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Entry version 68 (16 Jan 2019)
Sequence version 2 (03 Apr 2013)
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Protein
Submitted name:

Talin 2

Gene

Tln2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Talin 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tln2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Rat genome database

More...
RGDi
1565416 Tln2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
D3ZT58

PeptideAtlas

More...
PeptideAtlasi
D3ZT58

PRoteomics IDEntifications database

More...
PRIDEi
D3ZT58

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000018373 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
D3ZT58 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3ZT58

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini77 – 238Talin_middleInterPro annotationAdd BLAST162
Domaini246 – 347I/LWEQInterPro annotationAdd BLAST102
Domaini679 – 783VBSInterPro annotationAdd BLAST105
Domaini1067 – 1191VBSInterPro annotationAdd BLAST125

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili635 – 662Sequence analysisAdd BLAST28
Coiled coili820 – 840Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4261 Eukaryota
ENOG410XQ0V LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154699

TreeFam database of animal gene trees

More...
TreeFami
TF314677

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036723 Alpha-catenin/vinculin-like_sf
IPR035964 I/LWEQ_dom_sf
IPR002558 ILWEQ_dom
IPR015224 Talin_cent
IPR036476 Talin_cent_sf
IPR015009 Vinculin-bd_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01608 I_LWEQ, 1 hit
PF09141 Talin_middle, 1 hit
PF08913 VBS, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109880 SSF109880, 1 hit
SSF109885 SSF109885, 3 hits
SSF47220 SSF47220, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

D3ZT58-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSQLCRVSF PKKRSTILQQ QFNRTGKAEH GSVALPAVMR SGSSGPETFN
60 70 80 90 100
VGSMPSPQQQ VMVGQMHRGH MPPLTSAQQA LMGTINTSMH AVQQAQDDLS
110 120 130 140 150
ELDSLPPLGQ DMASRVWVQN KVDESKHEIH SQVDAITAGT ASVVNLTAGD
160 170 180 190 200
PADTDYTAVG CAITTISSNL TEMSKGVKLL AALMDDDVGS GEDLLRAART
210 220 230 240 250
LAGAVSDLLK AVQPTSGEPR QTVLTAAGSI GQASGDLLRQ IGENETDERF
260 270 280 290 300
QDVLMSLAKA VANAAAMLVL KAKNVAQVAE DTVLQNRVIA AATQCALSTS
310 320 330 340 350
QLVACAKVVS PTISSPVCQE QLIEAGKLVD RSVENCVRAC QAATGDSELL
360 370 380 390 400
KQVSAAASVV SQALHDLLQH VRQFASRGEP IGRYDQATDT IMCVTESIFS
410 420 430 440 450
SMGDAGEMVR QARVLAQATS DLVNAMRSDA EAEIDMENSK KLLAAAKLLA
460 470 480 490 500
DSTARMVEAA KGAAANPENE DQQQRLREAA EGLRVATNAA AQNAIKKKIV
510 520 530 540 550
NRLEVAAKQA AAAATQTIAA SQNAAISNKN PSAQQQLVQS CKTVADHIPQ
560 570 580 590 600
LVQGVRGSQA QAEDLSAQLA LIISSQNFLQ PGSKMVSSAK AAVPTVSDQA
610 620 630 640 650
AAMQLSQCAK NLATSLAELR TASQKAHEAC GPMEIDSALN TVQTLKSELQ
660 670 680 690 700
DAKMAAAESQ LKPLPGETLE KCAQDLGSTS KGVGSSMAQL LTCAAQGNEH
710 720 730 740 750
YTGVAARETA QALKTLAQAA RGVAASTNDP EAAHAMLDSA RDVMEGSAML
760 770 780 790 800
IQEAKQALIA PGDTESQQRL AQVAKAVSHS LNNCVNCLPG QKDVDVALKS
810 820 830 840 850
IGESSKKLLV DSLPPSTKPF QEAQSELNQA AADLNQSAGE VVHATRGQSG
860 870 880 890 900
ELAAASGKFS DDFDEFLDAG IEMAGQAQTK EDQMQVIGNL KNISMASSKL
910 920 930 940 950
LLAAKSLSVD PGAPNAKNLL AAAARAVTES INQLIMLCTQ QAPGQKECDN
960 970 980 990 1000
ALRELETVKG MLENPNEPVS DLSYFDCIES VMENSKVLGE SMAGISQNAK
1010 1020 1030 1040 1050
TGGNPKAQHT HDAITEAAQL MKEAVDDIMV TLNEAASEVG LVGGMVDAIA
1060 1070 1080 1090 1100
EAMSKLDEGT PPEPKGTFVD YQTTVVKYSK AIAVTAQEMM TKSVTNPEEL
1110 1120 1130 1140 1150
GGLASQMTTD YGHLALQGQM AAATAEPEEI GFQIRTRVQD LGHGCIFLVQ
1160 1170 1180 1190 1200
KAGALQVCPT DSYTKRELIE CARSVTEKVS LVLSALQAGN KGTQACITAA
1210 1220 1230 1240 1250
TAVSGIIADL DTTIMFATAG TLNAENGETF ADHRENILKT AKALVEDTKL
1260 1270 1280 1290 1300
LVSGAASTPD KLAQAAQSSA ATITQLAEVV KLGAASLGSN DPETQVVLIN
1310 1320 1330 1340 1350
AIKDVAKALS DLIGATKGAA SKPADDPSMY QLKGAAKVMV TNVTSLLKTV
1360 1370 1380 1390 1400
KAVEDEATRG TRALEATIEY IKQELTVFQS KDIPEKTSSP EESIRMTKGI
1410 1420 1430
TMATAKAVAA GNSCRQEDVI ATANLSRKAV SDMLIACK
Length:1,438
Mass (Da):150,561
Last modified:April 3, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB94B006A1E7D4599
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D4A3B0D4A3B0_RAT
Talin 2
Tln2
2,375Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3ZA84D3ZA84_RAT
Talin 2
Tln2
2,542Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3ZE09D3ZE09_RAT
Talin 2
Tln2
1,452Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07070507 Genomic DNA No translation available.
AABR07070508 Genomic DNA No translation available.
AABR07070509 Genomic DNA No translation available.
AABR07070510 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000031988; ENSRNOP00000030866; ENSRNOG00000018373

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07070507 Genomic DNA No translation available.
AABR07070508 Genomic DNA No translation available.
AABR07070509 Genomic DNA No translation available.
AABR07070510 Genomic DNA No translation available.

3D structure databases

SMRiD3ZT58
ModBaseiSearch...

Proteomic databases

jPOSTiD3ZT58
PeptideAtlasiD3ZT58
PRIDEiD3ZT58

Genome annotation databases

EnsembliENSRNOT00000031988; ENSRNOP00000030866; ENSRNOG00000018373

Organism-specific databases

RGDi1565416 Tln2

Phylogenomic databases

eggNOGiKOG4261 Eukaryota
ENOG410XQ0V LUCA
GeneTreeiENSGT00940000154699
TreeFamiTF314677

Gene expression databases

BgeeiENSRNOG00000018373 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiD3ZT58 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR036723 Alpha-catenin/vinculin-like_sf
IPR035964 I/LWEQ_dom_sf
IPR002558 ILWEQ_dom
IPR015224 Talin_cent
IPR036476 Talin_cent_sf
IPR015009 Vinculin-bd_dom
PfamiView protein in Pfam
PF01608 I_LWEQ, 1 hit
PF09141 Talin_middle, 1 hit
PF08913 VBS, 2 hits
SUPFAMiSSF109880 SSF109880, 1 hit
SSF109885 SSF109885, 3 hits
SSF47220 SSF47220, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3ZT58_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZT58
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 3, 2013
Last modified: January 16, 2019
This is version 68 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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