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UniProtKB - D3ZTY1 (D3ZTY1_RAT)
Protein
Submitted name:
BTB (POZ) domain containing 4 (Predicted)
Gene
Zbtb46
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- transcription cis-regulatory region binding Source: RGD
GO - Biological processi
- negative regulation of dendritic cell differentiation Source: RGD
- negative regulation of granulocyte differentiation Source: RGD
- negative regulation of macrophage differentiation Source: RGD
- negative regulation of monocyte differentiation Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- positive regulation of dendritic cell differentiation Source: RGD
- regulation of transcription by RNA polymerase II Source: RGD
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: BTB (POZ) domain containing 4 (Predicted)ImportedSubmitted name: Zinc finger and BTB domain-containing 46 |
Gene namesi | ORF Names:rCG_38441Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1307408, Zbtb46 |
Subcellular locationi
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000014592, Expressed in spleen and 19 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 99 | BTBInterPro annotationAdd BLAST | 69 | |
Domaini | 419 – 446 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 447 – 474 | C2H2-typeInterPro annotationAdd BLAST | 28 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 173 – 219 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 255 – 278 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 514 – 601 | DisorderedSequence analysisAdd BLAST | 88 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 173 – 188 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 540 – 558 | Acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 559 – 585 | Basic and acidic residuesSequence analysisAdd BLAST | 27 |
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000158060 |
HOGENOMi | CLU_022356_2_0_1 |
OMAi | QSERTWD |
OrthoDBi | 755439at2759 |
TreeFami | TF341953 |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 1 hit |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 1 hit PS50157, ZINC_FINGER_C2H2_2, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
D3ZTY1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNNRKEDMEI TSHYRHLLRE LNEQRQHGVL CDVCVVVEGK VFKAHKNVLL
60 70 80 90 100
GSSRYFKTLY CQVQKTSDQA TVTHLDIVTA QGFKAIIDFM YSAHLALTSR
110 120 130 140 150
NVIEVMSAAS FLQMTDIVQA CHDFIKAALD ISIKSDASDE LSEFEIGTPA
160 170 180 190 200
SNSTEALISA VMAGRSISPW LARRTSPANS SGDSAIASCH EGGSSYGKED
210 220 230 240 250
QEPKADGPDD VSSQSLWPGD VGYGSLRIKE EQISPSHYGG SELSSSKDAA
260 270 280 290 300
IQNSLSEQGS GDGWQPTGRR KNRKNKETVR HITQQVEEDS QAGSPVPSFL
310 320 330 340 350
PTSGWPFSSR DSNVDLTVTE ASSLDSRGER AELYAHHIDE GLLGGETSYL
360 370 380 390 400
GPPLTPEKEE ALHQATAVAN LRAALMSKNS LLSLKADVLG DDGSLLFEYL
410 420 430 440 450
PKGAHSLSLN EFTVIRKKFK CPYCSFSAMH QCILKRHMRS HTGERPYPCE
460 470 480 490 500
ICGKKFTRRE HMKRHTLVHS KDKKYVCKVC SRVFMSAASV GIKHGSRRHG
510 520 530 540 550
VCADCAGRGV GTPLDHGGGG EGSPEALFAG EGPYLEDPDD PRGEVEEELG
560 570 580 590 600
EDEDEDVAKW KDDVGLAHED ALLGDDKDDE DSPQGPHSPA GEPDKDFAWI
S
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JXJ5 | A0A0G2JXJ5_RAT | Zinc finger and BTB domain-containi... | Zbtb46 | 434 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH474066 Genomic DNA Translation: EDL88718.1 |
RefSeqi | NP_001101278.1, NM_001107808.1 XP_008760732.1, XM_008762510.2 |
Genome annotation databases
Ensembli | ENSRNOT00000020168.7; ENSRNOP00000020168.4; ENSRNOG00000014592.8 |
GeneIDi | 311718 |
KEGGi | rno:311718 |
UCSCi | RGD:1307408, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH474066 Genomic DNA Translation: EDL88718.1 |
RefSeqi | NP_001101278.1, NM_001107808.1 XP_008760732.1, XM_008762510.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000020168 |
Genome annotation databases
Ensembli | ENSRNOT00000020168.7; ENSRNOP00000020168.4; ENSRNOG00000014592.8 |
GeneIDi | 311718 |
KEGGi | rno:311718 |
UCSCi | RGD:1307408, rat |
Organism-specific databases
CTDi | 140685 |
RGDi | 1307408, Zbtb46 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000158060 |
HOGENOMi | CLU_022356_2_0_1 |
OMAi | QSERTWD |
OrthoDBi | 755439at2759 |
TreeFami | TF341953 |
Gene expression databases
Bgeei | ENSRNOG00000014592, Expressed in spleen and 19 other tissues |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 1 hit |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 1 hit PS50157, ZINC_FINGER_C2H2_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | D3ZTY1_RAT | |
Accessioni | D3ZTY1Primary (citable) accession number: D3ZTY1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | May 25, 2022 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |