Tfap2e

Functionⁱ

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein heterodimerization activity Source: Ensembl
protein homodimerization activity Source: Ensembl
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
RNA polymerase II regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-RNO-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-RNO-8866907 Activation of the TFAP2 (AP-2) family of transcription factors

Reactomeⁱ

R-RNO-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-RNO-8866907 Activation of the TFAP2 (AP-2) family of transcription factors

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Transcription factor AP-2 epsilonImported
Gene namesⁱ	Name:Tfap2eImported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 5

Organism-specific databases

Rat genome database More...RGDⁱ	1563297 Tfap2e

RGDⁱ

1563297 Tfap2e

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	D3ZJ69
PRIDEⁱ	D3ZJ69

PTM databases

PhosphoSitePlusⁱ	D3ZJ69

PhosphoSitePlusⁱ

D3ZJ69

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000027595 Expressed in 3 organ(s), highest expression level in testis
Genevisibleⁱ	D3ZJ69 RN

Interactionⁱ

GO - Molecular functionⁱ

protein heterodimerization activity Source: Ensembl
protein homodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000032823

STRINGⁱ

10116.ENSRNOP00000032823

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	218 – 411	TF_AP-2InterPro annotationAdd BLAST		194

Phylogenomic databases

eggNOGⁱ	KOG3811 Eukaryota ENOG410XR9E LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074577
InParanoidⁱ	D3ZJ69
KEGG Orthology (KO) More...KOⁱ	K09179
OMAⁱ	EYLCRQS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PR6
PhylomeDBⁱ	D3ZJ69
TreeFamⁱ	TF313718

Family and domain databases

InterProⁱ	View protein in InterPro IPR004979 TF_AP2 IPR013854 TF_AP2_C
PANTHERⁱ	PTHR10812 PTHR10812, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03299 TF_AP-2, 1 hit
PRINTSⁱ	PR01748 AP2TNSCPFCT

Sequenceⁱ

Sequence statusⁱ: Complete.

D3ZJ69-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLVHTYSAME RPDGLCAAAG GTRLSSLPQA AYGPAPPLCH TPAASATTDY 
        60         70         80         90        100
HPPYFPPPYP QAQLPYGQGP DAAAAFPHLA PDPYGGLAPL AQPQPPQAAW 
       110        120        130        140        150
AAPRAAARAH DEPPGLLAPP ARALGLDPRR DYAAAVPRLL HSLADGAHGL 
       160        170        180        190        200
ADAPLGLPGL AAPPGLEELQ AIDDPGMSLL DQSVIKKVPV PSKAGSLSTL 
       210        220        230        240        250
SLSKDSLVGG INNPSEVFCS VPGRLSLLSS TSKYKVTVGE VQRRLSPPEC 
       260        270        280        290        300
LNASLLGGVL RRAKSKNGGR CLRERLEKIG LNLPAGRRKA ANVTLLTSLV 
       310        320        330        340        350
EGEAVHLARD FGYVCETEFP AKAAAEYLGR QHADPGELHS RKSMLLAAKQ 
       360        370        380        390        400
ICKEFADLMA QDRSPLGNSR PALILEPGVQ SCLTHFSLIT HGFGGPAICA 
       410        420        430        440 
ALTAFQNYLL ESLKGLDKMF LSSAGSGHGE TKASEKDAKH RK

Length:442

Mass (Da):46,341

Last modified:April 20, 2010 - v1

Checksum:ⁱ4DD30D6DA89FEBCB

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07049914 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001178693.1, NM_001191764.1
UniGeneⁱ	Rn.231431

Genome annotation databases

Ensemblⁱ	ENSRNOT00000038248; ENSRNOP00000032823; ENSRNOG00000027595
GeneIDⁱ	313596
KEGGⁱ	rno:313596
UCSC genome browser More...UCSCⁱ	RGD:1563297 rat

Protein	Similar proteins		Species	Score	Length	Source
D3ZJ69	Transcription factor AP-2-epsilon		MOUSE		442	UniRef90_Q6VUP9
Transcription factor AP-2-epsilon		HUMAN		442
Transcription factor AP-2 epsilon		CHLSB		446
transcription factor AP-2-epsilon		NEOSC		443
Uncharacterized protein		Cebus capucinus imitator		443
+34

Protein	Similar proteins		Species	Score	Length	Source
D3ZJ69	Isoform 4 of Transcription factor AP-2-alpha		MOUSE		466	UniRef50_P34056-4
Transcription factor AP-2-epsilon		HUMAN		442
Transcription factor AP-2-alpha		SHEEP		491
Transcription factor AP-2-beta		CANLF		460
transcription factor AP-2-alpha isoform X6		NEOSC		576
+1028

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07049914 Genomic DNA No translation available.
RefSeqⁱ	NP_001178693.1, NM_001191764.1
UniGeneⁱ	Rn.231431

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000032823

STRINGⁱ

10116.ENSRNOP00000032823

PTM databases

PhosphoSitePlusⁱ	D3ZJ69

PhosphoSitePlusⁱ

D3ZJ69

Proteomic databases

PaxDbⁱ	D3ZJ69
PRIDEⁱ	D3ZJ69

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000038248; ENSRNOP00000032823; ENSRNOG00000027595
GeneIDⁱ	313596
KEGGⁱ	rno:313596
UCSCⁱ	RGD:1563297 rat

Organism-specific databases

CTDⁱ	339488
RGDⁱ	1563297 Tfap2e

Phylogenomic databases

eggNOGⁱ	KOG3811 Eukaryota ENOG410XR9E LUCA
GeneTreeⁱ	ENSGT00550000074577
InParanoidⁱ	D3ZJ69
KOⁱ	K09179
OMAⁱ	EYLCRQS
OrthoDBⁱ	EOG091G0PR6
PhylomeDBⁱ	D3ZJ69
TreeFamⁱ	TF313718

Enzyme and pathway databases

Reactomeⁱ	R-RNO-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-RNO-8866907 Activation of the TFAP2 (AP-2) family of transcription factors

Reactomeⁱ

R-RNO-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-RNO-8866907 Activation of the TFAP2 (AP-2) family of transcription factors

Gene expression databases

Bgeeⁱ	ENSRNOG00000027595 Expressed in 3 organ(s), highest expression level in testis
Genevisibleⁱ	D3ZJ69 RN

Family and domain databases

InterProⁱ	View protein in InterPro IPR004979 TF_AP2 IPR013854 TF_AP2_C
PANTHERⁱ	PTHR10812 PTHR10812, 1 hit
Pfamⁱ	View protein in Pfam PF03299 TF_AP-2, 1 hit
PRINTSⁱ	PR01748 AP2TNSCPFCT
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D3ZJ69_RAT
Accessionⁱ	D3ZJ69Primary (citable) accession number: D3ZJ69
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 20, 2010
	Last sequence update:	April 20, 2010
	Last modified:	November 7, 2018
	This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

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Supporting data

UniProtKB - D3ZJ69 (D3ZJ69_RAT)

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Transcription factor AP-2 epsilon

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ