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Entry version 75 (29 Sep 2021)
Sequence version 1 (20 Apr 2010)
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Protein

Plexin-A3

Gene

Plxna3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-399954, Sema3A PAK dependent Axon repulsion
R-RNO-399955, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-RNO-399956, CRMPs in Sema3A signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Plexin-A3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Plxna3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X
  • UP000234681 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

Rat genome database

More...
RGDi
1584973, Plxna3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 1220ExtracellularSequence analysisAdd BLAST1201
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1221 – 1241HelicalSequence analysisAdd BLAST21
Topological domaini1242 – 1872CytoplasmicSequence analysisAdd BLAST631

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000041110520 – 1872Plexin-A3Add BLAST1853

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi78 ↔ 87PROSITE-ProRule annotation
Disulfide bondi113 ↔ 121PROSITE-ProRule annotation
Disulfide bondi267 ↔ 388PROSITE-ProRule annotation
Disulfide bondi283 ↔ 339PROSITE-ProRule annotation
Disulfide bondi357 ↔ 376PROSITE-ProRule annotation
Disulfide bondi492 ↔ 509PROSITE-ProRule annotation
Disulfide bondi498 ↔ 540PROSITE-ProRule annotation
Disulfide bondi501 ↔ 518PROSITE-ProRule annotation
Disulfide bondi512 ↔ 524PROSITE-ProRule annotation
Glycosylationi549N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi575 ↔ 595PROSITE-ProRule annotation
Glycosylationi1163N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1597PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D3ZPX4

PeptideAtlas

More...
PeptideAtlasi
D3ZPX4

PRoteomics IDEntifications database

More...
PRIDEi
D3ZPX4

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
D3ZPX4, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
D3ZPX4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
D3ZPX4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000060464, Expressed in brain and 22 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
D3ZPX4, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000053147

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3ZPX4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 489SemaPROSITE-ProRule annotationAdd BLAST470
Domaini841 – 934IPT/TIG 1Add BLAST94
Domaini936 – 1021IPT/TIG 2Add BLAST86
Domaini1024 – 1123IPT/TIG 3Add BLAST100
Domaini1126 – 1212IPT/TIG 4Add BLAST87

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1240 – 1294Sequence analysisAdd BLAST55

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plexin family.Curated

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3610, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01020000230473

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001436_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D3ZPX4

Identification of Orthologs from Complete Genome Data

More...
OMAi
RYYRDIT

Database of Orthologous Groups

More...
OrthoDBi
90434at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
D3ZPX4

TreeFam database of animal gene trees

More...
TreeFami
TF312962

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.506.10, 2 hits
2.130.10.10, 1 hit
2.60.40.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR031148, Plexin
IPR013548, Plexin_cytoplasmic_RasGAP_dom
IPR002165, Plexin_repeat
IPR016201, PSI
IPR008936, Rho_GTPase_activation_prot
IPR001627, Semap_dom
IPR036352, Semap_dom_sf
IPR041019, TIG1_plexin
IPR041362, TIG2_plexin
IPR015943, WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR22625, PTHR22625, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08337, Plexin_cytopl, 1 hit
PF01437, PSI, 2 hits
PF01403, Sema, 1 hit
PF01833, TIG, 4 hits
PF18020, TIG_2, 1 hit
PF17960, TIG_plexin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00429, IPT, 4 hits
SM00423, PSI, 3 hits
SM00630, Sema, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101912, SSF101912, 1 hit
SSF48350, SSF48350, 1 hit
SSF81296, SSF81296, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51004, SEMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

D3ZPX4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHTVCLLPLL FFTIGGCLGS SRPFRTFVVT DTTLTHLAVH RVTGEVFVGA
60 70 80 90 100
VNRVFKLASN LTELRAHVTG PIEDNARCYP PPSMRVCSHR LVPVDNVNKL
110 120 130 140 150
LLIDYAARRL VACGSIWQGI CQFLRLDDLF KLGEPHHRKE HYLSGAQEPD
160 170 180 190 200
SMAGVIVEQG QGPSKLFVGT AVDGKSEYFP TLSSRKLIDD EDSGDMFSLV
210 220 230 240 250
YQDEFVSSQI KIPSDTLSLY PAFDIYYIYG FVSASFVYFL TLQLDTQQTL
260 270 280 290 300
LDTAGEKFFT SKIVRMCAGD SEFYSYVEFP IGCSWRGVEY RLVQSAHLAK
310 320 330 340 350
PGLLLAQALG VPADEDVLFT IFSQGQKNRA NPPRQTILCL FTLSSINAHI
360 370 380 390 400
RRRIQSCYRG EGTLALPWLL NKELPCINTP MQINGNFCGL VLNQPLGGLH
410 420 430 440 450
VIEGLPLLAD STDGMASVAA YTYHQHSVVF IGTRSGNLKK VRVDGSQDAQ
460 470 480 490 500
LYETVSVVQG TPILRDLLFS PDHRHIYLLS EKQVSQLPVE TCEQYLSCAA
510 520 530 540 550
CLGSGDPHCG WCVLQHRCCR EGACPGASAP HGFAEELNKC IQVRVRPNNV
560 570 580 590 600
SVTSSGVQLT VAMRNVPDLS LGVSCSFEEV TESEAILLPS GELRCPSPSL
610 620 630 640 650
QELQTLTRGH GATHTVRLQL LSMETGVRFA GVDFVFYNCS ALQSCMSCVG
660 670 680 690 700
SPYPCHWCKY RHVCTSHPHE CSFQEGRVHS PEGCPEILPR GDLLIPVGVM
710 720 730 740 750
QPLTLRAKNL PQPQSGQKNY ECVVRVQGRQ HRVPAVRFNS SSVQCQNASY
760 770 780 790 800
FYEGDEFGDT ELDFSVVWDG DFPIDKPPSF RALLYKCWAQ RPSCGLCLKA
810 820 830 840 850
DPRFNCGWCI SEHRCQLRVH CPAPKSNWMH PSQKGARCSH PRITQIHPLT
860 870 880 890 900
GPKEGGTRVT IVGENLGLTS REVGLRVAGV RCNSIPTEYV SAERIVCEME
910 920 930 940 950
ESLVPSPPPG PAELCVGDCS ADFRTQSQQL YSFVTPTLDR VSPTRGPASG
960 970 980 990 1000
GTRLTISGTS LDAGSRVTVI IRDGECQFVR RDAEAIVCIS PISTLGPSQA
1010 1020 1030 1040 1050
PIILAIDHAN ISSTGVIYTY TQDPTVTHLE PTWSIINGST SITVSGTHLL
1060 1070 1080 1090 1100
TVQEPRVRAK YRGIETTNTC QVINDTAMLC KAPGIFLGHP QPRAQGEHPD
1110 1120 1130 1140 1150
EFGFLLDHVQ AARSLNRSSF TYYPDPSFEP LGPSGVLDVK PGSHVVLKGK
1160 1170 1180 1190 1200
NLIPAAAGSS RLNYTVLIGG QPCALTVSDT QLLCDSPSQT GRQPVMVLVG
1210 1220 1230 1240 1250
GLEFWLGTLH ITADRALTLP AMVGLAAGGG LLLLAITVVL VAYKRKTQDA
1260 1270 1280 1290 1300
DRTLKRLQLQ MDNLESRVAL ECKEAFAELQ TDINELTNHM DGVQIPFLDY
1310 1320 1330 1340 1350
RTYAVRVLFP GIEAHPVLKE LDTPPNVEKA LRLFGQLLHS RAFLLTFIHT
1360 1370 1380 1390 1400
LEAQSSFSMR DRGTVASLTM VALQSRLDYA TGLLKQLLAD LIEKNLESKN
1410 1420 1430 1440 1450
HPKLLLRRTE SVAEKMLTNW FTFLLHKFLK ECAGEPLFLL YCAIKQQMEK
1460 1470 1480 1490 1500
GPIDAITGEA RYSLSEDKLI RQQIDYKTLT LHCVCPESEG SAQVPVKVLN
1510 1520 1530 1540 1550
CDSITQAKDK LLDTVYKGIP YSQRPKAEDM DLEWRQGRMA RIILQDEDIT
1560 1570 1580 1590 1600
TKIECDWKRI NSLAHYQVTD GSLVALVPKQ VSAYNMANSF TFTRSLSRYE
1610 1620 1630 1640 1650
SLLRAASSPD SLRSRAPMLT PDQEAGTKLW HLVKNHDHAD HREGDRGSKM
1660 1670 1680 1690 1700
VSEIYLTRLL ATKGTLQKFV DDLFETVFST AHRGSALPLA IKYMFDFLDE
1710 1720 1730 1740 1750
QADQRQISDP DVRHTWKSNC LPLRFWVNVI KNPQFVFDIH KNSITDACLS
1760 1770 1780 1790 1800
VVAQTFMDSC STSEHRLGKD SPSNKLLYAK DIPNYKSWVE RYYRDIAKMA
1810 1820 1830 1840 1850
SISDQDMDAY LVEQSRLHAN DFNVLSALSE LYFYVTKYRQ EILTSLDRDA
1860 1870
SCRKHKLRQK LEQIITLVSS SS
Length:1,872
Mass (Da):207,982
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD8DACA874717E870
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC094668 Genomic DNA No translation available.
CH474099 Genomic DNA Translation: EDL84973.1

NCBI Reference Sequences

More...
RefSeqi
NP_001101051.2, NM_001107581.2
XP_006229639.1, XM_006229577.3
XP_017457512.1, XM_017602023.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000083148; ENSRNOP00000068735; ENSRNOG00000060464

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
309280

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:309280

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC094668 Genomic DNA No translation available.
CH474099 Genomic DNA Translation: EDL84973.1
RefSeqiNP_001101051.2, NM_001107581.2
XP_006229639.1, XM_006229577.3
XP_017457512.1, XM_017602023.1

3D structure databases

SMRiD3ZPX4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053147

PTM databases

GlyGeniD3ZPX4, 3 sites
iPTMnetiD3ZPX4
PhosphoSitePlusiD3ZPX4

Proteomic databases

PaxDbiD3ZPX4
PeptideAtlasiD3ZPX4
PRIDEiD3ZPX4

Genome annotation databases

EnsembliENSRNOT00000083148; ENSRNOP00000068735; ENSRNOG00000060464
GeneIDi309280
KEGGirno:309280

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55558
RGDi1584973, Plxna3

Phylogenomic databases

eggNOGiKOG3610, Eukaryota
GeneTreeiENSGT01020000230473
HOGENOMiCLU_001436_2_0_1
InParanoidiD3ZPX4
OMAiRYYRDIT
OrthoDBi90434at2759
PhylomeDBiD3ZPX4
TreeFamiTF312962

Enzyme and pathway databases

ReactomeiR-RNO-399954, Sema3A PAK dependent Axon repulsion
R-RNO-399955, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-RNO-399956, CRMPs in Sema3A signaling

Miscellaneous databases

Protein Ontology

More...
PROi
PR:D3ZPX4

Gene expression databases

BgeeiENSRNOG00000060464, Expressed in brain and 22 other tissues
GenevisibleiD3ZPX4, RN

Family and domain databases

Gene3Di1.10.506.10, 2 hits
2.130.10.10, 1 hit
2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR031148, Plexin
IPR013548, Plexin_cytoplasmic_RasGAP_dom
IPR002165, Plexin_repeat
IPR016201, PSI
IPR008936, Rho_GTPase_activation_prot
IPR001627, Semap_dom
IPR036352, Semap_dom_sf
IPR041019, TIG1_plexin
IPR041362, TIG2_plexin
IPR015943, WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625, PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337, Plexin_cytopl, 1 hit
PF01437, PSI, 2 hits
PF01403, Sema, 1 hit
PF01833, TIG, 4 hits
PF18020, TIG_2, 1 hit
PF17960, TIG_plexin, 1 hit
SMARTiView protein in SMART
SM00429, IPT, 4 hits
SM00423, PSI, 3 hits
SM00630, Sema, 1 hit
SUPFAMiSSF101912, SSF101912, 1 hit
SSF48350, SSF48350, 1 hit
SSF81296, SSF81296, 4 hits
PROSITEiView protein in PROSITE
PS51004, SEMA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLXA3_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZPX4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: April 20, 2010
Last modified: September 29, 2021
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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