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UniProtKB - D3ZMU8 (D3ZMU8_RAT)
Protein
Submitted name:
SIM bHLH transcription factor 1
Gene
Sim1
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- protein heterodimerization activity Source: RGD
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- nervous system development Source: UniProtKB-KW
- regulation of transcription, DNA-templated Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- ureteric bud development Source: RGD
Keywordsi
Molecular function | Developmental proteinARBA annotation, DNA-bindingARBA annotation |
Biological process | DifferentiationARBA annotation, NeurogenesisARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: SIM bHLH transcription factor 1Submitted name: Single-minded 1 (Predicted)Imported |
Gene namesi | ORF Names:rCG_58489Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1309949, Sim1 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000037600, Expressed in kidney and 10 other tissues |
Interactioni
GO - Molecular functioni
- protein heterodimerization activity Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000053843 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 53 | BHLHInterPro annotationAdd BLAST | 53 | |
Domaini | 77 – 140 | PASInterPro annotationAdd BLAST | 64 | |
Domaini | 233 – 270 | PASInterPro annotationAdd BLAST | 38 | |
Domaini | 336 – 765 | Single-minded C-terminalInterPro annotationAdd BLAST | 430 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 350 – 428 | DisorderedSequence analysisAdd BLAST | 79 | |
Regioni | 527 – 563 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 642 – 661 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 350 – 394 | Polar residuesSequence analysisAdd BLAST | 45 | |
Compositional biasi | 535 – 563 | Polar residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 645 – 661 | Polar residuesSequence analysisAdd BLAST | 17 |
Keywords - Domaini
RepeatARBA annotationPhylogenomic databases
eggNOGi | KOG3559, Eukaryota |
GeneTreei | ENSGT00940000156143 |
HOGENOMi | CLU_010044_4_0_1 |
OMAi | ANTSPCE |
OrthoDBi | 231698at2759 |
TreeFami | TF317772 |
Family and domain databases
CDDi | cd00130, PAS, 2 hits |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR001610, PAC IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold IPR013655, PAS_fold_3 IPR010578, SIM_C |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF00989, PAS, 1 hit PF08447, PAS_3, 1 hit PF06621, SIM_C, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00086, PAC, 1 hit SM00091, PAS, 2 hits |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 2 hits PS51302, SIM_C, 1 hit |
i Sequence
Sequence statusi: Complete.
D3ZMU8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKEKSKNAAR TRREKENSEF YELAKLLPLP SAITSQLDKA SIIRLTTSYL
60 70 80 90 100
KMRVVFPEGL GEAWGHTSRT SPLDNVGREL GSHLLQTLDG FIFVVAPDGK
110 120 130 140 150
IMYISETASV HLGLSQVELT GNSIYEYIHP ADHDEMTAVL TAHQPYHSHF
160 170 180 190 200
VQEYEIERSF FLRMKCVLAK RNAGLTCGGY KVIHCSGYLK IRQYSLDMSP
210 220 230 240 250
FDGCYQNVGL VAVGHSLPPS AVTEIKLHSN MFMFRASLDM KLIFLDSRVA
260 270 280 290 300
ELTGYEPQDL IEKTLYHHVH GCDTFHLRCA HHLLLVKGQV TTKYYRFLAK
310 320 330 340 350
HGGWVWVQSY ATIVHNSRSS RPHCIVSVNY VLTDTEYKGL QLSLDQISPS
360 370 380 390 400
KPTFSYTSSS TPTITDNRKG AKSRLSSSKS KSRTSPYPQY SGFHTERSES
410 420 430 440 450
DHDSQWGGSP LTDTASPQLL DPERPGSQHE LSCAYRQFPD RGSLCYGFAL
460 470 480 490 500
DHSRLVEDRH FHTQACEGGR CEAGRYFLGA PPAGRDPWWG SRAALPLTKA
510 520 530 540 550
SPESRETYEN SMPHITSVHR LHGRGHWDED SVVSSPDPGS ASESGDRYRS
560 570 580 590 600
EQYQNSPHEP SKIETLIRAT QQMIKEEENR LQLRKAPPDQ LASINGAGKK
610 620 630 640 650
HSLCFANYQQ PPPAGEVCHS SALTSTSPCD HIQQREGKML SPHENDYDNS
660 670 680 690 700
PTALSRISSP SSDRITKSSL ILAKDYLHSD MSPHQTAGDH PAISPNCFGS
710 720 730 740 750
HRQYFDKHAY TLTGYALEHL YDSETIRNYS LGCNGSHFDV TSHLRMQPDP
760
AQGHKGTSVI ITNGS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH474025 Genomic DNA Translation: EDL99652.1 |
RefSeqi | NP_001101111.1, NM_001107641.1 XP_006256666.1, XM_006256604.2 XP_008771216.1, XM_008772994.2 XP_008771217.1, XM_008772995.2 XP_008771218.1, XM_008772996.1 |
Genome annotation databases
Ensembli | ENSRNOT00000057010.3; ENSRNOP00000053843.2; ENSRNOG00000037600.3 |
GeneIDi | 309888 |
KEGGi | rno:309888 |
UCSCi | RGD:1309949, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH474025 Genomic DNA Translation: EDL99652.1 |
RefSeqi | NP_001101111.1, NM_001107641.1 XP_006256666.1, XM_006256604.2 XP_008771216.1, XM_008772994.2 XP_008771217.1, XM_008772995.2 XP_008771218.1, XM_008772996.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000053843 |
Genome annotation databases
Ensembli | ENSRNOT00000057010.3; ENSRNOP00000053843.2; ENSRNOG00000037600.3 |
GeneIDi | 309888 |
KEGGi | rno:309888 |
UCSCi | RGD:1309949, rat |
Organism-specific databases
CTDi | 6492 |
RGDi | 1309949, Sim1 |
Phylogenomic databases
eggNOGi | KOG3559, Eukaryota |
GeneTreei | ENSGT00940000156143 |
HOGENOMi | CLU_010044_4_0_1 |
OMAi | ANTSPCE |
OrthoDBi | 231698at2759 |
TreeFami | TF317772 |
Gene expression databases
Bgeei | ENSRNOG00000037600, Expressed in kidney and 10 other tissues |
Family and domain databases
CDDi | cd00130, PAS, 2 hits |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR001610, PAC IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold IPR013655, PAS_fold_3 IPR010578, SIM_C |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF00989, PAS, 1 hit PF08447, PAS_3, 1 hit PF06621, SIM_C, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00086, PAC, 1 hit SM00091, PAS, 2 hits |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 2 hits PS51302, SIM_C, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | D3ZMU8_RAT | |
Accessioni | D3ZMU8Primary (citable) accession number: D3ZMU8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | May 25, 2022 | |
This is version 100 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |