Transcription factor AP-4

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Exon-I is involved in positive as well as negative regulation of human angiotensinogen gene expression."
    Cui Y., Narayanan C.S., Zhou J., Kumar A.
    Gene 224:97-107(1998) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • "Regulation of the expression of caspase-9 by the transcription factor activator protein-4 in glucocorticoid-induced apoptosis."
    Tsujimoto K., Ono T., Sato M., Nishida T., Oguma T., Tadakuma T.
    J. Biol. Chem. 280:27638-27644(2005) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • "Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro."
    Mermod N., Williams T.J., Tjian R.
    Nature 332:557-561(1988) [PubMed] [Europe PMC] [Abstract]
• E-box binding Source: RGDInferred from sequence orthologyⁱ
  • "Transcription factor AP-4 is a ligand for immunoglobulin-kappa promoter E-box elements."
    Aranburu A., Carlsson R., Persson C., Leanderson T.
    Biochem. J. 354:431-438(2001) [PubMed] [Europe PMC] [Abstract]
  • "Functional cooperation between multiple regulatory elements in the untranslated exon 1 stimulates the basal transcription of the human GnRH-II gene."
    Cheng C.K., Hoo R.L., Chow B.K., Leung P.C.
    Mol. Endocrinol. 17:1175-1191(2003) [PubMed] [Europe PMC] [Abstract]
  • "AP4 encodes a c-MYC-inducible repressor of p21."
    Jung P., Menssen A., Mayr D., Hermeking H.
    Proc. Natl. Acad. Sci. U.S.A. 105:15046-15051(2008) [PubMed] [Europe PMC] [Abstract]
  • "Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2."
    Ku W.C., Chiu S.K., Chen Y.J., Huang H.H., Wu W.G., Chen Y.J.
    Mol. Cell Proteomics 8:2034-2050(2009) [PubMed] [Europe PMC] [Abstract]
  • "Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function."
    Ou S.H., Garcia-Martinez L.F., Paulssen E.J., Gaynor R.B.
    J. Virol. 68:7188-7199(1994) [PubMed] [Europe PMC] [Abstract]
• histone deacetylase binding Source: RGDInferred from sequence orthologyⁱ
  • "Transcriptional repression of human immunodeficiency virus type 1 by AP-4."
    Imai K., Okamoto T.
    J. Biol. Chem. 281:12495-12505(2006) [PubMed] [Europe PMC] [Abstract]
  • "A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells."
    Kim M.Y., Jeong B.C., Lee J.H., Kee H.J., Kook H., Kim N.S., Kim Y.H., Kim J.K., Ahn K.Y., Kim K.K.
    Proc. Natl. Acad. Sci. U.S.A. 103:13074-13079(2006) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: RGDInferred from sequence orthologyⁱ
  • "Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity."
    Hu Y.-F., Luescher B., Admon A., Mermod N., Tjian R.
    Genes Dev. 4:1741-1752(1990) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Regulation of the expression of caspase-9 by the transcription factor activator protein-4 in glucocorticoid-induced apoptosis."
    Tsujimoto K., Ono T., Sato M., Nishida T., Oguma T., Tadakuma T.
    J. Biol. Chem. 280:27638-27644(2005) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity."
    Hu Y.-F., Luescher B., Admon A., Mermod N., Tjian R.
    Genes Dev. 4:1741-1752(1990) [PubMed] [Europe PMC] [Abstract]
• transcription regulatory region DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "A promoter within the E6 ORF of human papillomavirus type 16 contributes to the expression of the E7 oncoprotein from a monocistronic mRNA."
    Glahder J.A., Hansen C.N., Vinther J., Madsen B.S., Norrild B.
    J. Gen. Virol. 84:3429-3441(2003) [PubMed] [Europe PMC] [Abstract]
  • "Transcriptional repression of human immunodeficiency virus type 1 by AP-4."
    Imai K., Okamoto T.
    J. Biol. Chem. 281:12495-12505(2006) [PubMed] [Europe PMC] [Abstract]
  • "A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells."
    Kim M.Y., Jeong B.C., Lee J.H., Kee H.J., Kook H., Kim N.S., Kim Y.H., Kim J.K., Ahn K.Y., Kim K.K.
    Proc. Natl. Acad. Sci. U.S.A. 103:13074-13079(2006) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cellular response to dexamethasone stimulus Source: RGDInferred from sequence orthologyⁱ
  • "Regulation of the expression of caspase-9 by the transcription factor activator protein-4 in glucocorticoid-induced apoptosis."
    Tsujimoto K., Ono T., Sato M., Nishida T., Oguma T., Tadakuma T.
    J. Biol. Chem. 280:27638-27644(2005) [PubMed] [Europe PMC] [Abstract]
• DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: RGDInferred from sequence orthologyⁱ
  • "AP4 encodes a c-MYC-inducible repressor of p21."
    Jung P., Menssen A., Mayr D., Hermeking H.
    Proc. Natl. Acad. Sci. U.S.A. 105:15046-15051(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation by host of viral transcription Source: RGDInferred from sequence orthologyⁱ
  • "A promoter within the E6 ORF of human papillomavirus type 16 contributes to the expression of the E7 oncoprotein from a monocistronic mRNA."
    Glahder J.A., Hansen C.N., Vinther J., Madsen B.S., Norrild B.
    J. Gen. Virol. 84:3429-3441(2003) [PubMed] [Europe PMC] [Abstract]
  • "Transcriptional repression of human immunodeficiency virus type 1 by AP-4."
    Imai K., Okamoto T.
    J. Biol. Chem. 281:12495-12505(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell cycle arrest Source: RGDInferred from sequence orthologyⁱ
  • "AP4 encodes a c-MYC-inducible repressor of p21."
    Jung P., Menssen A., Mayr D., Hermeking H.
    Proc. Natl. Acad. Sci. U.S.A. 105:15046-15051(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell population proliferation Source: RGDInferred from sequence orthologyⁱ
  • "AP4 encodes a c-MYC-inducible repressor of p21."
    Jung P., Menssen A., Mayr D., Hermeking H.
    Proc. Natl. Acad. Sci. U.S.A. 105:15046-15051(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: RGDInferred from sequence orthologyⁱ
  • "AP4 encodes a c-MYC-inducible repressor of p21."
    Jung P., Menssen A., Mayr D., Hermeking H.
    Proc. Natl. Acad. Sci. U.S.A. 105:15046-15051(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Transcriptional repression of human immunodeficiency virus type 1 by AP-4."
    Imai K., Okamoto T.
    J. Biol. Chem. 281:12495-12505(2006) [PubMed] [Europe PMC] [Abstract]
  • "Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function."
    Ou S.H., Garcia-Martinez L.F., Paulssen E.J., Gaynor R.B.
    J. Virol. 68:7188-7199(1994) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: RGDInferred from sequence orthologyⁱ
  • "A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells."
    Kim M.Y., Jeong B.C., Lee J.H., Kee H.J., Kook H., Kim N.S., Kim Y.H., Kim J.K., Ahn K.Y., Kim K.K.
    Proc. Natl. Acad. Sci. U.S.A. 103:13074-13079(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: RGDInferred from sequence orthologyⁱ
  • "A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells."
    Kim M.Y., Jeong B.C., Lee J.H., Kee H.J., Kook H., Kim N.S., Kim Y.H., Kim J.K., Ahn K.Y., Kim K.K.
    Proc. Natl. Acad. Sci. U.S.A. 103:13074-13079(2006) [PubMed] [Europe PMC] [Abstract]
  • "AP4 encodes a c-MYC-inducible repressor of p21."
    Jung P., Menssen A., Mayr D., Hermeking H.
    Proc. Natl. Acad. Sci. U.S.A. 105:15046-15051(2008) [PubMed] [Europe PMC] [Abstract]
  • "Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2."
    Ku W.C., Chiu S.K., Chen Y.J., Huang H.H., Wu W.G., Chen Y.J.
    Mol. Cell Proteomics 8:2034-2050(2009) [PubMed] [Europe PMC] [Abstract]
  • "Exon-I is involved in positive as well as negative regulation of human angiotensinogen gene expression."
    Cui Y., Narayanan C.S., Zhou J., Kumar A.
    Gene 224:97-107(1998) [PubMed] [Europe PMC] [Abstract]
• positive regulation by host of viral transcription Source: RGDInferred from sequence orthologyⁱ
  • "Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro."
    Mermod N., Williams T.J., Tjian R.
    Nature 332:557-561(1988) [PubMed] [Europe PMC] [Abstract]
• positive regulation of apoptotic process Source: RGDInferred from sequence orthologyⁱ
  • "AP4 encodes a c-MYC-inducible repressor of p21."
    Jung P., Menssen A., Mayr D., Hermeking H.
    Proc. Natl. Acad. Sci. U.S.A. 105:15046-15051(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Regulation of the expression of caspase-9 by the transcription factor activator protein-4 in glucocorticoid-induced apoptosis."
    Tsujimoto K., Ono T., Sato M., Nishida T., Oguma T., Tadakuma T.
    J. Biol. Chem. 280:27638-27644(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: RGDInferred from sequence orthologyⁱ
  • "Functional cooperation between multiple regulatory elements in the untranslated exon 1 stimulates the basal transcription of the human GnRH-II gene."
    Cheng C.K., Hoo R.L., Chow B.K., Leung P.C.
    Mol. Endocrinol. 17:1175-1191(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "Regulation of the expression of caspase-9 by the transcription factor activator protein-4 in glucocorticoid-induced apoptosis."
    Tsujimoto K., Ono T., Sato M., Nishida T., Oguma T., Tadakuma T.
    J. Biol. Chem. 280:27638-27644(2005) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex assembly Source: RGDInferred from sequence orthologyⁱ
  • "A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells."
    Kim M.Y., Jeong B.C., Lee J.H., Kee H.J., Kook H., Kim N.S., Kim Y.H., Kim J.K., Ahn K.Y., Kim K.K.
    Proc. Natl. Acad. Sci. U.S.A. 103:13074-13079(2006) [PubMed] [Europe PMC] [Abstract]
  • "Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2."
    Ku W.C., Chiu S.K., Chen Y.J., Huang H.H., Wu W.G., Chen Y.J.
    Mol. Cell Proteomics 8:2034-2050(2009) [PubMed] [Europe PMC] [Abstract]
• regulation of mitotic cell cycle phase transition Source: RGDInferred from sequence orthologyⁱ
  • "AP4 encodes a c-MYC-inducible repressor of p21."
    Jung P., Menssen A., Mayr D., Hermeking H.
    Proc. Natl. Acad. Sci. U.S.A. 105:15046-15051(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• histone deacetylase binding Source: RGDInferred from sequence orthologyⁱ
  • "Transcriptional repression of human immunodeficiency virus type 1 by AP-4."
    Imai K., Okamoto T.
    J. Biol. Chem. 281:12495-12505(2006) [PubMed] [Europe PMC] [Abstract]
  • "A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells."
    Kim M.Y., Jeong B.C., Lee J.H., Kee H.J., Kook H., Kim N.S., Kim Y.H., Kim J.K., Ahn K.Y., Kim K.K.
    Proc. Natl. Acad. Sci. U.S.A. 103:13074-13079(2006) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: RGDInferred from sequence orthologyⁱ
  • "Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity."
    Hu Y.-F., Luescher B., Admon A., Mermod N., Tjian R.
    Genes Dev. 4:1741-1752(1990) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MEYFMVPTQK VPSLQHFRKT EKEVIGGLCS LANIPLTPET QRDQERRIRR 
        60         70         80         90        100
EIANSNERRR MQSINAGFQS LKTLIPHTDG EKLSKAAILQ QTAEYIFSLE 
       110        120        130        140        150
QEKTRLLQQN TQLKRFIQEL SGSSPKRRRA EDKDEGIGSP DIWEDEKAED 
       160        170        180        190        200
LRREMIELRQ QLDKERSVRM MLEEQVRSLE AHMYPEKLKV IAQQVQLQQQ 
       210        220        230        240        250
QEQVRLLHQE KLEREQQHLR TQLLPPPAPT HHPTVIVPAP APPSSHHINV 
       260        270        280        290        300
VTMGPSSVIN SVSTSRQNLD TIVQAIQHIE GTQDRQELEE EQRRAVIVKS 
       310        320        330 
VRSCPEAHTS DTASDSEASD SDAMDQSREE PLGDGELP              

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ