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UniProtKB - D3ZTN3 (D3ZTN3_RAT)
Protein
Submitted name:
BCL6B, transcription repressor
Gene
Bcl6b
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: RGD
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: RGD
- regulation of cell differentiation Source: GO_Central
- regulation of cell population proliferation Source: GO_Central
- regulation of cytokine production Source: GO_Central
- regulation of immune system process Source: GO_Central
- regulation of inflammatory response Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
- type 2 immune response Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: BCL6B, transcription repressorImportedSubmitted name: Similar to BAZF (Predicted)Imported |
Gene namesi | ORF Names:rCG_33355Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1563179, Bcl6b |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000059956, Expressed in heart and 21 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 38 – 105 | BTBInterPro annotationAdd BLAST | 68 | |
Domaini | 321 – 348 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 349 – 376 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 377 – 404 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 405 – 432 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 433 – 461 | C2H2-typeInterPro annotationAdd BLAST | 29 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 143 – 190 | DisorderedSequence analysisAdd BLAST | 48 | |
Regioni | 209 – 250 | DisorderedSequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 146 – 165 | Pro residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 171 – 186 | Polar residuesSequence analysisAdd BLAST | 16 |
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159844 |
HOGENOMi | CLU_024196_2_0_1 |
OMAi | VCGARFN |
OrthoDBi | 1318335at2759 |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
i Sequence
Sequence statusi: Complete.
D3ZTN3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSTAAPEGA LGYVREFTRH SSDVLSNLNE LRLRGILTDV TLLVGGQPLR
60 70 80 90 100
AHKAVLIACS GFFYSIFRGR AGVGVDVLSL PGGPEARGFA PLLDFMYTSR
110 120 130 140 150
LRLSPATAPA VLAAATYLQM EHVVQACHRF IQASYEPLGI SLRPMEAEPP
160 170 180 190 200
RPPTVPPPGS PRRSEGHPDP PTESRSCSQG SPSPASPDPK ACNWKKYKFI
210 220 230 240 250
VLNSQSSQAG SLAGESSGQP CPQARLPSGD EACSSSSSSS SEEGATPGLQ
260 270 280 290 300
SRLSLATTTA RFKCGALANN SYLFTPPAQE TSKQAHPPPG SECLSCQNCE
310 320 330 340 350
AVAGCSSGIE PLAPGDEDKP YKCQLCRSAF RYKGNLASHR TVHTGEKPYR
360 370 380 390 400
CSVCGARFNR PANLKTHSRI HSGEKPYKCE TCGSRFVQVA HLRAHVLIHT
410 420 430 440 450
GEKPYPCPTC GTRFRHLQTL KSHVRIHTGE KPYHCDPCGL HFRHKSQLRL
460 470
HLRQKHGAAT NTKVRYHILG GP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07029870 Genomic DNA No translation available. AABR07072136 Genomic DNA No translation available. CH473948 Genomic DNA Translation: EDM04985.1 |
RefSeqi | NP_001101749.1, NM_001108279.1 XP_008766063.1, XM_008767841.1 XP_008766064.1, XM_008767842.1 XP_008766065.1, XM_008767843.1 |
Genome annotation databases
Ensembli | ENSRNOT00000090338; ENSRNOP00000071137; ENSRNOG00000059956 |
GeneIDi | 360551 |
KEGGi | rno:360551 |
UCSCi | RGD:1563179, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07029870 Genomic DNA No translation available. AABR07072136 Genomic DNA No translation available. CH473948 Genomic DNA Translation: EDM04985.1 |
RefSeqi | NP_001101749.1, NM_001108279.1 XP_008766063.1, XM_008767841.1 XP_008766064.1, XM_008767842.1 XP_008766065.1, XM_008767843.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000025430 |
Genome annotation databases
Ensembli | ENSRNOT00000090338; ENSRNOP00000071137; ENSRNOG00000059956 |
GeneIDi | 360551 |
KEGGi | rno:360551 |
UCSCi | RGD:1563179, rat |
Organism-specific databases
CTDi | 255877 |
RGDi | 1563179, Bcl6b |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159844 |
HOGENOMi | CLU_024196_2_0_1 |
OMAi | VCGARFN |
OrthoDBi | 1318335at2759 |
Gene expression databases
Bgeei | ENSRNOG00000059956, Expressed in heart and 21 other tissues |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | D3ZTN3_RAT | |
Accessioni | D3ZTN3Primary (citable) accession number: D3ZTN3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | January 19, 2022 | |
This is version 93 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |