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Protein
Submitted name:

MGA, MAX dimerization protein

Gene

Mga

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation
Biological processTranscription, Transcription regulationSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-8953750 Transcriptional Regulation by E2F6

Names & Taxonomyi

Protein namesi
Submitted name:
MGA, MAX dimerization proteinImported
Gene namesi
Name:MgaImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1561597 Mga

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiD3ZP58
PRIDEiD3ZP58

PTM databases

iPTMnetiD3ZP58
PhosphoSitePlusiD3ZP58

Expressioni

Gene expression databases

BgeeiENSRNOG00000006378 Expressed in 9 organ(s), highest expression level in spleen
ExpressionAtlasiD3ZP58 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060519

Structurei

3D structure databases

ProteinModelPortaliD3ZP58
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2403 – 2454BHLHInterPro annotationAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1128 – 1148Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3585 Eukaryota
ENOG410XSTS LUCA
GeneTreeiENSGT00900000140847
InParanoidiD3ZP58
OMAiMQEAQEF
OrthoDBiEOG091G0I8R
TreeFamiTF106341

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00182 TBOX, 1 hit
Gene3Di2.60.40.820, 1 hit
4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR032060 DUF4801
IPR036638 HLH_DNA-bd_sf
IPR037935 MAX_gene-associated_protein
IPR008967 p53-like_TF_DNA-bd
IPR036960 T-box_sf
IPR001699 TF_T-box
IPR018186 TF_T-box_CS
PANTHERiPTHR11267 PTHR11267, 1 hit
PTHR11267:SF32 PTHR11267:SF32, 1 hit
PfamiView protein in Pfam
PF16059 DUF4801, 1 hit
PF00010 HLH, 1 hit
PF00907 T-box, 1 hit
PRINTSiPR00937 TBOX
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00425 TBOX, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
SSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS01264 TBOX_2, 1 hit
PS50252 TBOX_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

D3ZP58-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEKQQIILA NQDGGTVTGA APTFFVILKQ PGNGKTDQGI LVTNRDARAL
60 70 80 90 100
LSRESSPGKS KEKICLPADC TVGKITVTLD NNSMWNEFHN RSTEMILTKQ
110 120 130 140 150
GRRMFPYCRY WITGLDSNLK YILVMDISPV DSHRYKWNGR WWEPSGKAEP
160 170 180 190 200
HILGRVFIHP ESPSTGHYWM HQPVSFYKLK LTNNTLDQEG HIILHSMHRY
210 220 230 240 250
LPRLHLVPAE KATEVIQLNG PGVHTFTFPQ TEFFAVTAYQ NIQITQLKID
260 270 280 290 300
YNPFAKGFRD DGLSSKPQRD GKQRNSSDQE GNSVSSSPGH RVRLTEGEGS
310 320 330 340 350
EIHSGDFDPV LRGHETSSLG LEKAPNNVKQ DFLGFMNTDS THEVPQLKRE
360 370 380 390 400
ISESHVSSFE ENSQISSPLN PNGNFNVVIK EEPLDDYDYE LGECPEGITV
410 420 430 440 450
KQEETDEETD VYSNSDDDPI LEKQLKRHNK VDNLEADHSS YKWLPNSPGV
460 470 480 490 500
AKAKMFKLDA GKMPVVYLEP CAVTKSTVKI SELPDNMLST SRKDKSMLAE
510 520 530 540 550
LEYLPAYIEN SDETGFCLSK DSENSLRKHS SDLRMVQKYT LLKEPHWKYP
560 570 580 590 600
DIFDSSSTEK THDSSKGSTE DSFSGKEDLG KKRTTMLKMA IPSKTVNASQ
610 620 630 640 650
SASPNTPGKR GRPRKLRLSK AGRPPKNTGK SLTASKNIPV GPGNTFPDVK
660 670 680 690 700
PDLEDVDGVL FVSFESKEAL DIHAVDGTTE EPSSVQTTTT NDSGSRTRIS
710 720 730 740 750
QLEKELIEDL KSLRHKQVIH PALQEVGLKL NSVDPTMSID LKYLGVQLPL
760 770 780 790 800
APATSFPLWN VTGTNPASPD AGFPFVSRTG KTNDFTKIKG WRGKFHNASA
810 820 830 840 850
SRNEGGNSET SLKNRSAFCS DKLDEYLENE GKLMETSMGF SSNAPTAPTS
860 870 880 890 900
PVVYQLPTKS TSYVRTLDSV LKKQSTISPS TSHSVKPHSV TTASRKTKAQ
910 920 930 940 950
NKQTTVSGRT KSSYKSILPY PVSPKQKNSH VSPGDKITKN SLSSASDNQV
960 970 980 990 1000
TNLVVPSIDE SAFPKQISLR QAQQQHIQQQ GTRPPGLSKS QVKLMDLEDC
1010 1020 1030 1040 1050
ALWEGKPRTY ITEERADVSL TTLLTAQASL KTKPIHTIIR KRAPPCNNDF
1060 1070 1080 1090 1100
CRLGCVCSSL ALEKRQPAHC RRPDCMFGCT CLKRKVVLVK GGSKTKHLHK
1110 1120 1130 1140 1150
KAANRDPLFY DTLGEGGREG GGGVREDEEQ LKEKKKRKKL EYTVCEAEPE
1160 1170 1180 1190 1200
QPVRHYPLWV KVDGEVDPEP VYIPTPSVIE PIKPLVLPQP DASSTTIKGK
1210 1220 1230 1240 1250
LTPGIKPTRA YTPKPNPVIR EEDKDPVYLY FESMMTCARV RVYERKKDEQ
1260 1270 1280 1290 1300
RQLSPPLSPS SSFQQQSSCY SSPENHATKE LDSEQTLKQL ICDLEDDSDK
1310 1320 1330 1340 1350
SQEKTWKSSC NEGESSSTSY VHQRSPGGPT KLIEIISDCN WEEDRNKILS
1360 1370 1380 1390 1400
ILSQHINSNM PQSLKVGSFI IELASQRKCR GEKTPPVYSS RVKISMPSSQ
1410 1420 1430 1440 1450
DQDDMAEKSG SETPDGPLSP GKMDDISPVQ TDALDSVRER LHGGKGLPFY
1460 1470 1480 1490 1500
AGLSPSGKLV AYKRKPSSTT SGLIQVASNA KVAASRKPRT LLPSTSNSKM
1510 1520 1530 1540 1550
ASSGPTTNRS GKNLKAFVPA KRPIAARPSP GGVFTQFVMS KVGALQQKIP
1560 1570 1580 1590 1600
GVRTPQPLTG PQKFSIRPSP VMVVAPVVSS EQVQVCSTVT AAVTTSPQVV
1610 1620 1630 1640 1650
LENVTAVPSL TANSDMGAKE ATYSSSASTA GVVEISETNN TTPVTSTQST
1660 1670 1680 1690 1700
ATVNLTKTTG ITTSPVASVS FPKPLVASPT ITLPVASTAS TSIVMVTTAA
1710 1720 1730 1740 1750
SSSVVTTPTS SLSSVPIILS GINGSPPVSQ RPENAPQIPV TTPQISPNNV
1760 1770 1780 1790 1800
KRTGPRLLLI PVQQGSPTLR PIPNPQLQGQ RMVLQPVRSP SGMNLFRHPN
1810 1820 1830 1840 1850
GQIVQLLPLH QIRGSNTQPS LQPVVFRNPG SVVGIRLPTP CKSSETPSSS
1860 1870 1880 1890 1900
SSSAFSVMSP VIQAVGSSPT VNVISQAPSL LSSGSSFVSQ AGTLTLRISP
1910 1920 1930 1940 1950
PETQNLASKT ASESKITPST GGQPVGTASL IPLQSGSFAL LQLPGQKPVP
1960 1970 1980 1990 2000
NSVLQHVASL QIKKESQNTD QKDESNSIKR EKETKKALSS KDEVVDPEAN
2010 2020 2030 2040 2050
IMKQNSGIIA SEDTFNNSLD DRGDLLDEES LREDTRPYEY SYSTGSHTDE
2060 2070 2080 2090 2100
DKDGDEESGN KNENSPKEKQ TVPEVRAGSE NINIMTLQNV RKVRPQKYVE
2110 2120 2130 2140 2150
VKVEQQQGSE NPDDFLVLSK EESKFELSGS QVKEQKSNSQ TEAKKDCEDS
2160 2170 2180 2190 2200
LGKDSLRERW RKHLKGPLTH KYVGISQDFK KEADVQLFTE MKPCQDNSER
2210 2220 2230 2240 2250
DISELLGKSG TIESGGIFKT EDGSWSGISS SAAFSIIPRR ATKGRRGSRR
2260 2270 2280 2290 2300
FQGHFLLSKE HMKPKQQANG GRSSADFTVL DLEDEDEEDE NEKTDDSIDE
2310 2320 2330 2340 2350
IVDVVSGYQS EEVDVEKNNY VDYIEDDEQV DVETVEELSE EINFTYKKTT
2360 2370 2380 2390 2400
AAHTQSFRQQ CHSLISADEK ASEKSRKVSL ISSKLKDDCW SDKPHKETEA
2410 2420 2430 2440 2450
FAYYRRTHTA NERRRRGEMR DLFEKLKITL GLLHSSKVSK SLILNRAFSE
2460 2470 2480 2490 2500
IQGLTDQADK LIGQKNLLSR KRSILIRKVS SLSGKTEEVV LKKLEYIYAK
2510 2520 2530 2540 2550
QQALEAQKRK KKMGSDEFGL SPRISTQLEG SSSSVDLGQM FMSNRRGKPL
2560 2570 2580 2590 2600
ILSRRRDQAT ENASPSDTPH SSANLVMTPQ GQLLTLKGPL FSAPVVAVSP
2610 2620 2630 2640 2650
ALLEAGLKPQ VASSTMAQSE NDDLFMMPRI VNVTSLAAEE DLGGMSGNKY
2660 2670 2680 2690 2700
LHEVPDGKPA LDHLRDVSGN EASSLKDTER ISSRGNHRDS RMALGPTQVF
2710 2720 2730 2740 2750
LANKDSGFPH VPDVSTMQAA QEFIPKKMSG DLRGHRHKWK ECELRGERLK
2760 2770 2780 2790 2800
SKESQFHKLK MKDLKDSSIE MELRKVASAI EEAALDPSEL LTNMEDEDDT
2810 2820 2830 2840 2850
DETLTSLLNE IAFLNQQLND DSGLAELSGS LDTEFPGDAQ QAFISKLAPG
2860 2870 2880 2890 2900
NRSAFQVGHL GTGVKELPDV QEESESISPL LLHLEDDDFS ENEKQLGDTA
2910 2920 2930 2940 2950
SEPDVLKIVI DSEIKDSLVS HRKSSDGGQS TSGLPAEPES VSSPPILHMK
2960 2970 2980 2990 3000
TGPENSSTDT LWRPMPKLAP LGLKVANPPS DADGQSLKVM PALAPIAAKV
3010 3020 3030 3040
GSVGHKMNTT GSDQEGRGSK MMPTLAPVVT KLGNSGVPSS SSGK
Length:3,044
Mass (Da):333,677
Last modified:April 3, 2013 - v2
Checksum:i7EF990750EE5EDE6
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D4A6F9D4A6F9_RAT
MGA, MAX dimerization protein
Mga
2,926Annotation score:
D3ZJB5D3ZJB5_RAT
MGA, MAX dimerization protein
Mga
3,005Annotation score:
D3ZMQ0D3ZMQ0_RAT
MGA, MAX dimerization protein
Mga
2,835Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07053506 Genomic DNA No translation available.
AABR07053507 Genomic DNA No translation available.
RefSeqiXP_006234862.1, XM_006234800.3

Genome annotation databases

EnsembliENSRNOT00000067865; ENSRNOP00000060519; ENSRNOG00000006378
GeneIDi499874

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07053506 Genomic DNA No translation available.
AABR07053507 Genomic DNA No translation available.
RefSeqiXP_006234862.1, XM_006234800.3

3D structure databases

ProteinModelPortaliD3ZP58
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060519

PTM databases

iPTMnetiD3ZP58
PhosphoSitePlusiD3ZP58

Proteomic databases

PaxDbiD3ZP58
PRIDEiD3ZP58

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000067865; ENSRNOP00000060519; ENSRNOG00000006378
GeneIDi499874

Organism-specific databases

CTDi23269
RGDi1561597 Mga

Phylogenomic databases

eggNOGiKOG3585 Eukaryota
ENOG410XSTS LUCA
GeneTreeiENSGT00900000140847
InParanoidiD3ZP58
OMAiMQEAQEF
OrthoDBiEOG091G0I8R
TreeFamiTF106341

Enzyme and pathway databases

ReactomeiR-RNO-8953750 Transcriptional Regulation by E2F6

Gene expression databases

BgeeiENSRNOG00000006378 Expressed in 9 organ(s), highest expression level in spleen
ExpressionAtlasiD3ZP58 baseline and differential

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00182 TBOX, 1 hit
Gene3Di2.60.40.820, 1 hit
4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR032060 DUF4801
IPR036638 HLH_DNA-bd_sf
IPR037935 MAX_gene-associated_protein
IPR008967 p53-like_TF_DNA-bd
IPR036960 T-box_sf
IPR001699 TF_T-box
IPR018186 TF_T-box_CS
PANTHERiPTHR11267 PTHR11267, 1 hit
PTHR11267:SF32 PTHR11267:SF32, 1 hit
PfamiView protein in Pfam
PF16059 DUF4801, 1 hit
PF00010 HLH, 1 hit
PF00907 T-box, 1 hit
PRINTSiPR00937 TBOX
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00425 TBOX, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
SSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS01264 TBOX_2, 1 hit
PS50252 TBOX_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD3ZP58_RAT
AccessioniPrimary (citable) accession number: D3ZP58
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 3, 2013
Last modified: November 7, 2018
This is version 76 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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