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Protein

Transcription factor MafA

Gene

Mafa

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that activates insulin gene expression (PubMed:15665000). Acts synergistically with NEUROD1/BETA2 and PDX1 (By similarity). Binds the insulin enhancer C1/RIPE3b element (PubMed:15665000). Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor MafA
Alternative name(s):
Pancreatic beta-cell-specific transcriptional activator
Gene namesi
Name:Mafa
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1562627 Mafa

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004452781 – 361Transcription factor MafAAdd BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineBy similarity1
Cross-linki32Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei49PhosphoserineBy similarity1
Modified residuei53PhosphothreonineBy similarity1
Modified residuei57PhosphothreonineBy similarity1
Modified residuei61PhosphoserineBy similarity1
Modified residuei65PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated, leading to its degradation by the proteasome.By similarity
Phosphorylated at tyrosines.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiD3ZNT6

Expressioni

Inductioni

Up-regulated by glucose in Langerhans islets (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000007668 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue

Interactioni

Subunit structurei

Forms homodimers. Monomers and dimers are able to bind DNA, but the off-rate is faster for monomers (By similarity). Interacts with NEUROD1 and PDX1 (By similarity). May interact with MAFB, FOS, JUN and PCAF (By similarity).By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini262 – 325bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni262 – 287Basic motifPROSITE-ProRule annotationAdd BLAST26
Regioni290 – 311Leucine-zipperPROSITE-ProRule annotationAdd BLAST22

Sequence similaritiesi

Belongs to the bZIP family.SAAS annotation

Phylogenomic databases

eggNOGiENOG410KDH9 Eukaryota
ENOG4112BJ1 LUCA
GeneTreeiENSGT00550000074549
InParanoidiD3ZNT6
KOiK07595
OMAiQRHILES
OrthoDBiEOG091G0H46
PhylomeDBiD3ZNT6
TreeFamiTF325689

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR004826 bZIP_Maf
IPR013592 Maf_TF_N
IPR028562 MafA
IPR008917 TF_DNA-bd_sf
IPR024874 Transciption_factor_Maf_fam
PANTHERiPTHR10129 PTHR10129, 1 hit
PTHR10129:SF30 PTHR10129:SF30, 1 hit
PfamiView protein in Pfam
PF03131 bZIP_Maf, 1 hit
PF08383 Maf_N, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SUPFAMiSSF47454 SSF47454, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit

Sequencei

Sequence statusi: Complete.

D3ZNT6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAELAMGAE LPSSPLAIEY VNDFDLMKFE VKKEPPEAER FCHRLPPGSL
60 70 80 90 100
SSTPLSTPCS SVPSSPSFCA PSPGTGSSAG GGGSAAQAGG APGPPSGGPG
110 120 130 140 150
TVGGASGKAV LEDLYWMSGY QHHLNPEALN LTPEDAVEAL IGSGHHSAHH
160 170 180 190 200
GAHHPAAAAA YEAFRGQSFA GGGGGGADDM GAGHHHGAHH TAHHHHSAHH
210 220 230 240 250
HHHHHHHHGG SGHHGGGAGH GGGGAGHHVR LEERFSDDQL VSMSVRELNR
260 270 280 290 300
QLRGFSKEEV IRLKQKRRTL KNRGYAQSCR FKRVQQRHIL ESEKCQLQSQ
310 320 330 340 350
VEQLKLEVGR LAKERDLYKE KYEKLAGRGG PGGAGGAGFP REPSPAQAGP
360
GAAKGAPDFF L
Length:361
Mass (Da):37,780
Last modified:April 20, 2010 - v1
Checksum:i0055A8D0DBE65620
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133673 Genomic DNA No translation available.
RefSeqiXP_006241965.1, XM_006241903.2

Genome annotation databases

EnsembliENSRNOT00000010084; ENSRNOP00000010084; ENSRNOG00000007668
GeneIDi366949
KEGGirno:366949
UCSCiRGD:1562627 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133673 Genomic DNA No translation available.
RefSeqiXP_006241965.1, XM_006241903.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiD3ZNT6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010084; ENSRNOP00000010084; ENSRNOG00000007668
GeneIDi366949
KEGGirno:366949
UCSCiRGD:1562627 rat

Organism-specific databases

CTDi389692
RGDi1562627 Mafa

Phylogenomic databases

eggNOGiENOG410KDH9 Eukaryota
ENOG4112BJ1 LUCA
GeneTreeiENSGT00550000074549
InParanoidiD3ZNT6
KOiK07595
OMAiQRHILES
OrthoDBiEOG091G0H46
PhylomeDBiD3ZNT6
TreeFamiTF325689

Gene expression databases

BgeeiENSRNOG00000007668 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR004826 bZIP_Maf
IPR013592 Maf_TF_N
IPR028562 MafA
IPR008917 TF_DNA-bd_sf
IPR024874 Transciption_factor_Maf_fam
PANTHERiPTHR10129 PTHR10129, 1 hit
PTHR10129:SF30 PTHR10129:SF30, 1 hit
PfamiView protein in Pfam
PF03131 bZIP_Maf, 1 hit
PF08383 Maf_N, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SUPFAMiSSF47454 SSF47454, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMAFA_RAT
AccessioniPrimary (citable) accession number: D3ZNT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2018
Last sequence update: April 20, 2010
Last modified: October 10, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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