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Entry version 92 (29 Sep 2021)
Sequence version 1 (20 Apr 2010)
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Protein

Mitogen-activated protein kinase kinase kinase 14

Gene

Map3k14

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity.

UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei432ATPPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
LigandATP-bindingUniRule annotationARBA annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-389357, CD28 dependent PI3K/Akt signaling
R-RNO-5607761, Dectin-1 mediated noncanonical NF-kB signaling
R-RNO-5668541, TNFR2 non-canonical NF-kB pathway
R-RNO-5676590, NIK-->noncanonical NF-kB signaling
R-RNO-5676594, TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase 14UniRule annotation (EC:2.7.11.25UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Map3k14Imported
Synonyms:Map3k14_predictedImported
ORF Names:rCG_33043Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Rat genome database

More...
RGDi
1310487, Map3k14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000003278, Expressed in spleen and 21 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000004532

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3ZTD1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini402 – 657Protein kinaseInterPro annotationAdd BLAST256

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni134 – 179DisorderedSequence analysisAdd BLAST46
Regioni295 – 319DisorderedSequence analysisAdd BLAST25
Regioni660 – 756DisorderedSequence analysisAdd BLAST97
Regioni801 – 825DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi134 – 153Basic residuesSequence analysisAdd BLAST20
Compositional biasi707 – 721Pro residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0198, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156497

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010641_1_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
LNWGKEE

Database of Orthologous Groups

More...
OrthoDBi
162528at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
D3ZTD1

TreeFam database of animal gene trees

More...
TreeFami
TF105120

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13991, STKc_NIK, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR042787, M3K14_STKc
IPR017425, MAPKKK14
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

The PANTHER Classification System

More...
PANTHERi
PTHR48016:SF9, PTHR48016:SF9, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069, Pkinase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF038175, MAPKKK14, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3ZTD1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVMEVACPG TPGSAVGQQK EFAKAKEKTQ SPGKKQSCIF QLEAVEKSPV
60 70 80 90 100
FCGKWEILND VITKGTAKEG SEGGPPAISI IAQAECENSQ EFSPTFSERI
110 120 130 140 150
FIAGSQQYSQ SESLDQIPNN VAHATEGKMA RVCRKGKRHS KARKKRRKRR
160 170 180 190 200
SKSLAQAGVA LAKPLPRTPE QESCTIPVQE DESPLGNLYA RNVSQFTKPL
210 220 230 240 250
KGPGLGHLCF KKQDEGLRPV LPRPELHKLI SPLQCLNHVW KLHHPQATGP
260 270 280 290 300
LPHPTHPFPF SRMPHPFPFY PLEPWRPYTL NPAFLDKLAA VSGQRPLPGP
310 320 330 340 350
PHLSKPAYRD SQKPLPGPHL ESSCLSREAL EKVPAEEYLV HALQGSVSSG
360 370 380 390 400
QAHSLASLAK TWSSGSSKLQ RFSPETEDNE GVLLTEKLKP VDYEYREEVH
410 420 430 440 450
WMTHQPRVGR GSFGEVHRMK DKQTGFQCAV KKVRLEVFRA EELIACAGLS
460 470 480 490 500
SPRIVPLYGA VREGPWVNIF MELLEGGSLG QLIKQKGCLP EDRALYYLGQ
510 520 530 540 550
ALEGLEYLHT HRVLHGDVKA DNVLLSSDGS RAALCDFGHA LCLQPDGLGK
560 570 580 590 600
SLLTGDYIPG TETHMAPEVV LGKPCDAKVD IWSSCCMMLH MLNGCHPWTQ
610 620 630 640 650
YFRGPLCLKI ASEPPPVREI PPSCTPLTAQ AIQEGLRKEP IHRASAMELR
660 670 680 690 700
RKVGKALQEV GGLKSPWKGE YKEPRPPPQD QAPCPQTLHT LPRENPPAKA
710 720 730 740 750
NTDGAPERQP PLPPEPPEPN KAPALNLSKE ESGTWEPLPL SSLDPAPAKG
760 770 780 790 800
PSLPDRRATF PELELQQLEI ELFLNSLSQP FSLEEQEQIL SCLSIDSLSL
810 820 830 840 850
SEDSEKNPSK ASQSSRDTLS SGVHSWSSQA EARSSSCSMA LARGRPTDIP
860 870 880 890 900
SYFNGVKVQI QSLNGEHLHI REFHRVKVGD IATGISSQIP ATAFSLVTKD
910 920 930 940
GQPVCYDMEV PDSGIDLQCT LAPDGSFAWA WRVKHGQLEN RP
Length:942
Mass (Da):103,584
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i05B3CF9C42C567F4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC136172 Genomic DNA No translation available.
CH473948 Genomic DNA Translation: EDM06262.1

NCBI Reference Sequences

More...
RefSeqi
NP_001101771.1, NM_001108301.1
XP_017452896.1, XM_017597407.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000004532; ENSRNOP00000004532; ENSRNOG00000003278

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
360640

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:360640

UCSC genome browser

More...
UCSCi
RGD:1310487, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136172 Genomic DNA No translation available.
CH473948 Genomic DNA Translation: EDM06262.1
RefSeqiNP_001101771.1, NM_001108301.1
XP_017452896.1, XM_017597407.1

3D structure databases

SMRiD3ZTD1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004532

Genome annotation databases

EnsembliENSRNOT00000004532; ENSRNOP00000004532; ENSRNOG00000003278
GeneIDi360640
KEGGirno:360640
UCSCiRGD:1310487, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9020
RGDi1310487, Map3k14

Phylogenomic databases

eggNOGiKOG0198, Eukaryota
GeneTreeiENSGT00940000156497
HOGENOMiCLU_010641_1_0_1
OMAiLNWGKEE
OrthoDBi162528at2759
PhylomeDBiD3ZTD1
TreeFamiTF105120

Enzyme and pathway databases

ReactomeiR-RNO-389357, CD28 dependent PI3K/Akt signaling
R-RNO-5607761, Dectin-1 mediated noncanonical NF-kB signaling
R-RNO-5668541, TNFR2 non-canonical NF-kB pathway
R-RNO-5676590, NIK-->noncanonical NF-kB signaling
R-RNO-5676594, TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Miscellaneous databases

Protein Ontology

More...
PROi
PR:D3ZTD1

Gene expression databases

BgeeiENSRNOG00000003278, Expressed in spleen and 21 other tissues

Family and domain databases

CDDicd13991, STKc_NIK, 1 hit
InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR042787, M3K14_STKc
IPR017425, MAPKKK14
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PANTHERiPTHR48016:SF9, PTHR48016:SF9, 1 hit
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
PIRSFiPIRSF038175, MAPKKK14, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3ZTD1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZTD1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: September 29, 2021
This is version 92 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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