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Protein
Submitted name:

NLR family, pyrin domain-containing 4

Gene

Nlrp4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

Keywordsi

LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-3134975 Regulation of innate immune responses to cytosolic DNA
R-RNO-3270619 IRF3-mediated induction of type I IFN

Names & Taxonomyi

Protein namesi
Submitted name:
NLR family, pyrin domain-containing 4Imported
Gene namesi
Name:Nlrp4Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1563529 Nlrp4

PTM / Processingi

Proteomic databases

PaxDbiD3ZP31

Expressioni

Gene expression databases

BgeeiENSRNOG00000021996
ExpressionAtlasiD3ZP31 baseline

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000046459

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 92PyrinInterPro annotationAdd BLAST84
Domaini147 – 279NACHTInterPro annotationAdd BLAST133

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG4308 Eukaryota
ENOG410ZBX3 LUCA
GeneTreeiENSGT00900000140813
InParanoidiD3ZP31
OMAiYCLFEMQ
OrthoDBiEOG091G01CG

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR004020 DAPIN
IPR011029 DEATH-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR007111 NACHT_NTPase
PfamiView protein in Pfam
PF13516 LRR_6, 3 hits
PF05729 NACHT, 1 hit
PF02758 PYRIN, 1 hit
SMARTiView protein in SMART
SM01289 PYRIN, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50824 DAPIN, 1 hit
PS50837 NACHT, 1 hit

Sequencei

Sequence statusi: Complete.

D3ZP31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ASFFSDFGLM WYLEELNKKE FVKFKEFLKQ EILQLRLKQI SWTKVKKASR
60 70 80 90 100
EDLANLLLKH YEEKQAWDMT FKIFQKMNRK DLIERAGREI AGHSKLYQAH
110 120 130 140 150
LKKKLTHDYA RKFNIKAQDL FKQKFTQDDC DRFENLLVSK ATGKKPHMVF
160 170 180 190 200
LQGVAGIGKS LMLTKLMLAW SEGIVFQNKF SYIFYFCCQD VKQLKRASLA
210 220 230 240 250
ELISREWPNA SAPTAEILSQ PEKLLFIIDS LEVMECNMSE RESELCDNCT
260 270 280 290 300
EKQPVSLLLS SLLRRKMLPE SSFLISATPE TFEKMEDRIE CTNVKIITGF
310 320 330 340 350
NENNIKMYFR SLFQDKNRTL EAFSLVRENE QLFNVCQVPV LCWMVATCIK
360 370 380 390 400
KEIEKGRDPV FICRRTTSLY TTHIFNLFTP QNAQYPSKKS QDQLQGLCSL
410 420 430 440 450
AAEGMWTDTF VFSEEALRRN GILDSDIPTL LDRRILERSK ESESCYIFLH
460 470 480 490 500
PSLQEVCAAV FYLLKSHLDH PSQDVKSVEA LLFTFLKKAK VQWIFLGCFL
510 520 530 540 550
FGLLHESEQE KLEMFFGHQL SQEIKHQLYQ CLETISVNEE LQEQIDGMKL
560 570 580 590 600
FYCLFEMEDE AFLMQAMNCM EQINFVAKDY SDVIVAAYCL KHCSTLKKLS
610 620 630 640 650
FSTQNILSEE QEHSYTEKLL ICWHHMCSVL ISSKDIHVLQ VKDTNLNETA
660 670 680 690 700
FWVLYNHLKY PSCTLKVLVV NNVTFLCDNH LFFELIQNQR LQHLNLSLTF
710 720 730 740 750
LSHSDVKLLC DVLNQAECNI EKLMIAACNL SPDDCKVFAS VLISSKMLKH
760 770 780 790 800
LNLSSNNLDK GISSLCKALC HPDCILKHLV LANCSLSEQC WDYLSEVVRR
810 820 830 840 850
NKTLSHLDIS SNDLKDEGLK VLCGALTLPD SGLISLSVRH CLITTSGCQD
860 870 880 890 900
LAEVLRHNQN LRSLQVSNNK IEDAGVKLLC DAIKQPNCHL ENIGLEACEL
910 920 930 940 950
TGACCKDLAS AFVHCKTLWG INLLENALDH SGLVVLFEAL KQQKCTLHVL
960 970 980
GLRITDFDKE TQEFLIAEEE KNPYLSILSN VT
Length:982
Mass (Da):112,946
Last modified:July 22, 2015 - v3
Checksum:i1DC089CA929EE49D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07002350 Genomic DNA No translation available.
AABR07002351 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSRNOT00000046152; ENSRNOP00000046459; ENSRNOG00000021996

Similar proteinsi

Entry informationi

Entry nameiD3ZP31_RAT
AccessioniPrimary (citable) accession number: D3ZP31
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: July 22, 2015
Last modified: June 20, 2018
This is version 73 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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