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Protein

Alpha-galactosidase

Gene

Gla

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • glycoside catabolic process Source: GO_Central
  • glycosylceramide catabolic process Source: GO_Central
  • oligosaccharide metabolic process Source: GO_Central

Keywordsi

Molecular functionGlycosidaseUniRule annotationSAAS annotation, Hydrolase

Enzyme and pathway databases

ReactomeiR-RNO-1660662 Glycosphingolipid metabolism
R-RNO-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-galactosidaseUniRule annotation (EC:3.2.1.-UniRule annotation)
Gene namesi
Name:GlaImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1589721 Gla

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4110

PTM / Processingi

Keywords - PTMi

Disulfide bondUniRule annotation

Proteomic databases

PaxDbiD3ZJF9
PeptideAtlasiD3ZJF9
PRIDEiD3ZJF9

Expressioni

Gene expression databases

BgeeiENSRNOG00000011513 Expressed in 9 organ(s), highest expression level in adult mammalian kidney
GenevisibleiD3ZJF9 RN

Interactioni

Subunit structurei

Homodimer.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015494

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini326 – 412Melibiase_2_CInterPro annotationAdd BLAST87

Sequence similaritiesi

Belongs to the glycosyl hydrolase 27 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2366 Eukaryota
ENOG410XPF1 LUCA
GeneTreeiENSGT00390000008751
InParanoidiD3ZJF9
OMAiLFMQMAE
OrthoDBiEOG091G0BGV
TreeFamiTF312909

Family and domain databases

CDDicd14792 GH27, 1 hit
Gene3Di2.60.40.1180, 1 hit
3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR002241 Glyco_hydro_27
IPR000111 Glyco_hydro_27/36_CS
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
IPR035373 Melibiase/NAGA_C
PANTHERiPTHR11452 PTHR11452, 1 hit
PfamiView protein in Pfam
PF16499 Melibiase_2, 1 hit
PF17450 Melibiase_2_C, 1 hit
PRINTSiPR00740 GLHYDRLASE27
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00512 ALPHA_GALACTOSIDASE, 1 hit

Sequencei

Sequence statusi: Complete.

D3ZJF9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMKLLSGDT PLVCELALRP LALVFWSILG ARALDNGLAR TPTMGWLHWE
60 70 80 90 100
RFMCNLDCQE EPDACISEQL FMQMAELMVS DGWRDAGYEY LCIDDCWMAP
110 120 130 140 150
ERDSKGRLQA DPKRFPSGIK HLANYVHSKG LKLGIYADVG KKTCAGFPGS
160 170 180 190 200
FGSYDIDAQT FADWGIDLLK FDGCHCDSVV SLANGYKYMS LALNRTGRSI
210 220 230 240 250
VYSCEWPLYL RPFHKPNYTD IQYYCNHWRN FDDVYDSWES IKSILAWTVT
260 270 280 290 300
HQKDIEVAGP GGWNDPDMLV IGNFGLSWDQ QVTQMALWAI MAAPLLMSND
310 320 330 340 350
LRQISSQAKA LLQNEDVIAI NQDPLGKQGY CFRKENEIEV WERPLSNLAW
360 370 380 390 400
AVAVRNLQEI GGPRFYTIQI SSLGRGLACN PGCIITQILP EKVHLGFYEW
410 420
PLTLKTRINP SGTVLLRLER
Length:420
Mass (Da):47,574
Last modified:April 3, 2013 - v2
Checksum:i91F183763EDC467F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07073538 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSRNOT00000015494; ENSRNOP00000015494; ENSRNOG00000011513
UCSCiRGD:1589721 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07073538 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015494

Chemistry databases

ChEMBLiCHEMBL4110

Proteomic databases

PaxDbiD3ZJF9
PeptideAtlasiD3ZJF9
PRIDEiD3ZJF9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015494; ENSRNOP00000015494; ENSRNOG00000011513
UCSCiRGD:1589721 rat

Organism-specific databases

RGDi1589721 Gla

Phylogenomic databases

eggNOGiKOG2366 Eukaryota
ENOG410XPF1 LUCA
GeneTreeiENSGT00390000008751
InParanoidiD3ZJF9
OMAiLFMQMAE
OrthoDBiEOG091G0BGV
TreeFamiTF312909

Enzyme and pathway databases

ReactomeiR-RNO-1660662 Glycosphingolipid metabolism
R-RNO-6798695 Neutrophil degranulation

Gene expression databases

BgeeiENSRNOG00000011513 Expressed in 9 organ(s), highest expression level in adult mammalian kidney
GenevisibleiD3ZJF9 RN

Family and domain databases

CDDicd14792 GH27, 1 hit
Gene3Di2.60.40.1180, 1 hit
3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR002241 Glyco_hydro_27
IPR000111 Glyco_hydro_27/36_CS
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
IPR035373 Melibiase/NAGA_C
PANTHERiPTHR11452 PTHR11452, 1 hit
PfamiView protein in Pfam
PF16499 Melibiase_2, 1 hit
PF17450 Melibiase_2_C, 1 hit
PRINTSiPR00740 GLHYDRLASE27
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00512 ALPHA_GALACTOSIDASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD3ZJF9_RAT
AccessioniPrimary (citable) accession number: D3ZJF9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 3, 2013
Last modified: November 7, 2018
This is version 75 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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