
DTFDPYLDIT LEIKAAQSVT KALEQFVKPE QLDGENSYKC SKCKKMVPAS
310 320 330 340 350
KRFTIHRSSN VLTISLKRFA NFTGGKIAKD VKYPEYLDIR PYMSQPNGEP
360 370 380 390 400
IIYVLYAVLV HTGFNCHAGH YFCYIKASNG LWYQMNDSIV STSDIRSVLN
410 420 430 440 450
QQAYVLFYIR SHDVKNGGET THPAHSPGQS SPRPGISQRV VNSKQAAPGF
460 470 480 490 500
IGPQLPPHVM KNTPHLNGTT PVKDTPSSSV SSPNGNTSVN RASPATASTS
510 520 530 540 550
VQNWSVNRPS VIPEHPKKQK ITISIHNKLP VRQGQAQLNN NLHGPCLEAP
560 570 580 590 600
SKAAPSSTIT NPSAIQSTSN APTTSVSPSE SCPKPMVNGK AKVGSSVLVP
610 620 630 640 650
YGAESSEESD EESKGLAKEN GVDMMTSTQS SRPETADEDG EASPHELQES
660 670 680 690 700
VMLNGANSAD SDSRESSLAF DSASCQVQPD LHTENLFNKL NGLPGKVTPA
710 720 730 740 750
PLQSVPEDKI LETFKLTNQA KGPAVEESWT TTGGSSPRAS VSQPEPITDE
760 770 780 790 800
TSPLEIPEAV TNGSMKTPST TSPLEPTISC TKEDSSVVVV SAEPMEVLPS
810 820 830 840 850
VPALCNSTGT TLGDAPVPES CDPGDLTANP SQPSQAVKGD PAENSENSTL
860 870 880 890 900
AEVVERLSPA PSVLTGDGCE QKLFLYLSTE GSEEAEDSSR SSAVSADTVP
910 920 930 940 950
PQPDRTTSSC AGAAEQAAGD RGDGGSVGPK AQEPSPAKEK MNSLRKVDRG
960 970 980 990 1000
HYRSRRDRSS SGEHVRDSRA RPEDHHHKKR RCYSRERPKQ ERHPANTYCN
1010 1020 1030 1040 1050
GGQHLGHGDR ASPERRSLSR YSHHHSRVRS GLEQDWSRYH HSENEPAWAR
1060 1070 1080 1090 1100
ERFYPDKMRW DKCRYYHDRY TTTLYTAREA AREWRPLHGR EHERLVQSGR
1110 1120 1130 1140 1150
PHKDSYWGRK GWDLQSRGKE RPHFHSPREA PGLAVPLERH LQEKAALSVQ
1160 1170 1180 1190 1200
DSSHSLPERF HEHESVKLRK RRYETLDNND DHPEKKVHKS LEKDALEEPR
1210 1220 1230 1240 1250
AKKHKKSKKK KKSKDKHRAR DSRHQQESDF SGAYSDADLH RHRKKKKKKK
1260 1270 1280 1290 1300
RHSRKSEDFI KDVEMHLPKL SSYEAVGHFR RTEGTFLLAD GLPVEDSGPF
1310 1320
REKTKHLRME SRPDRCHLSE YGQGN
Length:1,325
Mass (Da):146,357
Last modified:April 20, 2010 - v1
Checksum:iEAC3721C860F59EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474012 Genomic DNA Translation: EDL89655.1
RefSeqiNP_001099379.1, NM_001105909.1
XP_017453778.1, XM_017598289.1
UniGeneiRn.25011

Genome annotation databases

EnsembliENSRNOT00000001404; ENSRNOP00000001404; ENSRNOG00000001059
GeneIDi288482
KEGGirno:288482

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474012 Genomic DNA Translation: EDL89655.1
RefSeqiNP_001099379.1, NM_001105909.1
XP_017453778.1, XM_017598289.1
UniGeneiRn.25011

3D structure databases

SMRiD3ZU96
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001404

PTM databases

iPTMnetiD3ZU96
PhosphoSitePlusiD3ZU96

Proteomic databases

PaxDbiD3ZU96
PeptideAtlasiD3ZU96
PRIDEiD3ZU96

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001404; ENSRNOP00000001404; ENSRNOG00000001059
GeneIDi288482
KEGGirno:288482

Organism-specific databases

CTDi84132
RGDi1305231 Usp42

Phylogenomic databases

eggNOGiKOG1865 Eukaryota
ENOG410XQ92 LUCA
GeneTreeiENSGT00890000139343
InParanoidiD3ZU96
KOiK11855
OMAiLPSHMIK
OrthoDBiEOG091G02D8
PhylomeDBiD3ZU96
TreeFamiTF315281

Enzyme and pathway databases

ReactomeiR-RNO-5689880 Ub-specific processing proteases

Miscellaneous databases

PROiPR:D3ZU96

Gene expression databases

BgeeiENSRNOG00000001059 Expressed in 9 organ(s), highest expression level in testis
GenevisibleiD3ZU96 RN

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUBP42_RAT
AccessioniPrimary (citable) accession number: D3ZU96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: April 20, 2010
Last modified: September 12, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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