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Entry version 85 (10 Feb 2021)
Sequence version 1 (20 Apr 2010)
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Protein
Submitted name:

Roundabout guidance receptor 3

Gene

Robo3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Roundabout guidance receptor 3Imported
Submitted name:
Roundabout homolog 3 (Drosophila) (Predicted)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Robo3Imported
Synonyms:Robo3_predictedImported
ORF Names:rCG_58871Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Rat genome database

More...
RGDi
1311018, Robo3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
D3ZKA2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000030016, Expressed in kidney and 15 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000060623

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3ZKA2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 98Ig-likeInterPro annotationAdd BLAST97
Domaini104 – 191Ig-likeInterPro annotationAdd BLAST88
Domaini196 – 280Ig-likeInterPro annotationAdd BLAST85
Domaini285 – 378Ig-likeInterPro annotationAdd BLAST94
Domaini388 – 469Ig-likeInterPro annotationAdd BLAST82
Domaini496 – 590Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini610 – 704Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini709 – 805Fibronectin type-IIIInterPro annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni479 – 499DisorderedSequence analysisAdd BLAST21
Regioni577 – 599DisorderedSequence analysisAdd BLAST23
Regioni689 – 711DisorderedSequence analysisAdd BLAST23
Regioni903 – 927DisorderedSequence analysisAdd BLAST25
Regioni970 – 1283DisorderedSequence analysisAdd BLAST314

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi580 – 594PolarSequence analysisAdd BLAST15
Compositional biasi972 – 991PolarSequence analysisAdd BLAST20
Compositional biasi1018 – 1033Pro-richSequence analysisAdd BLAST16
Compositional biasi1036 – 1064PolyampholyteSequence analysisAdd BLAST29
Compositional biasi1078 – 1094PolarSequence analysisAdd BLAST17
Compositional biasi1095 – 1109Pro-richSequence analysisAdd BLAST15
Compositional biasi1155 – 1171PolarSequence analysisAdd BLAST17

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Immunoglobulin domainARBA annotation, RepeatARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4222, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155457

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003227_5_1_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
GKAVQMP

Database of Orthologous Groups

More...
OrthoDBi
173520at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063, FN3, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR032987, Robo3

The PANTHER Classification System

More...
PANTHERi
PTHR12231:SF236, PTHR12231:SF236, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041, fn3, 2 hits
PF07679, I-set, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060, FN3, 3 hits
SM00409, IG, 5 hits
SM00408, IGc2, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 5 hits
SSF49265, SSF49265, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853, FN3, 3 hits
PS50835, IG_LIKE, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3ZKA2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRIVEQPPD LLVSRGEPAT LPCRAEGRPR PNIEWYKNGA RVATAREDPR
60 70 80 90 100
AHRLLLPSGA LFFPRIVHGR RSRPDEGVYT CVARNYLGAA ASRNASLEVA
110 120 130 140 150
VLRDDFRQSP GNVVVAVGEP AVMECVPPKG HPEPLVTWKK GNTKLKEEEG
160 170 180 190 200
RITIRGGKLM MSHTFKSDAG MYMCVASNMA GERESGAAEL VVLERPSFLR
210 220 230 240 250
RPINQVVLAD APVNFLCEVQ GDPQPNLRWR KDDGELPTGR YEIRSDHSLW
260 270 280 290 300
IEQVSAEDEG TYTCVAENSV GRAEASGSLS VHVPPQFVTK PQNQTAAPGE
310 320 330 340 350
NVSFQCETKG NPPPAIFWQK EGSQVLLFPS QSLQPMGRLL VSPRGQLNIT
360 370 380 390 400
EVKIGDGGYY VCQAVSVAGS ILAKALLEIK GASIDGLPPI ILQGPANQTL
410 420 430 440 450
VLGSSVWLPC RVIGNPQPNV QWKKDETWLQ GDNSQFNLMD NGTLYIASVQ
460 470 480 490 500
EMDMGFYSCV AKSSIGEATW NSWLRKREHW GASPGPATEP GNPPGPPSQP
510 520 530 540 550
IVTEVTTNSI TLTWKPNPQS GARATSYVIE AFSQAAGNTW RTVADGVQLE
560 570 580 590 600
THTVSGLQPN TIYLFLVRAV GAWGLSEPSP VSEPVQTQDS SLSRPVEDPW
610 620 630 640 650
KGQQGLAEVA VRMQEPIVLG PRTLQVSWTV EGPGQLVQGF RVSWRIAGLD
660 670 680 690 700
QGSWTALDVQ SPHKQSTVLR GLPPGSQIQI KVQVQGQEGL GAESPSVTRS
710 720 730 740 750
IPEEAPSGPP QGVAVALGGD RNSSITVSWE PPLPSQQNGV ITEYQIWCLG
760 770 780 790 800
NESRFHLNRS AAGWARSVMF RGLLPGLLYR AIVAAATSAG VGVASAPVLV
810 820 830 840 850
QLPFPPVAEP GPEVSEGLAE RLSRVLRKPA FLAGSSAACG ALLLGLCAAL
860 870 880 890 900
YRRQKQRKEL SHYTASFAYT PAVSFPHSEG LSGSSSRPPM GLGPAAYPWL
910 920 930 940 950
ADSWPHPSRS PSAQEPRGSC CPSNPDPDDR YYNEAGISLY LAQTARGANA
960 970 980 990 1000
PGEGPVYSTI DPVGEELQTF HGGFPQHSSG DPSTWSQYAP PEWSEGDSGA
1010 1020 1030 1040 1050
RGGKGKLLGK PVQMPSLSWP EALPPPPPSC ELSCPEGPEE ELKGSSDLEE
1060 1070 1080 1090 1100
WCPPMPEKKH LIDSRSSGAC MVAPARGETP SPTSSYGQQS TATLTPSPPD
1110 1120 1130 1140 1150
PPQPPSDIPH LHQMPRRVPL GPSSPLSVSQ PALSSHDGRP VGLGAGPIVS
1160 1170 1180 1190 1200
YHPSPSPVPS TASSAPGRTR QVTGEMTPPL HGHRARIRKK TKALPHRREH
1210 1220 1230 1240 1250
SPGDLPPPPL PPPEEETSWP LGLRAAGSMS SLEREHSGER RVAQAVPLGA
1260 1270 1280 1290 1300
QPPGAQRGPH PDGKESQGNG RGLEACRSPQ SPQIQLDSRV WSTLILSLIS

FTSSK
Length:1,305
Mass (Da):139,885
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i35BF4B4530D7BEA8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07069791 Genomic DNA No translation available.
CH474096 Genomic DNA Translation: EDL84064.1

NCBI Reference Sequences

More...
RefSeqi
NP_001101605.1, NM_001108135.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000064141; ENSRNOP00000060623; ENSRNOG00000030016

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
315564

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:315564

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07069791 Genomic DNA No translation available.
CH474096 Genomic DNA Translation: EDL84064.1
RefSeqiNP_001101605.1, NM_001108135.1

3D structure databases

SMRiD3ZKA2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060623

Proteomic databases

PRIDEiD3ZKA2

Genome annotation databases

EnsembliENSRNOT00000064141; ENSRNOP00000060623; ENSRNOG00000030016
GeneIDi315564
KEGGirno:315564

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64221
RGDi1311018, Robo3

Phylogenomic databases

eggNOGiKOG4222, Eukaryota
GeneTreeiENSGT00940000155457
HOGENOMiCLU_003227_5_1_1
OMAiGKAVQMP
OrthoDBi173520at2759

Gene expression databases

BgeeiENSRNOG00000030016, Expressed in kidney and 15 other tissues

Family and domain databases

CDDicd00063, FN3, 3 hits
Gene3Di2.60.40.10, 8 hits
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR032987, Robo3
PANTHERiPTHR12231:SF236, PTHR12231:SF236, 1 hit
PfamiView protein in Pfam
PF00041, fn3, 2 hits
PF07679, I-set, 3 hits
SMARTiView protein in SMART
SM00060, FN3, 3 hits
SM00409, IG, 5 hits
SM00408, IGc2, 5 hits
SUPFAMiSSF48726, SSF48726, 5 hits
SSF49265, SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 3 hits
PS50835, IG_LIKE, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3ZKA2_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZKA2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: February 10, 2021
This is version 85 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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