UniProtKB - D3ZJ08 (D3ZJ08_RAT)
Protein
Histone H3
Gene
Hist2h3c2
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- chromatin binding Source: Ensembl
- DNA binding Source: InterPro
- protein domain specific binding Source: RGD
- protein heterodimerization activity Source: InterPro
GO - Biological processi
- DNA replication-dependent nucleosome assembly Source: RGD
- DNA replication-independent nucleosome assembly Source: RGD
- negative regulation of megakaryocyte differentiation Source: RGD
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- nucleosome assembly Source: RGD
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
Reactomei | R-RNO-1266695, Interleukin-7 signaling R-RNO-201722, Formation of the beta-catenin:TCF transactivating complex R-RNO-212300, PRC2 methylates histones and DNA R-RNO-2299718, Condensation of Prophase Chromosomes R-RNO-2559580, Oxidative Stress Induced Senescence R-RNO-2559582, Senescence-Associated Secretory Phenotype (SASP) R-RNO-3214841, PKMTs methylate histone lysines R-RNO-3214842, HDMs demethylate histones R-RNO-3214847, HATs acetylate histones R-RNO-3214858, RMTs methylate histone arginines R-RNO-3247509, Chromatin modifying enzymes R-RNO-427359, SIRT1 negatively regulates rRNA expression R-RNO-427413, NoRC negatively regulates rRNA expression R-RNO-5250924, B-WICH complex positively regulates rRNA expression R-RNO-5578749, Transcriptional regulation by small RNAs R-RNO-5625886, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-RNO-73728, RNA Polymerase I Promoter Opening R-RNO-73772, RNA Polymerase I Promoter Escape R-RNO-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-RNO-9018519, Estrogen-dependent gene expression R-RNO-983231, Factors involved in megakaryocyte development and platelet production |
Names & Taxonomyi
Protein namesi | Recommended name: Histone H3UniRule annotation |
Gene namesi | Name:Hist2h3c2Imported Synonyms:Hist1h3aImported, Hist1h3cImported, Hist1h3fImported, LOC102548682Imported, LOC102549173Imported, LOC684762Imported, LOC684819Imported, LOC684841Imported, LOC690126Imported ORF Names:rCG_45187Imported, rCG_45215Imported, rCG_51970Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1306445, Hist2h3c2 7725170, LOC102548682 7709329, LOC102549173 1586732, LOC684762 |
Subcellular locationi
Nucleus
- nuclear chromosome Source: RGD
- nuclear nucleosome Source: RGD
- nucleus Source: RGD
Other locations
- nucleosome Source: RGD
- protein-containing complex Source: RGD
Keywords - Cellular componenti
Chromosome, Nucleosome coreUniRule annotation, NucleusUniRule annotationPTM / Processingi
Keywords - PTMi
ADP-ribosylationARBA annotation, MethylationARBA annotationProteomic databases
PRIDEi | D3ZJ08 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000028975, Expressed in thymus and 17 other tissues |
Interactioni
Subunit structurei
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
UniRule annotationGO - Molecular functioni
- protein domain specific binding Source: RGD
- protein heterodimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000067675 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 132 | HistoneInterPro annotationAdd BLAST | 132 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 43 | DisorderedSequence analysisAdd BLAST | 43 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1745, Eukaryota |
GeneTreei | ENSGT01010000222250 |
HOGENOMi | CLU_078295_4_0_1 |
OMAi | FTTQMAR |
OrthoDBi | 1564596at2759 |
TreeFami | TF314241 |
Family and domain databases
Gene3Di | 1.10.20.10, 1 hit |
InterProi | View protein in InterPro IPR009072, Histone-fold IPR007125, Histone_H2A/H2B/H3 IPR000164, Histone_H3/CENP-A |
PANTHERi | PTHR11426, PTHR11426, 1 hit |
Pfami | View protein in Pfam PF00125, Histone, 1 hit |
PRINTSi | PR00622, HISTONEH3 |
SMARTi | View protein in SMART SM00428, H3, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit |
PROSITEi | View protein in PROSITE PS00322, HISTONE_H3_1, 1 hit PS00959, HISTONE_H3_2, 1 hit |
i Sequence
Sequence statusi: Complete.
D3ZJ08-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARTKQTARK STGGKAPRKQ LATKAARKSA PATGGVKKPH RYRPGTVALR
60 70 80 90 100
EIRRYQKSTE LLIRKLPFQR LVREIAQDFK TDLRFQSSAV MALQEASEAY
110 120 130
LVGLFEDTNL CAIHAKRVTI MPKDIQLARR IRGERA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07012582 Genomic DNA No translation available. AABR07012583 Genomic DNA No translation available. AABR07027752 Genomic DNA No translation available. AABR07027753 Genomic DNA No translation available. AC130391 Genomic DNA No translation available. CH474015 Genomic DNA Translation: EDL85636.1 CH474064 Genomic DNA Translation: EDL86583.1 CH474064 Genomic DNA Translation: EDL86588.1 |
RefSeqi | NP_001101168.1, NM_001107698.1 XP_006222460.2, XM_006222398.2 XP_006254041.2, XM_006253979.2 XP_008769899.1, XM_008771677.2 XP_008772193.1, XM_008773971.2 XP_017443211.1, XM_017587722.1 XP_017456207.1, XM_017600718.1 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07012582 Genomic DNA No translation available. AABR07012583 Genomic DNA No translation available. AABR07027752 Genomic DNA No translation available. AABR07027753 Genomic DNA No translation available. AC130391 Genomic DNA No translation available. CH474015 Genomic DNA Translation: EDL85636.1 CH474064 Genomic DNA Translation: EDL86583.1 CH474064 Genomic DNA Translation: EDL86588.1 |
RefSeqi | NP_001101168.1, NM_001107698.1 XP_006222460.2, XM_006222398.2 XP_006254041.2, XM_006253979.2 XP_008769899.1, XM_008771677.2 XP_008772193.1, XM_008773971.2 XP_017443211.1, XM_017587722.1 XP_017456207.1, XM_017600718.1 |
3D structure databases
SMRi | D3ZJ08 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000067675 |
Proteomic databases
PRIDEi | D3ZJ08 |
Genome annotation databases
Organism-specific databases
CTDi | 310678 653604 |
RGDi | 1306445, Hist2h3c2 7725170, LOC102548682 7709329, LOC102549173 1586732, LOC684762 |
Phylogenomic databases
eggNOGi | KOG1745, Eukaryota |
GeneTreei | ENSGT01010000222250 |
HOGENOMi | CLU_078295_4_0_1 |
OMAi | FTTQMAR |
OrthoDBi | 1564596at2759 |
TreeFami | TF314241 |
Enzyme and pathway databases
Reactomei | R-RNO-1266695, Interleukin-7 signaling R-RNO-201722, Formation of the beta-catenin:TCF transactivating complex R-RNO-212300, PRC2 methylates histones and DNA R-RNO-2299718, Condensation of Prophase Chromosomes R-RNO-2559580, Oxidative Stress Induced Senescence R-RNO-2559582, Senescence-Associated Secretory Phenotype (SASP) R-RNO-3214841, PKMTs methylate histone lysines R-RNO-3214842, HDMs demethylate histones R-RNO-3214847, HATs acetylate histones R-RNO-3214858, RMTs methylate histone arginines R-RNO-3247509, Chromatin modifying enzymes R-RNO-427359, SIRT1 negatively regulates rRNA expression R-RNO-427413, NoRC negatively regulates rRNA expression R-RNO-5250924, B-WICH complex positively regulates rRNA expression R-RNO-5578749, Transcriptional regulation by small RNAs R-RNO-5625886, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-RNO-73728, RNA Polymerase I Promoter Opening R-RNO-73772, RNA Polymerase I Promoter Escape R-RNO-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-RNO-9018519, Estrogen-dependent gene expression R-RNO-983231, Factors involved in megakaryocyte development and platelet production |
Gene expression databases
Bgeei | ENSRNOG00000028975, Expressed in thymus and 17 other tissues |
Family and domain databases
Gene3Di | 1.10.20.10, 1 hit |
InterProi | View protein in InterPro IPR009072, Histone-fold IPR007125, Histone_H2A/H2B/H3 IPR000164, Histone_H3/CENP-A |
PANTHERi | PTHR11426, PTHR11426, 1 hit |
Pfami | View protein in Pfam PF00125, Histone, 1 hit |
PRINTSi | PR00622, HISTONEH3 |
SMARTi | View protein in SMART SM00428, H3, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit |
PROSITEi | View protein in PROSITE PS00322, HISTONE_H3_1, 1 hit PS00959, HISTONE_H3_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D3ZJ08_RAT | |
Accessioni | D3ZJ08Primary (citable) accession number: D3ZJ08 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | February 10, 2021 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |