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UniProtKB - D3ZRW6 (D3ZRW6_RAT)

Entry version 72 (10 Feb 2021)
Sequence version 1 (20 Apr 2010)
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Protein
Submitted name:

Erythroid differentiation regulatory factor 1

Gene

Edrf1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Erythroid differentiation regulatory factor 1Imported
Submitted name:
Similar to erythroid differentiation-related factor 1 (Predicted), isoform CRA_bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Edrf1Imported
Synonyms:RGD1306820Imported, RGD1306820_predictedImported
ORF Names:rCG_47894Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...RGDi		1306820, Edrf1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		D3ZRW6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000017728, Expressed in pancreas and 21 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		D3ZRW6, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000023873

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 42DisorderedSequence analysisAdd BLAST42
Regioni220 – 265DisorderedSequence analysisAdd BLAST46
Regioni484 – 528DisorderedSequence analysisAdd BLAST45
Regioni589 – 615DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi22 – 36PolarSequence analysisAdd BLAST15
Compositional biasi225 – 242PolarSequence analysisAdd BLAST18
Compositional biasi498 – 515AcidicSequence analysisAdd BLAST18

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QTNC, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000014797

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008729_0_0_1

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

D3ZRW6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMGDPKEAGA EASPSGAAAR GGLSLLSQTE SEEPSAQGSA LFLGGNEVKS 
        60         70         80         90        100
RAVVKYSSAP PRTAFARLEE KTDLKLPPAN WLRESAKLGP AGTTILGNSK 
       110        120        130        140        150
KSKPFSSFGM AYDFIDSVGN DVDVVSDSEN IKKLLKIPYS KSHVSMAVHR 
       160        170        180        190        200
IGRTLLLDEL DIQELFMRSS QTGDWTWLKE FYQRLIDQKW QRKKKSKEHW 
       210        220        230        240        250
YQKAILSKFL YYSINGDGAA QPVPSPAEQQ ESASSDQTHE SEGASWPAPF 
       260        270        280        290        300
EMPSSVSEDP SASSQGLKND FVRNILWTFE DIHMLVGSNM PIFGGGRYPA 
       310        320        330        340        350
VSLRLRDNNK PINVLTGIDY WLDNLICNVP ELVMCFHVNG IVQKYEMIKT 
       360        370        380        390        400
EEIPNLENSN FSTKVIKDIA QNILSFLKSN CTKEGHTYWL FKASSSDIVK 
       410        420        430        440        450
LYDLTTLCEE TEDKYQNPFT MPVAILLYKV ACNMMMKKNQ NKKHYGTIRT 
       460        470        480        490        500
LLLNCVKLLD KSRHPQIIAS ANYMLSELFQ LDEPKKEESS DSPLNENSDE 
       510        520        530        540        550
SYSEEEEEEE MADSDENGSY GTSSDPADDN KAVAIIKSVG ELSVPEKYKS 
       560        570        580        590        600
IHQIRPSCAF PVCHDTEERC RLVLSYVLEG LKSVDSSIKK ESDLPAADPS 
       610        620        630        640        650
TPIPLKYEDE STRGGPEGLE KQMALFLDKM GSLQKGNCSG QSGMTPGSWQ 
       660        670        680        690        700
HKMKLQLILK SSKAYYILSD AAMSLQKYGR ALRYIKLALQ SHDTYCCLCT 
       710        720        730        740        750
NMLSEVLLFL SQYLTLCGDI QLMLAQNANN RAAHLEEFNY QTKEDQEILH 
       760        770        780        790        800
SLHRESSCQG FAWATDLSTD LESQLSVSCK CYEAANEILQ FSDLKSQNPE 
       810        820        830        840        850
HYVQVLKRMG NIRNEIGVFY MNQAAALQGE RVVSKSVSAA EQQLWKKSFS 
       860        870        880        890        900
CFEKGIHNFE SIDDATNAAL LLCNTGRLMR VCAQAHCGAE DEFKREFSPE 
       910        920        930        940        950
EGLYYSKAVD YYLKALRSLG TRDMHPVVWD SVNWELSTTY FTMATLQQDY 
       960        970        980        990       1000
APLSRKAQEQ IEKEVSEAMM KSLKHCDVDS ATARQPLCQY RAATIHHRLA 
      1010       1020       1030       1040       1050
SMYHSCLRNQ VGDEHLRKQH RVLADLHYSK AAKLFQLLKD APCELLRVQL 
      1060       1070       1080       1090       1100
ERVAFAEFQM SSQNSNVGKL KTLSGALDIM VRTEHAFQLI RKELVEECDQ 
      1110       1120       1130       1140       1150
PKNDEATPAA DSSPNLNREE VIKLLSIFES RLSFLLLQSI KLMSSSKRKM 
      1160       1170       1180       1190       1200
SSNTEDDAAL QTNKQIYSQL LRATANRNST LLERIEVVIC LLEQLASGSS 

GSSGSAVP
Length:1,208
Mass (Da):135,493
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9D828F795CED1ABA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K4K6A0A0G2K4K6_RAT
Erythroid differentiation regulator...
Edrf1 RGD1306820_predicted, rCG_47894
1,242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC135404 Genomic DNA No translation available.
CH473953 Genomic DNA Translation: EDM11752.1

NCBI Reference Sequences

More...RefSeqi		NP_001101027.1, NM_001107557.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000023877; ENSRNOP00000023873; ENSRNOG00000017728

Database of genes from NCBI RefSeq genomes

More...GeneIDi		309069

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:309069

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC135404 Genomic DNA No translation available.
CH473953 Genomic DNA Translation: EDM11752.1
RefSeqiNP_001101027.1, NM_001107557.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023873

Proteomic databases

PRIDEiD3ZRW6

Genome annotation databases

EnsembliENSRNOT00000023877; ENSRNOP00000023873; ENSRNOG00000017728
GeneIDi309069
KEGGirno:309069

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		26098
RGDi1306820, Edrf1

Phylogenomic databases

eggNOGiENOG502QTNC, Eukaryota
GeneTreeiENSGT00390000014797
HOGENOMiCLU_008729_0_0_1

Gene expression databases

BgeeiENSRNOG00000017728, Expressed in pancreas and 21 other tissues
ExpressionAtlasiD3ZRW6, baseline and differential

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3ZRW6_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZRW6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: February 10, 2021
This is version 72 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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