UniProtKB - D3ZS58 (D3ZS58_RAT)
Protein
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
Gene
Ndufa2
Organism
Rattus norvegicus (Rat)
Status
Functioni
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.UniRule annotationARBA annotation
GO - Biological processi
- blastocyst hatching Source: RGD
- mitochondrial respiratory chain complex I assembly Source: RGD
- oxidation-reduction process Source: UniProtKB-KW
Keywordsi
Biological process | Electron transport, Respiratory chainUniRule annotationARBA annotation, Transport |
Ligand | UbiquinoneImported |
Enzyme and pathway databases
Reactomei | R-RNO-611105, Respiratory electron transport R-RNO-6799198, Complex I biogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2UniRule annotation |
Gene namesi | ORF Names:rCG_49583Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1309997, Ndufa2 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane UniRule annotationARBA annotation; Peripheral membrane protein UniRule annotationARBA annotation; Matrix side UniRule annotationARBA annotation
Mitochondrion
- mitochondrial membrane Source: RGD
- mitochondrial respiratory chain complex I Source: RGD
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotationARBA annotationPTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 22 ↔ 56 | Redox-activeUniRule annotation |
Keywords - PTMi
Disulfide bondUniRule annotationProteomic databases
PRIDEi | D3ZS58 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000017571, Expressed in brain and 22 other tissues |
Interactioni
Subunit structurei
Complex I is composed of 45 different subunits.
ARBA annotationProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000023811 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 96 | L51_S25_CI-B8InterPro annotationAdd BLAST | 74 |
Sequence similaritiesi
Belongs to the complex I NDUFA2 subunit family.ARBA annotation
Phylogenomic databases
eggNOGi | KOG3446, Eukaryota |
GeneTreei | ENSGT00390000006178 |
HOGENOMi | CLU_110897_0_0_1 |
OMAi | QHYVTLK |
OrthoDBi | 1633416at2759 |
TreeFami | TF300229 |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR016464, NADH_Ub_cplx-1_asu_su-2 IPR007741, Ribosome/NADH_DH IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR12878, PTHR12878, 1 hit |
Pfami | View protein in Pfam PF05047, L51_S25_CI-B8, 1 hit |
PIRSFi | PIRSF005822, NDUA2, 1 hit |
SMARTi | View protein in SMART SM00916, L51_S25_CI-B8, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
i Sequence
Sequence statusi: Complete.
D3ZS58-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAASRVVGA KQVLREIRIH LCQRSPGSQG VRDFIQQRYV ELKKAHPDLP
60 70 80 90
ILIRECSEVQ PKLWARYAFG QEKNVSLNNL SAAEVTKAME NVLSGKA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07031718 Genomic DNA No translation available. CH473974 Genomic DNA Translation: EDL76311.1 |
RefSeqi | NP_001099623.1, NM_001106153.1 |
Genome annotation databases
Ensembli | ENSRNOT00000023811; ENSRNOP00000023811; ENSRNOG00000017571 |
GeneIDi | 291660 |
KEGGi | rno:291660 |
UCSCi | RGD:1309997, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07031718 Genomic DNA No translation available. CH473974 Genomic DNA Translation: EDL76311.1 |
RefSeqi | NP_001099623.1, NM_001106153.1 |
3D structure databases
SMRi | D3ZS58 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000023811 |
Proteomic databases
PRIDEi | D3ZS58 |
Genome annotation databases
Ensembli | ENSRNOT00000023811; ENSRNOP00000023811; ENSRNOG00000017571 |
GeneIDi | 291660 |
KEGGi | rno:291660 |
UCSCi | RGD:1309997, rat |
Organism-specific databases
CTDi | 4695 |
RGDi | 1309997, Ndufa2 |
Phylogenomic databases
eggNOGi | KOG3446, Eukaryota |
GeneTreei | ENSGT00390000006178 |
HOGENOMi | CLU_110897_0_0_1 |
OMAi | QHYVTLK |
OrthoDBi | 1633416at2759 |
TreeFami | TF300229 |
Enzyme and pathway databases
Reactomei | R-RNO-611105, Respiratory electron transport R-RNO-6799198, Complex I biogenesis |
Gene expression databases
Bgeei | ENSRNOG00000017571, Expressed in brain and 22 other tissues |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR016464, NADH_Ub_cplx-1_asu_su-2 IPR007741, Ribosome/NADH_DH IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR12878, PTHR12878, 1 hit |
Pfami | View protein in Pfam PF05047, L51_S25_CI-B8, 1 hit |
PIRSFi | PIRSF005822, NDUA2, 1 hit |
SMARTi | View protein in SMART SM00916, L51_S25_CI-B8, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D3ZS58_RAT | |
Accessioni | D3ZS58Primary (citable) accession number: D3ZS58 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | February 10, 2021 | |
This is version 76 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |