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UniProtKB - D3ZMK9 (PRAG1_RAT)

Entry version 78 (16 Oct 2019)
Sequence version 1 (20 Apr 2010)
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Protein

Inactive tyrosine-protein kinase PRAG1

Gene

Prag1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytically inactive protein kinase that acts as a scaffold protein (PubMed:29503074). Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (PubMed:16481321). Promotes Src family kinase (SFK) signallig by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (PubMed:27116701, PubMed:21873224). Acts as a critical coactivator of Notch signaling (By similarity).By similarity4 Publications

Caution

Despite of the presence of a putative ATP-binding motif, this protein does not bind ATP, suggesting that it has no protein kinase activity (PubMed:29503074).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • protein kinase activity Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inactive tyrosine-protein kinase PRAG1Curated
Alternative name(s):
PEAK1-related kinase-activating pseudokinase 1
Pragma of Rnd21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Prag1Imported
Synonyms:Pragmin1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Rat genome database

More...RGDi		1311793 Prag1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi391Y → A: Does not affect cytoplasmic localization. 1 Publication1
Mutagenesisi391Y → F: Decreases the interaction with CSK. 2 Publications1
Mutagenesisi939L → E: Does not affect homodimerization. 1 Publication1
Mutagenesisi978D → N: No ATP-binding activity. 1 Publication1
Mutagenesisi981Y → F: No ATP-binding activity. 1 Publication1
Mutagenesisi997K → A: Does not affect PRAG1-CSK complex formation. Does not affect PRAG1-induced protein tyrosine phosphorylation. 1 Publication1
Mutagenesisi1021Q → E: No ATP-binding activity. 1 Publication1
Mutagenesisi1329A → E: Strong reduction of homodimerization; Does not affect PRAG1-CSK complex formation. Reduces CSK activation. 1 Publication1
Mutagenesisi1349Y → E: Does not affect homodimerization. 1 Publication1
Mutagenesisi1362L → E: Does not affect homodimerization. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004446341 – 1368Inactive tyrosine-protein kinase PRAG1Add BLAST1368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei238Phosphotyrosine; by CSK1 Publication1
Modified residuei343Phosphotyrosine; by CSK1 Publication1
Modified residuei391Phosphotyrosine; by CSK3 Publications1
Modified residuei667PhosphoserineBy similarity1
Modified residuei716PhosphoserineBy similarity1
Modified residuei753PhosphoserineBy similarity1
Modified residuei797PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by CSK on Tyr-238, Tyr-343, and Tyr-391; Tyr-391 is a primary site of phosphorylation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		D3ZMK9

PRoteomics IDEntifications database

More...PRIDEi		D3ZMK9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		D3ZMK9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		D3ZMK9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly-expressed in brain, including cortical and hippocampal pyramidal neurons, as well as in kidney, spleen, colon and small intestine (PubMed:16481321).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000011407 Expressed in 9 organ(s), highest expression level in brain

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:29503074). Dimerization leads to the catalytic activation of CSK (PubMed:29503074).

Interacts (via C-terminus) with RND2 (PubMed:16481321).

Interacts with CSK (via SH2 domain) in a Tyr-391 phosphorylation-dependent manner; this interaction potentiates kinase activity of CSK (PubMed:29503074, PubMed:21873224, PubMed:27116701).

Interacts with NOTCH1 intracellular domain (N1ICD) (By similarity).

Forms a complex with N1ICD and MAML1, in a MAML1-dependent manner (By similarity).

By similarity4 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		D3ZMK9

Protein interaction database and analysis system

More...IntActi		D3ZMK9, 2 interactors

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000015166

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11368
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		D3ZMK9

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini940 – 1291Protein kinasePROSITE-ProRule annotationAdd BLAST352

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni906 – 949Required for homodimerization1 PublicationAdd BLAST44
Regioni1293 – 1368Required for homodimerization1 PublicationAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi890 – 920Ser-richPROSITE-ProRule annotationAdd BLAST31

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The dimerization region encompasses helices both from the N- and C-terminal of the protein kinase domain.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IJMD Eukaryota
ENOG4110SRP LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157066

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		D3ZMK9

KEGG Orthology (KO)

More...KOi		K17537

Identification of Orthologs from Complete Genome Data

More...OMAi		TTWHRLH

Database of Orthologous Groups

More...OrthoDBi		49921at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		D3ZMK9

TreeFam database of animal gene trees

More...TreeFami		TF331193

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008266 Tyr_kinase_AS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3ZMK9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSACSDFVEH IWKPGSCKNC FCLRSDHQLT AGHPKARASS LPAGARLPAR 
        60         70         80         90        100
PEICRLEDEG VNGLAYSKPT IAVKPTMMTS ETADLWTEAS LSAEVPKVNW 
       110        120        130        140        150
RRTPGKLLLQ KQEDGPIVYL GSFRGMQKAA GPLACTDSNS RCPPAYTMVG 
       160        170        180        190        200
LHNLEARVDR NTALQPVNFQ EEKAGREELP SAQESFRQKL AAFTGMTSSC 
       210        220        230        240        250
LKGPRPCTSP QPLRESLPSE DDSDQRCSPS GDSEGGEYCS ILDCRPESRD 
       260        270        280        290        300
AVHNTEGSGR RRGDCSPICW EQGTCTRPTE EEKQALNFPR ECCGQGSTAN 
       310        320        330        340        350
PPHLGPKKPS LNSEAASSSD GLSCGSSRSG ANSPFAPHLE NDYCSLVKEP 
       360        370        380        390        400
TSVKQQDSGC HLVNSGKYVG QAVDLQPPAL PREAVQPEPI YAESAKRKKA 
       410        420        430        440        450
APVPQRPEPK KEQVSSGQVW TGDTWSQKTP SGWSQEREGP NAAPQVATTI 
       460        470        480        490        500
TVIAAHPEED HRTIYLSSPD SAVGVQWPRG SLNQDLHGSG EEPLVVQGLS 
       510        520        530        540        550
SRESHPHNMT ENSSKEKPAI PPKLSKSSPG GSPVSPAAPP LTDHSDGNTS 
       560        570        580        590        600
GSSVGSQPSS RVPTNLTSSC QTNGVAAGDP AKCPPQANSS VLDQRRPRYQ 
       610        620        630        640        650
TGAWSRQCRI EEEEEVGQEL LSQSWGRELE NGIADHSNSS TWHRLHPIDG 
       660        670        680        690        700
ASGQNGKTNS GMSKSASFAF EFPKDRGRLE SFSPPPPPPK SRHLLKMNKS 
       710        720        730        740        750
SSDLEKVSQS SAESLSPSFR GAHVSFTTGS TDSLASDSRT CSDGGPSCEA 
       760        770        780        790        800
THSPTISGKK LFAPVPFPSG STEDVSPSGP AQPPPLPQKK IVSRAASSPD 
       810        820        830        840        850
GFFWTQGSPK PRTASPKLNL SHSETNVCAH DEPPLSYSLN SGNHPHHVFS 
       860        870        880        890        900
SSEPLEKAFK GSVPWAPALG PANSKGGCGS PNLQGRAATS TSSSQLSVSS 
       910        920        930        940        950
QASTGSSQLQ LHSLLSSISS KEGTYAKLGG LYTQSLARLV TKCEDLFMGG 
       960        970        980        990       1000
LKTELRFDEN SWSLFKLICN KPCCDSGDAI YYGATCSKDP DSIYAVKICK 
      1010       1020       1030       1040       1050
TPEPKSASYC SPSVPVHFNI QQDCGHFVAS VPSSMLAFPD TSSKDPAPAA 
      1060       1070       1080       1090       1100
PSHTPAQEQD CVVVITREVP HQTASDFVRD SVASHRAEPE VYERRVCFLL 
      1110       1120       1130       1140       1150
LQLCNGLEHL KEHGIIHRDL CLENLLLVHC NPQSSPGPSA NPSVPTTTSR 
      1160       1170       1180       1190       1200
CPSAAPAATT ACQGGPGEKH LPRLIISNFL KAKQKPGGTT NLQQKKSQAR 
      1210       1220       1230       1240       1250
LAPEIVSASQ YRKFDEFQTG ILIYELLHQP NPFEVRAQLR ERDYRREDLP 
      1260       1270       1280       1290       1300
PLPTLSLYSP GLQQLAHLLL EADPIKRIRI GEAKRVLQCL LWGPRRELVE 
      1310       1320       1330       1340       1350
QPCPSEEVLC NTLHNWIDMK RALMMMKFAE KAVERRRGVE LEDWLCCQYL 
      1360 
ASAEPGALLQ SLKLLQLL
Length:1,368
Mass (Da):147,716
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i31BF773387FD28B7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AABR07026025 Genomic DNA No translation available.
AABR07026026 Genomic DNA No translation available.
CH473970 Genomic DNA Translation: EDM09203.1

NCBI Reference Sequences

More...RefSeqi		NP_001100785.1, NM_001107315.1
XP_017455620.1, XM_017600131.1
XP_017455621.1, XM_017600132.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000015166; ENSRNOP00000015166; ENSRNOG00000011407

Database of genes from NCBI RefSeq genomes

More...GeneIDi		306506

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:306506

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07026025 Genomic DNA No translation available.
AABR07026026 Genomic DNA No translation available.
CH473970 Genomic DNA Translation: EDM09203.1
RefSeqiNP_001100785.1, NM_001107315.1
XP_017455620.1, XM_017600131.1
XP_017455621.1, XM_017600132.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6EWXX-ray2.77A/B906-1368[»]
SMRiD3ZMK9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

ELMiD3ZMK9
IntActiD3ZMK9, 2 interactors
STRINGi10116.ENSRNOP00000015166

PTM databases

iPTMnetiD3ZMK9
PhosphoSitePlusiD3ZMK9

Proteomic databases

PaxDbiD3ZMK9
PRIDEiD3ZMK9

Genome annotation databases

EnsembliENSRNOT00000015166; ENSRNOP00000015166; ENSRNOG00000011407
GeneIDi306506
KEGGirno:306506

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		157285
RGDi1311793 Prag1

Phylogenomic databases

eggNOGiENOG410IJMD Eukaryota
ENOG4110SRP LUCA
GeneTreeiENSGT00940000157066
InParanoidiD3ZMK9
KOiK17537
OMAiTTWHRLH
OrthoDBi49921at2759
PhylomeDBiD3ZMK9
TreeFamiTF331193

Miscellaneous databases

Protein Ontology

More...PROi		PR:D3ZMK9

Gene expression databases

BgeeiENSRNOG00000011407 Expressed in 9 organ(s), highest expression level in brain

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008266 Tyr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRAG1_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZMK9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 18, 2018
Last sequence update: April 20, 2010
Last modified: October 16, 2019
This is version 78 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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