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Protein

Matrix metalloproteinase

Gene

Mmp27

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cofactori

Protein has several cofactor binding sites:
  • Ca2+UniRule annotation
  • Zn2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei218UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, MetalloproteaseUniRule annotationSAAS annotation, Protease
LigandCalciumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Protein family/group databases

MEROPSiM10.027

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix metalloproteinaseUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:Mmp27Imported
Synonyms:Mmp27_predictedImported
ORF Names:rCG_31882Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1306642 Mmp27

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17UniRule annotationAdd BLAST17
ChainiPRO_501521009518 – 511Matrix metalloproteinaseUniRule annotationAdd BLAST494

Keywords - PTMi

Disulfide bondSAAS annotation, ZymogenUniRule annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000040208

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000058603

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 263ZnMcInterPro annotationAdd BLAST162
Repeati283 – 326HemopexinPROSITE-ProRule annotationAdd BLAST44
Repeati327 – 372HemopexinPROSITE-ProRule annotationAdd BLAST46
Repeati374 – 422HemopexinPROSITE-ProRule annotationAdd BLAST49
Repeati423 – 466HemopexinPROSITE-ProRule annotationAdd BLAST44

Sequence similaritiesi

Belongs to the peptidase M10A family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
GeneTreeiENSGT00760000118870
KOiK08005
OMAiPHACDPD
OrthoDBiEOG091G03DP
TreeFamiTF315428

Family and domain databases

CDDicd00094 HX, 1 hit
cd04278 ZnMc_MMP, 1 hit
Gene3Di1.10.101.10, 1 hit
2.110.10.10, 1 hit
3.40.390.10, 2 hits
InterProiView protein in InterPro
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR033739 M10A_MMP
IPR024079 MetalloPept_cat_dom_sf
IPR028732 MMP27
IPR001818 Pept_M10_metallopeptidase
IPR021190 Pept_M10A
IPR021158 Pept_M10A_Zn_BS
IPR006026 Peptidase_Metallo
IPR002477 Peptidoglycan-bd-like
IPR036365 PGBD-like_sf
IPR036366 PGBDSf
PANTHERiPTHR10201:SF115 PTHR10201:SF115, 1 hit
PfamiView protein in Pfam
PF00045 Hemopexin, 3 hits
PF00413 Peptidase_M10, 1 hit
PF01471 PG_binding_1, 1 hit
PIRSFiPIRSF001191 Peptidase_M10A_matrix, 1 hit
PRINTSiPR00138 MATRIXIN
SMARTiView protein in SMART
SM00120 HX, 4 hits
SM00235 ZnMc, 1 hit
SUPFAMiSSF47090 SSF47090, 1 hit
SSF50923 SSF50923, 1 hit
PROSITEiView protein in PROSITE
PS00546 CYSTEINE_SWITCH, 1 hit
PS00024 HEMOPEXIN, 1 hit
PS51642 HEMOPEXIN_2, 4 hits

Sequencei

Sequence statusi: Complete.

D3ZQ07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKCLLPLMVN FITLSSAFLP DRKDKNEENN QLAQAYLNQF YSLEIEGSHL
60 70 80 90 100
VQSKNRSLLD GKLQEMQAFF GLTVTGKLDS DTLEIMKVPR CGVPDVGQYG
110 120 130 140 150
YTLPGWRKYN LTYRIMNYTP DMTHADVDEA IQKALQVWSK VTPLMFTRIS
160 170 180 190 200
KGVADIMIAF RTRVHGWCPR HFDGPLGVLG HAFPPGLGLG GDTHFDEDET
210 220 230 240 250
WTTGDGEGFN LFLVAAHEFG HSLGLSHSSD QTALMFPNYV SLDPNKYPLS
260 270 280 290 300
QDDINGIQSI YGSPSKVPTK PNGNPVPCAC EPNLTFDAVT TFRREIMFLK
310 320 330 340 350
GRHLWRVYSD ITGAEFEFID SFWPSLPADL QAAYESPRDE VLVFKDENFW
360 370 380 390 400
VIRGNSVLPG YPKSIHTLGF PRRVKKIDAA VCDHDTKKTF FFVGIWCWRY
410 420 430 440 450
DEMAQAMDRG FPQRIMKRFP GIRLRVDAVF QRNGFFYFFR GSRQFEYDMK
460 470 480 490 500
AKNITQVMKT NTWFLCNEPL NSSSNVSVEG KAHSIGTVIF HHKSASLLSF
510
SIVHVLTKAY S
Length:511
Mass (Da):58,054
Last modified:April 20, 2010 - v1
Checksum:iF437C8F386AF0D86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07069020 Genomic DNA No translation available.
CH473993 Genomic DNA Translation: EDL78529.1
RefSeqiNP_001100269.1, NM_001106799.1
UniGeneiRn.218678

Genome annotation databases

EnsembliENSRNOT00000061887; ENSRNOP00000058603; ENSRNOG00000040208
GeneIDi300340
KEGGirno:300340
UCSCiRGD:1306642 rat

Similar proteinsi

Entry informationi

Entry nameiD3ZQ07_RAT
AccessioniPrimary (citable) accession number: D3ZQ07
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: July 18, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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