UniProtKB - D3ZK56 (D3ZK56_RAT)
Protein
Ras-related protein Rap-2
Gene
Rap2c
Organism
Rattus norvegicus (Rat)
Status
Functioni
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.UniRule annotation
Catalytic activityi
- EC:3.6.5.2ARBA annotation
GO - Molecular functioni
- GDP binding Source: RGD
- GTPase activity Source: GO_Central
- GTP binding Source: RGD
- transcription coactivator activity Source: RGD
GO - Biological processi
- establishment of endothelial intestinal barrier Source: RGD
- negative regulation of cell migration Source: RGD
- positive regulation of protein autophosphorylation Source: RGD
- Rap protein signal transduction Source: RGD
- regulation of protein tyrosine kinase activity Source: RGD
Keywordsi
Ligand | GTP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-RNO-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Ras-related protein Rap-2UniRule annotation |
Gene namesi | Name:Rap2cImported ORF Names:rCG_53223Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1588562, Rap2c |
Subcellular locationi
Endosome
- Endosome membrane ARBA annotation; Lipid-anchor ARBA annotation; Cytoplasmic side ARBA annotation
- Recycling endosome membrane UniRule annotationARBA annotation; Lipid-anchor UniRule annotationARBA annotation; Cytoplasmic side UniRule annotationARBA annotation
Cytosol
- cytosol Source: RGD
Endosome
- recycling endosome Source: RGD
- recycling endosome membrane Source: RGD
Plasma Membrane
- plasma membrane Source: RGD
Other locations
- bicellular tight junction Source: RGD
- cell-cell contact zone Source: RGD
- cytoplasm Source: RGD
- membrane Source: RGD
Keywords - Cellular componenti
EndosomeUniRule annotationARBA annotation, MembraneUniRule annotationPTM / Processingi
Post-translational modificationi
Palmitoylated.UniRule annotation
Keywords - PTMi
Lipoprotein, MethylationUniRule annotation, PalmitateUniRule annotationARBA annotation, PrenylationUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000002529, Expressed in thymus and 20 other tissues |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000157245 |
HOGENOMi | CLU_041217_9_8_1 |
OMAi | QQIYRIK |
OrthoDBi | 1353024at2759 |
TreeFami | TF313014 |
Family and domain databases
CDDi | cd04176, Rap2, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR041840, Rap2 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
i Sequence
Sequence statusi: Complete.
D3ZK56-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MREYKVVVLG SGGVGKSALT VQFVTGTFIE KYDPTIEDFY RKEIEVDSSP
60 70 80 90 100
SVLEILDTAG TEQFASMRDL YIKNGQGFIL VYSLVNQQSF QDIKPMRDQI
110 120 130 140 150
VRVKRYEKVP LILVGNKVDL EPEREVMSSE GRALAQEWGC PFMETSAKSK
160 170 180
SMVDELFAEI VRQMNYSSLP EKQDQCCTTC VVQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07041736 Genomic DNA No translation available. CH473991 Genomic DNA Translation: EDM10944.1 |
RefSeqi | NP_001100420.1, NM_001106950.2 |
Genome annotation databases
Ensembli | ENSRNOT00000003414; ENSRNOP00000003414; ENSRNOG00000002529 |
GeneIDi | 302495 |
KEGGi | rno:302495 |
UCSCi | RGD:1588562, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07041736 Genomic DNA No translation available. CH473991 Genomic DNA Translation: EDM10944.1 |
RefSeqi | NP_001100420.1, NM_001106950.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000003414 |
Genome annotation databases
Ensembli | ENSRNOT00000003414; ENSRNOP00000003414; ENSRNOG00000002529 |
GeneIDi | 302495 |
KEGGi | rno:302495 |
UCSCi | RGD:1588562, rat |
Organism-specific databases
CTDi | 57826 |
RGDi | 1588562, Rap2c |
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000157245 |
HOGENOMi | CLU_041217_9_8_1 |
OMAi | QQIYRIK |
OrthoDBi | 1353024at2759 |
TreeFami | TF313014 |
Enzyme and pathway databases
Reactomei | R-RNO-6798695, Neutrophil degranulation |
Gene expression databases
Bgeei | ENSRNOG00000002529, Expressed in thymus and 20 other tissues |
Family and domain databases
CDDi | cd04176, Rap2, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR041840, Rap2 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D3ZK56_RAT | |
Accessioni | D3ZK56Primary (citable) accession number: D3ZK56 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 3, 2013 | |
Last modified: | December 2, 2020 | |
This is version 89 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |