Transcription factor AP-2 epsilon

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Cloning and characterization of the mouse AP-2 epsilon gene: a novel family member expressed in the developing olfactory bulb."
    Feng W., Williams T.
    Mol. Cell. Neurosci. 24:460-475(2003) [PubMed] [Europe PMC] [Abstract]
  • "Identification and embryonic expression of a new AP-2 transcription factor, AP-2 epsilon."
    Wang H.V., Vaupel K., Buettner R., Bosserhoff A.K., Moser M.
    Dev. Dyn. 231:128-135(2004) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • "Cloning and characterization of the mouse AP-2 epsilon gene: a novel family member expressed in the developing olfactory bulb."
    Feng W., Williams T.
    Mol. Cell. Neurosci. 24:460-475(2003) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: RGDInferred from sequence orthologyⁱ
  • "Cloning and characterization of the mouse AP-2 epsilon gene: a novel family member expressed in the developing olfactory bulb."
    Feng W., Williams T.
    Mol. Cell. Neurosci. 24:460-475(2003) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: RGDInferred from sequence orthologyⁱ
  • "Cloning and characterization of the mouse AP-2 epsilon gene: a novel family member expressed in the developing olfactory bulb."
    Feng W., Williams T.
    Mol. Cell. Neurosci. 24:460-475(2003) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Cloning and characterization of the mouse AP-2 epsilon gene: a novel family member expressed in the developing olfactory bulb."
    Feng W., Williams T.
    Mol. Cell. Neurosci. 24:460-475(2003) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• positive regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "Cloning and characterization of the mouse AP-2 epsilon gene: a novel family member expressed in the developing olfactory bulb."
    Feng W., Williams T.
    Mol. Cell. Neurosci. 24:460-475(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of cell population proliferation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• protein heterodimerization activity Source: RGDInferred from sequence orthologyⁱ
  • "Cloning and characterization of the mouse AP-2 epsilon gene: a novel family member expressed in the developing olfactory bulb."
    Feng W., Williams T.
    Mol. Cell. Neurosci. 24:460-475(2003) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: RGDInferred from sequence orthologyⁱ
  • "Cloning and characterization of the mouse AP-2 epsilon gene: a novel family member expressed in the developing olfactory bulb."
    Feng W., Williams T.
    Mol. Cell. Neurosci. 24:460-475(2003) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MLVHTYSAME RPDGLCAAAG GTRLSSLPQA AYGPAPPLCH TPAASATTDY 
        60         70         80         90        100
HPPYFPPPYP QAQLPYGQGP DAAAAFPHLA PDPYGGLAPL AQPQPPQAAW 
       110        120        130        140        150
AAPRAAARAH DEPPGLLAPP ARALGLDPRR DYAAAVPRLL HSLADGAHGL 
       160        170        180        190        200
ADAPLGLPGL AAPPGLEELQ AIDDPGMSLL DQSVIKKVPV PSKAGSLSTL 
       210        220        230        240        250
SLSKDSLVGG INNPSEVFCS VPGRLSLLSS TSKYKVTVGE VQRRLSPPEC 
       260        270        280        290        300
LNASLLGGVL RRAKSKNGGR CLRERLEKIG LNLPAGRRKA ANVTLLTSLV 
       310        320        330        340        350
EGEAVHLARD FGYVCETEFP AKAAAEYLGR QHADPGELHS RKSMLLAAKQ 
       360        370        380        390        400
ICKEFADLMA QDRSPLGNSR PALILEPGVQ SCLTHFSLIT HGFGGPAICA 
       410        420        430        440 
ALTAFQNYLL ESLKGLDKMF LSSAGSGHGE TKASEKDAKH RK         

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ