Fosb

Functionⁱ

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: RGD
Inferred from mutant phenotypeⁱ
- 10830307
double-stranded DNA binding
Source: RGD
Inferred from direct assayⁱ
- 10830307
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
sequence-specific DNA binding
Source: RGD
Inferred from direct assayⁱ
- 10830307
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to calcium ion Source: Ensembl
cellular response to hormone stimulus
Source: RGD
Inferred from expression patternⁱ
- 11460264
female pregnancy
Source: RGD
Inferred from expression patternⁱ
- 12080023
response to cAMP
Source: RGD
Inferred from expression patternⁱ
- 10934195
response to corticosterone
Source: RGD
Inferred from expression patternⁱ
- 18485334
response to drug
Source: RGD
Inferred from expression patternⁱ
- 12093589
response to mechanical stimulus
Source: RGD
Inferred from expression patternⁱ
- 15126239
response to morphine
Source: RGD
Inferred from expression patternⁱ
- 15772255
response to progesterone
Source: RGD
Inferred from expression patternⁱ
- 11750070
- 12080023
transcription by RNA polymerase II
Source: RGD
Inferred from mutant phenotypeⁱ
- 10830307

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-bindingSAAS annotation

Molecular function

DNA-bindingSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: FosB proto-oncogene, AP-1 transcription factor subunitImported Submitted name: RCG54346Imported
Gene namesⁱ	Name:FosbImported ORF Names:rCG_54346Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 1

Organism-specific databases

Rat genome database More...RGDⁱ	1308198 Fosb

RGDⁱ

1308198 Fosb

Subcellular locationⁱ

GO - Cellular component

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000046667 Expressed in 10 organ(s), highest expression level in lung
ExpressionAtlasⁱ	D3ZLB7 baseline and differential

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000065427

STRINGⁱ

10116.ENSRNOP00000065427

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	155 – 218	BZIPInterPro annotationAdd BLAST		64

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	153 – 214	Sequence analysisAdd BLAST		62

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG1414 Eukaryota ENOG4111CH5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110541
KEGG Orthology (KO) More...KOⁱ	K09029
OMAⁱ	YPEGACG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GGW
TreeFamⁱ	TF326301

Family and domain databases

InterProⁱ	View protein in InterPro IPR000837 AP-1 IPR004827 bZIP IPR029813 FosB
PANTHERⁱ	PTHR23351 PTHR23351, 1 hit PTHR23351:SF3 PTHR23351:SF3, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00170 bZIP_1, 1 hit
PRINTSⁱ	PR00042 LEUZIPPRFOS
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

D3ZLB7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM 
        60         70         80         90        100
PGSFVPTVTA ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPAVDPYDMP 
       110        120        130        140        150
GTSYSTPGLS AYSTGGASGS GGPSTSTSTS GPVSARPARA RPRRPREETL 
       160        170        180        190        200
TPEEEEKRRV RRERNKLAAA KCRNRRRELT DRLQAETDQL EEEKAELESE 
       210        220        230        240        250
IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD LPGSTSAKED 
       260        270        280        290        300
GFGWLLPPPP PPPLPFQSSR DAPPNLTASL FTHSEVQVLG DPFPVVSPSY 
       310        320        330 
TSSFVLTCPE VSAFAGSQRT SGSEQPSDPL NSPSLLAL

Length:338

Mass (Da):35,979

Last modified:April 20, 2010 - v1

Checksum:ⁱDBB043A69B971C0E

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	S5NB67	S5NB67_RAT		FBJ osteosarcoma viral oncogene iso... FBJ osteosarcoma viral oncogene isoform deltaFosb-2 (FosB proto-oncogene, AP-1 transcription factor subunit)	Fosb	302	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07002674 Genomic DNA No translation available. CH473979 Genomic DNA Translation: EDM08212.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001243438.1, NM_001256509.1
UniGeneⁱ	Rn.32994

Genome annotation databases

Ensemblⁱ	ENSRNOT00000072149; ENSRNOP00000065427; ENSRNOG00000046667
GeneIDⁱ	100360880
KEGGⁱ	rno:100360880
UCSC genome browser More...UCSCⁱ	RGD:2321278 rat

Protein	Similar proteins		Species	Score	Length	Source
D3ZLB7	Protein fosB	)	HUMAN		338	UniRef90_P53539
Protein fosB		CANLF		338
Protein fosB		MOUSE		338
FBJ murine osteosarcoma viral oncogene homolog B		PANTR		338
FOSB isoform 6		PONAB		338
+155

Protein	Similar proteins		Species	Score	Length	Source
D3ZLB7	Protein fosB	)	HUMAN		338	UniRef50_P53539
Protein fosB		MOUSE		338
Protein fosB		CANLF		338
FBJ murine osteosarcoma viral oncogene homolog B		PANTR		338
FOSB isoform 6		PONAB		338
+201

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07002674 Genomic DNA No translation available. CH473979 Genomic DNA Translation: EDM08212.1
RefSeqⁱ	NP_001243438.1, NM_001256509.1
UniGeneⁱ	Rn.32994

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000065427

STRINGⁱ

10116.ENSRNOP00000065427

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000072149; ENSRNOP00000065427; ENSRNOG00000046667
GeneIDⁱ	100360880
KEGGⁱ	rno:100360880
UCSCⁱ	RGD:2321278 rat

Organism-specific databases

CTDⁱ	2354
RGDⁱ	1308198 Fosb

Phylogenomic databases

eggNOGⁱ	KOG1414 Eukaryota ENOG4111CH5 LUCA
GeneTreeⁱ	ENSGT00730000110541
KOⁱ	K09029
OMAⁱ	YPEGACG
OrthoDBⁱ	EOG091G0GGW
TreeFamⁱ	TF326301

Gene expression databases

Bgeeⁱ	ENSRNOG00000046667 Expressed in 10 organ(s), highest expression level in lung
ExpressionAtlasⁱ	D3ZLB7 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR000837 AP-1 IPR004827 bZIP IPR029813 FosB
PANTHERⁱ	PTHR23351 PTHR23351, 1 hit PTHR23351:SF3 PTHR23351:SF3, 1 hit
Pfamⁱ	View protein in Pfam PF00170 bZIP_1, 1 hit
PRINTSⁱ	PR00042 LEUZIPPRFOS
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D3ZLB7_RAT
Accessionⁱ	D3ZLB7Primary (citable) accession number: D3ZLB7
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 20, 2010
	Last sequence update:	April 20, 2010
	Last modified:	October 10, 2018
	This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - D3ZLB7 (D3ZLB7_RAT)

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FosB proto-oncogene, AP-1 transcription factor subunit

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ