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Entry version 53 (10 Apr 2019)
Sequence version 3 (22 Jul 2015)
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Protein
Submitted name:

Interactor of little elongation complex ELL subunit 1

Gene

Ice1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-6807505 RNA polymerase II transcribes snRNA genes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Interactor of little elongation complex ELL subunit 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ice1Imported
Synonyms:RGD1309747Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...
RGDi
1309747 Ice1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
D3ZK16

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D3ZK16

PRoteomics IDEntifications database

More...
PRIDEi
D3ZK16

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
D3ZK16

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
D3ZK16

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000023053 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000058589

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3ZK16

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili22 – 42Sequence analysisAdd BLAST21
Coiled coili60 – 80Sequence analysisAdd BLAST21
Coiled coili84 – 111Sequence analysisAdd BLAST28
Coiled coili115 – 184Sequence analysisAdd BLAST70

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IE47 Eukaryota
ENOG4111F6B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183199

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D3ZK16

Identification of Orthologs from Complete Genome Data

More...
OMAi
QCQISTV

Database of Orthologous Groups

More...
OrthoDBi
265329at2759

TreeFam database of animal gene trees

More...
TreeFami
TF330760

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3ZK16-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMPGETHPAA PGPADLARCQ GCASLQQNLN EYVEALIALK QKIINTDNLL
60 70 80 90 100
TEYQKKCDEL QFARRENSTL HHQVEQMLQK ISPLQKCQEE LGTLKAELEE
110 120 130 140 150
KKSSLKLYQD THQEYARVKE ECLRTDAQKK KLEAKVKKLE EAAVKQTQDF
160 170 180 190 200
KQLRNEKKIL EKEFRKTQER LDEFSKQKNE KELRHIGTQI SSDSHGSIDK
210 220 230 240 250
RKVKVLLKEL WLCVNTAHRL SGESSRRIPE KPTKGNSAPR ESGQDELLPV
260 270 280 290 300
PGSPSRASDM RSFFTKLSME MEGDFTSSES AEEELPTGAG PSTEHVFCEE
310 320 330 340 350
RHPEVSGQRP DDSNRTDVYD HEHFFDDDLQ AAIDFFKLPP PLLSPVPSPP
360 370 380 390 400
PMASGPLPSS LAPESFFGEF TDSSDSDSVP PRDSLESALE DYTAESRGYF
410 420 430 440 450
DLLEKIKRSD MCIETPGPLG TAQAVNKLTP LGVVTGKAAL GEPSATSSLA
460 470 480 490 500
WGRHLTASSE FLRDRGDAVE DAERKVEARE VDKSVQVGKG LRKHNRRLWL
510 520 530 540 550
EVTSRGPAAQ KEAGAGPSEV WFSPLGKRTF SELIDSEGKT LSSKALCPSQ
560 570 580 590 600
SEFSKRILTD GFVPKSHCVT GSGHFQRRER DVQESTPQSG ACVAAAGRDR
610 620 630 640 650
SASLSSSSSA TSIPVSIFSN RQTSWPGCVS VGTPAEVTCR DLHHSEQKSP
660 670 680 690 700
TRTLNTFLRS EPTAHLKEND PKNSLSTLSS KSKLGTSTFS DWKSKGLESF
710 720 730 740 750
SIFKSTAKGH SLPQSVFQKP TGGGQCGGRG PGTTLILPKS DWTSLARSQA
760 770 780 790 800
GFTRRSPGSA DSTSWHRSDI LRRGSGGSPR ATSEYQQRAR LQLEKEAPAS
810 820 830 840 850
QNSRLTAMLG PPGESTIPLG LKAAAALLPN QVSVITKQAR PKRVLSSSLE
860 870 880 890 900
PWGPCGSTLS SAVNGGKGIA LTPSVSACVR DGDPTAQVSE QVTDEEVPSP
910 920 930 940 950
EVSVSWREPN CDSPGGSLLA ENFDCSTDRK LPFSSEDNLF QCVVNEHLLQ
960 970 980 990 1000
QPRKSPQTTQ PGASRLEAGE LIPSGVTSGV FPAEQMPHGP RPQANTEAPV
1010 1020 1030 1040 1050
AAPRNASAPL IVPSRGPLRA RVPVGPVCPS GLCRADETQG TSQSSLPGAS
1060 1070 1080 1090 1100
YSYTGIRGRT EEDTEVEDEA VSCSEGEHET EAVMGRRQQA AAGDPNRPLG
1110 1120 1130 1140 1150
DPEAGQPSDV GDLTSALEEC NLSTFLYIDK LSTSEMVMVL ESCQLKDYSS
1160 1170 1180 1190 1200
GASVSDCSSK GTLNEEMNKE LRQSEISTKK CGKRFCEEEL LSASEEWAES
1210 1220 1230 1240 1250
EGDDCCGSKS CQDAQCPLEV PSDVLTKTGE ELHTNPVDCG GKDPEHALPV
1260 1270 1280 1290 1300
HTHHNQAAED LTENALPEET SSSMPHTAQL PEPSPVGGGD SSPLRSRSDA
1310 1320 1330 1340 1350
EHTQSRDEGE PSSEGSLSTG EESLAEPGEL LTLSSDSPAQ PRLEQSSECM
1360 1370 1380 1390 1400
AETAFHYQIS AVTSEVISVL INKDQDLVIE EGDNWTIISG VAISPGMEQV
1410 1420 1430 1440 1450
VLCDTLGDAA PSQAQEDLDD GSMEKSPGAS PSGPLPQEPP CGGDLSGAQE
1460 1470 1480 1490 1500
DVSSSGQSVN FDKSRLRNRP VKPSIWIRSQ IYDQTLETEK VTSDHTYYNW
1510 1520 1530 1540 1550
KLEPLCKNKP RSKISNKDQA SKLTKTPGLN RGEVHVSEVP QPVSGERTNT
1560 1570 1580 1590 1600
QTPRSQAQPT TAGTDMSTPT NCSPDTLSKI RQEVGPPLPP LLPPLIATPP
1610 1620 1630 1640 1650
RTSRTLSPLV PSSSPSSRSS PAGRVSPLCE VPGPPVLSPW PEELQQASPL
1660 1670 1680 1690 1700
DPSPSPSTAT ASGRIVSSPL QFCAATPKHA LPVPGRLPSC APGHTAVSGP
1710 1720 1730 1740 1750
QENSVKILDT MYPELSARAR TLSLLKGNMQ LSRSSTVDGK VLPGRVSALL
1760 1770 1780 1790 1800
GLKAITSTST AFVLTGSSSG GDSNQGKSQD AGGKRTLAVS MLRSAKRLRL
1810 1820 1830 1840 1850
DNESPEPDTR EVTGEGVPKD PQGGIPPAKV VPAEEEQTDV PGCSSAPLLR
1860 1870 1880 1890 1900
VNPREMAESY KIAITRALRK IAESSFDLLP VIRSHVYVGN ISKKPVMRDQ
1910 1920 1930 1940 1950
EKEVVYEFST TNKHLGEYLL RSILSELKIQ KTSLDHSYIH ALCRVYVGIC
1960 1970 1980 1990 2000
RQLGDLERAR LFCYSLLKED FPESEKLTLF IANMWREVFL SQSAISDAMQ
2010 2020 2030 2040 2050
LVARQRARGE VLNCLRAFLS WEKNAPIDVG IVVSKLLLTI QLCPKTEFQS
2060 2070 2080 2090 2100
SEEFGEDLSA NIWEYIFAID LLCCHQRWIW THDNIISKEL WPVMDKWIKY
2110 2120 2130 2140 2150
RKGHSNIAYT PDIIVASVLR LIGRLGQLGL KEGFPTAVKN ISSVIGMFIQ
2160 2170 2180 2190 2200
HAQDEDIPWG VQLAAVYALC DLSPSNPAEI SKILEAWRTQ TSNTIPSAIV
2210 2220
SCLEEVGSLS TDGSADSPSK GDCTP
Length:2,225
Mass (Da):241,089
Last modified:July 22, 2015 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0E2F04E47618A95A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07001039 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_001062297.2, XM_001062297.4
XP_225143.5, XM_225143.7

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000061873; ENSRNOP00000058589; ENSRNOG00000023053

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
306665

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:306665

UCSC genome browser

More...
UCSCi
RGD:1309747 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07001039 Genomic DNA No translation available.
RefSeqiXP_001062297.2, XM_001062297.4
XP_225143.5, XM_225143.7

3D structure databases

SMRiD3ZK16
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000058589

PTM databases

iPTMnetiD3ZK16
PhosphoSitePlusiD3ZK16

Proteomic databases

jPOSTiD3ZK16
PaxDbiD3ZK16
PRIDEiD3ZK16

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000061873; ENSRNOP00000058589; ENSRNOG00000023053
GeneIDi306665
KEGGirno:306665
UCSCiRGD:1309747 rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23379
RGDi1309747 Ice1

Phylogenomic databases

eggNOGiENOG410IE47 Eukaryota
ENOG4111F6B LUCA
GeneTreeiENSGT00950000183199
InParanoidiD3ZK16
OMAiQCQISTV
OrthoDBi265329at2759
TreeFamiTF330760

Enzyme and pathway databases

ReactomeiR-RNO-6807505 RNA polymerase II transcribes snRNA genes

Gene expression databases

BgeeiENSRNOG00000023053 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3ZK16_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZK16
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: July 22, 2015
Last modified: April 10, 2019
This is version 53 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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