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UniProtKB - D3ZPD6 (D3ZPD6_RAT)
Protein
Submitted name:
Fez family zinc finger 1
Gene
Fezf1
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific DNA binding Source: RGD
- transcription cis-regulatory region binding Source: RGD
GO - Biological processi
- axon guidance Source: RGD
- cell dedifferentiation Source: RGD
- forebrain anterior/posterior pattern specification Source: RGD
- forebrain development Source: RGD
- negative regulation of cell population proliferation Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- neuron migration Source: RGD
- olfactory bulb development Source: RGD
- positive regulation of neuron differentiation Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- regulation of neurogenesis Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- telencephalon development Source: RGD
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Fez family zinc finger 1ImportedSubmitted name: Similar to zinc finger protein 312 (Predicted)Imported |
Gene namesi | ORF Names:rCG_28081Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1560480, Fezf1 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000007608, Expressed in brain and 2 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 260 – 287 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 288 – 315 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 316 – 343 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 344 – 371 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 372 – 399 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 400 – 423 | C2H2-typeInterPro annotationAdd BLAST | 24 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 425 – 475 | DisorderedSequence analysisAdd BLAST | 51 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 436 – 465 | Pro residuesSequence analysisAdd BLAST | 30 |
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159477 |
HOGENOMi | CLU_021813_2_1_1 |
OMAi | VNLHPMA |
OrthoDBi | 1318335at2759 |
TreeFami | TF316780 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
i Sequence
Sequence statusi: Complete.
D3ZPD6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDSSCLNATT KMLATAPARG NVMSTSKPLA FSIERIMART PEPKALPVPH
60 70 80 90 100
FLQGAVPKGD PKHSLHLNSS IPCMIPFVPV AYDTNSKAGV NGSEPRKASL
110 120 130 140 150
EVPAPPAVAP SAPAFSCSDL LNCALSLKGD LARDALPLQQ YKLVRPRVVN
160 170 180 190 200
HSSFHAMGAL CYLNRGDGPC HPAAGVNIHP VASYFLSSPL HPQPKTYLAE
210 220 230 240 250
RNKLVVPAVE KLPSGVAFKD LSQAQLHNYM KESAQLLSEK IAFKTSDFSR
260 270 280 290 300
GSPNAKPKVF TCEVCGKVFN AHYNLTRHMP VHTGARPFVC KVCGKGFRQA
310 320 330 340 350
STLCRHKIIH TQEKPHKCNQ CGKAFNRSST LNTHTRIHAG YKPFVCEFCG
360 370 380 390 400
KGFHQKGNYK NHKLTHSGEK QFKCNICNKA FHQVYNLTFH MHTHNDKKPF
410 420 430 440 450
TCPTCGKGFC RNFDLKKHVR KLHDSSLGLT RTPTGEPGSD PPPQLQQPPP
460 470
APLPPLQPTL PPPGPLQSGL HQGHQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07060027 Genomic DNA No translation available. CH473959 Genomic DNA Translation: EDM15160.1 |
RefSeqi | NP_001102694.1, NM_001109224.1 |
Genome annotation databases
Ensembli | ENSRNOT00000010019; ENSRNOP00000010019; ENSRNOG00000007608 |
GeneIDi | 500048 |
KEGGi | rno:500048 |
UCSCi | RGD:1560480, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07060027 Genomic DNA No translation available. CH473959 Genomic DNA Translation: EDM15160.1 |
RefSeqi | NP_001102694.1, NM_001109224.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000010019 |
Genome annotation databases
Ensembli | ENSRNOT00000010019; ENSRNOP00000010019; ENSRNOG00000007608 |
GeneIDi | 500048 |
KEGGi | rno:500048 |
UCSCi | RGD:1560480, rat |
Organism-specific databases
CTDi | 389549 |
RGDi | 1560480, Fezf1 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159477 |
HOGENOMi | CLU_021813_2_1_1 |
OMAi | VNLHPMA |
OrthoDBi | 1318335at2759 |
TreeFami | TF316780 |
Gene expression databases
Bgeei | ENSRNOG00000007608, Expressed in brain and 2 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | D3ZPD6_RAT | |
Accessioni | D3ZPD6Primary (citable) accession number: D3ZPD6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | January 19, 2022 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |