PLAG1-like zinc finger 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • "Pleiomorphic adenoma gene-like-2, a zinc finger protein, transactivates the surfactant protein-C promoter."
    Yang M.C., Weissler J.C., Terada L.S., Deng F., Yang Y.S.
    Am. J. Respir. Cell Mol. Biol. 32:35-43(2005) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Pleiomorphic adenoma gene-like-2, a zinc finger protein, transactivates the surfactant protein-C promoter."
    Yang M.C., Weissler J.C., Terada L.S., Deng F., Yang Y.S.
    Am. J. Respir. Cell Mol. Biol. 32:35-43(2005) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• chylomicron assembly Source: RGDInferred from sequence orthologyⁱ
  • "Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons."
    Van Dyck F., Braem C.V., Chen Z., Declercq J., Deckers R., Kim B.M., Ito S., Wu M.K., Cohen D.E., Dewerchin M., Derua R., Waelkens E., Fiette L., Roebroek A., Schuit F., Van de Ven W.J., Shivdasani R.A.
    Cell Metab. 6:406-413(2007) [PubMed] [Europe PMC] [Abstract]
• lipid metabolic process Source: RGDInferred from sequence orthologyⁱ
  • "Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons."
    Van Dyck F., Braem C.V., Chen Z., Declercq J., Deckers R., Kim B.M., Ito S., Wu M.K., Cohen D.E., Dewerchin M., Derua R., Waelkens E., Fiette L., Roebroek A., Schuit F., Van de Ven W.J., Shivdasani R.A.
    Cell Metab. 6:406-413(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of intrinsic apoptotic signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "A zinc-finger protein, PLAGL2, induces the expression of a proapoptotic protein Nip3, leading to cellular apoptosis."
    Mizutani A., Furukawa T., Adachi Y., Ikehara S., Taketani S.
    J. Biol. Chem. 277:15851-15858(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "A zinc-finger protein, PLAGL2, induces the expression of a proapoptotic protein Nip3, leading to cellular apoptosis."
    Mizutani A., Furukawa T., Adachi Y., Ikehara S., Taketani S.
    J. Biol. Chem. 277:15851-15858(2002) [PubMed] [Europe PMC] [Abstract]
• post-embryonic development Source: RGDInferred from sequence orthologyⁱ
  • "Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons."
    Van Dyck F., Braem C.V., Chen Z., Declercq J., Deckers R., Kim B.M., Ito S., Wu M.K., Cohen D.E., Dewerchin M., Derua R., Waelkens E., Fiette L., Roebroek A., Schuit F., Van de Ven W.J., Shivdasani R.A.
    Cell Metab. 6:406-413(2007) [PubMed] [Europe PMC] [Abstract]
• transcription, DNA-templated Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MTTFFTSVPP WIQDAKQEEE VGWKLVPRPR GREAESQVKC QCEISGTPFS 
        60         70         80         90        100
NGEKLRPHSL PHPEQRPYSC PQLHCGKAFA SKYKLYRHMA THSAQKPHQC 
       110        120        130        140        150
MYCDKMFHRK DHLRNHLQTH DPNKEALHCS ECGKNYNTKL GYRRHLAMHA 
       160        170 
ASSGDLSCKV CNWVFSKYIM TPSSS                            

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ