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Protein
Submitted name:

Neurexin-2

Gene

Nrxn2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Neurexin-2Imported
Gene namesi
Name:Nrxn2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620211 Nrxn2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1568 – 1588HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500672260229 – 1642Sequence analysisAdd BLAST1614

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000021103 Expressed in 10 organ(s), highest expression level in brain
ExpressionAtlasiD3ZTM0 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 206LAM_G_DOMAINInterPro annotationAdd BLAST179
Domaini202 – 242EGF-likeInterPro annotationAdd BLAST41
Domaini265 – 455LAM_G_DOMAINInterPro annotationAdd BLAST191
Domaini462 – 655LAM_G_DOMAINInterPro annotationAdd BLAST194
Domaini659 – 696EGF-likeInterPro annotationAdd BLAST38
Domaini701 – 864LAM_G_DOMAINInterPro annotationAdd BLAST164
Domaini878 – 1053LAM_G_DOMAINInterPro annotationAdd BLAST176
Domaini1056 – 1093EGF-likeInterPro annotationAdd BLAST38
Domaini1097 – 1275LAM_G_DOMAINInterPro annotationAdd BLAST179

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3514 Eukaryota
ENOG410XNU6 LUCA
GeneTreeiENSGT00760000118991

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR001791 Laminin_G
IPR037440 Neurexin
IPR003585 Neurexin-like
IPR027789 Syndecan/Neurexin_dom
PANTHERiPTHR44287 PTHR44287, 2 hits
PfamiView protein in Pfam
PF02210 Laminin_G_2, 6 hits
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
SM00181 EGF, 3 hits
SM00282 LamG, 6 hits
SUPFAMiSSF49899 SSF49899, 6 hits
PROSITEiView protein in PROSITE
PS50026 EGF_3, 3 hits
PS50025 LAM_G_DOMAIN, 6 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

D3ZTM0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALGSRWRPP PQLPPLLLLL ALVAGVRGLE FGGGPGQWAR YARWAGAAST
60 70 80 90 100
GELSFSLRTN ATRALLLYLD DGGDCDFLEL LLVDGRLRLR FTLSCAEPAT
110 120 130 140 150
LQLDTPVADD RWHMVLLTRD ARRTALAVDG EARAAEVRSK RREMQVASDL
160 170 180 190 200
FVGGIPPDVR LSALTLSTVK YEPPFRGLLA NLKLGERPPA LLGSQGLRGA
210 220 230 240 250
AADPLCAPAR NPCANGGLCT VLAPGEVGCD CSHTGFGGKF CSEEEHPMEG
260 270 280 290 300
PAHLTLNSEG KEEFVATFKG NEFFCYDLSH NPIQSSTDEI TLAFRTLQRN
310 320 330 340 350
GLMLHTGKSA DYVNLSLKSG AVWLVINLGS GAFEALVEPV NGKFNDNAWH
360 370 380 390 400
DVRVTRNLRQ HAGIGHAMVT ISVDGILTTT GYTQEDYTML GSDDFFYIGG
410 420 430 440 450
SPNTADLPGS PVSNNFMGCL KDVVYKNNDF KLELSRLAKE GDPKMKLQGD
460 470 480 490 500
LSFRCEDVAA LDPVTFESPE AFVALPRWSA KRTGSISLDF RTTEPNGLLL
510 520 530 540 550
FSQGRRAGAG VGSHSSSQRA DYFAMELLDG YLYLLLDMGS GGIKLRASSR
560 570 580 590 600
KVNDGEWCHV DFQRDGRKGS ISVNSRSTPF LATGESEVLD LESELYLGGL
610 620 630 640 650
PEGGRVDLPL PPEVWTAALR AGYVGCVRDL FIDGRSRDLR GLAEAQGAVG
660 670 680 690 700
VAPFCSRETL KQCASAPCRN GGICREGWNR FVCDCIGTGF LGRVCEREAT
710 720 730 740 750
VLSYDGSMYM KIMLPNAMHT EAEDVSLRFM SQRAYGLMMA TTSRESADTL
760 770 780 790 800
RLELDGGQMK LTVNLGKGPE TLFAGHKLND NEWHTVRVVR RGKSLQLSVD
810 820 830 840 850
NVTVEGQMAG AHTRLEFHNI ETGIMTERRF ISVVPSNFIG HLSGLVFNGQ
860 870 880 890 900
PYMDQCKDGD ITYCELNARF GLRAIVADPV TFKSRSSYLA LATLQAYASM
910 920 930 940 950
HLFFQFKTTA PDGLLLFNSG NGNDFIVIEL VKGYIHYVFD LGNGPSLMKG
960 970 980 990 1000
NSDKPVNDNQ WHNVVVSRDP GNVHTLKIDS RTVTQHSNGA RNLDLKGELY
1010 1020 1030 1040 1050
IGGLSKNMFS NLPKLVASRD GFQGCLASVD LNGRLPDLIA DALHRIGQVE
1060 1070 1080 1090 1100
RGCDGPSTTC TEESCANQGV CLQQWDGFTC DCTMTSYGGP VCNDPGTTYI
1110 1120 1130 1140 1150
FGKGGALITY TWPPNDRPST RMDRLAVGFS THQRSAVLVR VDSASGLGDY
1160 1170 1180 1190 1200
LQLHIDQGTV GVIFNVGTDD ITIDEPNAIV SDGKYHVVRF TRSGGNATLQ
1210 1220 1230 1240 1250
VDSWPVNERY PAGRQLTIFN SQAAIKIGGR DQGRPFQGQV SGLYYNGLKV
1260 1270 1280 1290 1300
LALAAESDPN VRTEGHLRLV GEGPSVLLSA ETTATTLLAD MATTIMETTT
1310 1320 1330 1340 1350
TMATTTTRRG RSPTMRDSTT QNTDDLLVAS AECPSDDEDL EECEPSTGGE
1360 1370 1380 1390 1400
LILPIITEDS LDPPPVATRS PFVPPPPTFY PFLTGVGATQ DTLPPPAARR
1410 1420 1430 1440 1450
PSSGGPCQAE RDDSDCEEPV EASGFASGEV FDSSLPPTDD EDFYTTFPLV
1460 1470 1480 1490 1500
TDRTTLLSPR KPAPRPNLRT DGATGAPGVL LAPSAPAPNL PAGKMNHRDP
1510 1520 1530 1540 1550
LQPLLENPPL GPGVPTAFEP RRPPPLRPGV TSVPGFPRLP TANPTGPGER
1560 1570 1580 1590 1600
GPPGAVEVIR ESSSTTGMVV GIVAAAALCI LILLYAMYKY RNRDEGSYQV
1610 1620 1630 1640
DQSRNYISNS AQSNGAVVKE KAPAAPKTPS KAKKNKDKEY YV
Length:1,642
Mass (Da):177,385
Last modified:February 17, 2016 - v4
Checksum:i746BC4B7B5335890
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q63374NRX2A_RAT
Neurexin-2
Nrxn2
1,715Annotation score:
D3ZAD6D3ZAD6_RAT
Neurexin-2
Nrxn2
1,715Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC128900 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSRNOT00000054828; ENSRNOP00000051712; ENSRNOG00000021103

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC128900 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000054828; ENSRNOP00000051712; ENSRNOG00000021103

Organism-specific databases

RGDi620211 Nrxn2

Phylogenomic databases

eggNOGiKOG3514 Eukaryota
ENOG410XNU6 LUCA
GeneTreeiENSGT00760000118991

Gene expression databases

BgeeiENSRNOG00000021103 Expressed in 10 organ(s), highest expression level in brain
ExpressionAtlasiD3ZTM0 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR001791 Laminin_G
IPR037440 Neurexin
IPR003585 Neurexin-like
IPR027789 Syndecan/Neurexin_dom
PANTHERiPTHR44287 PTHR44287, 2 hits
PfamiView protein in Pfam
PF02210 Laminin_G_2, 6 hits
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
SM00181 EGF, 3 hits
SM00282 LamG, 6 hits
SUPFAMiSSF49899 SSF49899, 6 hits
PROSITEiView protein in PROSITE
PS50026 EGF_3, 3 hits
PS50025 LAM_G_DOMAIN, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiD3ZTM0_RAT
AccessioniPrimary (citable) accession number: D3ZTM0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: February 17, 2016
Last modified: September 12, 2018
This is version 69 of the entry and version 4 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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