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UniProtKB - D3ZPH3 (D3ZPH3_RAT)
Protein
Submitted name:
Metastasis-associated 1 family, member 3
Gene
Mta3
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- chromatin binding Source: InterPro
- histone deacetylase binding Source: GO_Central
- protein-containing complex binding Source: RGD
- sequence-specific DNA binding Source: InterPro
- transcription coactivator activity Source: GO_Central
- transcription corepressor activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- histone deacetylation Source: GO_Central
- negative regulation of transcription, DNA-templated Source: RGD
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- positive regulation of cell population proliferation Source: RGD
- positive regulation of G2/M transition of mitotic cell cycle Source: RGD
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Metastasis-associated 1 family, member 3Imported |
Gene namesi | Name:Mta3Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1306803, Mta3 |
Subcellular locationi
Nucleus
- nucleoplasm Source: GO_Central
- nucleus Source: RGD
- NuRD complex Source: RGD
Other locations
- cytoplasm Source: RGD
Keywords - Cellular componenti
NucleusARBA annotationPTM / Processingi
Keywords - PTMi
Isopeptide bondARBA annotation, Ubl conjugationARBA annotationProteomic databases
jPOSTi | D3ZPH3 |
PaxDbi | D3ZPH3 |
PeptideAtlasi | D3ZPH3 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000004685, Expressed in thymus and 21 other tissues |
ExpressionAtlasi | D3ZPH3, baseline and differential |
Interactioni
GO - Molecular functioni
- histone deacetylase binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000058637 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 82 | BAHInterPro annotationAdd BLAST | 82 | |
Domaini | 83 – 194 | ELM2InterPro annotationAdd BLAST | 112 | |
Domaini | 201 – 253 | SANTInterPro annotationAdd BLAST | 53 |
Keywords - Domaini
Zinc-fingerARBA annotationPhylogenomic databases
eggNOGi | KOG3554, Eukaryota |
GeneTreei | ENSGT01030000234573 |
InParanoidi | D3ZPH3 |
Family and domain databases
CDDi | cd00202, ZnF_GATA, 1 hit |
Gene3Di | 2.30.30.490, 1 hit |
InterProi | View protein in InterPro IPR001025, BAH_dom IPR043151, BAH_sf IPR000949, ELM2_dom IPR009057, Homeobox-like_sf IPR040138, MIER/MTA IPR035170, MTA1_R1 IPR017930, Myb_dom IPR001005, SANT/Myb IPR017884, SANT_dom IPR000679, Znf_GATA |
PANTHERi | PTHR10865, PTHR10865, 1 hit |
Pfami | View protein in Pfam PF01426, BAH, 1 hit PF01448, ELM2, 1 hit PF00320, GATA, 1 hit PF17226, MTA_R1, 1 hit PF00249, Myb_DNA-binding, 1 hit |
SMARTi | View protein in SMART SM01189, ELM2, 1 hit SM00717, SANT, 1 hit SM00401, ZnF_GATA, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51038, BAH, 1 hit PS51156, ELM2, 1 hit PS51293, SANT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
D3ZPH3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
ETEEESETTV EADLTEKQKH QLKHRELFLS RQYESLPATH IRGRCSSALL
60 70 80 90 100
NDAESVLSLP DGSDTFYSLV YDPSVKTLLA DKGEIRVGPK YQADIPDVLP
110 120 130 140 150
EGDSDEREQS KLEVKVWDPN SPLTDRQIDQ FLVVARAVGT FARALDCSSS
160 170 180 190 200
VRQPSLHMSA AAASRDITLF HAMDTLYRHG YDLSSAISVL VPLGGPVLCR
210 220 230 240 250
DEMEEWSASE ASLFEEALEK YGKDFNDIRQ DFLPWKSLTS IIEYYYMWKT
260 270 280 290 300
TDRYVQQKRL KAAEAESKLK QVYIPTYKPN PNQISSSNGK AGTVNGAVGT
310 320 330 340 350
PFQPQSALLG RACESCYATQ SHQWYSWGPP NMQCRLCATC WLYWKKYGGL
360 370 380 390 400
KMPTQTDEEK APSPAAEDPR VRSHLSRQAL QGMPVRNTGS PKSAVKTRQA
410 420 430 440 450
FFLHTTYFTK IARQVCKNTL RLRQAARRPF VAINYAAIRA EYADRHAELS
460 470 480 490 500
GSPLKSKSTR KPLSCIIGYL EIHPAKKPNV IRSPPSLQTP TTKRMLTTPN
510 520 530 540 550
HTSLSILGKR NYSHHNGLDA SKIRMANSLI FGRGGHELRS LQLETVKEIA
560 570
FVSPVDQRAE SPSPRASSTS E
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JTK6 | A0A0G2JTK6_RAT | Metastasis-associated 1 family, mem... | Mta3 | 582 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07062763 Genomic DNA No translation available. AABR07062764 Genomic DNA No translation available. AABR07062765 Genomic DNA No translation available. AABR07062766 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSRNOT00000061921; ENSRNOP00000058637; ENSRNOG00000004685 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07062763 Genomic DNA No translation available. AABR07062764 Genomic DNA No translation available. AABR07062765 Genomic DNA No translation available. AABR07062766 Genomic DNA No translation available. |
3D structure databases
SMRi | D3ZPH3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000058637 |
Proteomic databases
jPOSTi | D3ZPH3 |
PaxDbi | D3ZPH3 |
PeptideAtlasi | D3ZPH3 |
Genome annotation databases
Ensembli | ENSRNOT00000061921; ENSRNOP00000058637; ENSRNOG00000004685 |
Organism-specific databases
RGDi | 1306803, Mta3 |
Phylogenomic databases
eggNOGi | KOG3554, Eukaryota |
GeneTreei | ENSGT01030000234573 |
InParanoidi | D3ZPH3 |
Gene expression databases
Bgeei | ENSRNOG00000004685, Expressed in thymus and 21 other tissues |
ExpressionAtlasi | D3ZPH3, baseline and differential |
Family and domain databases
CDDi | cd00202, ZnF_GATA, 1 hit |
Gene3Di | 2.30.30.490, 1 hit |
InterProi | View protein in InterPro IPR001025, BAH_dom IPR043151, BAH_sf IPR000949, ELM2_dom IPR009057, Homeobox-like_sf IPR040138, MIER/MTA IPR035170, MTA1_R1 IPR017930, Myb_dom IPR001005, SANT/Myb IPR017884, SANT_dom IPR000679, Znf_GATA |
PANTHERi | PTHR10865, PTHR10865, 1 hit |
Pfami | View protein in Pfam PF01426, BAH, 1 hit PF01448, ELM2, 1 hit PF00320, GATA, 1 hit PF17226, MTA_R1, 1 hit PF00249, Myb_DNA-binding, 1 hit |
SMARTi | View protein in SMART SM01189, ELM2, 1 hit SM00717, SANT, 1 hit SM00401, ZnF_GATA, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51038, BAH, 1 hit PS51156, ELM2, 1 hit PS51293, SANT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | D3ZPH3_RAT | |
Accessioni | D3ZPH3Primary (citable) accession number: D3ZPH3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | July 22, 2015 | |
Last modified: | January 19, 2022 | |
This is version 77 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |