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Entry version 82 (07 Oct 2020)
Sequence version 1 (20 Apr 2010)
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Protein
Submitted name:

ERCC excision repair 6, chromatin-remodeling factor

Gene

Ercc6

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ERCC excision repair 6, chromatin-remodeling factorImported
Submitted name:
Excision repair cross-complementing rodent repair deficiency, complementation group 6 (Predicted)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ercc6Imported
Synonyms:Ercc6_predictedImported
ORF Names:rCG_42322Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Rat genome database

More...
RGDi
1311509, Ercc6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000030017, Expressed in brain and 22 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000063005

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3ZS47

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini474 – 599Helicase ATP-bindingInterPro annotationAdd BLAST126
Domaini747 – 906Helicase C-terminalInterPro annotationAdd BLAST160

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 51DisorderedSequence analysisAdd BLAST51
Regioni287 – 374DisorderedSequence analysisAdd BLAST88
Regioni395 – 430DisorderedSequence analysisAdd BLAST36
Regioni944 – 1140DisorderedSequence analysisAdd BLAST197

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili164 – 191Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 18PolarSequence analysisAdd BLAST18
Compositional biasi305 – 322PolarSequence analysisAdd BLAST18
Compositional biasi351 – 365PolyampholyteSequence analysisAdd BLAST15
Compositional biasi409 – 430PolyampholyteSequence analysisAdd BLAST22
Compositional biasi944 – 958PolyampholyteSequence analysisAdd BLAST15
Compositional biasi961 – 990PolarSequence analysisAdd BLAST30
Compositional biasi1027 – 1066PolarSequence analysisAdd BLAST40
Compositional biasi1068 – 1097PolyampholyteSequence analysisAdd BLAST30
Compositional biasi1104 – 1140PolyampholyteSequence analysisAdd BLAST37

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0387, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158057

KEGG Orthology (KO)

More...
KOi
K10841

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10810, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR038718, SNF2-like_sf
IPR000330, SNF2_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00271, Helicase_C, 1 hit
PF00176, SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

D3ZS47-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPHEEIPNST QPQGQDWLPG QHVSADRDIP AGQETAGDSE AGKCLSSPSC
60 70 80 90 100
DHGPSTSAEA CVLAATRWGP ALLHIDRHQI PAVEPSAQAL ELQGLGVDVY
110 120 130 140 150
DQAVLEEGVL QQVDSAMHEA SRVAQRADAE KEYQSVLDDL MSCTTSLRQI
160 170 180 190 200
NKIIEQLSPQ AASNRDINRK LDSVKRQKYN KEQQLKKITA KQKRLQAILG
210 220 230 240 250
GAEVHVELDH GSLEEEDAEP GPSCLGSMLM PAQESAWEEL IRTGQMTPFG
260 270 280 290 300
TPAPQKQEKK PRKIMLNEAS GFEKYLADQA QLSFKRKKQA ANKRTAKKAV
310 320 330 340 350
VVSESSRGPN ETKPNQRSQA LSQTDKRLKK HIRKLQRRAL QFQGKVGLQR
360 370 380 390 400
GKRPLEPEER PGAEGDTEAV LSSDDISYEL KPLRKGQKYE KKVPVQEIDD
410 420 430 440 450
DFFPSSEEED EAVEGRGGGR KVSRRPDDGD EDYYKQRLRR WNRLRLQDKE
460 470 480 490 500
KLKLEDDSEE SDAEFDEGFK VPGFLFKKLF KFEGLGPTLI VCPTTVMHQW
510 520 530 540 550
VKEFHTWWPP FRVAILHETG SCAHRKERLV RDIVHCHGVL ITSYSYIRLM
560 570 580 590 600
QDDISRHDWH YVILDEGHKI RNPNAAVTLA CKQNNLRELW SLFDFTFPGK
610 620 630 640 650
LGTLPVFMEQ FSVPITMGGY SNASPVQVKT AYKCACVLRD TINPYLLRRM
660 670 680 690 700
KSDVKMSLSL PDKNEQVLFC RLTDEQHKVY QNFIDSKAVY RILNGENQIF
710 720 730 740 750
SGLVALRKIC NHPDLFSGGP KNTSALPEDG LEEEQFGYWK RSGKMIVVES
760 770 780 790 800
LLKIWHKQGQ RVLLFSQSRQ MLHILEVFLR AHKYSYLKMD GTTTIASRQP
810 820 830 840 850
LITKYNEDTS IFVFLLTTRV GGLGVNLTGA NRVIIYDPDW NPSTDTQARE
860 870 880 890 900
RAWRIGQKKQ VTVYRLLTAG TIEEKIYHRQ IFKQFLTNRV LKDPKQRRFF
910 920 930 940 950
KSNDLYELFT LTSPDASQGT ETSAIFAGTG SNIQTLKCHF KKRTPPVLQM
960 970 980 990 1000
DPKRKKPLVS DTSVNGATVM EEKSQGSGAT GSVPSTESGP LKSDRHTDGS
1010 1020 1030 1040 1050
RASSVGFGEE ADAGSTLEHL SGLSGDSPAV DHTSRLSAVA STSEKQGSSY
1060 1070 1080 1090 1100
EGECCQAQTG PVHLSEQTEG HFSKHKSKRK HDAAEEETTE KCPQPKQKAK
1110 1120 1130 1140 1150
NSRHHRDAKF EGTRVPHLVK KRRYHQQTTE QESGAKDRSS DDYVLEKLFK
1160 1170 1180 1190 1200
KSVGVHSVVK HDAIIDGSSP DYVLVEAEAN RVAQDALKAL RLSRQQCLGA
1210 1220 1230 1240 1250
TSGVPTWTGH RGISGAPAGV KMRARNHMIL PERLESDGEQ LAGAAAAAAP
1260 1270 1280 1290 1300
PCSTEHDALL VDMRNFIAFQ AQVDGQASTQ EILQAFESKL SVAQSCVFRE
1310 1320
LLRNLCNFHR TPGGEGIWKL KPEYC
Length:1,325
Mass (Da):148,487
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i79AA94D3EF86E768
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JTU1A0A0G2JTU1_RAT
ERCC excision repair 6, chromatin-r...
Ercc6
1,474Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC141211 Genomic DNA No translation available.
CH474046 Genomic DNA Translation: EDL88913.1

NCBI Reference Sequences

More...
RefSeqi
NP_001100766.1, NM_001107296.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000064255; ENSRNOP00000063005; ENSRNOG00000030017

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
306274

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:306274

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC141211 Genomic DNA No translation available.
CH474046 Genomic DNA Translation: EDL88913.1
RefSeqiNP_001100766.1, NM_001107296.1

3D structure databases

SMRiD3ZS47
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063005

Genome annotation databases

EnsembliENSRNOT00000064255; ENSRNOP00000063005; ENSRNOG00000030017
GeneIDi306274
KEGGirno:306274

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2074
RGDi1311509, Ercc6

Phylogenomic databases

eggNOGiKOG0387, Eukaryota
GeneTreeiENSGT00940000158057
KOiK10841

Gene expression databases

BgeeiENSRNOG00000030017, Expressed in brain and 22 other tissues

Family and domain databases

Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR038718, SNF2-like_sf
IPR000330, SNF2_N
PfamiView protein in Pfam
PF00271, Helicase_C, 1 hit
PF00176, SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3ZS47_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZS47
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: October 7, 2020
This is version 82 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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