Sim1

Functionⁱ

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein heterodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription, DNA-templated Source: UniProtKB-UniRule
ureteric bud development Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-bindingSAAS annotation
Biological process	Transcription, Transcription regulationPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: SIM bHLH transcription factor 1Imported Submitted name: Single-minded 1 (Predicted)Imported
Gene namesⁱ	Name:Sim1Imported Synonyms:Sim1_predictedImported ORF Names:rCG_58489Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 20

Organism-specific databases

Rat genome database More...RGDⁱ	1309949 Sim1

RGDⁱ

1309949 Sim1

Keywords - Cellular componentⁱ

NucleusPROSITE-ProRule annotationSAAS annotation

PTM / Processingⁱ

Proteomic databases

PRIDEⁱ	D3ZMU8

PRIDEⁱ

D3ZMU8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000037600 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Bgeeⁱ

ENSRNOG00000037600 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Interactionⁱ

GO - Molecular functionⁱ

protein heterodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000053843

STRINGⁱ

10116.ENSRNOP00000053843

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 53	BHLHInterPro annotationAdd BLAST	53
Domainⁱ	77 – 140	PASInterPro annotationAdd BLAST	64
Domainⁱ	233 – 270	PASInterPro annotationAdd BLAST	38
Domainⁱ	336 – 765	Single-minded C-terminalInterPro annotationAdd BLAST	430

Keywords - Domainⁱ

RepeatSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG3559 Eukaryota ENOG410XY57 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118788
KEGG Orthology (KO) More...KOⁱ	K09100
OMAⁱ	ERPGSQH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06FQ
TreeFamⁱ	TF317772

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit cd00130 PAS, 2 hits
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR001610 PAC IPR000014 PAS IPR035965 PAS-like_dom_sf IPR013767 PAS_fold IPR013655 PAS_fold_3 IPR010578 SIM_C
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit PF00989 PAS, 1 hit PF08447 PAS_3, 1 hit PF06621 SIM_C, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit SM00086 PAC, 1 hit SM00091 PAS, 2 hits
SUPFAMⁱ	SSF47459 SSF47459, 1 hit SSF55785 SSF55785, 2 hits
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS50112 PAS, 2 hits PS51302 SIM_C, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

D3ZMU8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKEKSKNAAR TRREKENSEF YELAKLLPLP SAITSQLDKA SIIRLTTSYL 
        60         70         80         90        100
KMRVVFPEGL GEAWGHTSRT SPLDNVGREL GSHLLQTLDG FIFVVAPDGK 
       110        120        130        140        150
IMYISETASV HLGLSQVELT GNSIYEYIHP ADHDEMTAVL TAHQPYHSHF 
       160        170        180        190        200
VQEYEIERSF FLRMKCVLAK RNAGLTCGGY KVIHCSGYLK IRQYSLDMSP 
       210        220        230        240        250
FDGCYQNVGL VAVGHSLPPS AVTEIKLHSN MFMFRASLDM KLIFLDSRVA 
       260        270        280        290        300
ELTGYEPQDL IEKTLYHHVH GCDTFHLRCA HHLLLVKGQV TTKYYRFLAK 
       310        320        330        340        350
HGGWVWVQSY ATIVHNSRSS RPHCIVSVNY VLTDTEYKGL QLSLDQISPS 
       360        370        380        390        400
KPTFSYTSSS TPTITDNRKG AKSRLSSSKS KSRTSPYPQY SGFHTERSES 
       410        420        430        440        450
DHDSQWGGSP LTDTASPQLL DPERPGSQHE LSCAYRQFPD RGSLCYGFAL 
       460        470        480        490        500
DHSRLVEDRH FHTQACEGGR CEAGRYFLGA PPAGRDPWWG SRAALPLTKA 
       510        520        530        540        550
SPESRETYEN SMPHITSVHR LHGRGHWDED SVVSSPDPGS ASESGDRYRS 
       560        570        580        590        600
EQYQNSPHEP SKIETLIRAT QQMIKEEENR LQLRKAPPDQ LASINGAGKK 
       610        620        630        640        650
HSLCFANYQQ PPPAGEVCHS SALTSTSPCD HIQQREGKML SPHENDYDNS 
       660        670        680        690        700
PTALSRISSP SSDRITKSSL ILAKDYLHSD MSPHQTAGDH PAISPNCFGS 
       710        720        730        740        750
HRQYFDKHAY TLTGYALEHL YDSETIRNYS LGCNGSHFDV TSHLRMQPDP 
       760 
AQGHKGTSVI ITNGS

Length:765

Mass (Da):85,532

Last modified:April 20, 2010 - v1

Checksum:ⁱF49BC0AA9EE52F80

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07045656 Genomic DNA No translation available. AABR07045657 Genomic DNA No translation available. AABR07045658 Genomic DNA No translation available. CH474025 Genomic DNA Translation: EDL99652.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001101111.1, NM_001107641.1 XP_006256666.1, XM_006256604.2 XP_008771216.1, XM_008772994.2 XP_008771217.1, XM_008772995.2 XP_008771218.1, XM_008772996.1
UniGeneⁱ	Rn.165946

Genome annotation databases

Ensemblⁱ	ENSRNOT00000057010; ENSRNOP00000053843; ENSRNOG00000037600
GeneIDⁱ	309888
KEGGⁱ	rno:309888
UCSC genome browser More...UCSCⁱ	RGD:1309949 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
D3ZMU8	Single-minded homolog 1		MOUSE		765	UniRef90_Q61045
Single-minded homolog 1		HUMAN		766
SIM bHLH transcription factor 1		GORGO		766
Single-minded family bHLH transcription factor 1		MACMU		766
Uncharacterized protein		MACFA		766
+67

Protein	Similar proteins		Species	Score	Length	Source
D3ZMU8	Single-minded homolog 1		MOUSE		765	UniRef50_Q61045
Single-minded homolog 1		HUMAN		766
Single-minded homolog 1		PANTR		766
Single-minded homolog 1		PANPA		766
Uncharacterized protein		NOMLE		766
+254

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07045656 Genomic DNA No translation available. AABR07045657 Genomic DNA No translation available. AABR07045658 Genomic DNA No translation available. CH474025 Genomic DNA Translation: EDL99652.1
RefSeqⁱ	NP_001101111.1, NM_001107641.1 XP_006256666.1, XM_006256604.2 XP_008771216.1, XM_008772994.2 XP_008771217.1, XM_008772995.2 XP_008771218.1, XM_008772996.1
UniGeneⁱ	Rn.165946

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000053843

STRINGⁱ

10116.ENSRNOP00000053843

Proteomic databases

PRIDEⁱ	D3ZMU8

PRIDEⁱ

D3ZMU8

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000057010; ENSRNOP00000053843; ENSRNOG00000037600
GeneIDⁱ	309888
KEGGⁱ	rno:309888
UCSCⁱ	RGD:1309949 rat

Organism-specific databases

CTDⁱ	6492
RGDⁱ	1309949 Sim1

Phylogenomic databases

eggNOGⁱ	KOG3559 Eukaryota ENOG410XY57 LUCA
GeneTreeⁱ	ENSGT00760000118788
KOⁱ	K09100
OMAⁱ	ERPGSQH
OrthoDBⁱ	EOG091G06FQ
TreeFamⁱ	TF317772

Gene expression databases

Bgeeⁱ	ENSRNOG00000037600 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Bgeeⁱ

ENSRNOG00000037600 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit cd00130 PAS, 2 hits
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR001610 PAC IPR000014 PAS IPR035965 PAS-like_dom_sf IPR013767 PAS_fold IPR013655 PAS_fold_3 IPR010578 SIM_C
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit PF00989 PAS, 1 hit PF08447 PAS_3, 1 hit PF06621 SIM_C, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit SM00086 PAC, 1 hit SM00091 PAS, 2 hits
SUPFAMⁱ	SSF47459 SSF47459, 1 hit SSF55785 SSF55785, 2 hits
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS50112 PAS, 2 hits PS51302 SIM_C, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D3ZMU8_RAT
Accessionⁱ	D3ZMU8Primary (citable) accession number: D3ZMU8
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 20, 2010
	Last sequence update:	April 20, 2010
	Last modified:	November 7, 2018
	This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - D3ZMU8 (D3ZMU8_RAT)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

SIM bHLH transcription factor 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ