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Entry version 79 (07 Apr 2021)
Sequence version 2 (03 Apr 2013)
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Protein

Netrin-5

Gene

Ntn5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • signaling receptor binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processNeurogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Netrin-5
Alternative name(s):
Netrin-1-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ntn5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...
RGDi
1565197, Ntn5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 34Sequence analysisAdd BLAST34
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500305298835 – 456Netrin-5Sequence analysisAdd BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi173 ↔ 182PROSITE-ProRule annotation
Disulfide bondi175 ↔ 191PROSITE-ProRule annotation
Disulfide bondi193 ↔ 202PROSITE-ProRule annotation
Disulfide bondi205 ↔ 225PROSITE-ProRule annotation
Disulfide bondi228 ↔ 240PROSITE-ProRule annotation
Disulfide bondi230 ↔ 247PROSITE-ProRule annotation
Disulfide bondi249 ↔ 258PROSITE-ProRule annotation
Disulfide bondi261 ↔ 275PROSITE-ProRule annotation
Disulfide bondi298 ↔ 384PROSITE-ProRule annotation
Disulfide bondi302 ↔ 386PROSITE-ProRule annotation
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi317 ↔ 442PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D3ZT86

PRoteomics IDEntifications database

More...
PRIDEi
D3ZT86

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
D3ZT86, 2 sites

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the olfactory bulb, the cerebral cortex, the hippocampus, and the cerebellum in the adult brain (at protein level) (PubMed:25941474). Strongly expressed in the subventricular zone,rostral migrate stream, and the subgranular zone of the dentate gyrus in the hippocampus (PubMed:25941474).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000021016, Expressed in skeletal muscle tissue and 15 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000028524

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3ZT86

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini173 – 227Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST55
Domaini228 – 277Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST50
Domaini298 – 442NTRPROSITE-ProRule annotationAdd BLAST145

Keywords - Domaini

Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3512, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161874

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_018213_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D3ZT86

Identification of Orthologs from Complete Genome Data

More...
OMAi
SCPQACA

Database of Orthologous Groups

More...
OrthoDBi
858946at2759

TreeFam database of animal gene trees

More...
TreeFami
TF352481

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.50.120, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002049, Laminin_EGF
IPR001134, Netrin_domain
IPR018933, Netrin_module_non-TIMP
IPR008993, TIMP-like_OB-fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00053, Laminin_EGF, 2 hits
PF01759, NTR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00643, C345C, 1 hit
SM00180, EGF_Lam, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50242, SSF50242, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01248, EGF_LAM_1, 1 hit
PS50027, EGF_LAM_2, 2 hits
PS50189, NTR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

D3ZT86-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADYRTLFSP SGTGSAVTVL VALSLLLLLS QATSDPCYDP GGRPRFCLPP
60 70 80 90 100
VTQLVGKAAA PCSQTCALPA DSPDPVCNGT LTLDLDGSFL LTSVTLRFCT
110 120 130 140 150
AGPPALVLSA AWAIGGPWRP LWRRPAWPGV LGGPKKVTFH SPPGPKTRIV
160 170 180 190 200
ASYLRVELGG KAGLVTTGVR GRCQCHGHAA RCAARAQPPR CRCRHHTTGP
210 220 230 240 250
GCESCRPSHR DWPWRPATPQ HPHPCLPCQC HPIGATGGMC NQTSGQCSCK
260 270 280 290 300
LGVTGLTCNH CGPGYQQSRS PRMPCQRIPE ATTALATTPV ASRSDPQCQG
310 320 330 340 350
YCNVSVSSVH MNLQKYCQQD YVLHARVAES AQVSASSSLS SLSEAVGPEW
360 370 380 390 400
WRLAVHVLAV FKQRAWPVRR GSQEAWVPRA DLSCGCLRLR PGADYLLLGR
410 420 430 440 450
AAENHTDPAH LILNRHSLAL PWRPRWAGPL RRLQQKERGG ACRGLLPPTR

SPGPRN
Length:456
Mass (Da):49,030
Last modified:April 3, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD3B0E08613FB7CBF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07071908 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001166997.1, NM_001173526.1
XP_017444634.1, XM_017589145.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000028524; ENSRNOP00000028524; ENSRNOG00000021016

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
308587

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:308587

UCSC genome browser

More...
UCSCi
RGD:1565197, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07071908 Genomic DNA No translation available.
RefSeqiNP_001166997.1, NM_001173526.1
XP_017444634.1, XM_017589145.1

3D structure databases

SMRiD3ZT86
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028524

PTM databases

GlyGeniD3ZT86, 2 sites

Proteomic databases

PaxDbiD3ZT86
PRIDEiD3ZT86

Genome annotation databases

EnsembliENSRNOT00000028524; ENSRNOP00000028524; ENSRNOG00000021016
GeneIDi308587
KEGGirno:308587
UCSCiRGD:1565197, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
126147
RGDi1565197, Ntn5

Phylogenomic databases

eggNOGiKOG3512, Eukaryota
GeneTreeiENSGT00940000161874
HOGENOMiCLU_018213_0_0_1
InParanoidiD3ZT86
OMAiSCPQACA
OrthoDBi858946at2759
TreeFamiTF352481

Miscellaneous databases

Protein Ontology

More...
PROi
PR:D3ZT86

Gene expression databases

BgeeiENSRNOG00000021016, Expressed in skeletal muscle tissue and 15 other tissues

Family and domain databases

Gene3Di2.40.50.120, 1 hit
InterProiView protein in InterPro
IPR002049, Laminin_EGF
IPR001134, Netrin_domain
IPR018933, Netrin_module_non-TIMP
IPR008993, TIMP-like_OB-fold
PfamiView protein in Pfam
PF00053, Laminin_EGF, 2 hits
PF01759, NTR, 1 hit
SMARTiView protein in SMART
SM00643, C345C, 1 hit
SM00180, EGF_Lam, 2 hits
SUPFAMiSSF50242, SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS01248, EGF_LAM_1, 1 hit
PS50027, EGF_LAM_2, 2 hits
PS50189, NTR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNET5_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZT86
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2018
Last sequence update: April 3, 2013
Last modified: April 7, 2021
This is version 79 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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