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Protein
Submitted name:

ASH1-like histone lysine methyltransferase

Gene

Ash1l

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferaseSAAS annotation, Transferase
LigandMetal-binding, S-adenosyl-L-methionineSAAS annotation, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-3214841 PKMTs methylate histone lysines

Names & Taxonomyi

Protein namesi
Submitted name:
ASH1-like histone lysine methyltransferaseImported
Gene namesi
Name:Ash1lImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1306350 Ash1l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PeptideAtlasiD3ZKH4
PRIDEiD3ZKH4

PTM databases

iPTMnetiD3ZKH4
PhosphoSitePlusiD3ZKH4

Expressioni

Gene expression databases

BgeeiENSRNOG00000020386 Expressed in 9 organ(s), highest expression level in Ammon's horn
ExpressionAtlasiD3ZKH4 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2081 – 2132AWSInterPro annotationAdd BLAST52
Domaini2135 – 2251SETInterPro annotationAdd BLAST117
Domaini2259 – 2275Post-SETInterPro annotationAdd BLAST17
Domaini2452 – 2522BromoInterPro annotationAdd BLAST71
Domaini2650 – 2787BAHInterPro annotationAdd BLAST138

Keywords - Domaini

BromodomainPROSITE-ProRule annotation, Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiKOG1083 Eukaryota
COG2940 LUCA
COG5076 LUCA
GeneTreeiENSGT00780000121845
OMAiHSEMTDY
OrthoDBiEOG091G02U7
TreeFamiTF106416

Family and domain databases

Gene3Di1.20.920.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR017956 AT_hook_DNA-bd_motif
IPR006560 AWS_dom
IPR001025 BAH_dom
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01426 BAH, 1 hit
PF00439 Bromodomain, 1 hit
PF00856 SET, 1 hit
SMARTiView protein in SMART
SM00384 AT_hook, 4 hits
SM00570 AWS, 1 hit
SM00439 BAH, 1 hit
SM00297 BROMO, 1 hit
SM00249 PHD, 1 hit
SM00317 SET, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51215 AWS, 1 hit
PS51038 BAH, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS50868 POST_SET, 1 hit
PS50280 SET, 1 hit
PS01359 ZF_PHD_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

D3ZKH4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPRNTAMLG LGSDSEGFSR KSPSAISSGT LASKREVEIE GNTDEEDPRK
60 70 80 90 100
RNRERAIEAG KDDGLTDAQQ QFSVKETNFS EGNLKLKIGL QAKRTKKPPK
110 120 130 140 150
NLENYVCRPA IKTTVKHSRK ALKSGKMTDE KNEHCPSKWD SSKLFKKAGD
160 170 180 190 200
ATAIECQSEE SVHLHSQGEN NPLSKKLSPV HSQMADYIPA APPLVGSRDP
210 220 230 240 250
DIKDRALLNG GTSVTEKLAQ LIATCPPSKS SKAKPKKLGT GTTVGLVSKD
260 270 280 290 300
LIRKPGVGSI AGIIHKDLIK KPALSTAVGL VTKDPGKKPM FNAAVSLINK
310 320 330 340 350
DSVKKLGTGT TAVFINKDLG KKPGTVTTVG LLSKDPGKKL GIGIVPGLVN
360 370 380 390 400
KESGKKLGLG TVVGLVNKEL GKKLSSTVGL VAKDVTKKIV ASSAMGLVNK
410 420 430 440 450
DIGKKLLSCP IAGQLGSKDA LNLKSEALLP TQEQLKASCS ANISNHESQE
460 470 480 490 500
LPESLKDSAT SKTFEKNVMR HSKESMLEKF SVRKEITNLE KEMFNEGTCI
510 520 530 540 550
QQDSFSSNER GAFETSKHEK QPPVYCTSPD FQIGGASDAS TAKSPFGAVG
560 570 580 590 600
ESNLPSSSPT VSVNPLTRNP PETSSQLVPN PLLLNSTAEQ MEEISESIGK
610 620 630 640 650
NQFTAESTHL NVGHRSLGHS ISIECKGIDK ELNESKSTHL DISRISSSLG
660 670 680 690 700
KKPSLASDSG IHTITPSVVN FTSLFSNKPF LKLGAVAAPD KHCQVAESLS
710 720 730 740 750
TSFQSKPLKK RKGRKARWTK VVARSTCRSP KGLDLERSEL FKNVSCSSLS
760 770 780 790 800
NSSEPAKFMK TIGASSFVDH DFLKRRLPKL SKSSAPSLAL LADSEKASHK
810 820 830 840 850
SFITHKLSSS MCVTSDLLSD IYKPKRGRPK SKEMPQLEGP PKRTLKIPAS
860 870 880 890 900
KVFSLQSKEE QEPPILQPEI EIPSFKQSLS VSPFPKKRGR PKRQMRSPVK
910 920 930 940 950
MKPPVLSVAP FVATESPSKL ESESENHRSS SDFFESEDQL QDTDDLEDSH
960 970 980 990 1000
RQSVCSVSDL EMEPDKKISK RNNGQLMKTI IRKINKMKTL KRKKLLNQIL
1010 1020 1030 1040 1050
SSSVESSNKG KVQSKLHNTV SSLAATFGSK LGQQINVSKK GTIYIGKRRG
1060 1070 1080 1090 1100
RKPKTVLNGL LSGSPASLAV LEQTAQQAAG SALGQILPPL LPSPASSSEI
1110 1120 1130 1140 1150
LPSPICSQSS GTSGGQSPVS SDAGFVEPSS VPYLHVHSRQ GSMIQTLAMK
1160 1170 1180 1190 1200
KAAKGRRRLS PPTLLPNSPS HLSELTSLKE ATPSPVSESH SDETIPSDSG
1210 1220 1230 1240 1250
IGTDNNSTSD RAEKFCGQKK RRHSFEHISL IPPETSTVLN SLKEKHKHKC
1260 1270 1280 1290 1300
KRRSHDYLSY DKMKRQKRKR KKKYPQLRNR QDPDFIAELE ELISRLSEIR
1310 1320 1330 1340 1350
ITHRSHHFIP RDLLPTIFRI NFNSFYTHPS FPLDPLHYIR KPDLKKKRGR
1360 1370 1380 1390 1400
PPKMREAMAE MPFMHSLSFP LSSTGFYPSY GMPYSPSPLT AAPIGLGYYG
1410 1420 1430 1440 1450
RYPPTLYPPP PSPSFTTPLP PPSYMHAGHL LLNPTKYHKK KHKLLRQEAF
1460 1470 1480 1490 1500
LTTSRTPLLS MSTYPSVPPE MAYGWMVEHK HRHRHKHREH RSEQPQVSMD
1510 1520 1530 1540 1550
TGSSRSVLES LKRYRFGKDT VGDRYKHKEK HRCHMSCPHL SPSKSLINRE
1560 1570 1580 1590 1600
EQWVSREPSE SSSLALGLQT PLQIDCSESS PSLSLGGFTP NSEPASSDEH
1610 1620 1630 1640 1650
MNLFTSAIGS CRVSNPNSSC RKKLTDSPGL FPVQDTALSR PHRKEPLPST
1660 1670 1680 1690 1700
ERAIQSLAGS QSASDKPSQR SSESTNCSPT RKRSSSESTS STVNGIPSRS
1710 1720 1730 1740 1750
PRLVASLDDS VDCLLQRIVQ HDEQESVEKN GDAPITTVSA PPSSSPGHSY
1760 1770 1780 1790 1800
SKERTLGKSD SLLVPAVPSD SCNSIPLLSE KLASRCSPHH IKRSVVEAMQ
1810 1820 1830 1840 1850
RQARKMCNYD KILATKKNLD HVNKILKAKK LQRQARTGNN FVKRRPGRPR
1860 1870 1880 1890 1900
KCPLQAVVSM QAFQAAQFVN PELNEGEEVS LHLSPDTVTD VIEAVVQSVN
1910 1920 1930 1940 1950
LNSEHKKGWK RKNWLLEEQT RKKQKTVPEE EEQENNKSFI EKPVEIPSPL
1960 1970 1980 1990 2000
ETPAEPSEPE SNLQPVLALI PREKKAPRPP KKKYQRAGLY SDVYKTTDPK
2010 2020 2030 2040 2050
SRLIQLKKEK LEYTPGEHEY GLFPAPIHVG KYLRQKRIDF QLPYDILWQW
2060 2070 2080 2090 2100
KHNQLYKKPD VPLYKKIRSN VYVDVKPLSG YEATTCNCKK PDDDTRKGCG
2110 2120 2130 2140 2150
DDCLNRMIFA ECSPNTCPCG EQCCNQRIQR HEWVQCLERF RAEEKGWGIR
2160 2170 2180 2190 2200
TKEPLKAGQF IIEYLGEVVS EQEFRNRMIE QYHNHSDHYC LNLDSGMVID
2210 2220 2230 2240 2250
SYRMGNEARF INHSCDPNCE MQKWSVNGVY RIGLYALKDV PAGTELTYDY
2260 2270 2280 2290 2300
NFHSFNVEKQ QLCKCGFEKC RGIIGGKSQR MNGLPSHKGS QPASTHRKSA
2310 2320 2330 2340 2350
RSKEKRKSKH KLKKRRGHPS EEPSENINTP TRLTPQLQMK PMSNRERNFV
2360 2370 2380 2390 2400
LKHHVFLVRN WEKIHQKQEE VKHSRDIHST SLYTRWNGIC RDDGNIKSDV
2410 2420 2430 2440 2450
FMTQFSALQT ARSVRTRRLA AAEENLEVAR AARLAQIFKE ICDGIISYKD
2460 2470 2480 2490 2500
SSQQALAAPL LNLPPKKKNA DYYEKISDPL DLSTIEKQIL TGYYKTVEAF
2510 2520 2530 2540 2550
DADMLKVFRN AEKYYGRKSP IGRDVCRLRK AYYSARHEAS AQIDEIVGET
2560 2570 2580 2590 2600
ASEADSSETS VSEKENSHEK DDDVIRCICG LYKDEGLMIQ CDKCMVWQHC
2610 2620 2630 2640 2650
DCMGVNTDVE HYLCEQCDPR PVDREVPMIP RPHYAQPGCV YFICLLRDDL
2660 2670 2680 2690 2700
LLRQGDCVYL MRDSRRTPDG HPVRQSYRLL SHINRDKLDI FRIEKLWKNE
2710 2720 2730 2740 2750
KEERFAFGHH YFRPHETHHS PSRRFYHNEL FRVPLYEIIP LEAVVGTCCV
2760 2770 2780 2790 2800
LDLYTYCKGR PKGVKEQDVY ICDYRLDKSA HLFYKIHRNR YPVCTKPYAF
2810 2820 2830 2840 2850
DHFPKKLTPK RDFSPHYVPD NYKRNGGRSS WKSERSKPLL KDLGQDDDAL
2860 2870 2880 2890 2900
PLIEEVLASQ EQAANEMPSP EEPDQERVTG DVSDAEKKPE ESSQEPQLAS
2910 2920 2930 2940 2950
TPEERRHSQR ERLNQILLNL LEKIPGKNAI DVTYLLEEGS GRKLRRRTLF

IPENSFRK
Length:2,958
Mass (Da):331,559
Last modified:July 22, 2015 - v3
Checksum:i1524E2AD5034FCB2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K2W6A0A0G2K2W6_RAT
ASH1-like histone lysine methyltran...
Ash1l Ash1l_predicted, rCG_62830
2,918Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097039 Genomic DNA No translation available.
AC097294 Genomic DNA No translation available.
RefSeqiXP_008759376.1, XM_008761154.2
XP_008759377.1, XM_008761155.2
XP_008759380.1, XM_008761158.1
XP_008759381.1, XM_008761159.2
XP_008759382.1, XM_008761160.2
XP_017446373.1, XM_017590884.1
XP_017446374.1, XM_017590885.1
UniGeneiRn.86973

Genome annotation databases

EnsembliENSRNOT00000027629; ENSRNOP00000027629; ENSRNOG00000020386
GeneIDi310638
UCSCiRGD:1306350 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097039 Genomic DNA No translation available.
AC097294 Genomic DNA No translation available.
RefSeqiXP_008759376.1, XM_008761154.2
XP_008759377.1, XM_008761155.2
XP_008759380.1, XM_008761158.1
XP_008759381.1, XM_008761159.2
XP_008759382.1, XM_008761160.2
XP_017446373.1, XM_017590884.1
XP_017446374.1, XM_017590885.1
UniGeneiRn.86973

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiD3ZKH4
PhosphoSitePlusiD3ZKH4

Proteomic databases

PeptideAtlasiD3ZKH4
PRIDEiD3ZKH4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027629; ENSRNOP00000027629; ENSRNOG00000020386
GeneIDi310638
UCSCiRGD:1306350 rat

Organism-specific databases

CTDi55870
RGDi1306350 Ash1l

Phylogenomic databases

eggNOGiKOG1083 Eukaryota
COG2940 LUCA
COG5076 LUCA
GeneTreeiENSGT00780000121845
OMAiHSEMTDY
OrthoDBiEOG091G02U7
TreeFamiTF106416

Enzyme and pathway databases

ReactomeiR-RNO-3214841 PKMTs methylate histone lysines

Gene expression databases

BgeeiENSRNOG00000020386 Expressed in 9 organ(s), highest expression level in Ammon's horn
ExpressionAtlasiD3ZKH4 baseline and differential

Family and domain databases

Gene3Di1.20.920.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR017956 AT_hook_DNA-bd_motif
IPR006560 AWS_dom
IPR001025 BAH_dom
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01426 BAH, 1 hit
PF00439 Bromodomain, 1 hit
PF00856 SET, 1 hit
SMARTiView protein in SMART
SM00384 AT_hook, 4 hits
SM00570 AWS, 1 hit
SM00439 BAH, 1 hit
SM00297 BROMO, 1 hit
SM00249 PHD, 1 hit
SM00317 SET, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51215 AWS, 1 hit
PS51038 BAH, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS50868 POST_SET, 1 hit
PS50280 SET, 1 hit
PS01359 ZF_PHD_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD3ZKH4_RAT
AccessioniPrimary (citable) accession number: D3ZKH4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: July 22, 2015
Last modified: November 7, 2018
This is version 81 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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