FosB proto-oncogene, AP-1 transcription factor subunit

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Multiple basic-leucine zipper proteins regulate induction of the mouse heme oxygenase-1 gene by arsenite."
    Gong P., Stewart D., Hu B., Vinson C., Alam J.
    Arch. Biochem. Biophys. 405:265-274(2002) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • "The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1."
    Hall M.C., Young D.A., Waters J.G., Rowan A.D., Chantry A., Edwards D.R., Clark I.M.
    J. Biol. Chem. 278:10304-10313(2003) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site."
    Varghese S., Rydziel S., Canalis E.
    Endocrinology 141:2185-2191(2000) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• double-stranded DNA binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site."
    Varghese S., Rydziel S., Canalis E.
    Endocrinology 141:2185-2191(2000) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1."
    Hall M.C., Young D.A., Waters J.G., Rowan A.D., Chantry A., Edwards D.R., Clark I.M.
    J. Biol. Chem. 278:10304-10313(2003) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: RGDInferred from direct assayⁱ
  • "Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site."
    Varghese S., Rydziel S., Canalis E.
    Endocrinology 141:2185-2191(2000) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cellular response to calcium ion Source: RGDInferred from sequence orthologyⁱ
  • "Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells."
    Ezhkova E., Pasolli H.A., Parker J.S., Stokes N., Su I.H., Hannon G., Tarakhovsky A., Fuchs E.
    Cell 136:1122-1135(2009) [PubMed] [Europe PMC] [Abstract]
• cellular response to hormone stimulus Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Rapid effects of triiodothyronine on immediate-early gene expression in Schwann cells."
    Mercier G., Turque N., Schumacher M.
    Glia 35:81-89(2001) [PubMed] [Europe PMC] [Abstract]
• female pregnancy Source: RGDInferred from expression patternⁱ
  • "Differential expression of activator protein-1 transcription factors in pregnant rat myometrium."
    Mitchell J.A., Lye S.J.
    Biol. Reprod. 67:240-246(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1."
    Hall M.C., Young D.A., Waters J.G., Rowan A.D., Chantry A., Edwards D.R., Clark I.M.
    J. Biol. Chem. 278:10304-10313(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• response to cAMP Source: RGDInferred from expression patternⁱ
  • "Regulation of AP1 (Jun/Fos) factor expression and activation in ovarian granulosa cells. Relation of JunD and Fra2 to terminal differentiation."
    Sharma S.C., Richards J.S.
    J. Biol. Chem. 275:33718-33728(2000) [PubMed] [Europe PMC] [Abstract]
• response to corticosterone Source: RGDInferred from expression patternⁱ
  • "Time-course of immediate early gene expression in hippocampal subregions of adrenalectomized rats after acute corticosterone challenge."
    Hansson A.C., Fuxe K.
    Brain Res. 1215:1-10(2008) [PubMed] [Europe PMC] [Abstract]
• response to drug Source: RGDInferred from expression patternⁱ
  • "Chronic antipsychotic drug treatment induces long-lasting expression of fos and jun family genes and activator protein 1 complex in the rat prefrontal cortex."
    Kontkanen O., Lakso M., Wong G., Castren E.
    Neuropsychopharmacology 27:152-162(2002) [PubMed] [Europe PMC] [Abstract]
• response to mechanical stimulus Source: RGDInferred from expression patternⁱ
  • "Mechanical stretch and progesterone differentially regulate activator protein-1 transcription factors in primary rat myometrial smooth muscle cells."
    Mitchell J.A., Shynlova O., Langille B.L., Lye S.J.
    Am. J. Physiol. Endocrinol. Metab. 287:E439-45(2004) [PubMed] [Europe PMC] [Abstract]
• response to morphine Source: RGDInferred from expression patternⁱ
  • "D1 dopamine receptors modulate deltaFosB induction in rat striatum after intermittent morphine administration."
    Muller D.L., Unterwald E.M.
    J. Pharmacol. Exp. Ther. 314:148-154(2005) [PubMed] [Europe PMC] [Abstract]
• response to progesterone Source: RGDInferred from expression patternⁱ
  • "Early activation of transcription factor expression in Schwann cells by progesterone."
    Mercier G., Turque N., Schumacher M.
    Brain Res. Mol. Brain Res. 97:137-148(2001) [PubMed] [Europe PMC] [Abstract]
  • "Differential expression of activator protein-1 transcription factors in pregnant rat myometrium."
    Mitchell J.A., Lye S.J.
    Biol. Reprod. 67:240-246(2002) [PubMed] [Europe PMC] [Abstract]
• transcription by RNA polymerase II Source: RGDInferred from mutant phenotypeⁱ
  • "Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site."
    Varghese S., Rydziel S., Canalis E.
    Endocrinology 141:2185-2191(2000) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM 
        60         70         80         90        100
PGSFVPTVTA ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPAVDPYDMP 
       110        120        130        140        150
GTSYSTPGLS AYSTGGASGS GGPSTSTSTS GPVSARPARA RPRRPREETL 
       160        170        180        190        200
TPEEEEKRRV RRERNKLAAA KCRNRRRELT DRLQAETDQL EEEKAELESE 
       210        220        230        240        250
IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD LPGSTSAKED 
       260        270        280        290        300
GFGWLLPPPP PPPLPFQSSR DAPPNLTASL FTHSEVQVLG DPFPVVSPSY 
       310        320        330 
TSSFVLTCPE VSAFAGSQRT SGSEQPSDPL NSPSLLAL              

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ