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Protein

Calponin

Gene

Cnn2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-bindingUniRule annotation, Calmodulin-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
CalponinUniRule annotation
Gene namesi
Name:Cnn2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1589807 Cnn2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiD3ZRX9
PeptideAtlasiD3ZRX9
PRIDEiD3ZRX9

PTM databases

iPTMnetiD3ZRX9
PhosphoSitePlusiD3ZRX9

Expressioni

Gene expression databases

BgeeiENSRNOG00000043044

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063042

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 132Calponin-homology (CH)InterPro annotationAdd BLAST105

Sequence similaritiesi

Belongs to the calponin family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2046 Eukaryota
COG5199 LUCA
GeneTreeiENSGT00550000074447
InParanoidiD3ZRX9
OMAiFIKAMAS
OrthoDBiEOG091G0LY2
TreeFamiTF313921

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001997 Calponin/LIMCH1
IPR000557 Calponin_repeat
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR029974 CNN2
IPR003096 SM22_calponin
PANTHERiPTHR18959:SF47 PTHR18959:SF47, 1 hit
PfamiView protein in Pfam
PF00402 Calponin, 2 hits
PF00307 CH, 1 hit
PRINTSiPR00889 CALPONIN
PR00888 SM22CALPONIN
SMARTiView protein in SMART
SM00033 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS01052 CALPONIN_1, 1 hit
PS51122 CALPONIN_2, 2 hits
PS50021 CH, 1 hit

Sequencei

Sequence statusi: Fragment.

D3ZRX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTQFNKGP SYGLSAEVKN RLLSKYDPQK EAELRSWIEG LTGLSIGPDF
60 70 80 90 100
QKGLKDGVIL CTLMNKLQPG SVPKINRSMQ NWHQLENLSN FIKAMVSYGM
110 120 130 140 150
NPVDLFEAND LFESGNMTQV QVSLLALAGK AKTKGLQSGV DIGVKYSEKQ
160 170 180 190 200
ERNFDDATMK AGQCVIGLQM GTNKCASQSG MTAYGTRRHL YDPKNHILPP
210
MDHCTISLQM GTNKCASQV
Length:219
Mass (Da):24,070
Last modified:June 7, 2017 - v3
Checksum:i8DF680CE5343D976
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei219Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07055848 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSRNOT00000065093; ENSRNOP00000063042; ENSRNOG00000043044

Similar proteinsi

Entry informationi

Entry nameiD3ZRX9_RAT
AccessioniPrimary (citable) accession number: D3ZRX9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: June 7, 2017
Last modified: May 23, 2018
This is version 56 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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