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UniProtKB - D3ZU59 (D3ZU59_RAT)
Protein
Submitted name:
Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_a
Gene
Nfatc3
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- chromatin binding Source: RGD
- DNA binding Source: RGD
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- blood vessel remodeling Source: RGD
- branching involved in blood vessel morphogenesis Source: RGD
- calcineurin-NFAT signaling cascade Source: RGD
- cardiac muscle hypertrophy in response to stress Source: RGD
- cellular respiration Source: RGD
- cellular response to calcium ion Source: RGD
- cellular response to lithium ion Source: RGD
- heart development Source: RGD
- muscle cell development Source: RGD
- myotube cell development Source: RGD
- myotube differentiation Source: RGD
- negative regulation of pri-miRNA transcription by RNA polymerase II Source: RGD
- negative regulation of vascular associated smooth muscle cell differentiation Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of store-operated calcium entry Source: RGD
- regulation of transcription, DNA-templated Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to hypoxia Source: RGD
- skeletal muscle fiber development Source: RGD
- smooth muscle cell differentiation Source: RGD
- T cell differentiation Source: RGD
- thymus development Source: RGD
Keywordsi
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_aImportedSubmitted name: Nuclear factor of-activated T-cells 3Imported |
Gene namesi | ORF Names:rCG_51043Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1308692, Nfatc3 |
Subcellular locationi
Cytosol
- cytosol Source: RGD
Nucleus
- nucleus Source: RGD
Other locations
- cytoplasm Source: RGD
- transcription regulator complex Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000054264, Expressed in thymus and 20 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 416 – 597 | RHDInterPro annotationAdd BLAST | 182 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 206 – 307 | DisorderedSequence analysisAdd BLAST | 102 | |
Regioni | 359 – 390 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 700 – 744 | DisorderedSequence analysisAdd BLAST | 45 | |
Regioni | 863 – 987 | DisorderedSequence analysisAdd BLAST | 125 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 230 – 273 | Polar residuesSequence analysisAdd BLAST | 44 | |
Compositional biasi | 362 – 376 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 712 – 738 | Polar residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 863 – 943 | Polar residuesSequence analysisAdd BLAST | 81 | |
Compositional biasi | 950 – 987 | Polar residuesSequence analysisAdd BLAST | 38 |
Phylogenomic databases
eggNOGi | ENOG502QWQ4, Eukaryota |
GeneTreei | ENSGT00940000156131 |
OMAi | GKEQHML |
OrthoDBi | 95502at2759 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR008366, NFAT IPR008967, p53-like_TF_DNA-bd IPR032397, RHD_dimer IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf |
PANTHERi | PTHR12533, PTHR12533, 1 hit |
Pfami | View protein in Pfam PF16179, RHD_dimer, 1 hit PF00554, RHD_DNA_bind, 1 hit |
PRINTSi | PR01789, NUCFACTORATC |
SMARTi | View protein in SMART SM00429, IPT, 1 hit |
SUPFAMi | SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS50254, REL_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
D3ZU59-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTTANCGAHD ELDFKLVFGE DGAPTPVSQV SRPADLEPDD CASIYIFNVD
60 70 80 90 100
PPPSTLNSSL GLPHHGLLQS HSSVLSPSFQ LQGFKNYEGT DDISESKYSS
110 120 130 140 150
LSGPKPFECP SIQITSISPN CHQETDAHED DLHVNDPERE YLERPSRDHL
160 170 180 190 200
YLPLEPSYRE SSLSPSPASS VSSRSWFSDA SSCESLSHIY DDVDSELNEA
210 220 230 240 250
AARFTLGSPL TSPGGSPGGC PGEESWHQQY GPGHSLSPRQ SPCHSPRSSI
260 270 280 290 300
TDENWLSPRP ASGPSSRPTS PCGKRRHSSA EVCYAGSLSP HHSPVPSPGH
310 320 330 340 350
SPRGSVTEDT WLTAPVHTGS GLSPAPFPFQ YCVETDIPLK TRKTSDDQAA
360 370 380 390 400
ILPGKLEVCS DDQGSLSPSR ETSVDDGLGS QYPLKKDSSG DQFLSVPSPF
410 420 430 440 450
TWSKPKPGHT PIFRTSSLPP LDWPLPTHFG QCELKIEVQP KTHHRAHYET
460 470 480 490 500
EGSRGAVKAS TGGHPVVKLL GYSEKPINLQ MFIGTADDRY LRPHAFYQVH
510 520 530 540 550
RITGKTVATA SQEIIIASTK VLEIPLLPEN NMSASIDCAG ILKLRNSDIE
560 570 580 590 600
LRKGETDIGR KNTRVRLVFR VHIPQPSGKV LSLQIASIPV ECSQRSAQEL
610 620 630 640 650
PHIEKYSINS CSVNGGHEMI VTGSNFLPES KIIFLEKGQD GRPHWEAEGK
660 670 680 690 700
IIREKCQGGH IVLEVPPYHN PAVTSAVQVH FYLCNGKRKK SQSQRFTYTP
710 720 730 740 750
VLMKQEQRED TDLSSVPSLP VPHSAQTQRP SSDTGHPHDS ALSAPRSLIC
760 770 780 790 800
PVQPAYASMI TSTHLPQLQC RDEGAGKEQH IIPSSVMHQP FQVTPTSPMG
810 820 830 840 850
SSYQSIQTNM YNGPTCLPMN PASSQEFDPV LFQQDAALSN LVNLGCQPLS
860 870 880 890 900
PIPFHSSNSD ATGHLLAHSP HSVQTPPHLQ SMGYHCSSAG QRSLSSPVAA
910 920 930 940 950
QVTGQPSSHL QPITYCPSHP GSATAASPAA SHALSSSPIS GPPSPQLQSM
960 970 980 990 1000
PYQSPSSGTA SSPSPVTRMH SGQHSTQAQS TGQGGLSVPS SLVCHSLCDP
1010 1020 1030 1040 1050
ASFPPGGAAV SIKPEPEDQE PNFATIGLQD ITLDDDQFMS DLEHQPSGST
1060
EKWPNHSEFS CPVPFWRI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JTY4 | A0A0G2JTY4_RAT | Nuclear factor of activated T-cells... | Nfatc3 Nfatc3_predicted, rCG_51043 | 1,076 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC128800 Genomic DNA No translation available. CH473972 Genomic DNA Translation: EDL92434.1 |
RefSeqi | NP_001101917.1, NM_001108447.1 |
Genome annotation databases
Ensembli | ENSRNOT00000089783; ENSRNOP00000069756; ENSRNOG00000054264 |
GeneIDi | 361400 |
KEGGi | rno:361400 |
UCSCi | RGD:1308692, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC128800 Genomic DNA No translation available. CH473972 Genomic DNA Translation: EDL92434.1 |
RefSeqi | NP_001101917.1, NM_001108447.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000025402 |
Genome annotation databases
Ensembli | ENSRNOT00000089783; ENSRNOP00000069756; ENSRNOG00000054264 |
GeneIDi | 361400 |
KEGGi | rno:361400 |
UCSCi | RGD:1308692, rat |
Organism-specific databases
CTDi | 4775 |
RGDi | 1308692, Nfatc3 |
Phylogenomic databases
eggNOGi | ENOG502QWQ4, Eukaryota |
GeneTreei | ENSGT00940000156131 |
OMAi | GKEQHML |
OrthoDBi | 95502at2759 |
Gene expression databases
Bgeei | ENSRNOG00000054264, Expressed in thymus and 20 other tissues |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR008366, NFAT IPR008967, p53-like_TF_DNA-bd IPR032397, RHD_dimer IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf |
PANTHERi | PTHR12533, PTHR12533, 1 hit |
Pfami | View protein in Pfam PF16179, RHD_dimer, 1 hit PF00554, RHD_DNA_bind, 1 hit |
PRINTSi | PR01789, NUCFACTORATC |
SMARTi | View protein in SMART SM00429, IPT, 1 hit |
SUPFAMi | SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS50254, REL_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | D3ZU59_RAT | |
Accessioni | D3ZU59Primary (citable) accession number: D3ZU59 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | January 19, 2022 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |