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Entry version 73 (16 Oct 2019)
Sequence version 1 (20 Apr 2010)
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Protein
Submitted name:

Leucine-rich repeat-containing G protein-coupled receptor 6

Gene

Lgr6

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-4641263 Regulation of FZD by ubiquitination

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Leucine-rich repeat-containing G protein-coupled receptor 6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lgr6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Rat genome database

More...
RGDi
1560339 Lgr6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei566 – 587HelicalSequence analysisAdd BLAST22
Transmembranei599 – 619HelicalSequence analysisAdd BLAST21
Transmembranei689 – 708HelicalSequence analysisAdd BLAST20
Transmembranei728 – 754HelicalSequence analysisAdd BLAST27
Transmembranei775 – 801HelicalSequence analysisAdd BLAST27
Transmembranei807 – 830HelicalSequence analysisAdd BLAST24

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500305352123 – 965Sequence analysisAdd BLAST943

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D3ZJU9

PeptideAtlas

More...
PeptideAtlasi
D3ZJU9

PRoteomics IDEntifications database

More...
PRIDEi
D3ZJU9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000005093 Expressed in 7 organ(s), highest expression level in heart

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000006969

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 70LRRNTInterPro annotationAdd BLAST37

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619 Eukaryota
KOG2087 Eukaryota
COG4886 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159939

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D3ZJU9

KEGG Orthology (KO)

More...
KOi
K08399

Identification of Orthologs from Complete Genome Data

More...
OMAi
PRDLSMN

Database of Orthologous Groups

More...
OrthoDBi
340670at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
D3ZJU9

TreeFam database of animal gene trees

More...
TreeFami
TF316814

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR002131 Gphrmn_rcpt_fam
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855 LRR_8, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00373 GLYCHORMONER
PR00237 GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 14 hits
SM00013 LRRNT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 14 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3ZJU9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHSSPLLLAL CLCVVLCALA RAGSDPQPGP GRPACPAPCH CQEDGIMLSA
60 70 80 90 100
DCSELGLSEV PADLDPLTAY LDLSMNNLTE LQPGLFHHLR FLEELRLSGN
110 120 130 140 150
HLSHIPRQAF SGLHSLKILM LQSNQLRGIP AEALWELPSL QSLRLDANLI
160 170 180 190 200
SLVPERSFEG LSSLRHLWLD DNALTEIPVR ALNNLPALQA MTLALNRIRH
210 220 230 240 250
IPDYAFQNLT SLVVLHLHNN RIQHVGTHSF EGLHNLETLD LNYNELQEFP
260 270 280 290 300
VAIRTLGRLQ ELGFHNNNIK AIPEKAFMGN PLLQTIHFYD NPIQFVGRSA
310 320 330 340 350
FQYLSKLHTL SLNGATDIQE FPDLKGTTSL EILTLTRAGI RLLPAGMCQQ
360 370 380 390 400
LPRLRILELS HNQIEELPSL HRCQKLEEIG LQHNRIWEIG ADTFSQLSSL
410 420 430 440 450
QALDLSWNAI RAIHPEAFST LRSLVKLDLT DNQLTTLPLA GLGGLMHLKL
460 470 480 490 500
KGNLALSQAF SKDSFPKLRI LEVPYAYQCC AYGLCANFFK TSGQWQAEDF
510 520 530 540 550
HAEEEEAPKR PLGLLAGQAE NHYDLDLDEL QMETEDSKPH PSVQCSPVPG
560 570 580 590 600
PFKPCEHLFE SWGIRLAVWA IVLLSVLCNG LVLLTVFAGG PSPLSPVKLV
610 620 630 640 650
VGAIAGANAL TGISCGLLAS VDALTFGQFA EYGARWETGL GCQATGFLAV
660 670 680 690 700
LGSEASVLLL TLAAVQCSVS VTCVRAYGKA PSPGSVRAGA LGCLALAGLA
710 720 730 740 750
AALPLASVGE YGASPLCLPY APPEGRPAAL GFAVALVMMN SLCFLVVAGA
760 770 780 790 800
YIKLYCDLPR GDFEAVWDCA MVRHVAWLIF ADGLLYCPVA FLSFASMLGL
810 820 830 840 850
FPVTPEAVKS VLLVVLPLPA CLNPLLYLLF NPHFREDLRR LWPSPRSPGP
860 870 880 890 900
LAYTAAGELE KSSCDSTQAL VAFSDVDLIL EASEAGQPPG LETYGFPSVT
910 920 930 940 950
LISRHQPGAT RLEGNHFVEP DGTKLGNPQP PMNEELLLRA EGATLADCSA
960
GGALWPSGPL FASHL
Length:965
Mass (Da):104,537
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i69CBEA4EB83F73DE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07020994 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_001062538.1, XM_001062538.6
XP_573455.1, XM_573455.7

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000006969; ENSRNOP00000006969; ENSRNOG00000005093

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
498233

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:498233

UCSC genome browser

More...
UCSCi
RGD:1560339 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07020994 Genomic DNA No translation available.
RefSeqiXP_001062538.1, XM_001062538.6
XP_573455.1, XM_573455.7

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006969

Proteomic databases

PaxDbiD3ZJU9
PeptideAtlasiD3ZJU9
PRIDEiD3ZJU9

Genome annotation databases

EnsembliENSRNOT00000006969; ENSRNOP00000006969; ENSRNOG00000005093
GeneIDi498233
KEGGirno:498233
UCSCiRGD:1560339 rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
59352
RGDi1560339 Lgr6

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
KOG2087 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000159939
InParanoidiD3ZJU9
KOiK08399
OMAiPRDLSMN
OrthoDBi340670at2759
PhylomeDBiD3ZJU9
TreeFamiTF316814

Enzyme and pathway databases

ReactomeiR-RNO-4641263 Regulation of FZD by ubiquitination

Miscellaneous databases

Protein Ontology

More...
PROi
PR:D3ZJU9

Gene expression databases

BgeeiENSRNOG00000005093 Expressed in 7 organ(s), highest expression level in heart

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR002131 Gphrmn_rcpt_fam
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF13855 LRR_8, 4 hits
PRINTSiPR00373 GLYCHORMONER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM00369 LRR_TYP, 14 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 14 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3ZJU9_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZJU9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: October 16, 2019
This is version 73 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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