Tfap4

Functionⁱ

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
E-box binding Source: Ensembl
histone deacetylase binding Source: Ensembl
protein homodimerization activity Source: Ensembl
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to dexamethasone stimulus Source: Ensembl
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: Ensembl
negative regulation by host of viral transcription Source: Ensembl
negative regulation of cell cycle arrest Source: Ensembl
negative regulation of cell proliferation Source: Ensembl
negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
negative regulation of DNA binding Source: Ensembl
negative regulation of transcription, DNA-templated Source: Ensembl
positive regulation by host of viral transcription Source: Ensembl
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: Ensembl
protein-containing complex assembly Source: Ensembl
regulation of mitotic cell cycle phase transition Source: Ensembl
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Transcription factor AP-4Imported Submitted name: Transcription factor AP4 (Predicted)Imported
Gene namesⁱ	Name:Tfap4Imported Synonyms:Tcfap4_predictedImported ORF Names:rCG_49828Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 10

Organism-specific databases

Rat genome database More...RGDⁱ	1308357 Tfap4

RGDⁱ

1308357 Tfap4

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Proteomic databases

PRIDEⁱ	D3ZJT6

PRIDEⁱ

D3ZJT6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000005227 Expressed in 9 organ(s), highest expression level in colon

Bgeeⁱ

ENSRNOG00000005227 Expressed in 9 organ(s), highest expression level in colon

Interactionⁱ

GO - Molecular functionⁱ

histone deacetylase binding Source: Ensembl
protein homodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000006979

STRINGⁱ

10116.ENSRNOP00000006979

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	48 – 99	BHLHInterPro annotationAdd BLAST		52

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	99 – 119	Sequence analysisAdd BLAST	21
Coiled coilⁱ	148 – 182	Sequence analysisAdd BLAST	35
Coiled coilⁱ	197 – 217	Sequence analysisAdd BLAST	21

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG0561 Eukaryota ENOG4111JPE LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015189
KEGG Orthology (KO) More...KOⁱ	K09108
OMAⁱ	HHVNVVT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G194I
TreeFamⁱ	TF316489

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

D3ZJT6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEYFMVPTQK VPSLQHFRKT EKEVIGGLCS LANIPLTPET QRDQERRIRR 
        60         70         80         90        100
EIANSNERRR MQSINAGFQS LKTLIPHTDG EKLSKAAILQ QTAEYIFSLE 
       110        120        130        140        150
QEKTRLLQQN TQLKRFIQEL SGSSPKRRRA EDKDEGIGSP DIWEDEKAED 
       160        170        180        190        200
LRREMIELRQ QLDKERSVRM MLEEQVRSLE AHMYPEKLKV IAQQVQLQQQ 
       210        220        230        240        250
QEQVRLLHQE KLEREQQHLR TQLLPPPAPT HHPTVIVPAP APPSSHHINV 
       260        270        280        290        300
VTMGPSSVIN SVSTSRQNLD TIVQAIQHIE GTQDRQELEE EQRRAVIVKS 
       310        320        330 
VRSCPEAHTS DTASDSEASD SDAMDQSREE PLGDGELP

Length:338

Mass (Da):38,769

Last modified:April 20, 2010 - v1

Checksum:ⁱ457D36FFBD2B4F2D

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07029167 Genomic DNA No translation available. AABR07029168 Genomic DNA No translation available. CH474017 Genomic DNA Translation: EDL96299.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001101737.1, NM_001108267.1
UniGeneⁱ	Rn.145139

Genome annotation databases

Ensemblⁱ	ENSRNOT00000006979; ENSRNOP00000006979; ENSRNOG00000005227
GeneIDⁱ	360482
KEGGⁱ	rno:360482
UCSC genome browser More...UCSCⁱ	RGD:1308357 rat

Protein	Similar proteins		Species	Score	Length	Source
D3ZJT6	Transcription factor AP-4		HUMAN		338	UniRef90_Q01664
Uncharacterized protein		MONDO		347
Uncharacterized protein		SARHA		346
transcription factor AP-4 isoform X1		BALAS		342
transcription factor AP-4 isoform X1		DELLE		342
+120

Protein	Similar proteins		Species	Score	Length	Source
D3ZJT6	Transcription factor AP-4		HUMAN		338	UniRef50_Q01664
Uncharacterized protein		MONDO		347
Uncharacterized protein		SARHA		346
transcription factor AP-4 isoform X1		BALAS		342
transcription factor AP-4 isoform X1		DELLE		342
+302

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07029167 Genomic DNA No translation available. AABR07029168 Genomic DNA No translation available. CH474017 Genomic DNA Translation: EDL96299.1
RefSeqⁱ	NP_001101737.1, NM_001108267.1
UniGeneⁱ	Rn.145139

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000006979

STRINGⁱ

10116.ENSRNOP00000006979

Proteomic databases

PRIDEⁱ	D3ZJT6

PRIDEⁱ

D3ZJT6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000006979; ENSRNOP00000006979; ENSRNOG00000005227
GeneIDⁱ	360482
KEGGⁱ	rno:360482
UCSCⁱ	RGD:1308357 rat

Organism-specific databases

CTDⁱ	7023
RGDⁱ	1308357 Tfap4

Phylogenomic databases

eggNOGⁱ	KOG0561 Eukaryota ENOG4111JPE LUCA
GeneTreeⁱ	ENSGT00390000015189
KOⁱ	K09108
OMAⁱ	HHVNVVT
OrthoDBⁱ	EOG091G194I
TreeFamⁱ	TF316489

Gene expression databases

Bgeeⁱ	ENSRNOG00000005227 Expressed in 9 organ(s), highest expression level in colon

Bgeeⁱ

ENSRNOG00000005227 Expressed in 9 organ(s), highest expression level in colon

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D3ZJT6_RAT
Accessionⁱ	D3ZJT6Primary (citable) accession number: D3ZJT6
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 20, 2010
	Last sequence update:	April 20, 2010
	Last modified:	November 7, 2018
	This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - D3ZJT6 (D3ZJT6_RAT)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Transcription factor AP-4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ