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UniProtKB - D3ZJ69 (D3ZJ69_RAT)
Protein
Submitted name:
Transcription factor AP-2 epsilon
Gene
Tfap2e
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: RGD
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- identical protein binding Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- anatomical structure development Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of cell population proliferation Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Enzyme and pathway databases
Reactomei | R-RNO-8866904, Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-RNO-8866907, Activation of the TFAP2 (AP-2) family of transcription factors |
Names & Taxonomyi
Protein namesi | Submitted name: Transcription factor AP-2 epsilon |
Gene namesi | Name:Tfap2eImported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1563297, Tfap2e |
Subcellular locationi
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000027595, Expressed in esophagus and 7 other tissues |
Genevisiblei | D3ZJ69, RN |
Interactioni
GO - Molecular functioni
- identical protein binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000032823 |
Structurei
3D structure databases
AlphaFoldDBi | D3ZJ69 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 218 – 410 | TF_AP-2InterPro annotationAdd BLAST | 193 |
Sequence similaritiesi
Belongs to the AP-2 family.ARBA annotation
Phylogenomic databases
eggNOGi | KOG3811, Eukaryota |
GeneTreei | ENSGT00950000182848 |
HOGENOMi | CLU_035175_4_1_1 |
InParanoidi | D3ZJ69 |
OMAi | QEAGYPH |
OrthoDBi | 641707at2759 |
PhylomeDBi | D3ZJ69 |
TreeFami | TF313718 |
Family and domain databases
InterProi | View protein in InterPro IPR004979, TF_AP2 IPR013854, TF_AP2_C |
PANTHERi | PTHR10812, PTHR10812, 1 hit |
Pfami | View protein in Pfam PF03299, TF_AP-2, 1 hit |
PRINTSi | PR01748, AP2TNSCPFCT |
i Sequence
Sequence statusi: Complete.
D3ZJ69-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLVHTYSAME RPDGLCAAAG GTRLSSLPQA AYGPAPPLCH TPAASATTDY
60 70 80 90 100
HPPYFPPPYP QAQLPYGQGP DAAAAFPHLA PDPYGGLAPL AQPQPPQAAW
110 120 130 140 150
AAPRAAARAH DEPPGLLAPP ARALGLDPRR DYAAAVPRLL HSLADGAHGL
160 170 180 190 200
ADAPLGLPGL AAPPGLEELQ AIDDPGMSLL DQSVIKKVPV PSKAGSLSTL
210 220 230 240 250
SLSKDSLVGG INNPSEVFCS VPGRLSLLSS TSKYKVTVGE VQRRLSPPEC
260 270 280 290 300
LNASLLGGVL RRAKSKNGGR CLRERLEKIG LNLPAGRRKA ANVTLLTSLV
310 320 330 340 350
EGEAVHLARD FGYVCETEFP AKAAAEYLGR QHADPGELHS RKSMLLAAKQ
360 370 380 390 400
ICKEFADLMA QDRSPLGNSR PALILEPGVQ SCLTHFSLIT HGFGGPAICA
410 420 430 440
ALTAFQNYLL ESLKGLDKMF LSSAGSGHGE TKASEKDAKH RK
Sequence databases
RefSeqi | NP_001178693.1, NM_001191764.1 |
Genome annotation databases
Ensembli | ENSRNOT00000038248.6; ENSRNOP00000032823.4; ENSRNOG00000027595.6 |
GeneIDi | 313596 |
KEGGi | rno:313596 |
UCSCi | RGD:1563297, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | NP_001178693.1, NM_001191764.1 |
3D structure databases
AlphaFoldDBi | D3ZJ69 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000032823 |
PTM databases
PhosphoSitePlusi | D3ZJ69 |
Proteomic databases
PaxDbi | D3ZJ69 |
Genome annotation databases
Ensembli | ENSRNOT00000038248.6; ENSRNOP00000032823.4; ENSRNOG00000027595.6 |
GeneIDi | 313596 |
KEGGi | rno:313596 |
UCSCi | RGD:1563297, rat |
Organism-specific databases
CTDi | 339488 |
RGDi | 1563297, Tfap2e |
Phylogenomic databases
eggNOGi | KOG3811, Eukaryota |
GeneTreei | ENSGT00950000182848 |
HOGENOMi | CLU_035175_4_1_1 |
InParanoidi | D3ZJ69 |
OMAi | QEAGYPH |
OrthoDBi | 641707at2759 |
PhylomeDBi | D3ZJ69 |
TreeFami | TF313718 |
Enzyme and pathway databases
Reactomei | R-RNO-8866904, Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-RNO-8866907, Activation of the TFAP2 (AP-2) family of transcription factors |
Gene expression databases
Bgeei | ENSRNOG00000027595, Expressed in esophagus and 7 other tissues |
Genevisiblei | D3ZJ69, RN |
Family and domain databases
InterProi | View protein in InterPro IPR004979, TF_AP2 IPR013854, TF_AP2_C |
PANTHERi | PTHR10812, PTHR10812, 1 hit |
Pfami | View protein in Pfam PF03299, TF_AP-2, 1 hit |
PRINTSi | PR01748, AP2TNSCPFCT |
MobiDBi | Search... |
Entry informationi
Entry namei | D3ZJ69_RAT | |
Accessioni | D3ZJ69Primary (citable) accession number: D3ZJ69 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | May 25, 2022 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |