UniProtKB - D3ZLB7 (FOSB_RAT)
Protein FosB
Fosb
Functioni
Heterodimerizes with proteins of the JUN family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing their transcriptional activity (By similarity).
Exhibits transactivation activity in vitro (By similarity).
As part of the AP-1 complex, facilitates enhancer selection together with cell-type-specific transcription factors by collaboratively binding to nucleosomal enhancers and recruiting the SWI/SNF (BAF) chromatin remodeling complex to establish accessible chromatin (By similarity).
Together with JUN, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (By similarity).
Involved in the display of nurturing behavior towards newborns (By similarity).
May play a role in neurogenesis in the hippocampus and in learning and memory-related tasks by regulating the expression of various genes involved in neurogenesis, depression and epilepsy (By similarity).
Implicated in behavioral responses related to morphine reward and spatial memory (By similarity).
By similarityGO - Molecular functioni
- DNA binding Source: RGD
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- double-stranded DNA binding Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- cellular response to calcium ion Source: RGD
- cellular response to hormone stimulus Source: RGD
- female pregnancy Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to cAMP Source: RGD
- response to corticosterone Source: RGD
- response to mechanical stimulus Source: RGD
- response to morphine Source: RGD
- response to progesterone Source: RGD
- response to xenobiotic stimulus Source: RGD
- transcription by RNA polymerase II Source: RGD
Names & Taxonomyi
Protein namesi | Recommended name: Protein FosBCuratedAlternative name(s): Transcription factor AP-1 subunit FosBCurated |
Gene namesi | Name:FosbImported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1308198, Fosb |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: RGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000454709 | 1 – 338 | Protein FosBAdd BLAST | 338 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 27 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 172 | Interchain (with C-279 in JUND)By similarity |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, PhosphoproteinProteomic databases
PaxDbi | D3ZLB7 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSRNOG00000046667, Expressed in frontal cortex and 21 other tissues |
ExpressionAtlasi | D3ZLB7, baseline and differential |
Interactioni
Subunit structurei
Heterodimer; binds to DNA as heterodimer (By similarity).
Component of an AP-1 transcription factor complex; composed of FOS-JUN heterodimers (By similarity). As part of the AP-1 transcription factor complex, forms heterodimers with JUN, JUNB or JUND, thereby binding to the AP-1 consensus sequence and stimulating transcription (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000065427 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 155 – 218 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 157 – 182 | Basic motifPROSITE-ProRule annotationAdd BLAST | 26 | |
Regioni | 183 – 211 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 29 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1414, Eukaryota |
GeneTreei | ENSGT00940000160358 |
HOGENOMi | CLU_049742_0_0_1 |
InParanoidi | D3ZLB7 |
OMAi | QGMMQEV |
OrthoDBi | 1221590at2759 |
PhylomeDBi | D3ZLB7 |
TreeFami | TF326301 |
Family and domain databases
InterProi | View protein in InterPro IPR000837, AP-1 IPR004827, bZIP IPR046347, bZIP_sf IPR029813, FosB |
PANTHERi | PTHR23351, PTHR23351, 1 hit PTHR23351:SF3, PTHR23351:SF3, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
PRINTSi | PR00042, LEUZIPPRFOS |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM
60 70 80 90 100
PGSFVPTVTA ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPAVDPYDMP
110 120 130 140 150
GTSYSTPGLS AYSTGGASGS GGPSTSTSTS GPVSARPARA RPRRPREETL
160 170 180 190 200
TPEEEEKRRV RRERNKLAAA KCRNRRRELT DRLQAETDQL EEEKAELESE
210 220 230 240 250
IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD LPGSTSAKED
260 270 280 290 300
GFGWLLPPPP PPPLPFQSSR DAPPNLTASL FTHSEVQVLG DPFPVVSPSY
310 320 330
TSSFVLTCPE VSAFAGSQRT SGSEQPSDPL NSPSLLAL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketS5NB67 | S5NB67_RAT | FBJ osteosarcoma viral oncogene iso... | Fosb | 302 | Annotation score: | ||
A0A8I6AEQ0 | A0A8I6AEQ0_RAT | Protein FosB | Fosb | 237 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07002674 Genomic DNA No translation available. CH473979 Genomic DNA Translation: EDM08212.1 |
RefSeqi | NP_001243438.1, NM_001256509.1 |
Genome annotation databases
Ensembli | ENSRNOT00000072149; ENSRNOP00000065427; ENSRNOG00000046667 |
GeneIDi | 100360880 |
KEGGi | rno:100360880 |
UCSCi | RGD:2321278, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07002674 Genomic DNA No translation available. CH473979 Genomic DNA Translation: EDM08212.1 |
RefSeqi | NP_001243438.1, NM_001256509.1 |
3D structure databases
AlphaFoldDBi | D3ZLB7 |
SMRi | D3ZLB7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000065427 |
Proteomic databases
PaxDbi | D3ZLB7 |
Genome annotation databases
Ensembli | ENSRNOT00000072149; ENSRNOP00000065427; ENSRNOG00000046667 |
GeneIDi | 100360880 |
KEGGi | rno:100360880 |
UCSCi | RGD:2321278, rat |
Organism-specific databases
CTDi | 2354 |
RGDi | 1308198, Fosb |
Phylogenomic databases
eggNOGi | KOG1414, Eukaryota |
GeneTreei | ENSGT00940000160358 |
HOGENOMi | CLU_049742_0_0_1 |
InParanoidi | D3ZLB7 |
OMAi | QGMMQEV |
OrthoDBi | 1221590at2759 |
PhylomeDBi | D3ZLB7 |
TreeFami | TF326301 |
Gene expression databases
Bgeei | ENSRNOG00000046667, Expressed in frontal cortex and 21 other tissues |
ExpressionAtlasi | D3ZLB7, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000837, AP-1 IPR004827, bZIP IPR046347, bZIP_sf IPR029813, FosB |
PANTHERi | PTHR23351, PTHR23351, 1 hit PTHR23351:SF3, PTHR23351:SF3, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
PRINTSi | PR00042, LEUZIPPRFOS |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FOSB_RAT | |
Accessioni | D3ZLB7Primary (citable) accession number: D3ZLB7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 23, 2022 |
Last sequence update: | April 20, 2010 | |
Last modified: | May 25, 2022 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families