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Entry version 73 (29 Sep 2021)
Sequence version 3 (22 Jul 2015)
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Protein

E3 ubiquitin-protein ligase TTC3

Gene

Ttc3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains (By similarity).

Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus (By similarity).

Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation (By similarity).

Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2 (By similarity).

Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK (PubMed:24695496).

Inhibits cell proliferation (By similarity).

By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.By similarity EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1952 – 1991RING-type; atypicalPROSITE-ProRule annotationAdd BLAST40

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TTC3By similarity (EC:2.3.2.27By similarity)
Alternative name(s):
RING-type E3 ubiquitin transferase TTC3Curated
TPR repeat protein DBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ttc3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Rat genome database

More...
RGDi
1308654, Ttc3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004486971 – 2000E3 ubiquitin-protein ligase TTC3Add BLAST2000

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei397PhosphoserineBy similarity1
Modified residuei1029PhosphoserineBy similarity1
Modified residuei1080PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation on Ser-397 by Akt is required for ubiquitin ligase activity.By similarity
Proteolytically cleaved into differently sized N- and C-terminal fragments.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
D3ZSP7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D3ZSP7

PeptideAtlas

More...
PeptideAtlasi
D3ZSP7

PRoteomics IDEntifications database

More...
PRIDEi
D3ZSP7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000001682, Expressed in Ammon's horn and 20 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (when phosphorylated on Ser-397) with AKT1, AKT2 and AKT3 (when phosphorylated) (By similarity).

Interacts with CIT (By similarity).

Interacts with POLG (By similarity).

Interacts with HSP70 (By similarity).

Interacts with SMURF2 (By similarity).

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000059742

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati250 – 283TPR 1PROSITE-ProRule annotationAdd BLAST34
Repeati284 – 317TPR 2PROSITE-ProRule annotationAdd BLAST34
Repeati556 – 592TPR 3Sequence analysisAdd BLAST37
Repeati596 – 629TPR 4PROSITE-ProRule annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni20 – 249Interaction with POLGBy similarityAdd BLAST230
Regioni442 – 478DisorderedSequence analysisAdd BLAST37
Regioni804 – 828DisorderedSequence analysisAdd BLAST25
Regioni1041 – 1087DisorderedSequence analysisAdd BLAST47
Regioni1233 – 1308DisorderedSequence analysisAdd BLAST76
Regioni1423 – 1448DisorderedSequence analysisAdd BLAST26
Regioni1806 – 1839DisorderedSequence analysisAdd BLAST34
Regioni1894 – 1947DisorderedSequence analysisAdd BLAST54

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi804 – 826Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi1266 – 1280Polar residuesSequence analysisAdd BLAST15
Compositional biasi1808 – 1839Polar residuesSequence analysisAdd BLAST32
Compositional biasi1894 – 1913Basic and acidic residuesSequence analysisAdd BLAST20

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1952 – 1991RING-type; atypicalPROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Repeat, TPR repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0800, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154465

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001829_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D3ZSP7

Identification of Orthologs from Complete Genome Data

More...
OMAi
HDDQGLV

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.533.10, 1 hit
1.25.40.10, 2 hits
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011029, DEATH-like_dom_sf
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
IPR043866, TTC3/DZIP3_dom
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF19179, DUF5861, 1 hit
PF13639, zf-RING_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00184, RING, 1 hit
SM00028, TPR, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005, TPR, 3 hits
PS50293, TPR_REGION, 2 hits
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3ZSP7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGHRGAPHL PPWVCGLCSM DDFAEGGLSL ADDILLEDYP YEDDCICTPD
60 70 80 90 100
FTTDDYVRVT QLYYEGVGMQ YKDYAQSEKN LEYDICNIWC SKPLSILQDY
110 120 130 140 150
CDAIKLYIFW PLLFQHQHSS IISRLHPCVE AIRSRAAEIS LKKLQHLELM
160 170 180 190 200
EDIVDLAKKV ANDSFLIEGL LKIGYKIENK ILAMEDALNW IKYTGDVTIL
210 220 230 240 250
PKLGSVDSGW PMLSIFFTEY KYHITRVVTE NCNLLEEFRR HSCMQCVKQG
260 270 280 290 300
ELMKMRGNEE FAKEKFEIAV IYYTRAIEYR PENHLLYGNR ALCFLRMGQF
310 320 330 340 350
RNALSDGKRA IVLKNTWPKG HYRYCDALSM LGEYDWALQA NIKAQKLCKN
360 370 380 390 400
DPEGIKDLIQ QHIKLQKQIE DLQGRTSNRN PIKAFYESRA YIPRNSSAPA
410 420 430 440 450
FRTSLNFVET ERGFRKTKYR MANGGGHQNQ KVADEALKGD DCDCHPEFLP
460 470 480 490 500
PPSQPPRHKG KQKSRNNESE KPSSNSQVTL QVDLKSILEK QFSKSSRAAH
510 520 530 540 550
QDFANIMKML RSLIQDGYTA LLEQRCRSAA QAFTELLNGL DPQKIKQLNL
560 570 580 590 600
AMINYVLVVY GLAVSLLGIG RPEELSEAEN QFKRIIEHYP NEGLDCLAYC
610 620 630 640 650
GIGKVYLKKN RFLEALNHFE KAKTLICRLP GILTWPTSNV IIEESKPEKV
660 670 680 690 700
KVMLEKFVEE CKFPPVPDAV CCYQKCRGFS KIQIYLTDPD FKGFIRISCC
710 720 730 740 750
QYCKVEFHMN CWKKLKTTTF NDKIDKDFLQ GICLTPDCEG IISKIIIFSS
760 770 780 790 800
GGQVKCEFEH KVVKEKAPSR PVLKQKCSSL EKLRLKEDKK LKRKIQKQEA
810 820 830 840 850
KKLAQERMEE DLRESNPPKP EEPEETVESA QSCQFLDDRI LQCIKQNADK
860 870 880 890 900
IKSVVLNTST LLKELLSWKV LSTEDYTTCF SSKNFVHEAV DYVIGHLIQE
910 920 930 940 950
KNRVKTRIFL HVLSELKELD PKLAPWIQRL NSFGLDATGP FFTRYGASLK
960 970 980 990 1000
ELDFNIVTFL WSEKYGHKLG SIEGKQLDYF CEPASVMEAR CLIWLLEEHR
1010 1020 1030 1040 1050
DKFPALHSAL DEFFDIMDSR CTVLRKQDSD EMPFGCIKVK NKGKKKKPKD
1060 1070 1080 1090 1100
SKPMLVGSGT ASVTPSSETV TPEDHNRRNS DSAGPFAVPD HLRQDVEEFE
1110 1120 1130 1140 1150
ALYDQHSSEY VVRNKKLWDI NPKQKCSTLY DYFSQLLEEH GPLDMSDRMF
1160 1170 1180 1190 1200
SEEYEFFPEE TRQILEKAGG LKSFLLGCPR FVVIDNCIAL KKVASRLKKK
1210 1220 1230 1240 1250
RKKKNIKTKV EEISKTGEYL RVKLPLNPTA REFQPDVKSE AAAEDVTSIP
1260 1270 1280 1290 1300
GPADSSAPAA EDLKPQLDSD SSSGSASEDS RLEVVSPDLP TPLCEDASPS
1310 1320 1330 1340 1350
PTPAPEDAKP TYWTQSHLVT GFCTYLPFQG FGIAQSRPAY INMVPSLSQF
1360 1370 1380 1390 1400
TSIYTPLANI SSEYPMPRSM PVVPSFVASE RADGNAAAYF ESHRLNTENA
1410 1420 1430 1440 1450
SDDHTASETQ ILEGPLGMCV KSQSSTADAR TALSEPEGNS RHSGSSDSLW
1460 1470 1480 1490 1500
EASLENVSGI TDVPPAPSVA IQVSRSLIHQ EVNTEPYAPF ERQQGDLSQK
1510 1520 1530 1540 1550
EKECHLLREQ LQVACEECEQ MELRSSQETR DLEEKLQRHA EENKVSLPEL
1560 1570 1580 1590 1600
QWALGKLDRE IKKWHQEKKE IQERLKALKK KIKKVINTSD MSAQKNDGLD
1610 1620 1630 1640 1650
KECESQPDQS LGISSALTDE KAKVEESVRK GKELYEESQQ RAVAAEVSVL
1660 1670 1680 1690 1700
ENWKEREVCK LQGVATQAEA CLKSLKLMNS DSAAYPDVEC DILSWETFLS
1710 1720 1730 1740 1750
TVTEEIENTK CQFEEQIKAI KSGSRLSDLS SVQVSELLFP ACSMIHPQLL
1760 1770 1780 1790 1800
SESSRHEDHG LVACVDSMTG AVLNDPYVGP DSGCSEEVPE LSLGSPTHHP
1810 1820 1830 1840 1850
EGAQQLEVKK ASQVSPSEQN PEADEKPSGQ ATRSSQSQKN PFNSIIEHLS
1860 1870 1880 1890 1900
VIFPCYASSE LSGFIKKVRN KSKNSFSGLS IEEIVERVTE HIVEEQKKKK
1910 1920 1930 1940 1950
PNPGKDKKTS EAHPAASVSK SSPSPPLAAA GPSAKTKGQK KDDVPAPDGN
1960 1970 1980 1990 2000
SCQICHEIFK SKNMRVLKCG HKFHKGCFKQ WLKGQSTCPT CGSSDLLSEE
Length:2,000
Mass (Da):225,783
Last modified:July 22, 2015 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2716C704140F51AE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07033674 Genomic DNA No translation available.
AABR07033675 Genomic DNA No translation available.
AABR07033676 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000065600; ENSRNOP00000059742; ENSRNOG00000001682

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07033674 Genomic DNA No translation available.
AABR07033675 Genomic DNA No translation available.
AABR07033676 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059742

Proteomic databases

jPOSTiD3ZSP7
PaxDbiD3ZSP7
PeptideAtlasiD3ZSP7
PRIDEiD3ZSP7

Genome annotation databases

EnsembliENSRNOT00000065600; ENSRNOP00000059742; ENSRNOG00000001682

Organism-specific databases

RGDi1308654, Ttc3

Phylogenomic databases

eggNOGiKOG0800, Eukaryota
GeneTreeiENSGT00940000154465
HOGENOMiCLU_001829_1_0_1
InParanoidiD3ZSP7
OMAiHDDQGLV

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

Protein Ontology

More...
PROi
PR:D3ZSP7

Gene expression databases

BgeeiENSRNOG00000001682, Expressed in Ammon's horn and 20 other tissues

Family and domain databases

Gene3Di1.10.533.10, 1 hit
1.25.40.10, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR011029, DEATH-like_dom_sf
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
IPR043866, TTC3/DZIP3_dom
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF19179, DUF5861, 1 hit
PF13639, zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184, RING, 1 hit
SM00028, TPR, 4 hits
SUPFAMiSSF48452, SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005, TPR, 3 hits
PS50293, TPR_REGION, 2 hits
PS50089, ZF_RING_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTC3_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZSP7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 11, 2019
Last sequence update: July 22, 2015
Last modified: September 29, 2021
This is version 73 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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