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Entry version 62 (29 Sep 2021)
Sequence version 2 (03 Apr 2013)
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Protein
Submitted name:

Family with sequence similarity 171, member A2

Gene

Fam171a2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Family with sequence similarity 171, member A2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fam171a2Imported
Synonyms:RGD1307966Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Rat genome database

More...
RGDi
1307966, Fam171a2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei286 – 304HelicalSequence analysisAdd BLAST19
Transmembranei316 – 339HelicalSequence analysisAdd BLAST24

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500305321327 – 822Sequence analysisAdd BLAST796

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
D3ZT47

PeptideAtlas

More...
PeptideAtlasi
D3ZT47

PRoteomics IDEntifications database

More...
PRIDEi
D3ZT47

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
D3ZT47

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
D3ZT47

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
D3ZT47

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000021041, Expressed in frontal cortex and 20 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000028563

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni378 – 403DisorderedSequence analysisAdd BLAST26
Regioni416 – 450DisorderedSequence analysisAdd BLAST35
Regioni554 – 607DisorderedSequence analysisAdd BLAST54
Regioni670 – 822DisorderedSequence analysisAdd BLAST153

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi684 – 708Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi724 – 742Polar residuesSequence analysisAdd BLAST19
Compositional biasi763 – 790Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi798 – 822Basic and acidic residuesSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM171 family.ARBA annotation

Keywords - Domaini

SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QTDH, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183184

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_019729_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D3ZT47

Identification of Orthologs from Complete Genome Data

More...
OMAi
HSYIDVS

Database of Orthologous Groups

More...
OrthoDBi
615320at2759

TreeFam database of animal gene trees

More...
TreeFami
TF331338

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018890, Uncharacterised_FAM171

The PANTHER Classification System

More...
PANTHERi
PTHR31626, PTHR31626, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10577, UPF0560, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3ZT47-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPPSGPGVL ARLLPLLGLL LGGASRAPGK SPPEPPSPQE ILIKVQVYVS
60 70 80 90 100
GELVPLARAS VDVFGNRTLL AAGTTDSEGV ATLPLSYRLG TWVLVTAARP
110 120 130 140 150
GFLTNSVPWR VDKLPLYASV SLYLLPERPA TLILYEDLVH ILLGSPGARS
160 170 180 190 200
QPWVQFQRRA ARLPVSSTYN QLWASLTPAS TQQEMRAFPA FLGTEASSSG
210 220 230 240 250
NGSWLELIPL TAVSVHLLTG NGTEVPLSGP IHLSLPVPSE PRALAVGTSI
260 270 280 290 300
PAWRFDPKSG LWVRNGTGVI RKEGRQLYWT FVSPQLGYWV AAMASPTSGL
310 320 330 340 350
VTITSGIQDI GTYHTIFLLT ILAALALLVL ILLCLLIYYC RRRCLKPRQQ
360 370 380 390 400
HRKLQLSGPS DNKRDQATSM SQLHLICGGP LEPTSSGDPE APPPGSLHSA
410 420 430 440 450
FSSSRDLASS RDDFFRAKPR SASRPAAEPP GARSVEGAGL KGARSVEGPG
460 470 480 490 500
VLEPSLEEYR RGPAGAAAFL HEAPSPPPSF DHYLGHKGAA ESKTPDFLLS
510 520 530 540 550
QSVDQLARPP SLSQPGQLIF CGSIDHLKDN VYRNVMPTLV IPAHYVRLGG
560 570 580 590 600
EAGAAGVGDE ATPPEGSAAG PARPFPQPDP QRPLIQGHAG AGGDGGGGEG
610 620 630 640 650
WGGGRSAPVS GSVTIPVLFN ESTMAQLNGE LQALTEKKLL ELGVKPHPRA
660 670 680 690 700
WFVSLDGRSN SQVRHSYIDL QAGGGGRSTD ASLDSGVDVH EARPARRRPP
710 720 730 740 750
REERERAQPP APPPPAPPRL ALSEDTEPSS SESRTGLCSP EDNSLTPLLD
760 770 780 790 800
EVVAPEGRAA TVPRGRGRSR GDSSRSSASE LRRDSLTSPE DELGAEVGDE
810 820
AGDKKSPWQR REERPLMVFN VK
Length:822
Mass (Da):87,420
Last modified:April 3, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8E34264431399E59
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC134158 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
XP_002727867.2, XM_002727821.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000028563; ENSRNOP00000028563; ENSRNOG00000021041

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100361389

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:100361389

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC134158 Genomic DNA No translation available.
RefSeqiXP_002727867.2, XM_002727821.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028563

PTM databases

iPTMnetiD3ZT47
PhosphoSitePlusiD3ZT47
SwissPalmiD3ZT47

Proteomic databases

PaxDbiD3ZT47
PeptideAtlasiD3ZT47
PRIDEiD3ZT47

Genome annotation databases

EnsembliENSRNOT00000028563; ENSRNOP00000028563; ENSRNOG00000021041
GeneIDi100361389
KEGGirno:100361389

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
284069
RGDi1307966, Fam171a2

Phylogenomic databases

eggNOGiENOG502QTDH, Eukaryota
GeneTreeiENSGT00950000183184
HOGENOMiCLU_019729_0_0_1
InParanoidiD3ZT47
OMAiHSYIDVS
OrthoDBi615320at2759
TreeFamiTF331338

Gene expression databases

BgeeiENSRNOG00000021041, Expressed in frontal cortex and 20 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR018890, Uncharacterised_FAM171
PANTHERiPTHR31626, PTHR31626, 1 hit
PfamiView protein in Pfam
PF10577, UPF0560, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3ZT47_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZT47
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 3, 2013
Last modified: September 29, 2021
This is version 62 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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